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  1. Article ; Online: Pre-treatment Emotional Distress in Patients Irradiated for Malignant Glioma.

    Rades, Dirk / Al-Salool, Ahmed / Yu, Nathan Y / Trillenberg, Peter / Bonsanto, Matteo M / Leppert, Jan

    In vivo (Athens, Greece)

    2023  Volume 37, Issue 3, Page(s) 1198–1204

    Abstract: Background/aim: A recommendation of radiotherapy for patients with malignant gliomas may trigger emotional distress. Frequency and risk factors of this complication were investigated.: Patients and methods: Prevalence of six emotional problems and 11 ...

    Abstract Background/aim: A recommendation of radiotherapy for patients with malignant gliomas may trigger emotional distress. Frequency and risk factors of this complication were investigated.
    Patients and methods: Prevalence of six emotional problems and 11 potential risk factors were evaluated in 103 patients irradiated for grade II-IV gliomas. p-Values <0.0045 were considered significant.
    Results: Seventy-six patients (74%) had ≥1 emotional problem. Prevalence of specific emotional problems ranged between 23% and 63%. Associations were found between ≥5 physical problems and worry (p=0.0010), fear (p=0.0001), sadness (p=0.0023), depression (p=0.0006), and loss of interest (p=0.0006), and Karnofsky performance score ≤80 and depression (p=0.0002). Trends were found for physical problems and nervousness (p=0.040), age ≥60 years and depression (p=0.043) or loss of interest (p=0.045), grade IV glioma and sadness (p=0.042), and ≥2 involved sites and loss of interest (p=0.022).
    Conclusion: Three-fourths of glioma patients had pre-radiotherapy emotional distress. Psychological support should be offered very soon, particularly for high-risk patients.
    MeSH term(s) Humans ; Middle Aged ; Brain Neoplasms/radiotherapy ; Brain Neoplasms/pathology ; Glioma/radiotherapy ; Glioma/pathology ; Radiotherapy Dosage ; Risk Factors ; Psychological Distress
    Language English
    Publishing date 2023-04-27
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 807031-3
    ISSN 1791-7549 ; 0258-851X
    ISSN (online) 1791-7549
    ISSN 0258-851X
    DOI 10.21873/invivo.13196
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2288: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: Identification of Patients With Glioblastoma Who May Benefit from Hypofractionated Radiotherapy.

    Zemskova, Oksana / Yu, Nathan Y / Trillenberg, Peter / Bonsanto, Matteo M / Leppert, Jan / Rades, Dirk

    Anticancer research

    2023  Volume 43, Issue 6, Page(s) 2725–2732

    Abstract: Background/aim: Standard radiotherapy (RT) for glioblastoma lasts 6 weeks. We aimed to identify patients who would benefit from a hypofractionated approach.: Patients and methods: In 167 patients receiving standard fractionation, 10 factors were ... ...

    Abstract Background/aim: Standard radiotherapy (RT) for glioblastoma lasts 6 weeks. We aimed to identify patients who would benefit from a hypofractionated approach.
    Patients and methods: In 167 patients receiving standard fractionation, 10 factors were analyzed for local control (LC) and overall survival (OS). A survival score was developed and compared to a previous instrument.
    Results: On multivariate analysis, better LC was significantly associated with the presence of only one lesion and O
    Conclusion: A new survival score with higher accuracy was developed for patients with glioblastoma. Our model can be utilized to individualize RT dose-fractionation recommendations for glioblastoma.
    MeSH term(s) Humans ; Glioblastoma/genetics ; Glioblastoma/radiotherapy ; Glioblastoma/drug therapy ; Temozolomide/therapeutic use ; Antineoplastic Agents, Alkylating/therapeutic use ; Dacarbazine/therapeutic use ; Brain Neoplasms/genetics ; Brain Neoplasms/radiotherapy ; Brain Neoplasms/drug therapy ; DNA Modification Methylases/genetics ; DNA Repair Enzymes/genetics ; DNA Methylation ; Prognosis
    Chemical Substances Temozolomide (YF1K15M17Y) ; Antineoplastic Agents, Alkylating ; Dacarbazine (7GR28W0FJI) ; DNA Modification Methylases (EC 2.1.1.-) ; DNA Repair Enzymes (EC 6.5.1.-)
    Language English
    Publishing date 2023-05-27
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    DOI 10.21873/anticanres.16439
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1642: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  3. Article ; Online: A New Survival Score for Patients Receiving Radiotherapy for Newly Diagnosed Glioblastoma Multiforme.

    Rades, Dirk / Witteler, Jaspar / Schild, Steven E / Trillenberg, Peter / Bonsanto, Matteo M / Leppert, Jan

    Anticancer research

    2021  Volume 41, Issue 1, Page(s) 379–384

    Abstract: Background/aim: In a previous study investigating radiotherapy for newly diagnosed glioblastoma multiforme (GBM), significant or almost significant associations with survival were found for performance status, upfront resection, O: Patients and ... ...

    Abstract Background/aim: In a previous study investigating radiotherapy for newly diagnosed glioblastoma multiforme (GBM), significant or almost significant associations with survival were found for performance status, upfront resection, O
    Patients and methods: Most of the 81 patients included received resection of GBM followed by radiochemotherapy (59.4 Gy/33 or 60 Gy/30 fractions). The previously identified predictors of survival were re-evaluated. Factors significantly associated with survival were used for the score.
    Results: All factors were significantly associated with survival. For each factor, 0 points (less favorable survival) or 1 point (more favorable survival) were assigned and added for each patient. Three groups were designed, 0-1 (n=10), 2 (n=21) and 3-4 points (n=50); 12-month survival rates were 0%, 38% and 78% (p<0.001).
    Conclusion: A new survival score was created for patients requiring radiotherapy for GBM that can improve treatment personalization.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Combined Modality Therapy ; Disease Management ; Female ; Glioblastoma/diagnosis ; Glioblastoma/etiology ; Glioblastoma/mortality ; Glioblastoma/radiotherapy ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Prognosis ; Radiotherapy ; Time Factors ; Treatment Outcome ; Young Adult
    Language English
    Publishing date 2021-01-08
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    DOI 10.21873/anticanres.14786
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1642: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Differentiation of different stages of brain tumor infiltration using optical coherence tomography: Comparison of two systems and histology.

    Strenge, Paul / Lange, Birgit / Draxinger, Wolfgang / Grill, Christin / Danicke, Veit / Theisen-Kunde, Dirk / Hagel, Christian / Spahr-Hess, Sonja / Bonsanto, Matteo M / Handels, Heinz / Huber, Robert / Brinkmann, Ralf

    Frontiers in oncology

    2022  Volume 12, Page(s) 896060

    Abstract: The discrimination of tumor-infiltrated tissue from non-tumorous brain tissue during neurosurgical tumor excision is a major challenge in neurosurgery. It is critical to achieve full tumor removal since it directly correlates with the survival rate of ... ...

    Abstract The discrimination of tumor-infiltrated tissue from non-tumorous brain tissue during neurosurgical tumor excision is a major challenge in neurosurgery. It is critical to achieve full tumor removal since it directly correlates with the survival rate of the patient. Optical coherence tomography (OCT) might be an additional imaging method in the field of neurosurgery that enables the classification of different levels of tumor infiltration and non-tumorous tissue. This work investigated two OCT systems with different imaging wavelengths (930 nm/1310 nm) and different resolutions (axial (air): 4.9 μm/16 μm, lateral: 5.2 μm/22 μm) in their ability to identify different levels of tumor infiltration based on freshly excised
    Language English
    Publishing date 2022-08-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.896060
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  5. Article ; Online: Registration of histological brain images onto optical coherence tomography images based on shape information.

    Strenge, Paul / Lange, Birgit / Grill, Christin / Draxinger, Wolfgang / Danicke, Veit / Theisen-Kunde, Dirk / Hagel, Christian / Spahr-Hess, Sonja / Bonsanto, Matteo M / Huber, Robert / Handels, Heinz / Brinkmann, Ralf

    Physics in medicine and biology

    2022  Volume 67, Issue 13

    Abstract: Identifying tumour infiltration zones during tumour resection in order to excise as much tumour tissue as possible without damaging healthy brain tissue is still a major challenge in neurosurgery. The detection of tumour infiltrated regions so far ... ...

    Abstract Identifying tumour infiltration zones during tumour resection in order to excise as much tumour tissue as possible without damaging healthy brain tissue is still a major challenge in neurosurgery. The detection of tumour infiltrated regions so far requires histological analysis of biopsies taken from at expected tumour boundaries. The gold standard for histological analysis is the staining of thin cut specimen and the evaluation by a neuropathologist. This work presents a way to transfer the histological evaluation of a neuropathologist onto optical coherence tomography (OCT) images. OCT is a method suitable for real time
    MeSH term(s) Biopsy ; Brain/diagnostic imaging ; Neurosurgical Procedures ; Staining and Labeling ; Tomography, Optical Coherence/methods
    Language English
    Publishing date 2022-06-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 208857-5
    ISSN 1361-6560 ; 0031-9155
    ISSN (online) 1361-6560
    ISSN 0031-9155
    DOI 10.1088/1361-6560/ac6d9d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 199: Show issues Location:
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  6. Conference proceedings: Automatically ICD code-based search in routine data for detecting adverse events in neurosurgery. Is the sensitivity of this method comparable to the “gold standard” morbidity & mortality conference?

    Zech, Lotta / Tronnier, Volker M. / Bonsanto, Matteo M.

    2015  , Page(s) P 180

    Event/congress 66. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC); Karlsruhe; Deutsche Gesellschaft für Neurochirurgie; 2015
    Keywords Medizin, Gesundheit ; M&M conference ; hospital information system ; adverse events
    Publishing date 2015-06-02
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/15dgnc578
    Database German Medical Science

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  7. Conference proceedings: Data-processing during a morbidity & mortality conference – necessary, out of favor & full pitfalls

    Zech, L. / Tronnier, Volker M. / Bonsanto, Matteo M.

    2013  , Page(s) P 041

    Event/congress 64. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC); Düsseldorf; Deutsche Gesellschaft für Neurochirurgie; 2013
    Keywords Medizin, Gesundheit ; data-processing ; morbidity & mortality ; pifalls
    Publishing date 2013-05-21
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/13dgnc459
    Database German Medical Science

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  8. Conference proceedings: Imaging of the ulnar nerve – correlation of high-resolution ultrasonography and MR neurography in preoperative diagnostics

    Brunswig, Klaus / Spuck, Sebastian / Tronnier, Volker M. / Bonsanto, Matteo M.

    2010  , Page(s) P1814

    Event/congress 61. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC) im Rahmen der Neurowoche 2010; Mannheim; Deutsche Gesellschaft für Neurochirurgie; 2010
    Keywords Medizin, Gesundheit
    Publishing date 2010-09-16
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/10dgnc285
    Database German Medical Science

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  9. Article: The role of postoperative radiotherapy for the treatment of gangliogliomas.

    Rades, Dirk / Zwick, Lena / Leppert, Jan / Bonsanto, Matteo M / Tronnier, Volker / Dunst, Juergen / Schild, Steven E

    Cancer

    2010  Volume 116, Issue 2, Page(s) 432–442

    Abstract: Background: Because of their rarity, no prospective studies have been performed regarding gangliogliomas. The optimal treatment regimen is unclear. In this study, the authors compared 4 therapies for local control (LC) and overall survival (OS) in ... ...

    Abstract Background: Because of their rarity, no prospective studies have been performed regarding gangliogliomas. The optimal treatment regimen is unclear. In this study, the authors compared 4 therapies for local control (LC) and overall survival (OS) in patients with ganglioglioma.
    Methods: In 402 patients with ganglioglioma, outcomes were compared for patients who underwent gross total resection alone (GTR) (n = 188), GTR plus radiotherapy (GTR + RT) (n = 21), subtotal resection alone (STR) (n = 113), and STR plus RT (STR + RT (n = 80). Age, sex, tumor site, and histologic grade also were investigated. Subgroup analyses were performed for both low-grade and high-grade tumors.
    Results: The 10-year LC rates were 89% after GTR, 90% after GTR + RT, 52% after STR, and 65% after STR + RT (P < .001); and the 10-year OS rates were 95%, 95%, 62%, and 74%, respectively (P < .001). After STR, irradiation significantly improved LC (P = .004) but not OS (P = .22). After GTR, irradiation did not significantly improve LC (P = .23) or OS (P = .29). On multivariate analyses, LC and OS were associated with therapy and pathologic grade, and OS also was associated with tumor site. In low-grade tumors, STR + RT resulted in better LC (P = .016) but not better OS (P = .18); and, after GTR, LC (P = .28) and OS (P = 1.0) were not improved with postoperative radiotherapy. In high-grade tumors, STR + RT resulted in better LC (P = .016) but not better OS (P = .41); after GTR, LC (P = .56) and OS (P = .61) were not improved with irradiation.
    Conclusions: According to this review, GTR should be performed whenever safely possible and does not require postoperative irradiation. If only STR is achieved, then RT improves LC of both low-grade and high-grade tumors and, thus, should be considered seriously.
    MeSH term(s) Adolescent ; Adult ; Brain Neoplasms/mortality ; Brain Neoplasms/radiotherapy ; Brain Neoplasms/surgery ; Child ; Child, Preschool ; Combined Modality Therapy ; Female ; Ganglioglioma/mortality ; Ganglioglioma/radiotherapy ; Ganglioglioma/surgery ; Humans ; Infant ; Infant, Newborn ; Male ; Postoperative Period ; Radiotherapy, Adjuvant ; Retrospective Studies ; Survival Analysis
    Language English
    Publishing date 2010-01-15
    Publishing country United States
    Document type Comparative Study ; Evaluation Studies ; Journal Article
    ZDB-ID 1429-1
    ISSN 1097-0142 ; 0008-543X ; 1934-662X
    ISSN (online) 1097-0142
    ISSN 0008-543X ; 1934-662X
    DOI 10.1002/cncr.24716
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  10. Conference proceedings: Gesture interaction with medical software for a neuronavigation device

    Kipshagen, Till / Graw, Mathis / Tronnier, Volker / Hofmann, Ulrich G. / Bonsanto, Matteo M.

    2010  , Page(s) P1820

    Event/congress 61. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC) im Rahmen der Neurowoche 2010; Mannheim; Deutsche Gesellschaft für Neurochirurgie; 2010
    Keywords Medizin, Gesundheit
    Publishing date 2010-09-16
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/10dgnc291
    Database German Medical Science

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