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  1. Book ; Conference proceedings: Old and new dopamine agonists in Parkinson's disease

    Bonuccelli, Ubaldo

    [papers presented at the First International Congress on Dopamine Agonists held in Pisa in December 1993]

    (Journal of neural transmission : Supplement ; 45)

    1995  

    Event/congress International Congress on Dopamine Agonists (1, 1993, Pisa)
    Author's details U. Bonuccelli ... (ed.)
    Series title Journal of neural transmission : Supplement ; 45
    Journal of neural transmission
    Journal of neural transmission ; Supplement
    Collection Journal of neural transmission
    Journal of neural transmission ; Supplement
    Keywords Parkinson Disease / physiopathology / congresses ; Parkinson Disease / drug therapy / congresses ; Dopamine Agonists / therapeutic use / congresses ; Receptors, Dopamine / drug therapy / congresses ; Parkinson-Krankheit ; Dopaminantagonist ; Dopaminagonist
    Subject Schüttellähmung ; Paralysis agitans ; Idiopathischer Parkinsonismus ; Morbus Parkinson ; Dopamin ; Dopaminrezeptorantagonist ; Dopaminrezeptorenblocker
    Language English
    Size VIII, 321 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Wien u.a.
    Publishing country Austria
    Document type Book ; Conference proceedings
    HBZ-ID HT006842230
    ISBN 3-211-82717-X ; 0-387-82717-X ; 978-3-211-82717-8 ; 978-0-387-82717-9
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Ui II Zs 150 -Suppl.45- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Essential tremor is a neurodegenerative disease.

    Bonuccelli, Ubaldo

    Journal of neural transmission (Vienna, Austria : 1996)

    2012  Volume 119, Issue 11, Page(s) 1383–7; discussion 1373

    Abstract: There are many lines of evidence supporting the idea that essential tremor is more than simply a monosymptomatic disorder and that all the clinical manifestations of this frequent disorder are sustained by a neurodegenerative process. The most important ... ...

    Abstract There are many lines of evidence supporting the idea that essential tremor is more than simply a monosymptomatic disorder and that all the clinical manifestations of this frequent disorder are sustained by a neurodegenerative process. The most important lines of evidence in favor of a neurodegenerative nature of essential tremor are: the anatomic and neuroimaging data demonstrating a pathologic process involving the cerebellum and/or brainstem; the progression of symptom severity with disease duration; and the lack of spontaneous remission of this condition. All of this evidence is supported by recent studies that are summarized in this review.
    MeSH term(s) Cerebellum/pathology ; Disease Progression ; Essential Tremor/diagnosis ; Essential Tremor/physiopathology ; Humans ; Neurodegenerative Diseases/pathology ; Neurodegenerative Diseases/physiopathology ; Neuroimaging
    Language English
    Publishing date 2012-08-23
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 184163-4
    ISSN 1435-1463 ; 0300-9564
    ISSN (online) 1435-1463
    ISSN 0300-9564
    DOI 10.1007/s00702-012-0878-8
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  3. Article: Non-pharmacological interventions for Parkinson's disease mild cognitive impairment: future directions for research.

    Cammisuli, Davide Maria / Ceravolo, Roberto / Bonuccelli, Ubaldo

    Neural regeneration research

    2020  Volume 15, Issue 9, Page(s) 1650–1651

    Language English
    Publishing date 2020-03-25
    Publishing country India
    Document type Journal Article
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.276329
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  4. Article: Transcranial Direct Current Stimulation (tDCS) as a Useful Rehabilitation Strategy to Improve Cognition in Patients With Alzheimer's Disease and Parkinson's Disease: An Updated Systematic Review of Randomized Controlled Trials.

    Cammisuli, Davide Maria / Cignoni, Fabio / Ceravolo, Roberto / Bonuccelli, Ubaldo / Castelnuovo, Gianluca

    Frontiers in neurology

    2022  Volume 12, Page(s) 798191

    Abstract: Alzheimer's disease (AD) and Parkinson's disease (PD) are neurodegenerative disorders characterized by cognitive impairment and functional decline increasing with disease progression. Within non-pharmacological interventions, transcranial direct current ... ...

    Abstract Alzheimer's disease (AD) and Parkinson's disease (PD) are neurodegenerative disorders characterized by cognitive impairment and functional decline increasing with disease progression. Within non-pharmacological interventions, transcranial direct current stimulation (tDCS) might represent a cost-effective rehabilitation strategy to implement cognitive abilities with positive implications for functional autonomy and quality-of-life of patients. Our systematic review aimed at evaluating the effects of tDCS upon cognition in people suffering from AD and PD. We searched for randomized controlled trials (RCTs) into PubMed, Web of Science, and Cochrane Library. Three review authors extracted data of interest, with neuropsychological tests or experimental cognitive tasks scores as outcome measures. A total of 17 RCTs (10 trials for AD and 7 trials for PD) were included. Compared with sham stimulation, tDCS may improve global cognition and recognition memory in patients with AD and also some executive functions (i.e., divided attention, verbal fluency, and reduction of sensitivity to interference) in patients with PD. Criticism remains about benefits for the other investigated cognitive domains. Despite preliminary emerging evidences, larger RCTs with common neuropsychological measures and long-term follow-ups establishing longevity of the observed effects are necessary for future research in applied psychology field, alongside improved clinical guidelines on the neurodegenerative disorders pertaining electrodes montage, sessions number, duration and intensity of the stimulation, and cognitive battery to be used.
    Language English
    Publishing date 2022-02-02
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2021.798191
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  5. Article ; Online: Early autonomic and cognitive dysfunction in PD, DLB and MSA: blurring the boundaries between α-synucleinopathies.

    Palermo, Giovanni / Del Prete, Eleonora / Bonuccelli, Ubaldo / Ceravolo, Roberto

    Journal of neurology

    2020  Volume 267, Issue 12, Page(s) 3444–3456

    Abstract: Differential diagnosis between Parkinson's disease, dementia with Lewy bodies and multiple system atrophy can be difficult, especially because in early phase they might present with overlapping clinical features. Notably, orthostatic hypotension and ... ...

    Abstract Differential diagnosis between Parkinson's disease, dementia with Lewy bodies and multiple system atrophy can be difficult, especially because in early phase they might present with overlapping clinical features. Notably, orthostatic hypotension and cognitive dysfunction are common nonmotor aspects of parkinsonian syndromes and can be both present from the earliest stages of all α-synucleinopathies, indicating a common neurobiological basis in their strong relationship. In view of the increasing awareness about the prevalence of mild cognitive dysfunction in multiple system atrophy, the relevance of autonomic dysfunction in demented parkinsonian patients, the critical role of non-motor symptoms in clustering Parkinson's disease patients and the shift to studying patients in the prodromal phase, we will discuss some intrinsic limitations of current clinical diagnostic criteria, even when applied by movement disorder specialists. In particular, we will focus on the early coexistence of autonomic and cognitive dysfunction in the setting of overt or latent parkinsonism as pitfalls in the differential diagnosis of α-synucleinopathies. As early and accurate diagnosis remains of outmost importance for counselling of patients and timely enrolment into disease-modifying clinical trials, a continuous effort of research community is ongoing to further improve the clinical diagnostic accuracy of α-synucleinopathies.
    MeSH term(s) Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/etiology ; Humans ; Lewy Body Disease/complications ; Lewy Body Disease/diagnosis ; Multiple System Atrophy/complications ; Multiple System Atrophy/diagnosis ; Parkinson Disease/complications ; Parkinson Disease/diagnosis ; Synucleinopathies
    Keywords covid19
    Language English
    Publishing date 2020-06-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s00415-020-09985-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui II Zs.40: Show issues Location:
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  6. Article ; Online: Tardive Syndrome Associated With Tetrabenazine in Huntington Disease: A Case Report.

    Palermo, Giovanni / Mazzucchi, Sonia / Unti, Elisa / Bonuccelli, Ubaldo / Ceravolo, Roberto

    Journal of clinical psychopharmacology

    2020  Volume 40, Issue 6, Page(s) 628–630

    MeSH term(s) Adrenergic Uptake Inhibitors/administration & dosage ; Adrenergic Uptake Inhibitors/adverse effects ; Aged ; Humans ; Huntington Disease/diagnosis ; Huntington Disease/drug therapy ; Huntington Disease/physiopathology ; Huntington Disease/psychology ; Male ; Motor Activity/drug effects ; Risk Assessment ; Risk Factors ; Tardive Dyskinesia/chemically induced ; Tardive Dyskinesia/diagnosis ; Tardive Dyskinesia/physiopathology ; Tetrabenazine/administration & dosage ; Tetrabenazine/adverse effects ; Treatment Outcome
    Chemical Substances Adrenergic Uptake Inhibitors ; Tetrabenazine (Z9O08YRN8O)
    Language English
    Publishing date 2020-11-01
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 604631-9
    ISSN 1533-712X ; 0271-0749
    ISSN (online) 1533-712X
    ISSN 0271-0749
    DOI 10.1097/JCP.0000000000001295
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Advances in the pharmacotherapeutic management of dementia with Lewy bodies.

    Palermo, Giovanni / Ceravolo, Roberto / Bonuccelli, Ubaldo

    Expert opinion on pharmacotherapy

    2018  Volume 19, Issue 15, Page(s) 1643–1653

    Abstract: Introduction: Dementia with Lewy bodies (DLB) is the second most common type of dementia in people over 65 years of age. Given the complex clinical phenotype, the management of DLB may be challenging, especially considering that there is limited ... ...

    Abstract Introduction: Dementia with Lewy bodies (DLB) is the second most common type of dementia in people over 65 years of age. Given the complex clinical phenotype, the management of DLB may be challenging, especially considering that there is limited evidence about specific interventions, and there are currently no Food and Drug Administration (FDA)/European Medicines Agency (EMA)-approved medications.
    Areas covered: This article provides an overview of the current pharmacotherapy in DLB and gives review to the most recent drug candidates in clinical trials.
    Expert opinion: Commonly prescribed drugs are primarily aimed at treating the most troublesome clinical features of DLB. Although these medications provide some benefit to symptoms, there is, unfortunately, a lack of DLB-specific evidence on effective treatments and their off-label use. Indeed, most treatments used come from clinical trials on patients with Alzheimer's disease or Parkinson's disease. Thus, there is an urgent need for randomized clinical trials in DLB patients. Despite several challenges, potential new drugs are in ongoing clinical trials; furthermore, as our understanding of molecular and cellular mechanisms underlying DLB broaden, it is likely that we will identify novel drug targets for the development of better and more effective symptomatic products and disease-modifying therapies.
    MeSH term(s) Aged ; Dementia/drug therapy ; Dementia/pathology ; Female ; Humans ; Lewy Body Disease/drug therapy ; Lewy Body Disease/pathology ; Male ; Parkinson Disease/drug therapy ; Parkinson Disease/pathology
    Language English
    Publishing date 2018-09-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2001535-5
    ISSN 1744-7666 ; 1465-6566
    ISSN (online) 1744-7666
    ISSN 1465-6566
    DOI 10.1080/14656566.2018.1519548
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  8. Article ; Online: Negative DAT-SPECT in Old Onset Parkinson's Disease: An Additional Pitfall?

    Palermo, Giovanni / Giannoni, Sara / Depalo, Tommaso / Frosini, Daniela / Volterrani, Duccio / Siciliano, Gabriele / Bonuccelli, Ubaldo / Ceravolo, Roberto

    Movement disorders clinical practice

    2022  Volume 9, Issue 4, Page(s) 530–534

    Abstract: Background: Scans without evidence of dopaminergic deficit (SWEDDs) refer to patients clinically diagnosed with Parkinson's disease (PD), but showing normal findings on dopamine transporter single-photon emission computed tomography (DAT-SPECT). This ... ...

    Abstract Background: Scans without evidence of dopaminergic deficit (SWEDDs) refer to patients clinically diagnosed with Parkinson's disease (PD), but showing normal findings on dopamine transporter single-photon emission computed tomography (DAT-SPECT). This entity remains highly debated, but recent findings suggesting that DAT-SPECT does not reflect either nigral cell bodies or striatal fibers of dopaminergic nigrostriatal neurons could improve our understanding of SWEDDs. Notably, compensatory downregulation of DAT in the early stages of PD seems to be less efficient in older-onset than in young-onset patients.
    Cases: We report eight patients with old-onset clinical parkinsonism and a positive response to levodopa in which DAT-SPECT was normal both visually and semiquantitatively. Two subjects demonstrated an abnormal scan when repeated later.
    Conclusions: We suggest that old-onset patients may truly have dopaminergic degeneration despite normal imaging results, presumably because they are diagnosed in the early stages confirming less efficient striatal compensatory strategies in old-age onset PD.
    Language English
    Publishing date 2022-04-15
    Publishing country United States
    Document type Case Reports
    ISSN 2330-1619
    ISSN (online) 2330-1619
    DOI 10.1002/mdc3.13441
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  9. Article: What Does the Brain Have to Keep Working at Its Best? Resilience Mechanisms Such as Antioxidants and Brain/Cognitive Reserve for Counteracting Alzheimer's Disease Degeneration.

    Cammisuli, Davide Maria / Franzoni, Ferdinando / Scarfò, Giorgia / Fusi, Jonathan / Gesi, Marco / Bonuccelli, Ubaldo / Daniele, Simona / Martini, Claudia / Castelnuovo, Gianluca

    Biology

    2022  Volume 11, Issue 5

    Abstract: Here we performed a narrative review highlighting the effect of brain/cognitive reserve and natural/synthetic antioxidants in exerting a neuroprotective effect against cognitive deterioration during physiological and pathological aging. Particularly, we ... ...

    Abstract Here we performed a narrative review highlighting the effect of brain/cognitive reserve and natural/synthetic antioxidants in exerting a neuroprotective effect against cognitive deterioration during physiological and pathological aging. Particularly, we discussed pathogenesis of Alzheimer's disease, brain and cognitive reserve as means of resilience towards deterioration, and evidence from the literature about antioxidants' role in sustaining cognitive functioning in the preclinical phase of dementia. During aging, the effects of disease-related brain changes upon cognition are reduced in individuals with higher cognitive reserve, which might lose its potential with emerging cognitive symptoms in the transitional phase over the
    Language English
    Publishing date 2022-04-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology11050650
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  10. Article: Aerobic Exercise and Healthy Nutrition as Neuroprotective Agents for Brain Health in Patients with Parkinson’s Disease: A Critical Review of the Literature

    Cammisuli, Davide Maria / Bonuccelli, Ubaldo / Daniele, Simona / Martini, Claudia / Fusi, Jonathan / Franzoni, Ferdinando

    Antioxidants. 2020 May 05, v. 9, no. 5

    2020  

    Abstract: Parkinson’s disease (PD) is characterized by motor and nonmotor features that have an influence on patients’ quality of life at different levels. To date, some evidences have arisen on the effectiveness of physical trainings and nutrients intake in ... ...

    Abstract Parkinson’s disease (PD) is characterized by motor and nonmotor features that have an influence on patients’ quality of life at different levels. To date, some evidences have arisen on the effectiveness of physical trainings and nutrients intake in ameliorating functional and cognitive outcomes in PD patients. Physical activity is effective in improving both motor and nonmotor features and recent epidemiological investigations have revealed the pivotal role that dietary patterns may play in reducing the risk of PD highlighting the pathogenesis of the neurodegeneration. Specifically, aerobic exercise shows beneficial effects in improving motor functions and executive control in PD patients, as well as proper nutrition may help in improving neuroprotective agents counteracting neurodegeneration and allows patients to better interact with the medication. Our narrative review critically focused on aerobic exercise and nutrition in PD in order to point out the best prescriptions for brain health of affected patients. Implications for a therapeutic plan and rehabilitation for these patients are also discussed.
    Keywords Parkinson disease ; brain ; cognition ; drug therapy ; eating habits ; epidemiological studies ; exercise ; nutrients ; nutrition ; pathogenesis ; patients ; quality of life
    Language English
    Dates of publication 2020-0505
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox9050380
    Database NAL-Catalogue (AGRICOLA)

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