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  1. Article ; Online: Proton beam radiotherapy head and neck cancer study design and endpoints.

    Boon, Cheng S / Ramkumar, Shanmugasundaram / Boon, Ian S

    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

    2024  Volume 195, Page(s) 110234

    MeSH term(s) Humans ; Head and Neck Neoplasms/radiotherapy ; Proton Therapy ; Research Design ; Endpoint Determination
    Language English
    Publishing date 2024-03-16
    Publishing country Ireland
    Document type Journal Article ; Letter
    ZDB-ID 605646-5
    ISSN 1879-0887 ; 0167-8140
    ISSN (online) 1879-0887
    ISSN 0167-8140
    DOI 10.1016/j.radonc.2024.110234
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1926: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Multidisciplinary and interprofessional collaboration as a necessity to drive modern oncology research trials in the era of precision oncology.

    Tan, Jian / Boon, Ian S

    Journal of medical imaging and radiation sciences

    2021  Volume 53, Issue 1, Page(s) 179–180

    MeSH term(s) Humans ; Interprofessional Relations ; Medical Oncology ; Neoplasms/radiotherapy ; Precision Medicine
    Language English
    Publishing date 2021-12-23
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2426513-5
    ISSN 1876-7982 ; 1939-8654
    ISSN (online) 1876-7982
    ISSN 1939-8654
    DOI 10.1016/j.jmir.2021.11.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2541: Show issues Location:
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  3. Article ; Online: Evaluation of the "Shared Community Follow-up" after a germ cell tumour-A novel initiative for remote cancer follow-up enhanced by online patient-reported outcome measures.

    Lindner, Oana C / Boon, Ian S / Joffe, Johnathan / Stark, Dan

    European journal of cancer care

    2020  Volume 29, Issue 5, Page(s) e13264

    Abstract: Objective: Replying to germ cell tumour patients' needs, we implemented "Shared Community Follow-up"-a collaborative initiative, enabling remote delivery of specialist cancer care across large geographical areas. Blood, radiological investigations and ... ...

    Abstract Objective: Replying to germ cell tumour patients' needs, we implemented "Shared Community Follow-up"-a collaborative initiative, enabling remote delivery of specialist cancer care across large geographical areas. Blood, radiological investigations and patient-reported outcome measures (PROMs) are completed remotely and integrated within the electronic patient records for specialist review without patients requiring appointments. We describe the service evaluation estimating the feasibility, safety and acceptability of this initiative versus traditional Standard Follow-up.
    Methods: This cross-sectional evaluation estimated feasibility (uptake, adherence) and safety (via missed appointments, timeliness, cancellations) using routinely collected service process data. An acceptability questionnaire, evaluating patient satisfaction, was administered to 91 patients.
    Results: The new service is feasible. Across 2 years (2014-2016), uptake increased 54% (N = 123 to N = 270) and only 4.8% (N = 13) of patients were non-adherent. Fewer missed/cancelled investigations (N = 39, 5.9% vs. N = 566, 85.5%), timelier investigations (seven vs. 14 timely investigations) and equal relapse detection suggest its safety. PROMs replaced 3 appointments/patient. Patients were as satisfied with both services (3.4/4 vs. 3.6/4).
    Conclusion: New follow-up services, with investigations completed remotely and shared between community providers and cancer centres, offer an alternative to traditional appointments with advantages for patients and the National Health Service.
    MeSH term(s) Cross-Sectional Studies ; Follow-Up Studies ; Humans ; Neoplasms, Germ Cell and Embryonal/therapy ; Patient Reported Outcome Measures ; State Medicine
    Language English
    Publishing date 2020-06-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 1303114-4
    ISSN 1365-2354 ; 0961-5423 ; 1360-5801
    ISSN (online) 1365-2354
    ISSN 0961-5423 ; 1360-5801
    DOI 10.1111/ecc.13264
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    Zs.A 3347: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Radiotherapy for COVID-19: Primum non nocere.

    Boon, Ian S / Au Yong, Tracy P T / Boon, Cheng S

    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

    2020  Volume 149, Page(s) 236–237

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-04
    Publishing country Ireland
    Document type Letter ; Comment
    ZDB-ID 605646-5
    ISSN 1879-0887 ; 0167-8140
    ISSN (online) 1879-0887
    ISSN 0167-8140
    DOI 10.1016/j.radonc.2020.05.046
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    Zs.A 1926: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Cancer oligometastases heterogeneity: Standardizing nomenclature. In regard to defining oligometastatic disease from a radiation oncology perspective: An ESTRO-ASTRO consensus document.

    Boon, Ian S / Au Yong, Tracy P T / Boon, Cheng S

    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

    2020  Volume 149, Page(s) 247–248

    MeSH term(s) Consensus ; Humans ; Neoplasms ; Radiation Oncology
    Language English
    Publishing date 2020-06-30
    Publishing country Ireland
    Document type Letter ; Comment
    ZDB-ID 605646-5
    ISSN 1879-0887 ; 0167-8140
    ISSN (online) 1879-0887
    ISSN 0167-8140
    DOI 10.1016/j.radonc.2020.06.042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1926: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: In the nick of time: arterial thrombosis on starting combination chemotherapy in metastatic gastric adenocarcinoma.

    Boon, Ian S / Boon, Cheng S

    BMJ case reports

    2016  Volume 2016

    Abstract: A 70-year-old man newly diagnosed with metastatic gastric adenocarcinoma was started on standard first-line palliative chemotherapy with anthracycline (epirubicin), platinum (oxaliplatin) and fluoropyrimidine (capecitabine); EOX combination chemotherapy. ...

    Abstract A 70-year-old man newly diagnosed with metastatic gastric adenocarcinoma was started on standard first-line palliative chemotherapy with anthracycline (epirubicin), platinum (oxaliplatin) and fluoropyrimidine (capecitabine); EOX combination chemotherapy. 5 days after the first cycle of chemotherapy, he presented with tachycardia with associated severe abdominal and lumbar pains. Initial investigations confirmed life-threatening metabolic acidosis with serum lactate of 9.7 mmol/L (normal range 0.5-2.2 mmol/L). CT angiogram identified acute arterial thrombosis within the abdominal aorta, lumbar and right common iliac artery, which was absent on staging contrast CT scan 6 weeks prior. The patient was immediately anticoagulated and chemotherapy discontinued. Urgent oncology and surgical opinions advised conservative management. The patient responded well to early treatment and survived this acute episode. He was subsequently started on life-long treatment dose enoxaparin and second-line single agent chemotherapy with docetaxel (taxotere), with no reported complications.
    MeSH term(s) Aged ; Anticoagulants/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Enoxaparin/administration & dosage ; Humans ; Male ; Palliative Care ; Stomach Neoplasms/blood ; Stomach Neoplasms/diagnostic imaging ; Stomach Neoplasms/drug therapy ; Thrombosis/chemically induced ; Thrombosis/drug therapy
    Chemical Substances Anticoagulants ; Enoxaparin
    Language English
    Publishing date 2016-02-25
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2015-214236
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  7. Article ; Online: Concurrent versus sequential chemoradiotherapy for unresectable locally advanced stage III non-small cell lung cancer: Retrospective analysis in a single United Kingdom cancer centre.

    Spencer, Alice / Williams, Jenna / Samuel, Robert / Boon, Ian S / Clarke, Katy / Jain, Pooja

    Cancer treatment and research communications

    2021  Volume 29, Page(s) 100460

    Abstract: Introduction: Stage III unresectable locally advanced non-small cell lung cancer (NSCLC) is a complex disease group with poor long-term survival. Clinical data suggests curative intent concurrent chemoradiotherapy (CCRT) is superior to a sequential ( ... ...

    Abstract Introduction: Stage III unresectable locally advanced non-small cell lung cancer (NSCLC) is a complex disease group with poor long-term survival. Clinical data suggests curative intent concurrent chemoradiotherapy (CCRT) is superior to a sequential (SCRT) approach but comes with additional toxicities. We report real world data regarding overall survival and toxicity to aid clinical decision making in balancing optimal management and treatment tolerability.
    Methods: Retrospective analysis of survival data, treatment toxicities, and rates of treatment completion were performed for 241 patients who underwent chemoradiotherapy for unresectable stage III NSCLC within Leeds Cancer Centre from January 2011 to December 2014.
    Results: Median survival was 18.8 months following SCRT compared to 22.7 months following CCRT HR 0.90 (95% CI 0.67-1.20, P = 0.46). Median follow up was 21 months. The clinical benefit rate for CCRT compared to SCRT was 22.7% versus 24%. In the CCRT group 63.8% patients completed treatment compared to 46% in the SCRT arm (P < 0.01). 90-day mortality rates were low in CCRT and SCRT cohorts at 4.3% and 1% respectively. There was greater pulmonary toxicity following CCRT versus SCRT (13.5% versus 1.0%, P < 0.01).
    Conclusion: This study provides real world data regarding the radical treatment of unresectable stage III NSCLC. Increased hospital admissions and pneumonitis toxicities did not adversely affect treatment completion for those undergoing CCRT; this was likely due to careful patient selection based on performance status. SCRT still remains an important treatment modality for patients who cannot tolerate the upfront CCRT approach but could still be treated with curative intent.
    MeSH term(s) Adult ; Aged ; Cancer Care Facilities ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/mortality ; Carcinoma, Non-Small-Cell Lung/pathology ; Carcinoma, Non-Small-Cell Lung/radiotherapy ; Female ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/mortality ; Lung Neoplasms/pathology ; Lung Neoplasms/radiotherapy ; Male ; Middle Aged ; Neoplasm Staging ; Retrospective Studies ; Survival Analysis ; United Kingdom
    Language English
    Publishing date 2021-09-28
    Publishing country England
    Document type Journal Article
    ISSN 2468-2942
    ISSN (online) 2468-2942
    DOI 10.1016/j.ctarc.2021.100460
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  8. Article ; Online: Cautionary tale: subdural haematoma following frequent hypoglycaemia from insulin-induced lipohypertrophy.

    Boon, Ian S / Saeed, Mujahid A

    BMJ case reports

    2015  Volume 2015

    MeSH term(s) Accidental Falls ; Diabetes Mellitus, Type 1/drug therapy ; Hematoma, Subdural/diagnostic imaging ; Hematoma, Subdural/surgery ; Humans ; Hypoglycemia/complications ; Insulin/administration & dosage ; Insulin/adverse effects ; Insulin/therapeutic use ; Lipomatosis/chemically induced ; Male ; Middle Aged ; Subdural Space/diagnostic imaging ; Subdural Space/surgery ; Tomography, X-Ray Computed
    Chemical Substances Insulin
    Language English
    Publishing date 2015-12-01
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2015-212855
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  9. Article ; Online: Application of artificial intelligence (AI) in Radiotherapy workflow: Paradigm shift in Precision Radiotherapy using Machine Learning.

    Boon, Ian S / Au Yong, Tracy P T / Boon, Cheng S

    The British journal of radiology

    2019  Volume 92, Issue 1103, Page(s) 20190716

    MeSH term(s) Algorithms ; Artificial Intelligence ; Machine Learning ; Radiation Oncology ; Workflow
    Language English
    Publishing date 2019-09-20
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2982-8
    ISSN 1748-880X ; 0007-1285
    ISSN (online) 1748-880X
    ISSN 0007-1285
    DOI 10.1259/bjr.20190716
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    Ue I Zs.11: Show issues Location:
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  10. Article ; Online: Digital healthcare and shifting equipoise in radiation oncology: The butterfly effect of the COVID-19 pandemic.

    Boon, Ian S / Lim, Jean S / Au Yong, Tracy P T / Boon, Cheng S

    Journal of medical imaging and radiation sciences

    2020  Volume 52, Issue 1, Page(s) 11–13

    MeSH term(s) Allied Health Personnel/education ; Allied Health Personnel/organization & administration ; COVID-19/epidemiology ; Evidence-Based Medicine ; Humans ; Pandemics ; Radiation Oncology/education ; Radiation Oncology/organization & administration ; Radiology/education ; SARS-CoV-2 ; Teleradiology/organization & administration ; Workflow
    Keywords covid19
    Language English
    Publishing date 2020-10-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2426513-5
    ISSN 1876-7982 ; 1939-8654
    ISSN (online) 1876-7982
    ISSN 1939-8654
    DOI 10.1016/j.jmir.2020.10.002
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