LIVIVO - Search results -

Search results

Result 1 - 10 of total 20

Search options

Article: Melatonin as a Mediator of the Gut Microbiota-Host Interaction: Implications for Health and Disease.

Bonmatí-Carrión, María-Ángeles / Rol, Maria-Angeles

2023 Volume 13, Issue 1

Abstract: In recent years, the role played by melatonin on the gut microbiota has gained increasingly greater attention. Additionally, the gut microbiota has been proposed as an alternative source of melatonin, suggesting that this antioxidant indoleamine could ... ...

Abstract	In recent years, the role played by melatonin on the gut microbiota has gained increasingly greater attention. Additionally, the gut microbiota has been proposed as an alternative source of melatonin, suggesting that this antioxidant indoleamine could act as a sort of messenger between the gut microbiota and the host. This review analyses the available scientific literature about possible mechanisms involved in this mediating role, highlighting its antioxidant effects and influence on this interaction. In addition, we also review the available knowledge on the effects of melatonin on gut microbiota composition, as well as its ability to alleviate dysbiosis related to sleep deprivation or chronodisruptive conditions. The melatonin-gut microbiota relationship has also been discussed in terms of its role in the development of different disorders, from inflammatory or metabolic disorders to psychiatric and neurological conditions, also considering oxidative stress and the reactive oxygen species-scavenging properties of melatonin as the main factors mediating this relationship.
Language	English
Publishing date	2023-12-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox13010034
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Extensive dynamic changes in the human transcriptome and its circadian organization during prolonged bed rest.

Archer, Simon N / Möller-Levet, Carla / Bonmatí-Carrión, María-Ángeles / Laing, Emma E / Dijk, Derk-Jan

iScience

2024 Volume 27, Issue 3, Page(s) 109331

Abstract: Physiological and molecular processes including the transcriptome change across the 24-h day, driven by molecular circadian clocks and behavioral and systemic factors. It is not known how the temporal organization of the human transcriptome responds to a ...

Abstract	Physiological and molecular processes including the transcriptome change across the 24-h day, driven by molecular circadian clocks and behavioral and systemic factors. It is not known how the temporal organization of the human transcriptome responds to a long-lasting challenge. This may, however, provide insights into adaptation, disease, and recovery. We investigated the human 24-h time series transcriptome in 20 individuals during a 90-day constant bed rest protocol. We show that the protocol affected 91% of the transcriptome with 76% of the transcriptome still affected after 10 days of recovery. Dimensionality-reduction approaches revealed that many affected transcripts were associated with mRNA translation and immune function. The number, amplitude, and phase of rhythmic transcripts, including clock genes, varied significantly across the challenge. These findings of long-lasting changes in the temporal organization of the transcriptome have implications for understanding the mechanisms underlying health consequences of conditions such as microgravity and bed rest.
Language	English
Publishing date	2024-02-22
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2024.109331
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Melatonin and Cancer: A Polyhedral Network Where the Source Matters

Bonmati-Carrion, Maria-Angeles / Tomas-Loba, Antonia

Antioxidants. 2021 Feb. 01, v. 10, no. 2

2021

Abstract: Melatonin is one of the most phylogenetically conserved signals in biology. Although its original function was probably related to its antioxidant capacity, this indoleamine has been “adopted” by multicellular organisms as the “darkness signal” when ... ...

Abstract	Melatonin is one of the most phylogenetically conserved signals in biology. Although its original function was probably related to its antioxidant capacity, this indoleamine has been “adopted” by multicellular organisms as the “darkness signal” when secreted in a circadian manner and is acutely suppressed by light at night by the pineal gland. However, melatonin is also produced by other tissues, which constitute its extrapineal sources. Apart from its undisputed chronobiotic function, melatonin exerts antioxidant, immunomodulatory, pro-apoptotic, antiproliferative, and anti-angiogenic effects, with all these properties making it a powerful antitumor agent. Indeed, this activity has been demonstrated to be mediated by interfering with various cancer hallmarks, and different epidemiological studies have also linked light at night (melatonin suppression) with a higher incidence of different types of cancer. In 2007, the World Health Organization classified night shift work as a probable carcinogen due to circadian disruption, where melatonin plays a central role. Our aim is to review, from a global perspective, the role of melatonin both from pineal and extrapineal origin, as well as their possible interplay, as an intrinsic factor in the incidence, development, and progression of cancer. Particular emphasis will be placed not only on those mechanisms related to melatonin’s antioxidant nature but also on the recently described novel roles of melatonin in microbiota and epigenetic regulation.
Keywords	World Health Organization ; antineoplastic agents ; antioxidant activity ; antioxidants ; apoptosis ; carcinogens ; epigenetics ; intrinsic factors ; melatonin ; microorganisms ; phylogeny ; pineal body ; work schedules
Language	English
Dates of publication	2021-0201
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox10020210
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article: Melatonin and Cancer: A Polyhedral Network Where the Source Matters.

Bonmati-Carrion, Maria-Angeles / Tomas-Loba, Antonia

Antioxidants (Basel, Switzerland)

2021 Volume 10, Issue 2

Abstract: Melatonin is one of the most phylogenetically conserved signals in biology. Although its original function was probably related to its antioxidant capacity, this indoleamine has been "adopted" by multicellular organisms as the "darkness signal" when ... ...

Abstract	Melatonin is one of the most phylogenetically conserved signals in biology. Although its original function was probably related to its antioxidant capacity, this indoleamine has been "adopted" by multicellular organisms as the "darkness signal" when secreted in a circadian manner and is acutely suppressed by light at night by the pineal gland. However, melatonin is also produced by other tissues, which constitute its extrapineal sources. Apart from its undisputed chronobiotic function, melatonin exerts antioxidant, immunomodulatory, pro-apoptotic, antiproliferative, and anti-angiogenic effects, with all these properties making it a powerful antitumor agent. Indeed, this activity has been demonstrated to be mediated by interfering with various cancer hallmarks, and different epidemiological studies have also linked light at night (melatonin suppression) with a higher incidence of different types of cancer. In 2007, the World Health Organization classified night shift work as a probable carcinogen due to circadian disruption, where melatonin plays a central role. Our aim is to review, from a global perspective, the role of melatonin both from pineal and extrapineal origin, as well as their possible interplay, as an intrinsic factor in the incidence, development, and progression of cancer. Particular emphasis will be placed not only on those mechanisms related to melatonin's antioxidant nature but also on the recently described novel roles of melatonin in microbiota and epigenetic regulation.
Language	English
Publishing date	2021-02-01
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox10020210
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Effect of 60 days of head down tilt bed rest on amplitude and phase of rhythms in physiology and sleep in men.

Bonmatí-Carrión, María-Ángeles / Santhi, Nayantara / Atzori, Giuseppe / Mendis, Jeewaka / Kaduk, Sylwia / Dijk, Derk-Jan / Archer, Simon N

NPJ microgravity

2024 Volume 10, Issue 1, Page(s) 42

Abstract: Twenty-four-hour rhythms in physiology and behaviour are shaped by circadian clocks, environmental rhythms, and feedback of behavioural rhythms onto physiology. In space, 24 h signals such as those associated with the light-dark cycle and changes in ... ...

Abstract	Twenty-four-hour rhythms in physiology and behaviour are shaped by circadian clocks, environmental rhythms, and feedback of behavioural rhythms onto physiology. In space, 24 h signals such as those associated with the light-dark cycle and changes in posture, are weaker, potentially reducing the robustness of rhythms. Head down tilt (HDT) bed rest is commonly used to simulate effects of microgravity but how HDT affects rhythms in physiology has not been extensively investigated. Here we report effects of -6° HDT during a 90-day protocol on 24 h rhythmicity in 20 men. During HDT, amplitude of light, motor activity, and wrist-temperature rhythms were reduced, evening melatonin was elevated, while cortisol was not affected during HDT, but was higher in the morning during recovery when compared to last session of HDT. During recovery from HDT, time in Slow-Wave Sleep increased. EEG activity in alpha and beta frequencies increased during NREM and REM sleep. These results highlight the profound effects of head-down-tilt-bed-rest on 24 h rhythmicity.
Language	English
Publishing date	2024-03-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2823626-9
ISSN	2373-8065
ISSN	2373-8065
DOI	10.1038/s41526-024-00387-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Author Correction: Effect of 60 days of head down tilt bed rest on amplitude and phase of rhythms in physiology and sleep in men.

Bonmatí-Carrión, María-Ángeles / Santhi, Nayantara / Atzori, Giuseppe / Mendis, Jeewaka / Kaduk, Sylwia / Dijk, Derk-Jan / Archer, Simon N

NPJ microgravity

2024 Volume 10, Issue 1, Page(s) 47

Language	English
Publishing date	2024-04-23
Publishing country	United States
Document type	Published Erratum
ZDB-ID	2823626-9
ISSN	2373-8065
ISSN	2373-8065
DOI	10.1038/s41526-024-00394-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Uncovering personal circadian responses to light through particle swarm optimization.

Vicente-Martínez, Jesús / Bonmatí-Carrión, María Ángeles / Madrid, Juan Antonio / Rol, Maria Angeles

Computer methods and programs in biomedicine

2023 Volume 243, Page(s) 107933

Abstract: Background and objectives: Kronauer's oscillator model of the human central pacemaker is one of the most commonly used approaches to study the human circadian response to light. Two sources of error when applying it to a personal light exposure have ... ...

Abstract	Background and objectives: Kronauer's oscillator model of the human central pacemaker is one of the most commonly used approaches to study the human circadian response to light. Two sources of error when applying it to a personal light exposure have been identified: (1) as a populational model, it does not consider inter-individual variability, and (2) the initial conditions needed to integrate the model are usually unknown, and thus subjectively estimated. In this work, we evaluate the ability of particle swarm optimization (PSO) algorithms to simultaneously uncover the optimal initial conditions and individual parameters of a pre-defined Kronauer's oscillator model. Methods: A Canonical PSO, a Dynamic Multi-Swarm PSO and a novel modification of the latter, namely Hierarchical Dynamic Multi-Swarm PSO, are evaluated. Two different target models (under a regular and an irregular schedule) are defined, and the same realistic light profile is fed to them. Based on their output, a fitness function is proposed, which is minimized by the algorithms to find the optimum set of parameters and initial conditions of the model. Results: We demonstrate that Dynamic Multi-Swarm and Hierarchical Dynamic Multi-Swarm algorithms can accurately uncover personal circadian parameters under both regular and irregular schedules, but as expected, optimization is easier under a regular schedule. Circadian parameters play the most important role in the optimization process and should be prioritized over initial conditions, although assessment of the impact of misestimating the latter is recommended. The log-log linear relationship between mean absolute error and computational cost shows that the number of particles to use is at the discretion of the user. Conclusions: The robustness and low errors achieved by the algorithms support their further testing, validation and systematic application to empirical data under a regular or irregular schedule. Uncovering personal circadian parameters can improve the assessment of the circadian status of a person and the applicability of personalized light therapies, as well as help to discover other factors that may lie behind the interindividual variability in the circadian response to light.
MeSH term(s)	Humans ; Algorithms ; Circadian Rhythm ; Light
Language	English
Publishing date	2023-11-19
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	632564-6
ISSN	1872-7565 ; 0169-2607
ISSN (online)	1872-7565
ISSN	0169-2607
DOI	10.1016/j.cmpb.2023.107933
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.B 521: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Phase Response Curve to Light under Ambulatory Conditions: A Pilot Study for Potential Application to Daylight Saving Time Transitions.

Arguelles-Prieto, Raquel / Madrid, Juan Antonio / Rol, Maria Angeles / Bonmatí-Carrión, María Ángeles

Biology

2022 Volume 11, Issue 11

Abstract: Several studies have investigated the relationship between daylight saving time (DST) and sleep alterations, psychiatric disorders, cardiovascular events and traffic accidents. However, very few have monitored participants while maintaining their usual ... ...

Abstract	Several studies have investigated the relationship between daylight saving time (DST) and sleep alterations, psychiatric disorders, cardiovascular events and traffic accidents. However, very few have monitored participants while maintaining their usual lifestyle before and after DST. Considering that DST transitions modify human behavior and, therefore, people's light exposure patterns, the aim of this study was to investigate the potential effects of DST on circadian variables, considering sleep and, for the first time, the human phase response curve to light. To accomplish this, eight healthy adults (33 ± 11 years old, mean ± SD) were recruited to monitor multivariable circadian markers and light exposure by means of a wearable ambulatory monitoring device: Kronowise
Language	English
Publishing date	2022-10-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology11111584
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Correlated color temperature and light intensity: Complementary features in non-visual light field.

Arguelles-Prieto, Raquel / Madrid, Juan Antonio / Rol, Maria Angeles / Bonmati-Carrion, Maria Angeles

PloS one

2021 Volume 16, Issue 7, Page(s) e0254171

Abstract: An appropriate exposure to the light-dark cycle, with high irradiances during the day and darkness during the night is essential to keep our physiology on time. However, considering the increasing exposure to artificial light at night and its potential ... ...

Abstract	An appropriate exposure to the light-dark cycle, with high irradiances during the day and darkness during the night is essential to keep our physiology on time. However, considering the increasing exposure to artificial light at night and its potential harmful effects on health (i.e. chronodisruption and associated health conditions), it is essential to understand the non-visual effects of light in humans. Melatonin suppression is considered the gold standard for nocturnal light effects, and the activation of intrinsically photosensitive retinal ganglion cells (ipRGCs) through the assessment of pupillary light reflex (PLR) has been recently gaining attention. Also, some theoretical models for melatonin suppression and retinal photoreceptors activation have been proposed. Our aim in this study was to determine the influence of correlated color temperature (CCT) on melatonin suppression and PLR, considering two commercial light sources, as well as to explore the possible correlation between both processes. Also, the contribution of irradiance (associated to CCT) was explored through mathematical modelling on a wider range of light sources. For that, melatonin suppression and PLR were experimentally assessed on 16 healthy and young volunteers under two light conditions (warmer, CCT 3000 K; and cooler, CCT 5700 K, at ~5·1018 photons/cm2/sec). Our experimental results yielded greater post-stimulus constriction under the cooler (5700 K, 13.3 ± 1.9%) than under the warmer light (3000 K, 8.7 ± 1.2%) (p < 0.01), although no significant differences were found between both conditions in terms of melatonin suppression. Interestingly, we failed to demonstrate correlation between PLR and melatonin suppression. Although methodological limitations cannot be discarded, this could be due to the existence of different subpopulations of Type 1 ipRGCs differentially contributing to PLR and melatonin suppression, which opens the way for further research on ipRGCs projection in humans. The application of theoretical modelling suggested that CCT should not be considered separately from irradiance when designing nocturnal/diurnal illumination systems. Further experimental studies on wider ranges of CCTs and light intensities are needed to confirm these conclusions.
MeSH term(s)	Circadian Rhythm/radiation effects ; Color ; Computer Simulation ; Female ; Humans ; Light ; Male ; Melatonin/metabolism ; Models, Biological ; Reflex, Pupillary/physiology ; Reflex, Pupillary/radiation effects ; Saliva/metabolism ; Temperature ; Vision, Ocular/radiation effects ; Young Adult
Chemical Substances	Melatonin (JL5DK93RCL)
Language	English
Publishing date	2021-07-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0254171
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Living at the Wrong Time: Effects of Unmatching Official Time in Portugal and Western Spain.

Bonmatí-Carrión, María-Ángeles / Casado-Ramirez, Elvira / Moreno-Casbas, María-Teresa / Campos, Manuel / ModulEN Consortium / Madrid, Juan Antonio / Rol, Maria-Angeles

Biology

2022 Volume 11, Issue 8

Abstract: Human circadian rhythmicity is subjected to the internal circadian clock, the sun and social clocks (official time, social/work schedules). The discrepancy among these clocks, as occurs when official time does not match its geographical time zone, may ... ...

Abstract	Human circadian rhythmicity is subjected to the internal circadian clock, the sun and social clocks (official time, social/work schedules). The discrepancy among these clocks, as occurs when official time does not match its geographical time zone, may produce circadian disruption. Western Spain (GMT+1/+2) and Portugal (GMT0/+1) share similar longitudes (sun time) but have different official times. This provides a unique opportunity to evaluate the effects of official time on circadian rhythmicity and sleep in elderly and retired populations (with no remunerated duties presumed, although other social commitments may be present) at both locations. Although both populations slept enough for their age (7-8 h), circadian robustness (e.g., interdaily stability, relative amplitude) was greater in Portugal, especially during weekdays, while greater desynchronization (both body temperature vs. motor activity and body temperature vs. light exposure) tended to occur in the Spaniards. Once corrected by GMT0, meals took place later in Spain than in Portugal, especially as the day progresses, and a possible interplay between bed/meal timings and internal desynchronization was found. Our results point to the possible deleterious effect on circadian system robustness when official time is misaligned with its geographical time zone.
Language	English
Publishing date	2022-07-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology11081130
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito