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Book ; Thesis: Role of the integrin inhibitor SHARPIN in angiogenesis

Bonini, Francesca

2019

Institution	Goethe-Universität Frankfurt am Main
Author's details	vorgelegt von Francesca Bonini M.Sc
Language	English
Size	123 Seiten, Illustrationen, Diagramme, 21 cm
Publishing place	Frankfurt am Main
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Dissertation, Johann Wolfgang Goethe-Universität Frankfurt am Main, 2020
Note	Zusammenfassung auf Deutsch und Englisch ; Literaturverzeichnis: Seite 102-115
HBZ-ID	HT020881816
Database	Catalogue ZB MED Medicine, Health

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Article: The landscape of drug resistant absence seizures in adolescents and adults: Pathophysiology, electroclinical spectrum and treatment options.

Daquin, G / Bonini, F

Revue neurologique

2024 Volume 180, Issue 4, Page(s) 256–270

Abstract: The persistence of typical absence seizures (AS) in adolescence and adulthood may reduce the quality of life of patients with genetic generalized epilepsies (GGEs). The prevalence of drug resistant AS is probably underestimated in this patient population, ...

Abstract	The persistence of typical absence seizures (AS) in adolescence and adulthood may reduce the quality of life of patients with genetic generalized epilepsies (GGEs). The prevalence of drug resistant AS is probably underestimated in this patient population, and treatment options are relatively scarce. Similarly, atypical absence seizures in developmental and epileptic encephalopathies (DEEs) may be unrecognized, and often persist into adulthood despite improvement of more severe seizures. These two seemingly distant conditions, represented by typical AS in GGE and atypical AS in DEE, share at least partially overlapping pathophysiological and genetic mechanisms, which may be the target of drug and neurostimulation therapies. In addition, some patients with drug-resistant typical AS may present electroclinical features that lie in between the two extremes represented by these generalized forms of epilepsy.
MeSH term(s)	Humans ; Epilepsy, Absence/therapy ; Epilepsy, Absence/physiopathology ; Epilepsy, Absence/drug therapy ; Epilepsy, Absence/epidemiology ; Epilepsy, Absence/diagnosis ; Adult ; Adolescent ; Drug Resistant Epilepsy/therapy ; Drug Resistant Epilepsy/physiopathology ; Drug Resistant Epilepsy/epidemiology ; Drug Resistant Epilepsy/diagnosis ; Electroencephalography ; Anticonvulsants/therapeutic use ; Seizures/therapy ; Seizures/epidemiology ; Seizures/diagnosis ; Seizures/etiology ; Young Adult
Chemical Substances	Anticonvulsants
Language	English
Publishing date	2024-02-26
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	4593-7
ISSN	2213-0004 ; 0035-3787
ISSN (online)	2213-0004
ISSN	0035-3787
DOI	10.1016/j.neurol.2023.11.010
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Article ; Online: "To learn by making mistakes": the analysis of the dark periods of Laboratory Medicine as a tool for planning the future.

Bonini, Fabio

Diagnosis (Berlin, Germany)

2018 Volume 5, Issue 2, Page(s) 35–37

MeSH term(s)	Clinical Laboratory Techniques ; Decision Making ; Forecasting ; Humans ; Laboratories ; Learning ; Medical Errors ; Medicine ; Planning Techniques ; Surveys and Questionnaires ; United States
Language	English
Publishing date	2018-05-29
Publishing country	Germany
Document type	Editorial ; Comment
ISSN	2194-802X
ISSN (online)	2194-802X
DOI	10.1515/dx-2018-0028
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Article: Sleep and epilepsy: A clinical and pathophysiological overview.

El Youssef, N / Marchi, A / Bartolomei, F / Bonini, F / Lambert, I

Revue neurologique

2023 Volume 179, Issue 7, Page(s) 687–702

Abstract: The interaction between sleep and epilepsy is complex. A better understanding of the mechanisms linking sleep and epilepsy appears increasingly important as it may improve diagnosis and therapeutic strategies in patients with epilepsy. In this narrative ... ...

Abstract	The interaction between sleep and epilepsy is complex. A better understanding of the mechanisms linking sleep and epilepsy appears increasingly important as it may improve diagnosis and therapeutic strategies in patients with epilepsy. In this narrative review, we aim to (i) provide an overview of the physiological and pathophysiological processes linking sleep and epilepsy; (ii) present common sleep disorders in patients with epilepsy; (iii) discuss how sleep and sleep disorders should be considered in new therapeutic approaches to epilepsy such as neurostimulation; and (iv) present the overall nocturnal manifestations and differential diagnosis between epileptic seizures and parasomnia.
MeSH term(s)	Humans ; Electroencephalography ; Sleep/physiology ; Epilepsy/complications ; Epilepsy/diagnosis ; Epilepsy/epidemiology ; Parasomnias/diagnosis ; Parasomnias/epidemiology ; Parasomnias/etiology ; Sleep Wake Disorders/diagnosis ; Sleep Wake Disorders/epidemiology ; Sleep Wake Disorders/etiology
Language	English
Publishing date	2023-08-17
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	4593-7
ISSN	2213-0004 ; 0035-3787
ISSN (online)	2213-0004
ISSN	0035-3787
DOI	10.1016/j.neurol.2023.07.006
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Article ; Online: New and emerging drugs for the treatment of advanced cutaneous squamous cell carcinoma.

Bonini, Flavia / de Sousa, Luana Guimarães / Ferrarotto, Renata

Expert opinion on emerging drugs

2023 Volume 28, Issue 2, Page(s) 97–106

Abstract: Introduction: Cutaneous squamous cell carcinoma (CSCC) is the second most common form of human cancer. Treatment of locally advanced and/or recurrent CSCC is often challenging. A subset of patients are not candidates for curative-intent therapies due to ...

Abstract	Introduction: Cutaneous squamous cell carcinoma (CSCC) is the second most common form of human cancer. Treatment of locally advanced and/or recurrent CSCC is often challenging. A subset of patients are not candidates for curative-intent therapies due to extent of loco-regional disease, refractoriness to prior local therapy, or presence of distant metastasis. Areas covered: Traditionally, CSCC has been treated with surgery and/or radiotherapy, but in some instances, local therapies can lead to significant functional morbidity or are no longer feasible. Until 2018, systemic therapy options to treat patients with advanced CSCC were limited. Recently, clinical studies have shown activity of Immune Checkpoint Inhibitors (ICI) in patients with advanced CSCC. This article reviews the current systemic therapy options for CSCC with a focus on ICI and emerging promising therapies in the treatment of this challenging disease. Expert opinion: ICI is currently the most effective and tolerable systemic therapy in the treatment of non-immunosuppressed advanced CSCC and can lead to cure in a subset of patients. Combinatorial therapies to overcome resistance to ICI may further increase the proportion of patients who will benefit from ICI and may help improve the quantity and quality of life of patients affected by this disease.
MeSH term(s)	Humans ; Carcinoma, Squamous Cell/drug therapy ; Skin Neoplasms/drug therapy ; Skin Neoplasms/pathology ; Quality of Life
Language	English
Publishing date	2023-06-23
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	2061369-6
ISSN	1744-7623 ; 1472-8214
ISSN (online)	1744-7623
ISSN	1472-8214
DOI	10.1080/14728214.2023.2208345
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Article ; Online: Robotic monitoring of grasslands: a dataset from the EU Natura2000 habitat 6210* in the central Apennines (Italy).

Angelini, Franco / Pollayil, Mathew J / Bonini, Federica / Gigante, Daniela / Garabini, Manolo

Scientific data

2023 Volume 10, Issue 1, Page(s) 418

Abstract: Despite the remarkable growth of the global market for robotics, robotic monitoring of habitats is still an understudied topic. This is true, among others, for the species-rich EU Annex I habitat "6210 - Semi-natural grasslands and scrubland facies on ... ...

Abstract	Despite the remarkable growth of the global market for robotics, robotic monitoring of habitats is still an understudied topic. This is true, among others, for the species-rich EU Annex I habitat "6210 - Semi-natural grasslands and scrubland facies on calcareous substrates". This habitat is typically surveyed by human operators. In this work, we present a dataset concerning relevés performed through the quadrupedal robot ANYmal C. The dataset contains information from three plots, which include the robot state, videos, and images acquired to assess the habitat conservation status. Additionally, a collection of videos and pictures about two typical and one early warning species of habitat 6210 is also presented. This database is publicly available in the provided Zenodo repository and will aid researchers in several fields. Robot state information can be used by engineers to validate their algorithms, while data gathered by the robot can be used to design new methodologies and new metrics to assess the habitat conservation status or train/test classifiers (e.g. neural networks) for plant classification.
Language	English
Publishing date	2023-06-27
Publishing country	England
Document type	Dataset ; Journal Article
ZDB-ID	2775191-0
ISSN	2052-4463 ; 2052-4463
ISSN (online)	2052-4463
ISSN	2052-4463
DOI	10.1038/s41597-023-02312-x
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Article ; Online: Leveraging Google Earth Engine for a More Effective Grassland Management: A Decision Support Application Perspective.

Parracciani, Cecilia / Gigante, Daniela / Bonini, Federica / Grassi, Anna / Morbidini, Luciano / Pauselli, Mariano / Valenti, Bernardo / Lilli, Emanuele / Antonielli, Francesco / Vizzari, Marco

Sensors (Basel, Switzerland)

2024 Volume 24, Issue 3

Abstract: Grasslands cover a substantial portion of the earth's surface and agricultural land and is crucial for human well-being and livestock farming. Ranchers and grassland management authorities face challenges in effectively controlling herders' grazing ... ...

Abstract	Grasslands cover a substantial portion of the earth's surface and agricultural land and is crucial for human well-being and livestock farming. Ranchers and grassland management authorities face challenges in effectively controlling herders' grazing behavior and grassland utilization due to underdeveloped infrastructure and poor communication in pastoral areas. Cloud-based grazing management and decision support systems (DSS) are needed to address this issue, promote sustainable grassland use, and preserve their ecosystem services. These systems should enable rapid and large-scale grassland growth and utilization monitoring, providing a basis for decision-making in managing grazing and grassland areas. In this context, this study contributes to the objectives of the EU LIFE IMAGINE project, aiming to develop a Web-GIS app for conserving and monitoring Umbria's grasslands and promoting more informed decisions for more sustainable livestock management. The app, called "Praterie" and developed in Google Earth Engine, utilizes historical Sentinel-2 satellite data and harmonic modeling of the EVI (Enhanced Vegetation Index) to estimate vegetation growth curves and maturity periods for the forthcoming vegetation cycle. The app is updated in quasi-real time and enables users to visualize estimates for the upcoming vegetation cycle, including the maximum greenness, the days remaining to the subsequent maturity period, the accuracy of the harmonic models, and the grassland greenness status in the previous 10 days. Even though future additional developments can improve the informative value of the Praterie app, this platform can contribute to optimizing livestock management and biodiversity conservation by providing timely and accurate data about grassland status and growth curves.
MeSH term(s)	Animals ; Humans ; Ecosystem ; Grassland ; Search Engine ; Biodiversity ; Agriculture ; Livestock
Language	English
Publishing date	2024-01-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s24030834
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Article: Designing Organoid Models to Monitor Cancer Progression, Plasticity and Resistance: The Right Set Up for the Right Question.

Doffe, Flora / Bonini, Fabien / Lakis, Emile / Terry, Stéphane / Chouaib, Salem / Savagner, Pierre

Cancers

2022 Volume 14, Issue 15

Abstract: The recent trend in 3D cell modeling has fostered the emergence of a wide range of models, addressing very distinct goals ranging from the fundamental exploration of cell-cell interactions to preclinical assays for personalized medicine. It is clear that ...

Abstract	The recent trend in 3D cell modeling has fostered the emergence of a wide range of models, addressing very distinct goals ranging from the fundamental exploration of cell-cell interactions to preclinical assays for personalized medicine. It is clear that no single model will recapitulate the complexity and dynamics of in vivo situations. The key is to define the critical points, achieve a specific goal and design a model where they can be validated. In this report, we focused on cancer progression. We describe our model which is designed to emulate breast carcinoma progression during the invasive phase. We chose to provide topological clues to the target cells by growing them on microsupports, favoring a polarized epithelial organization before they are embedded in a 3D matrix. We then watched for cell organization and differentiation for these models, adding stroma cells then immune cells to follow and quantify cell responses to drug treatment, including quantifying cell death and viability, as well as morphogenic and invasive properties. We used model cell lines including Comma Dβ, MCF7 and MCF10A mammary epithelial cells as well as primary breast cancer cells from patient-derived xenografts (PDX). We found that fibroblasts impacted cell response to Docetaxel and Palbociclib. We also found that NK92 immune cells could target breast cancer cells within the 3D configuration, providing quantitative monitoring of cell cytotoxicity. We also tested several sources for the extracellular matrix and selected a hyaluronan-based matrix as a promising alternative to mouse tumor basement membrane extracts for primary human cancer cells. Overall, we validated a new 3D model designed for breast cancer for preclinical use in personalized medicine.
Language	English
Publishing date	2022-07-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14153559
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Article ; Online: Spontaneous fast-ultradian dynamics of polymorphic interictal events in drug-resistant focal epilepsy.

Dellavale, Damián / Bonini, Francesca / Pizzo, Francesca / Makhalova, Julia / Wendling, Fabrice / Badier, Jean-Michel / Bartolomei, Fabrice / Bénar, Christian-George

Epilepsia

2023 Volume 64, Issue 8, Page(s) 2027–2043

Abstract: Objective: We studied the rate dynamics of interictal events occurring over fast-ultradian time scales, as commonly examined in clinics to guide surgical planning in epilepsy.: Methods: Stereo-electroencephalography (SEEG) traces of 35 patients with ... ...

Abstract	Objective: We studied the rate dynamics of interictal events occurring over fast-ultradian time scales, as commonly examined in clinics to guide surgical planning in epilepsy. Methods: Stereo-electroencephalography (SEEG) traces of 35 patients with good surgical outcome (Engel I) were analyzed. For this we developed a general data mining method aimed at clustering the plethora of transient waveform shapes including interictal epileptiform discharges (IEDs) and assessed the temporal fluctuations in the capability of mapping the epileptogenic zone (EZ) of each type of event. Results: We found that the fast-ultradian dynamics of the IED rate may effectively impair the precision of EZ identification, and appear to occur spontaneously, that is, not triggered by or exclusively associated with a particular cognitive task, wakefulness, sleep, seizure occurrence, post-ictal state, or antiepileptic drug withdrawal. Propagation of IEDs from the EZ to the propagation zone (PZ) could explain the observed fast-ultradian fluctuations in a reduced fraction of the analyzed patients, suggesting that other factors like the excitability of the epileptogenic tissue could play a more relevant role. A novel link was found between the fast-ultradian dynamics of the overall rate of polymorphic events and the rate of specific IEDs subtypes. We exploited this feature to estimate in each patient the 5 min interictal epoch for near-optimal EZ and resected-zone (RZ) localization. This approach produces at the population level a better EZ/RZ classification when compared to both (1) the whole time series available in each patient (p = .084 for EZ, p < .001 for RZ, Wilcoxon signed-rank test) and (2) 5 min epochs sampled randomly from the interictal recordings of each patient (p < .05 for EZ, p < .001 for RZ, 10 Significance: Our results highlight the relevance of the fast-ultradian IED dynamics in mapping the EZ, and show how this dynamics can be estimated prospectively to inform surgical planning in epilepsy.
MeSH term(s)	Humans ; Drug Resistant Epilepsy/surgery ; Seizures ; Epilepsy/surgery ; Electroencephalography/methods ; Epilepsies, Partial/surgery
Language	English
Publishing date	2023-06-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	216382-2
ISSN	1528-1167 ; 0013-9580
ISSN (online)	1528-1167
ISSN	0013-9580
DOI	10.1111/epi.17655
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Article ; Online: Pseudomonas aeruginosa

Gdaniec, Bartosz Gerard / Bonini, Fabien / Prodon, François / Braschler, Thomas / Köhler, Thilo / van Delden, Christian

iScience

2021 Volume 25, Issue 1, Page(s) 103669

Abstract: Efficient delivery of toxic compounds to bacterial competitors is essential during interspecies microbial warfare. Rhamnolipids (RLPs) are glycolipids produced ... ...

Abstract	Efficient delivery of toxic compounds to bacterial competitors is essential during interspecies microbial warfare. Rhamnolipids (RLPs) are glycolipids produced by
Language	English
Publishing date	2021-12-20
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2021.103669
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