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  1. Article ; Online: Computer-Aided Diagnosis Methods for High-Frequency Ultrasound Data Analysis: A Review.

    Czajkowska, Joanna / Borak, Martyna

    Sensors (Basel, Switzerland)

    2022  Volume 22, Issue 21

    Abstract: Over the last few decades, computer-aided diagnosis systems have become a part of clinical practice. They have the potential to assist clinicians in daily diagnostic tasks. The image processing techniques are fast, repeatable, and robust, which helps ... ...

    Abstract Over the last few decades, computer-aided diagnosis systems have become a part of clinical practice. They have the potential to assist clinicians in daily diagnostic tasks. The image processing techniques are fast, repeatable, and robust, which helps physicians to detect, classify, segment, and measure various structures. The recent rapid development of computer methods for high-frequency ultrasound image analysis opens up new diagnostic paths in dermatology, allergology, cosmetology, and aesthetic medicine. This paper, being the first in this area, presents a research overview of high-frequency ultrasound image processing techniques, which have the potential to be a part of computer-aided diagnosis systems. The reviewed methods are categorized concerning the application, utilized ultrasound device, and image data-processing type. We present the bridge between diagnostic needs and already developed solutions and discuss their limitations and future directions in high-frequency ultrasound image analysis. A search was conducted of the technical literature from 2005 to September 2022, and in total, 31 studies describing image processing methods were reviewed. The quantitative and qualitative analysis included 39 algorithms, which were selected as the most effective in this field. They were completed by 20 medical papers and define the needs and opportunities for high-frequency ultrasound application and CAD development.
    MeSH term(s) Diagnosis, Computer-Assisted/methods ; Ultrasonography ; Image Processing, Computer-Assisted/methods ; Algorithms
    Language English
    Publishing date 2022-10-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s22218326
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Renal biopsies from donors with acute kidney injury show different molecular patterns according to the post-transplant function.

    Neri, Flavia / Lo Faro, Maria Letizia / Kaisar, Maria / Tam, Ka Ho / Borak, Martyna / Lindeman, Jan / Angelini, Annalisa / Fedrigo, Marny / Kers, Jesper / Hunter, James / Ploeg, Rutger

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 6643

    Abstract: The utilization of kidneys from donors with acute kidney injury (AKI) is often limited by unpredictable post-transplantation outcomes. The aim of our study was to identify protein mediators implicated in either recovery or failure of these organs. Forty ... ...

    Abstract The utilization of kidneys from donors with acute kidney injury (AKI) is often limited by unpredictable post-transplantation outcomes. The aim of our study was to identify protein mediators implicated in either recovery or failure of these organs. Forty kidney biopsies from donors with (20) and without AKI (20) were selected and then subdivided according to the post-transplant outcome defined as a threshold of 45 ml/min for the eGFR at 1 year from transplantation. Tissue homogenates were analysed by western blot to assess how the levels of 17 pre-selected proteins varied across the four groups. Samples from AKI kidneys with a poor outcome showed a fourfold increase in the levels of PPARg and twofold reduction of STAT1 compared to the other groups (p < 0.05). On the contrary, antioxidant enzymes including TRX1 and PRX3 were increased in the AKI kidneys with a good outcome (p < 0.05). An opposite trend was observed for the detoxifying enzyme GSTp which was significantly increased in the AKI group with poor versus good outcome (p < 0.05). The importance of lipid metabolism (PPARg) and inflammatory signals (STAT1) in the function recovery of these kidneys hints to the therapeutical targeting of the involved pathways in the setting of organ reconditioning.
    MeSH term(s) Humans ; Kidney Transplantation/adverse effects ; PPAR gamma ; Graft Survival ; Tissue Donors ; Kidney/pathology ; Acute Kidney Injury/pathology ; Biopsy ; Retrospective Studies
    Chemical Substances PPAR gamma
    Language English
    Publishing date 2024-03-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-56277-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Performance characteristics of five immunoassays for SARS-CoV-2

    Ainsworth, Mark / Andersson, Monique / Auckland, Kathryn / Baillie, J Kenneth / Barnes, Eleanor / Beer, Sally / Beveridge, Amy / Bibi, Sagida / Blackwell, Luke / Borak, Martyna / Bown, Abbie / Brooks, Tim / Burgess-Brown, Nicola A / Camara, Susana / Catton, Matthew / Chau, Kevin K. / Christott, Thomas / Clutterbuck, Elizabeth / Coker, Jesse /
    Cornall, Richard J / Cox, Stuart / Crawford-Jones, David / Crook, Derrick W / D'Arcangelo, Silvia / Dejnirattsai, Wanwisa / Dequaire, Julie M M / Dimitriadis, Stavros / Dingle, Kate E / Doherty, George / Dold, Christina / Dong, Tao / Dunachie, Susanna J / Ebner, Daniel / Emmenegger, Marc / Espinosa, Alexis / Eyre, David W / Fairhead, Rory / Fassih, Shayan / Feehily, Conor / Felle, Sally / Fernandez-Cid, Alejandra / Fernandez Mendoza, Maria / Foord, Thomas H / Fordwoh, Thomas / Fox McKee, Deborah / Frater, John / Gallardo Sanchez, Veronica / Gent, Nick / Georgiou, Dominique / Groves, Christopher J / Hallis, Bassam / Hammond, Peter M / Hatch, Stephanie B. / Harvala, Heli J / Hill, Jennifer / Hoosdally, Sarah J / Horsington, Bryn / Howarth, Alison / James, Tim / Jeffery, Katie / Jones, Elizabeth / Justice, Anita / Karpe, Fredrik / Kavanagh, James / Kim, David S / Kirton, Richard / Klenerman, Paul / Knight, Julian C / Koukouflis, Leonidas / Kwok, Andrew / Leuschner, Ullrich / Levin, Robert / Linder, Aline / Lockett, Teresa / Lumley, Sheila F / Marinou, Spyridoula / Marsden, Brian D / Martinez, Jose / Martins Ferreira, Lucas / Mason, Lara / Matthews, Philippa C / Mentzer, Alexander J / Mobbs, Alexander / Mongkolsapaya, Juthathip / Morrow, Jordan / Mukhopadhyay, Shubhashish M M / Neville, Matthew J / Oakley, Sarah / Oliveira, Marta / Otter, Ashley / Paddon, Kevin / Pascoe, Jordan / Peng, Yanchun / Perez, Elena / Perumal, Prem K / Peto, Timothy E A / Pickford, Hayleah / Ploeg, Rutger J / Pollard, Andrew J / Richardson, Anastasia / Ritter, Thomas G / Roberts, David J / Rodger, Gillian / Rollier, Christine S / Rowe, Cathy / Rudkin, Justine K / Screaton, Gavin / Semple, Malcolm G / Sienkiewicz, Alex / Silva-Reyes, Laura / Skelly, Donal T / Sobrino Diaz, Alberto / Stafford, Lizzie / Stockdale, Lisa / Stoesser, Nicole / Street, Teresa / Stuart, David I / Sweed, Angela / Taylor, Adan / Thraves, Hannah / Tsang, Hoi P / Verheul, Marije K / Vipond, Richard / Walker, Timothy M / Wareing, Susan / Warren, Yolanda / Wells, Charlie / Wilson, Clare / Withycombe, Kate / Young, Rebecca K

    The Lancet Infectious Diseases ; ISSN 1473-3099

    a head-to-head benchmark comparison

    2020  

    Keywords Infectious Diseases ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1016/s1473-3099(20)30634-4
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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