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  1. AU="Bonney, Charles"
  2. AU="Balasubramanian, Jeya Balaji"
  3. AU="Soldano, Stefano"
  4. AU="Van Os, Jim"
  5. AU="Wang, Keshi"
  6. AU="Choi, Chi Young"
  7. AU="Mizen, Sara J"
  8. AU="Couttas, Timothy A"
  9. AU="Mendlovic, Joseph"
  10. AU="Amrhein, Carolin"
  11. AU="Türk, İlteriş"
  12. AU="Bell, T J"
  13. AU="Rapisarda, Annamaria"
  14. AU="Lambert, Finnlay"
  15. AU="Patel, Gourang"
  16. AU="Dey, S.R."
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  18. AU="Biggs, Brandon"
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  20. AU="Kumari, Kamlesh"
  21. AU="Jansen, Erica C"
  22. AU="Timpson, N J"
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  26. AU="Suhlrie, Adriana"
  27. AU="Palència, Laia"
  28. AU="Crump, Michael"
  29. AU="Noyori, Osamu"
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  1. Article: Some Considerations on the Early Diagnosis and Treatment of Mammary Cancer.

    Bonney, Charles W

    Buffalo medical journal

    2023  Volume 68, Issue 2, Page(s) 71–78

    Language English
    Publishing date 2023-03-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 426473-3
    ISSN 1040-3817
    ISSN 1040-3817
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    AMP -385/400-: Show issues

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  2. Article ; Online: Robotic high-throughput biomanufacturing and functional differentiation of human pluripotent stem cells.

    Tristan, Carlos A / Ormanoglu, Pinar / Slamecka, Jaroslav / Malley, Claire / Chu, Pei-Hsuan / Jovanovic, Vukasin M / Gedik, Yeliz / Jethmalani, Yogita / Bonney, Charles / Barnaeva, Elena / Braisted, John / Mallanna, Sunil K / Dorjsuren, Dorjbal / Iannotti, Michael J / Voss, Ty C / Michael, Sam / Simeonov, Anton / Singeç, Ilyas

    Stem cell reports

    2021  Volume 16, Issue 12, Page(s) 3076–3092

    Abstract: Efficient translation of human induced pluripotent stem cells (hiPSCs) requires scalable cell manufacturing strategies for optimal self-renewal and functional differentiation. Traditional manual cell culture is variable and labor intensive, posing ... ...

    Abstract Efficient translation of human induced pluripotent stem cells (hiPSCs) requires scalable cell manufacturing strategies for optimal self-renewal and functional differentiation. Traditional manual cell culture is variable and labor intensive, posing challenges for high-throughput applications. Here, we established a robotic platform and automated all essential steps of hiPSC culture and differentiation under chemically defined conditions. This approach allowed rapid and standardized manufacturing of billions of hiPSCs that can be produced in parallel from up to 90 different patient- and disease-specific cell lines. Moreover, we established automated multi-lineage differentiation and generated functional neurons, cardiomyocytes, and hepatocytes. To validate our approach, we compared robotic and manual cell culture operations and performed comprehensive molecular and cellular characterizations (e.g., single-cell transcriptomics, mass cytometry, metabolism, electrophysiology) to benchmark industrial-scale cell culture operations toward building an integrated platform for efficient cell manufacturing for disease modeling, drug screening, and cell therapy.
    MeSH term(s) Automation ; Cell Culture Techniques/methods ; Cell Differentiation ; Cell Lineage ; Cells, Cultured ; Embryoid Bodies/cytology ; Hepatocytes/cytology ; Hepatocytes/virology ; Human Embryonic Stem Cells/cytology ; Humans ; Induced Pluripotent Stem Cells/cytology ; Myocytes, Cardiac/cytology ; Myocytes, Cardiac/virology ; Neurons/cytology ; RNA-Seq ; Reference Standards ; Robotics ; Single-Cell Analysis ; Zika Virus Infection/pathology
    Language English
    Publishing date 2021-12-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural
    ZDB-ID 2720528-9
    ISSN 2213-6711 ; 2213-6711
    ISSN (online) 2213-6711
    ISSN 2213-6711
    DOI 10.1016/j.stemcr.2021.11.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Robotic High-Throughput Biomanufacturing and Functional Differentiation of Human Pluripotent Stem Cells.

    Tristan, Carlos A / Ormanoglu, Pinar / Slamecka, Jaroslav / Malley, Claire / Chu, Pei-Hsuan / Jovanovic, Vukasin M / Gedik, Yeliz / Bonney, Charles / Barnaeva, Elena / Braisted, John / Mallanna, Sunil K / Dorjsuren, Dorjbal / Iannotti, Michael J / Voss, Ty C / Michael, Sam / Simeonov, Anton / Singeç, Ilyas

    bioRxiv : the preprint server for biology

    2020  

    Abstract: Efficient translation of human induced pluripotent stem cells (hiPSCs) depends on implementing scalable cell manufacturing strategies that ensure optimal self-renewal and functional differentiation. Currently, manual culture of hiPSCs is highly variable ... ...

    Abstract Efficient translation of human induced pluripotent stem cells (hiPSCs) depends on implementing scalable cell manufacturing strategies that ensure optimal self-renewal and functional differentiation. Currently, manual culture of hiPSCs is highly variable and labor-intensive posing significant challenges for high-throughput applications. Here, we established a robotic platform and automated all essential steps of hiPSC culture and differentiation under chemically defined conditions. This streamlined approach allowed rapid and standardized manufacturing of billions of hiPSCs that can be produced in parallel from up to 90 different patient-and disease-specific cell lines. Moreover, we established automated multi-lineage differentiation to generate primary embryonic germ layers and more mature phenotypes such as neurons, cardiomyocytes, and hepatocytes. To validate our approach, we carefully compared robotic and manual cell culture and performed molecular and functional cell characterizations (e.g. bulk culture and single-cell transcriptomics, mass cytometry, metabolism, electrophysiology, Zika virus experiments) in order to benchmark industrial-scale cell culture operations towards building an integrated platform for efficient cell manufacturing for disease modeling, drug screening, and cell therapy. Combining stem cell-based models and non-stop robotic cell culture may become a powerful strategy to increase scientific rigor and productivity, which are particularly important during public health emergencies (e.g. opioid crisis, COVID-19 pandemic).
    Keywords covid19
    Language English
    Publishing date 2020-08-03
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2020.08.03.235242
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Robotic High-Throughput Biomanufacturing and Functional Differentiation of Human Pluripotent Stem Cells

    Tristan, Carlos A. / Ormanoglu, Pinar / Slamecka, Jaroslav / Malley, Claire / Chu, Pei-Hsuan / Jovanovic, Vukasin M. / Gedik, Yeliz / Bonney, Charles / Barnaeva, Elena / Braisted, John / Mallanna, Sunil K. / Dorjsuren, Dorjbal / Iannotti, Michael J. / Voss, Ty C. / Michael, Sam / Simeonov, Anton / Singeç, Ilyas

    bioRxiv : the preprint server for biology

    Abstract: Efficient translation of human induced pluripotent stem cells (hiPSCs) depends on implementing scalable cell manufacturing strategies that ensure optimal self-renewal and functional differentiation Currently, manual culture of hiPSCs is highly variable ... ...

    Abstract Efficient translation of human induced pluripotent stem cells (hiPSCs) depends on implementing scalable cell manufacturing strategies that ensure optimal self-renewal and functional differentiation Currently, manual culture of hiPSCs is highly variable and labor-intensive posing significant challenges for high-throughput applications Here, we established a robotic platform and automated all essential steps of hiPSC culture and differentiation under chemically defined conditions This streamlined approach allowed rapid and standardized manufacturing of billions of hiPSCs that can be produced in parallel from up to 90 different patient-and disease-specific cell lines Moreover, we established automated multi-lineage differentiation to generate primary embryonic germ layers and more mature phenotypes such as neurons, cardiomyocytes, and hepatocytes To validate our approach, we carefully compared robotic and manual cell culture and performed molecular and functional cell characterizations (e g bulk culture and single-cell transcriptomics, mass cytometry, metabolism, electrophysiology, Zika virus experiments) in order to benchmark industrial-scale cell culture operations towards building an integrated platform for efficient cell manufacturing for disease modeling, drug screening, and cell therapy Combining stem cell-based models and non-stop robotic cell culture may become a powerful strategy to increase scientific rigor and productivity, which are particularly important during public health emergencies (e g opioid crisis, COVID-19 pandemic)
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #721068
    Database COVID19

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  5. Book: A text-book of genito-urinary diseases,

    Casper, Leopold / Bonney, Charles W

    including functional sexual disorders in man,

    1909  

    Author's details by Doctor Leopold Casper ... tr. and ed. with additions by Charles W. Bonney
    Language English
    Size xvi, 645 p., XXIV pl., ill.
    Edition 2d ed., rev. and enl., with 230 illustrations and 24 full-page plates, of which 8 are in colors.
    Publisher P. Blakiston's son & co
    Publishing place Philadelphia
    Document type Book
    Note Translation of Lehrbuch der Urologie.
    Database Catalogue of the US National Library of Medicine (NLM)

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  6. Book: A text-book of genito-urinary diseases,

    Casper, Leopold / Bonney, Charles W

    including functional sexual disorders in man,

    1906  

    Author's details by Doctor Leopold Casper ... tr. and ed. with additions by Charles W. Bonney ... With 213 illustrations and 23 full page plates, of which 7 are in colors
    Language English
    Size xii, 618 p., XXIII pl., ill.
    Publisher P. Blakiston's son & co
    Publishing place Philadelphia
    Document type Book
    Note Translation of Lehrbuch der Urologie.
    Database Catalogue of the US National Library of Medicine (NLM)

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    Inter-library loan at ZB MED

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  7. Book ; Online: A summary of the law of marine, fire and life insurance

    Bonney, Charles Carroll

    with practical forms, modern cases, and computing rules

    1865  

    Author's details by Charles C. Bonney
    Keywords Insurance law ; Insurance law/Forms
    Language English
    Size Online-Ressource, forms, 23 cm
    Publisher E.B. Myers & Chandler
    Publishing place Chicago
    Document type Book ; Online
    Note Bibliography: p. 87-101 ; Includes index ; OCLC, 17219609 ; Reproduction of original from Harvard Law School Library
    Database Former special subject collection: coastal and deep sea fishing

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