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  1. Article: Doxycycline: From Ocular Rosacea to COVID-19 Anosmia. New Insight Into the Coronavirus Outbreak.

    Bonzano, Chiara / Borroni, Davide / Lancia, Andrea / Bonzano, Elisabetta

    Frontiers in medicine

    2020  Volume 7, Page(s) 200

    Keywords covid19
    Language English
    Publishing date 2020-05-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2020.00200
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cardiotoxicity Assessment After Different Adjuvant Hypofractionated Radiotherapy Concurrently Associated with Trastuzumab in Early Breast Cancer.

    Bonzano, Elisabetta / Guenzi, Marina / Corvò, Renzo

    In vivo (Athens, Greece)

    2018  Volume 32, Issue 4, Page(s) 879–882

    Abstract: Aim: To evaluate cardiotoxicity in patients with human epidermal growth factor receptor 2+ (HER2+) breast cancer (29 left-sided, 23 right-sided) treated with adjuvant whole-breast hypofractionated radiotherapy (HRT) concurrently administered with the ... ...

    Abstract Aim: To evaluate cardiotoxicity in patients with human epidermal growth factor receptor 2+ (HER2+) breast cancer (29 left-sided, 23 right-sided) treated with adjuvant whole-breast hypofractionated radiotherapy (HRT) concurrently administered with the humanized monoclonal antibody to HER2, trastuzumab.
    Patients and methods: From February 2008 to June 2017, 52 patients received three-dimensional conformal RT, with different HRT schemes. Echocardiogram monitoring was used to evaluate the decrease in left ventricular ejection fraction (LVEF).
    Results: At a median follow-up of 5 years, cardiotoxicity was as follows: among the 15 patients treated with 46 Gy: grade (G) 2 in two (13%), G1 in three (20%), and G0 in 10 (67%);in those treated with 39 Gy (16 patients): G1 in five (31%), and G0 in 11 (69%);among the 21 patients treated with 35 Gy: G2 in one (5%), G1 in five (24%), and G0 in 15 (71%).
    Conclusion: Trastuzumab was shown to be a safe adjuvant treatment when administered with concomitant HRT since it did not increase cardiotoxicity in those with left-sided breast cancer. No differences in LVEF were observed between the HRT schemes.
    MeSH term(s) Adult ; Aged ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Breast Neoplasms/radiotherapy ; Cardiotoxicity/diagnosis ; Cardiotoxicity/pathology ; Chemotherapy, Adjuvant/adverse effects ; Combined Modality Therapy ; Dose Hypofractionation ; Echocardiography ; Female ; Humans ; Middle Aged ; Neoplasm Staging ; Receptor, ErbB-2/genetics ; Trastuzumab/adverse effects ; Ventricular Function, Left/radiation effects
    Chemical Substances ERBB2 protein, human (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1) ; Trastuzumab (P188ANX8CK)
    Language English
    Publishing date 2018-06-21
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 807031-3
    ISSN 1791-7549 ; 0258-851X
    ISSN (online) 1791-7549
    ISSN 0258-851X
    DOI 10.21873/invivo.11322
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Recombinant Human Nerve Growth Factor (Cenegermin)-Driven Corneal Wound Healing Process: An Evidence-Based Analysis.

    Bonzano, Chiara / Olivari, Sara / Cutolo, Carlo Alberto / Macrì, Angelo / Sindaco, Daniele / Borroni, Davide / Bonzano, Elisabetta / Traverso, Carlo Enrico

    Frontiers in pharmacology

    2022  Volume 12, Page(s) 760507

    Abstract: Purpose: ...

    Abstract Purpose:
    Language English
    Publishing date 2022-01-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2021.760507
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Highly specialized Breast Centers did not experience delay of care during COVID-19 pandemic in Italy: the Senonetwork experience.

    Losurdo, Agnese / Lisa, Andrea Vittorio Emanuele / Tomatis, Mariano / Ponti, Antonio / Montemezzi, Stefania / Bonzano, Elisabetta / Fortunato, Lucio

    Breast cancer research and treatment

    2022  Volume 196, Issue 1, Page(s) 87–95

    Abstract: Aim of the study: The study aims to evaluate the performance of selected, high-volume, highly specialized, Italian Breast Centers at the time of COVID-19 pandemic (year 2020), compared to pre-pandemic time (year 2019), highlighting differences in terms ... ...

    Abstract Aim of the study: The study aims to evaluate the performance of selected, high-volume, highly specialized, Italian Breast Centers at the time of COVID-19 pandemic (year 2020), compared to pre-pandemic time (year 2019), highlighting differences in terms of clinical presentation of breast cancer (BC) and therapeutic strategies.
    Methods: Patients' data were provided by the Senonetwork data warehouse Senonet. In order to examine changes in the surgical and oncological management of BC patients during different phases of COVID-19 pandemic, we took advantage of a selection quality indicators (QIs). We performed the analyses in two time-frames, from July to September (Jul-Sep) (2019 versus 2020) and from October to December (Oct-Dec) (2019 versus 2020).
    Results: Our analysis did not show any statistically significant difference in terms of diagnosis, surgical, oncological and radiation therapy procedures between the two trimesters 2019 and 2020. Nevertheless, we observed statistically significant differences, favoring 2020, when analyzing time-to surgery and time-to radiotherapy. On the other hand, we observed a significant reduction of neoadjuvant chemotherapy and we did not recollect any data on a major use of neoadjuvant endocrine therapy.
    Conclusions: In Italian Breast Centers, partners of Senonetwork, we could not observe any treatment delay or change in standard clinical practice for BC care during the 2020 pandemic year, compared to 2019 pre-pandemic year. This finding is in contrast with the globally reported decrease in the performance of the Italian Breast Centers due to the COVID-19 pandemic, and has to be linked to the sharp selection of Senonetwork Breast Centers.
    MeSH term(s) Breast ; Breast Neoplasms/diagnosis ; Breast Neoplasms/epidemiology ; Breast Neoplasms/therapy ; COVID-19/epidemiology ; Female ; Humans ; Italy/epidemiology ; Neoadjuvant Therapy ; Pandemics
    Language English
    Publishing date 2022-08-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 604563-7
    ISSN 1573-7217 ; 0167-6806
    ISSN (online) 1573-7217
    ISSN 0167-6806
    DOI 10.1007/s10549-022-06694-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Doxycycline

    Bonzano, Chiara / Borroni, Davide / Lancia, Andrea / Bonzano, Elisabetta

    Frontiers in Medicine

    From Ocular Rosacea to COVID-19 Anosmia. New Insight Into the Coronavirus Outbreak

    2020  Volume 7

    Keywords covid19
    Publisher Frontiers Media SA
    Publishing country ch
    Document type Article ; Online
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2020.00200
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Doxycycline

    BONZANO, CHIARA / Borroni, Davide / Lancia, Andrea / BONZANO, ELISABETTA

    From Ocular Rosacea to COVID-19 Anosmia. New Insight Into the Coronavirus Outbreak

    2020  

    Keywords COVID-19 ; doxycycline ; coronavirus (CoV) ; SARS – CoV ; anosmia ; covid19
    Language English
    Publishing country it
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Radiotherapy in the era of COVID-19.

    Lancia, Andrea / Bonzano, Elisabetta / Bottero, Marta / Camici, Marta / Catellani, Francesco / Ingrosso, Gianluca

    Expert review of anticancer therapy

    2020  Volume 20, Issue 8, Page(s) 625–627

    MeSH term(s) Betacoronavirus/isolation & purification ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/epidemiology ; Coronavirus Infections/transmission ; Coronavirus Infections/virology ; Dose Fractionation, Radiation ; Expert Testimony ; Humans ; Neoplasms/radiotherapy ; Neoplasms/virology ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/transmission ; Pneumonia, Viral/virology ; Practice Guidelines as Topic/standards ; Radiotherapy/standards ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-07
    Publishing country England
    Document type Editorial
    ZDB-ID 2112544-2
    ISSN 1744-8328 ; 1473-7140
    ISSN (online) 1744-8328
    ISSN 1473-7140
    DOI 10.1080/14737140.2020.1785290
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: A Successful Therapeutic Challenge: Local Reirradiation of Breast Cancer with a Single Dose of 18 Gy Intraoperative Radiation Therapy (IORT).

    Bonzano, Elisabetta / Guenzi, Marina / Corvò, Renzo

    Cureus

    2017  Volume 9, Issue 6, Page(s) e1376

    Abstract: After standard treatment of primary breast cancer, local relapse can develop in a previously irradiated region. The decision to refer a patient for a second radiotherapy must be thoroughly evaluated due to the increased risk of side effects. We report a ... ...

    Abstract After standard treatment of primary breast cancer, local relapse can develop in a previously irradiated region. The decision to refer a patient for a second radiotherapy must be thoroughly evaluated due to the increased risk of side effects. We report a case of a 43-year-old Caucasian female with a history of left breast lumpectomy and radiation treatment in 1990 for an invasive ductal carcinoma who presented with a locoregional recurrence 19 years later. After careful evaluation, the patient has undergone a second breast-conserving surgery and successful reirradiation with 18 Gy single dose of intraoperative radiation therapy (IORT).
    Language English
    Publishing date 2017-06-20
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.1376
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Salvage Hypofractionated Radiotherapy in a Progressive Radiation-Induced Angiosarcoma: A Case Report.

    Bonzano, Elisabetta / Guenzi, Marina / Corvò, Renzo

    Cureus

    2017  Volume 9, Issue 11, Page(s) e1886

    Abstract: We report a case of a long-term local control and survival achieved in a patient affected by radiation-induced angiosarcoma (RIA). A 57-year-old woman had a history of breast-conserving surgery and radiation therapy for primary breast cancer. Eight years ...

    Abstract We report a case of a long-term local control and survival achieved in a patient affected by radiation-induced angiosarcoma (RIA). A 57-year-old woman had a history of breast-conserving surgery and radiation therapy for primary breast cancer. Eight years after the mastectomy, multiple nodal progression was diagnosed as RIA and subsequentially treated by salvage lymph node dissection followed by adjuvant intensified radiotherapy to control the residual disease. Two and a half years later, the patient is alive and cancer-free. This experience shows that radiotherapy may have the potential to be a feasible and effective treatment to control RIA progression, and it may also play a role in the management of RIA as adjuvant.
    Language English
    Publishing date 2017-11-28
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.1886
    Database MEDical Literature Analysis and Retrieval System OnLINE

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