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  1. Article ; Online: Inflammatory Bowel Disease Patients' Preferences for Subcutaneous versus Intravenous Therapies: A Mixed-Methods Study.

    van Deen, Welmoed K / Khalil, Carine / Bonthala, Nirupama N / Gale, Rebecca / Patel, Devin B / Warui, Esther / Melmed, Gil Y / Spiegel, Brennan M R

    Digestive diseases (Basel, Switzerland)

    2022  Volume 41, Issue 3, Page(s) 412–421

    Abstract: Background: Multiple biologics are available to treat inflammatory bowel disease (IBD), which can either be administered subcutaneously or intravenously. The factors that determine patients' preferences for SC/IV administration in IBD are largely ... ...

    Abstract Background: Multiple biologics are available to treat inflammatory bowel disease (IBD), which can either be administered subcutaneously or intravenously. The factors that determine patients' preferences for SC/IV administration in IBD are largely unknown. This study aims to elucidate how IBD patients trade off between medications' route of administration and other medication characteristics and to understand what drives patients' preferences.
    Methods: We employed a mixed methods design using data from a prior quantitative conjoint analysis survey and a series of 22 qualitative interviews. We quantitatively assessed individual patients' preferences for subcutaneous (SC) or intravenous (IV) medications based on the part-worth utilities derived from the conjoint analysis and identified predictors for these preferences. We used a qualitative analysis to identify key themes surrounding patients' preferences in the interview data.
    Results: Of 1,077 survey participants, 49% preferred an SC medication every 2 weeks, whereas 51% preferred an IV medication every 8 weeks. More people preferred SC at reduced administration frequencies, whereas less people preferred SC at the expense of lower efficacy or higher side-effects rates. Prior experience with SC/IV was the strongest predictor for patients' preferences. Qualitatively, we obtained in-depth insights in the perceived advantages and disadvantages of SC and IV medications and in patients' preconceived ideas.
    Conclusion: While prior SC/IV exposure was a strong predictor for SC/IV preferences, patients' preferences largely are determined by a variety of other personal factors. The themes we identified could help guide clinicians when discussing therapeutic options with their patients and support shared decision-making.
    MeSH term(s) Humans ; Patient Preference ; Injections, Subcutaneous ; Inflammatory Bowel Diseases/drug therapy ; Administration, Intravenous ; Surveys and Questionnaires
    Language English
    Publishing date 2022-12-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 632798-9
    ISSN 1421-9875 ; 0257-2753
    ISSN (online) 1421-9875
    ISSN 0257-2753
    DOI 10.1159/000528586
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Social Media for the Dissemination of Educational Videos About Inflammatory Bowel Diseases.

    van Deen, Welmoed K / Simpson, Mike / Dupuy, Taylor P / Khalil, Carine / Bonthala, Nirupama N / Spiegel, Brennan M R

    The American journal of gastroenterology

    2022  Volume 117, Issue 8, Page(s) 1320–1323

    Abstract: Introduction: To broadly disseminate 5 user-centered educational videos for patients with inflammatory bowel disease and their family and friends on social media.: Methods: Relevant social media users were iteratively identified based on their online ...

    Abstract Introduction: To broadly disseminate 5 user-centered educational videos for patients with inflammatory bowel disease and their family and friends on social media.
    Methods: Relevant social media users were iteratively identified based on their online behavior. For each video, 2 different accompanying texts were tested.
    Results: We reached 4.2 million social media users of whom 320,302 watched at least 50% of the video. A short description resulted in higher view rates than posing an open-ended question.
    Discussion: We showed the feasibility of large-scale dissemination of health-related educational videos through social media. Our findings can inform future online dissemination approaches of educational content.
    MeSH term(s) Humans ; Inflammatory Bowel Diseases ; Information Dissemination/methods ; Social Media ; Video Recording/methods
    Language English
    Publishing date 2022-05-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000001825
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Assessment of inflammatory bowel disease educational videos for increasing patient engagement and family and friends' levels of understanding.

    van Deen, Welmoed K / Khalil, Carine / Dupuy, Taylor P / Bonthala, Nirupama N / Spiegel, Brennan M R / Almario, Christopher V

    Patient education and counseling

    2021  Volume 105, Issue 3, Page(s) 660–669

    Abstract: Objective: We developed five educational videos through a user-centered approach for patients with inflammatory bowel diseases (IBD) and their families and friends. Here, we assessed if IBD patient activation and family and friends' abilities to ... ...

    Abstract Objective: We developed five educational videos through a user-centered approach for patients with inflammatory bowel diseases (IBD) and their families and friends. Here, we assessed if IBD patient activation and family and friends' abilities to understand IBD patients' thoughts, feelings, and behaviors (i.e., perspective taking) changed after watching the videos.
    Methods: Through a pre-post survey, we assessed patient activation and perspective taking levels in people with a self-reported IBD diagnosis and their family and friends, respectively, before and after watching one of the videos.
    Results: Among 767 participants with IBD, patient activation scores increased significantly after watching each video. In regression analyses, patient activation levels were less likely to increase in biologic-naïve participants after viewing the coping video. Among 232 people who knew someone with IBD, perspective taking scores increased significantly in 8/9 domains, which was more likely to occur among women.
    Conclusions: Educational videos developed through a user-centered approach were associated with higher self-reported IBD patient activation scores and perspective taking levels among family and friends.
    Practice implications: These videos, which are now widely disseminated on social media, serve as a model for how to create educational materials for improving patient activation and empathy in the social media era.
    MeSH term(s) Chronic Disease ; Female ; Friends ; Humans ; Inflammatory Bowel Diseases/therapy ; Patient Participation ; Social Media
    Language English
    Publishing date 2021-06-08
    Publishing country Ireland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 605590-4
    ISSN 1873-5134 ; 0738-3991
    ISSN (online) 1873-5134
    ISSN 0738-3991
    DOI 10.1016/j.pec.2021.06.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Comprehensive Association Analyses of Extraintestinal Manifestations in Inflammatory Bowel Disease.

    Khrom, Michelle / Long, Millie / Dube, Shishir / Robbins, Lori / Botwin, Gregory J / Yang, Shaohong / Mengesha, Emebet / Li, Dalin / Naito, Takeo / Bonthala, Nirupama N / Ha, Christina / Melmed, Gil / Rabizadeh, Shervin / Syal, Gaurav / Vasiliauskas, Eric / Ziring, David / Brant, Steven R / Cho, Judy / Duerr, Richard H /
    Rioux, John / Schumm, Phil / Silverberg, Mark / Ananthakrishnan, Ashwin N / Faubion, William A / Jabri, Bana / Lira, Sergio A / Newberry, Rodney D / Sandler, Robert S / Xavier, Ramnik J / Kugathasan, Subra / Hercules, David / Targan, Stephan R / Sartor, R Balfour / Haritunians, Talin / McGovern, Dermot P B

    Gastroenterology

    2024  

    Abstract: Background & aims: Patients with inflammatory bowel disease (IBD) frequently develop extraintestinal manifestations (EIMs) that contribute substantially to morbidity. We assembled the largest multicohort data set to date to investigate the clinical, ... ...

    Abstract Background & aims: Patients with inflammatory bowel disease (IBD) frequently develop extraintestinal manifestations (EIMs) that contribute substantially to morbidity. We assembled the largest multicohort data set to date to investigate the clinical, serologic, and genetic factors associated with EIM complications in IBD.
    Methods: Data were available in 12,083 unrelated European ancestry IBD cases with presence or absence of EIMs (eg, ankylosing spondylitis [ankylosing spondylitis and sacroiliitis], primary sclerosing cholangitis [PSC], peripheral arthritis, and skin and ocular manifestations) across 4 cohorts (Cedars-Sinai Medical Center, National Institute for Diabetes and Digestive and Kidney Diseases IBD Genetics Consortium, Sinai Helmsley Alliance for Research Excellence Consortium, and Risk Stratification and Identification of Immunogenetic and Microbial Markers of Rapid Disease Progression in Children with Crohn's Disease cohort). Clinical and serologic parameters were analyzed by means of univariable and multivariable regression analyses using a mixed-effects model. Within-case logistic regression was performed to assess genetic associations.
    Results: Most EIMs occurred more commonly in female subjects (overall EIM: P = 9.0E-05, odds ratio [OR], 1.2; 95% CI, 1.1-1.4), with CD (especially colonic disease location; P = 9.8E-09, OR, 1.7; 95% CI, 1.4-2.0), and in subjects who required surgery (both CD and UC; P = 3.6E-19, OR, 1.7; 95% CI, 1.5-1.9). Smoking increased risk of EIMs except for PSC, where there was a "protective" effect. Multiple serologic associations were observed, including with PSC (IgG and IgA, perinuclear anti-nuclear cytoplasmic antibody; anti-Saccharomyces cerevisiae antibodies; and anti-flagellin) and any EIM (IgG and IgA, perinuclear anti-nuclear cytoplasmic antibody; anti-Saccharomyces cerevisiae antibodies; and anti-Pseudomonas fluorescens-associated sequence). We identified genome-wide significant associations within major histocompatibility complex (ankylosing spondylitis and sacroiliitis, P = 1.4E-15; OR, 2.5; 95% CI, 2.0-3.1; PSC, P = 2.7E-10; OR, 2.8; 95% CI, 2.0-3.8; ocular, P = 2E-08, OR, 3.6; 95% CI, 2.3-5.6; and overall EIM, P = 8.4E-09; OR, 2.2; 95% CI, 1.7-2.9) and CPEB4 (skin, P = 2.7E-08; OR, 1.5; 95% CI, 1.3-1.8). Genetic associations implicated tumor necrosis factor, JAK-STAT, and IL6 as potential targets for EIMs. Contrary to previous reports, only 2% of our subjects had multiple EIMs and most co-occurrences were negatively correlated.
    Conclusions: We have identified demographic, clinical, and genetic associations with EIMs that revealed underlying mechanisms and implicated novel and existing drug targets-important steps toward a more personalized approach to IBD management.
    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2024.02.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Genetic coding variant in complement factor B (CFB) is associated with increased risk for perianal Crohn's disease and leads to impaired CFB cleavage and phagocytosis.

    Akhlaghpour, Marzieh / Haritunians, Talin / More, Shyam K / Thomas, Lisa S / Stamps, Dalton T / Dube, Shishir / Li, Dalin / Yang, Shaohong / Landers, Carol J / Mengesha, Emebet / Hamade, Hussein / Murali, Ramachandran / Potdar, Alka A / Wolf, Andrea J / Botwin, Gregory J / Khrom, Michelle / Ananthakrishnan, Ashwin N / Faubion, William A / Jabri, Bana /
    Lira, Sergio A / Newberry, Rodney D / Sandler, Robert S / Sartor, R Balfour / Xavier, Ramnik J / Brant, Steven R / Cho, Judy H / Duerr, Richard H / Lazarev, Mark G / Rioux, John D / Schumm, L Philip / Silverberg, Mark S / Zaghiyan, Karen / Fleshner, Phillip / Melmed, Gil Y / Vasiliauskas, Eric A / Ha, Christina / Rabizadeh, Shervin / Syal, Gaurav / Bonthala, Nirupama N / Ziring, David A / Targan, Stephan R / Long, Millie D / McGovern, Dermot P B / Michelsen, Kathrin S

    Gut

    2023  Volume 72, Issue 11, Page(s) 2068–2080

    Abstract: Objective: Perianal Crohn's disease (pCD) occurs in up to 40% of patients with CD and is associated with poor quality of life, limited treatment responses and poorly understood aetiology. We performed a genetic association study comparing CD subjects ... ...

    Abstract Objective: Perianal Crohn's disease (pCD) occurs in up to 40% of patients with CD and is associated with poor quality of life, limited treatment responses and poorly understood aetiology. We performed a genetic association study comparing CD subjects with and without perianal disease and subsequently performed functional follow-up studies for a pCD associated SNP in
    Design: Immunochip-based meta-analysis on 4056 pCD and 11 088 patients with CD from three independent cohorts was performed. Serological and clinical variables were analysed by regression analyses. Risk allele of rs4151651 was introduced into human CFB plasmid by site-directed mutagenesis. Binding of recombinant G252 or S252 CFB to C3b and its cleavage was determined in cell-free assays. Macrophage phagocytosis in presence of recombinant CFB or serum from
    Results: Perianal complications were associated with colonic involvement, OmpC and ASCA serology, and serology quartile sum score. We identified a genetic association for pCD (rs4151651), a non-synonymous SNP (G252S) in
    Conclusion: pCD-associated rs4151651 in
    MeSH term(s) Humans ; Complement Factor B/genetics ; Crohn Disease/complications ; Quality of Life ; Follow-Up Studies ; Phagocytosis
    Chemical Substances Complement Factor B (EC 3.4.21.47)
    Language English
    Publishing date 2023-04-20
    Publishing country England
    Document type Meta-Analysis ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2023-329689
    Database MEDical Literature Analysis and Retrieval System OnLINE

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