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  1. Article ; Online: The possible role of serum bactericidal titres in long-term suppressive antibiotic treatment for infective endocarditis: report of three cases.

    Valsecchi, Pietro / Calia, Matteo / Marvulli, Lea Nadia / Bono, Enrica / Monzillo, Vincenzina / Bruno, Raffaele / Seminari, Elena

    Infectious diseases (London, England)

    2023  Volume 55, Issue 7, Page(s) 514–518

    Abstract: Introduction: long term suppressive antibiotic treatment may be the only feasible option for patients with infective endocarditis (IE) not suitable for surgery.: Case reports: we present three cases of prosthetic valve endocarditis (PVE) caused by !## ...

    Abstract Introduction: long term suppressive antibiotic treatment may be the only feasible option for patients with infective endocarditis (IE) not suitable for surgery.
    Case reports: we present three cases of prosthetic valve endocarditis (PVE) caused by
    Conclusions: long term oral amoxicillin was effective and well-tolerated. SBTs after switch to oral therapy were quite heterogeneous, in some cases not reaching the conventionally established titre to assess bactericidal effect (1:8).Key pointsendovascular infection in non-suitable-for-surgery patients can be managed with long-term oral suppressive therapy.serum bactericidal assay confirmed high effectiveness of parenteral antibiotic therapy.serum bactericidal assay showed highly variable titres during oral therapy.
    MeSH term(s) Humans ; Endocarditis, Bacterial/drug therapy ; Anti-Bacterial Agents/therapeutic use ; Heart Valve Prosthesis ; Tomography, X-Ray Computed ; Endocarditis/drug therapy ; Anti-Infective Agents ; Amoxicillin/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents ; Amoxicillin (804826J2HU)
    Language English
    Publishing date 2023-06-02
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2839775-7
    ISSN 2374-4243 ; 2374-4235
    ISSN (online) 2374-4243
    ISSN 2374-4235
    DOI 10.1080/23744235.2023.2216271
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 600: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Reduction of BSI associated mortality after a sepsis project implementation in the ER of a tertiary referral hospital.

    Seminari, Elena / Colaneri, Marta / Corbella, Marta / De Silvestri, Annalisa / Muzzi, Alba / Perlini, Stefano / Martino, Ilaria Francesca / Marvulli, Lea Nadia / Arcuri, Alessia / Maffezzoni, Marcello / Minucci, Rita / Bono, Enrica / Cambieri, Patrizia / Marone, Piero / Bruno, Raffaele

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 5142

    Abstract: The emergency room (ER) is the first gateway for patients with sepsis to inpatient units, and identifying best practices and benchmarks to be applied in this setting might crucially result in better patient's outcomes. In this study, we want to evaluate ... ...

    Abstract The emergency room (ER) is the first gateway for patients with sepsis to inpatient units, and identifying best practices and benchmarks to be applied in this setting might crucially result in better patient's outcomes. In this study, we want to evaluate the results in terms of decreased the in-hospital mortality of patients with sepsis of a Sepsis Project developed in the ER. All patients admitted to the ER of our Hospital from the 1st January, 2016 to the 31stJuly 2019 with suspect of sepsis (MEWS score ≥ of 3) and positive blood culture upon ER admission were included in this retrospective observational study. The study comprises of two periods: Period A: From the 1st Jan 2016 to the 31st Dec 2017, before the implementation of the Sepsis project. Period B: From the 1st Jan 2018 to the 31stJul 2019, after the implementation of the Sepsis project. To analyze the difference in mortality between the two periods, a univariate and multivariate logistic regression was used. The risk of in-hospital mortality was expressed as an odds ratio (OR) and a 95% confidence interval (95% CI). Overall, 722 patients admitted in ER had positive BC on admissions, 408 in period A and 314 in period B. In-hospital mortality was 18.9% in period A and 12.7% in period B (p = 0.03). At multivariable analysis, mortality was still reduced in period B compared to period A (OR 0.64, 95% CI 0.41-0.98; p = 0.045). Having an infection due to GP bacteria or polymicrobial was associated with an increased risk of death, as it was having a neoplasm or diabetes. A marked reduction in in-hospital mortality of patients with documented BSI associated with signs or symptoms of sepsis after the implementation of a sepsis project based on the application of sepsis bundles in the ER.
    MeSH term(s) Humans ; Tertiary Care Centers ; Hospitalization ; Sepsis ; Retrospective Studies ; Hospital Mortality ; Emergency Service, Hospital
    Language English
    Publishing date 2023-03-29
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-31219-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Culture negative endocarditis and the role of proper blood culture collection: results from a tertiary care Centre of Northern Italy.

    Seminari, Elena / Cambieri, Patrizia / Pieri, Teresa Chiara / Roda, Silvia / Colaneri, Marta / Gallazzi, Ilaria / Asperges, Erika / Bono, Enrica / Lissandrin, Raffaella / Marvulli, Lea Nadia / Bruno, Raffaele

    Infectious diseases (London, England)

    2022  Volume 55, Issue 1, Page(s) 67–70

    MeSH term(s) Humans ; Blood Culture ; Tertiary Care Centers ; Endocarditis/diagnosis ; Endocarditis, Bacterial/diagnosis ; Italy
    Language English
    Publishing date 2022-09-09
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2839775-7
    ISSN 2374-4243 ; 2374-4235
    ISSN (online) 2374-4243
    ISSN 2374-4235
    DOI 10.1080/23744235.2022.2121854
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 600: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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