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Article: Crosstalk Between Innate and T Cell Adaptive Immunity With(in) the Muscle.

Bonomo, Adriana C / Pinto-Mariz, Fernanda / Riederer, Ingo / Benjamim, Claudia F / Butler-Browne, Gillian / Mouly, Vincent / Savino, Wilson

Frontiers in physiology

2020 Volume 11, Page(s) 573347

Abstract: Growing evidence demonstrates a continuous interaction between the immune system and the skeletal muscle in inflammatory diseases of different pathogenetic origins, in dystrophic conditions such as Duchenne Muscular Dystrophy as well as during normal ... ...

Abstract	Growing evidence demonstrates a continuous interaction between the immune system and the skeletal muscle in inflammatory diseases of different pathogenetic origins, in dystrophic conditions such as Duchenne Muscular Dystrophy as well as during normal muscle regeneration. Although one component of the innate immunity, the macrophage, has been extensively studied both in disease conditions and during cell or gene therapy strategies aiming at restoring muscular functions, much less is known about dendritic cells and their primary immunological targets, the T lymphocytes. This review will focus on the dendritic cells and T lymphocytes (including effector and regulatory T-cells), emphasizing the potential cross talk between these cell types and their influence on the structure and function of skeletal muscle.
Language	English
Publishing date	2020-09-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2020.573347
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Article: Mimicry of apoptotic cells by exposing phosphatidylserine participates in the establishment of amastigotes of Leishmania (L) amazonensis in mammalian hosts.

Wanderley, João L M / Moreira, Maria E C / Benjamin, Aline / Bonomo, Adriana C / Barcinski, Marcello A

Journal of immunology (Baltimore, Md. : 1950)

2006 Volume 176, Issue 3, Page(s) 1834–1839

Abstract: Signaling through exposed phosphatidylserine (PS) is fundamental for the TGFbeta1-dependent, noninflammatory phagocytosis of apoptotic cells. This same mechanism operates in the internalization of amastigotes of Leishmania (L) amazonensis (L(L)a) in a ... ...

Abstract	Signaling through exposed phosphatidylserine (PS) is fundamental for the TGFbeta1-dependent, noninflammatory phagocytosis of apoptotic cells. This same mechanism operates in the internalization of amastigotes of Leishmania (L) amazonensis (L(L)a) in a process quoted as apoptotic mimicry. Now we show that the host modulates PS exposure by the amastigotes and, as a consequence, BALB/c mice-derived amastigotes expose significantly more PS than those derived from C57BL/6 mice. Due to this difference in the density of surface PS molecules, the former are significantly more infective than the latter, both in vivo, in F1 (BALB/c x C57BL/6) mice, and in vitro, in thioglycollate-derived macrophages from this same mouse strain. PS exposure increases with progression of the lesion and reaches its maximum value in amastigotes obtained at the time point when the lesion in C57BL/6 mice begins to decrease in size and the lesions in BALB/c mice are still growing in size. Synthesis of active TGFbeta1, induction of IL-10 message, and inhibition of NO synthesis correlate with the amount of surface PS displayed by viable (propidium iodide-negative) infective amastigote. Furthermore, we also show that, similar to what happens with apoptotic cells, amastigotes of L(L)a are internalized by macropinocytosis. This mechanism of internalization is consistent with the large phagolysosomes characteristic of L(L)a infection. The intensity of macrophage macropinocytic activity is dependent on the amount of surface PS displayed by the infecting amastigote.
MeSH term(s)	Animals ; Apoptosis/immunology ; Cells, Cultured ; Host-Parasite Interactions/immunology ; Interleukin-10/biosynthesis ; Interleukin-10/genetics ; Leishmania mexicana/growth & development ; Leishmania mexicana/immunology ; Macrophages/immunology ; Macrophages/metabolism ; Macrophages/parasitology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Molecular Mimicry/immunology ; Nitric Oxide/biosynthesis ; Phosphatidylserines/metabolism ; Pinocytosis/immunology ; RNA, Messenger/metabolism ; Transforming Growth Factor beta/genetics ; Transforming Growth Factor beta/metabolism ; Transforming Growth Factor beta1
Chemical Substances	Phosphatidylserines ; RNA, Messenger ; Tgfb1 protein, mouse ; Transforming Growth Factor beta ; Transforming Growth Factor beta1 ; Interleukin-10 (130068-27-8) ; Nitric Oxide (31C4KY9ESH)
Language	English
Publishing date	2006-03-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.176.3.1834
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Article: G-CSF suppresses allergic pulmonary inflammation, downmodulating cytokine, chemokine and eosinophil production

Queto, Túlio / Vasconcelos, Zilton F.M / Luz, Ricardo Alves / Anselmo, Carina / Guiné, Ana Amélia A / Silva, Patricia Machado R. e / Farache, Júlia / Cunha, José Marcos T / Bonomo, Adriana C / Gaspar-Elsas, Maria Ignez C / Xavier-Elsas, Pedro

Life sciences. 2011 May 9, v. 88, no. 19-20

2011

Abstract: AIMS: Granulocyte Colony-Stimulating Factor (G-CSF), which mobilizes hemopoietic stem cells (HSC), is believed to protect HSC graft recipients from graft-versus-host disease by enhancing Th2 cytokine secretion. Accordingly, G-CSF should aggravate Th2- ... ...

Abstract	AIMS: Granulocyte Colony-Stimulating Factor (G-CSF), which mobilizes hemopoietic stem cells (HSC), is believed to protect HSC graft recipients from graft-versus-host disease by enhancing Th2 cytokine secretion. Accordingly, G-CSF should aggravate Th2-dependent allergic pulmonary inflammation and the associated eosinophilia. We evaluated the effects of G-CSF in a model of allergic pulmonary inflammation. MAIN METHODS: Allergic pulmonary inflammation was induced by repeated aerosol allergen challenge in ovalbumin-sensitized C57BL/6J mice. The effects of allergen challenge and of G-CSF pretreatment were evaluated by monitoring: a) eosinophilia and cytokine/chemokine content of bronchoalveolar lavage fluid, pulmonary interstitium, and blood; b) changes in airway resistance; and c) changes in bone-marrow eosinophil production. KEY FINDINGS: Contrary to expectations, G-CSF pretreatment neither induced nor enhanced allergic pulmonary inflammation. Instead, G-CSF: a) suppressed accumulation of infiltrating eosinophils in bronchoalveolar, peribronchial and perivascular spaces of challenged lungs; and b) prevented ovalbumin challenge-induced rises in airway resistance. G-CSF had multiple regulatory effects on cytokine and chemokine production: in bronchoalveolar lavage fluid, levels of IL-1 and IL-12 (p40), eotaxin and MIP-1a were decreased; in plasma, KC, a neutrophil chemoattractant, was increased, while IL-5 was decreased and eotaxin was unaffected. In bone-marrow, G-CSF: a) prevented the increase in bone-marrow eosinophil production induced by ovalbumin challenge of sensitized mice; and b) selectively stimulated neutrophil colony formation. SIGNIFICANCE: These observations challenge the view that G-CSF deviates cytokine production towards a Th2 profile in vivo, and suggest that this neutrophil-selective hemopoietin affects eosinophilic inflammation by a combination of effects on lung cytokine production and bone-marrow hemopoiesis.
Keywords	aerosols ; allergens ; bone marrow ; chemoattractants ; chemokines ; eosinophilia ; eosinophils ; granulocyte colony-stimulating factor ; hematopoiesis ; inflammation ; interleukin-1 ; interleukin-12 ; interleukin-5 ; lungs ; mice ; models ; monitoring ; neutrophils ; ovalbumin ; pneumonia ; secretion ; stem cells
Language	English
Dates of publication	2011-0509
Size	p. 830-838.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2011.03.001
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: G-CSF suppresses allergic pulmonary inflammation, downmodulating cytokine, chemokine and eosinophil production.

Queto, Túlio / Vasconcelos, Zilton F M / Luz, Ricardo Alves / Anselmo, Carina / Guiné, Ana Amélia A / e Silva, Patricia Machado R / Farache, Júlia / Cunha, José Marcos T / Bonomo, Adriana C / Gaspar-Elsas, Maria Ignez C / Xavier-Elsas, Pedro

Life sciences

2011 Volume 88, Issue 19-20, Page(s) 830–838

Abstract: Aims: Granulocyte Colony-Stimulating Factor (G-CSF), which mobilizes hemopoietic stem cells (HSC), is believed to protect HSC graft recipients from graft-versus-host disease by enhancing Th2 cytokine secretion. Accordingly, G-CSF should aggravate Th2- ... ...

Abstract	Aims: Granulocyte Colony-Stimulating Factor (G-CSF), which mobilizes hemopoietic stem cells (HSC), is believed to protect HSC graft recipients from graft-versus-host disease by enhancing Th2 cytokine secretion. Accordingly, G-CSF should aggravate Th2-dependent allergic pulmonary inflammation and the associated eosinophilia. We evaluated the effects of G-CSF in a model of allergic pulmonary inflammation. Main methods: Allergic pulmonary inflammation was induced by repeated aerosol allergen challenge in ovalbumin-sensitized C57BL/6J mice. The effects of allergen challenge and of G-CSF pretreatment were evaluated by monitoring: a) eosinophilia and cytokine/chemokine content of bronchoalveolar lavage fluid, pulmonary interstitium, and blood; b) changes in airway resistance; and c) changes in bone-marrow eosinophil production. Key findings: Contrary to expectations, G-CSF pretreatment neither induced nor enhanced allergic pulmonary inflammation. Instead, G-CSF: a) suppressed accumulation of infiltrating eosinophils in bronchoalveolar, peribronchial and perivascular spaces of challenged lungs; and b) prevented ovalbumin challenge-induced rises in airway resistance. G-CSF had multiple regulatory effects on cytokine and chemokine production: in bronchoalveolar lavage fluid, levels of IL-1 and IL-12 (p40), eotaxin and MIP-1a were decreased; in plasma, KC, a neutrophil chemoattractant, was increased, while IL-5 was decreased and eotaxin was unaffected. In bone-marrow, G-CSF: a) prevented the increase in bone-marrow eosinophil production induced by ovalbumin challenge of sensitized mice; and b) selectively stimulated neutrophil colony formation. Significance: These observations challenge the view that G-CSF deviates cytokine production towards a Th2 profile in vivo, and suggest that this neutrophil-selective hemopoietin affects eosinophilic inflammation by a combination of effects on lung cytokine production and bone-marrow hemopoiesis.
MeSH term(s)	Airway Resistance/immunology ; Animals ; Bronchoalveolar Lavage Fluid/cytology ; Bronchoalveolar Lavage Fluid/immunology ; Cell Migration Inhibition/immunology ; Chemokines/antagonists & inhibitors ; Chemokines/biosynthesis ; Cytokines/antagonists & inhibitors ; Cytokines/biosynthesis ; Down-Regulation/drug effects ; Down-Regulation/physiology ; Eosinophils/cytology ; Eosinophils/metabolism ; Female ; Granulocyte Colony-Stimulating Factor/administration & dosage ; Granulocyte Colony-Stimulating Factor/therapeutic use ; Growth Inhibitors/physiology ; Male ; Mice ; Mice, Inbred C57BL ; Pneumonia/immunology ; Pneumonia/pathology ; Pneumonia/prevention & control ; Respiratory Hypersensitivity/immunology ; Respiratory Hypersensitivity/pathology ; Respiratory Hypersensitivity/prevention & control
Chemical Substances	Chemokines ; Cytokines ; Growth Inhibitors ; Granulocyte Colony-Stimulating Factor (143011-72-7)
Language	English
Publishing date	2011-05-09
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2011.03.001
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Article: Flow cytometric assessment of Leishmania spp metacyclic differentiation: validation by morphological features and specific markers.

Saraiva, Elvira M / Pinto-da-Silva, Lucia H / Wanderley, João Luiz M / Bonomo, Adriana C / Barcinski, Marcello A / Moreira, Maria Elisabete C

Experimental parasitology

2005 Volume 110, Issue 1, Page(s) 39–47

Abstract: Characterization of infective metacyclic promastigotes of Leishmania spp can be an essential step in several experimental protocols. Metacyclic forms of all Leishmania species display a typical morphology with short, narrow cell body, and an elongated ... ...

Abstract	Characterization of infective metacyclic promastigotes of Leishmania spp can be an essential step in several experimental protocols. Metacyclic forms of all Leishmania species display a typical morphology with short, narrow cell body, and an elongated flagellum. This feature suggests that metacyclics can be distinguished from procyclic forms by non-fluorimetric flow cytometric parameters thus enabling the follow-up of their appearance and acquisition of specific properties, during metacyclogenesis in in vitro cultures. Here we describe the flow cytometric parameters of stage-specific promastigotes of Leishmania major, Leishmania donovani, Leishmania amazonensis, and Leishmania braziliensis. Our findings were validated by optical microscopy morphology and specific procyclic labeling with FITC-peanut agglutinin. Furthermore, we show that parasite's distribution in the plot during differentiation in culture is not species specific and that the parasites displaying low forward-angle light scatter (FSC(low)) are three times more infective than the FSC(high) ones. The method here described can be applied to the identification of metacyclics of different Leishmania spp within the whole stationary population.
MeSH term(s)	Animals ; Cells, Cultured ; Flow Cytometry ; Humans ; Leishmania/growth & development ; Leishmania/isolation & purification ; Leishmania/ultrastructure ; Leishmania braziliensis/growth & development ; Leishmania braziliensis/isolation & purification ; Leishmania braziliensis/ultrastructure ; Leishmania donovani/growth & development ; Leishmania donovani/isolation & purification ; Leishmania donovani/ultrastructure ; Leishmania major/growth & development ; Leishmania major/isolation & purification ; Leishmania major/ultrastructure ; Leishmania mexicana/growth & development ; Leishmania mexicana/isolation & purification ; Leishmania mexicana/ultrastructure ; Life Cycle Stages ; Macrophages, Peritoneal/parasitology ; Mice ; Mice, Inbred BALB C ; Reproducibility of Results ; Species Specificity
Language	English
Publishing date	2005-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Validation Studies
ZDB-ID	391089-1
ISSN	1090-2449 ; 0014-4894
ISSN (online)	1090-2449
ISSN	0014-4894
DOI	10.1016/j.exppara.2005.01.004
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Article: The role of apoptotic mimicry in host-parasite interplay: is death the only alternative for altruistic behavior?

Barcinski, Marcello A / Moreira, Maria Elisabete Costa / Balanco, José Mario De Freitas / Wanderley, João Luiz M / Bonomo, Adriana C

Kinetoplastid biology and disease

2003 Volume 2, Issue 1, Page(s) 6

Language	English
Publishing date	2003-06-25
Publishing country	England
Document type	Journal Article
ISSN	1475-9292
ISSN	1475-9292
DOI	10.1186/1475-9292-2-6
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Article: G-CSF suppresses allergic pulmonary inflammation, downmodulating cytokine, chemokine and eosinophil production

Queto, Túlio / Vasconcelos, Zilton F.M. / Luz, Ricardo Alves / Anselmo, Carina / Guiné, Ana Amélia A. / Silva, Patricia Machado R. e / Farache, Júlia / Cunha, José Marcos T. / Bonomo, Adriana C. / Gaspar-Elsas, Maria Ignez C. / Xavier-Elsas, Pedro

Life sciences

Volume v. 88,, Issue no. 1

Abstract	AIMS: Granulocyte Colony-Stimulating Factor (G-CSF), which mobilizes hemopoietic stem cells (HSC), is believed to protect HSC graft recipients from graft-versus-host disease by enhancing Th2 cytokine secretion. Accordingly, G-CSF should aggravate Th2-dependent allergic pulmonary inflammation and the associated eosinophilia. We evaluated the effects of G-CSF in a model of allergic pulmonary inflammation. MAIN METHODS: Allergic pulmonary inflammation was induced by repeated aerosol allergen challenge in ovalbumin-sensitized C57BL/6J mice. The effects of allergen challenge and of G-CSF pretreatment were evaluated by monitoring: a) eosinophilia and cytokine/chemokine content of bronchoalveolar lavage fluid, pulmonary interstitium, and blood; b) changes in airway resistance; and c) changes in bone-marrow eosinophil production. KEY FINDINGS: Contrary to expectations, G-CSF pretreatment neither induced nor enhanced allergic pulmonary inflammation. Instead, G-CSF: a) suppressed accumulation of infiltrating eosinophils in bronchoalveolar, peribronchial and perivascular spaces of challenged lungs; and b) prevented ovalbumin challenge-induced rises in airway resistance. G-CSF had multiple regulatory effects on cytokine and chemokine production: in bronchoalveolar lavage fluid, levels of IL-1 and IL-12 (p40), eotaxin and MIP-1a were decreased; in plasma, KC, a neutrophil chemoattractant, was increased, while IL-5 was decreased and eotaxin was unaffected. In bone-marrow, G-CSF: a) prevented the increase in bone-marrow eosinophil production induced by ovalbumin challenge of sensitized mice; and b) selectively stimulated neutrophil colony formation. SIGNIFICANCE: These observations challenge the view that G-CSF deviates cytokine production towards a Th2 profile in vivo, and suggest that this neutrophil-selective hemopoietin affects eosinophilic inflammation by a combination of effects on lung cytokine production and bone-marrow hemopoiesis.
Keywords	granulocyte colony-stimulating factor ; interleukin-1 ; secretion ; inflammation ; monitoring ; lungs ; chemoattractants ; eosinophilia ; neutrophils ; interleukin-5 ; bone marrow ; hematopoiesis ; models ; mice ; stem cells ; allergens ; interleukin-12 ; ovalbumin ; aerosols ; chemokines ; pneumonia ; eosinophils
Language	English
Document type	Article
ISSN	0024-3205
Database	AGRIS - International Information System for the Agricultural Sciences and Technology

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Article: Crosstalk Between Innate and T Cell Adaptive Immunity With(in) the Muscle.

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Article: Mimicry of apoptotic cells by exposing phosphatidylserine participates in the establishment of amastigotes of Leishmania (L) amazonensis in mammalian hosts.

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Article: G-CSF suppresses allergic pulmonary inflammation, downmodulating cytokine, chemokine and eosinophil production

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Article ; Online: G-CSF suppresses allergic pulmonary inflammation, downmodulating cytokine, chemokine and eosinophil production.

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Article: Flow cytometric assessment of Leishmania spp metacyclic differentiation: validation by morphological features and specific markers.

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Article: The role of apoptotic mimicry in host-parasite interplay: is death the only alternative for altruistic behavior?

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Article: G-CSF suppresses allergic pulmonary inflammation, downmodulating cytokine, chemokine and eosinophil production

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