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Article ; Online: Comment on: Survival and course of lung function in the presence or absence of antifibrotic treatment in patients with idiopathic pulmonary fibrosis.

Borchardt, Jakob

2021 Volume 57, Issue 3

MeSH term(s)	Humans ; Idiopathic Pulmonary Fibrosis/drug therapy ; Lung ; Vital Capacity
Language	English
Publishing date	2021-03-18
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	639359-7
ISSN	1399-3003 ; 0903-1936
ISSN (online)	1399-3003
ISSN	0903-1936
DOI	10.1183/13993003.04645-2020
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Zs.A 2322: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: S2K-Leitlinie zur Diagnostik und Therapie der idiopathischen Lungenfibrose.

Borchardt, Jakob

Pneumologie (Stuttgart, Germany)

2013 Volume 67, Issue 6, Page(s) 356

Title translation	S2K guideline on diagnosis and treatment of idiopathic pulmonary fibrosis.
MeSH term(s)	Anti-Inflammatory Agents/therapeutic use ; Humans ; Idiopathic Pulmonary Fibrosis/diagnosis ; Idiopathic Pulmonary Fibrosis/therapy ; Practice Guidelines as Topic ; Pulmonary Medicine/standards ; Tomography, X-Ray Computed/methods
Chemical Substances	Anti-Inflammatory Agents
Language	German
Publishing date	2013-06
Publishing country	Germany
Document type	Comment ; Letter
ZDB-ID	607630-0
ISSN	1438-8790 ; 0934-8387
ISSN (online)	1438-8790
ISSN	0934-8387
DOI	10.1055/s-0033-1344177
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Uh II Zs.142: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 54: Show issues

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Article: Endoscopic lung volume reduction with endobronchial valves in very low

Lenga, Pavlina / Ruwwe-Glösenkamp, Christoph / Grah, Christian / Pfannschmidt, Joachim / Rückert, Jens / Eggeling, Stephan / Gläser, Sven / Schmidt, Bernd / Schneider, Paul / Kurz, Sylke / Leschber, Gunda / Gebhardt, Andreas / Becke, Birgit / Schega, Olaf / Borchardt, Jakob / Hübner, Ralf-Harto

ERJ open research

2021 Volume 7, Issue 1

Abstract: Background: Endoscopic lung volume reduction (ELVR) with valves has been suggested to be the key strategy for patients with severe emphysema and concomitant low diffusing capacity of the lung for carbon monoxide (: Methods: We assessed : Results: ... ...

Abstract	Background: Endoscopic lung volume reduction (ELVR) with valves has been suggested to be the key strategy for patients with severe emphysema and concomitant low diffusing capacity of the lung for carbon monoxide ( Methods: We assessed Results: In total, 121 patients treated with ELVR were analysed. Thirty-four patients with a Conclusions: ELVR improves lung function as well as quality of life in patients with
Language	English
Publishing date	2021-01-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2827830-6
ISSN	2312-0541
ISSN	2312-0541
DOI	10.1183/23120541.00449-2020
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Book ; Online: Development of a small unmanned aircraft system to derive CO2 emissions of anthropogenic point sources

Reuter, Maximilian / Bovensmann, Heinrich / Buchwitz, Michael / Borchardt, Jakob / Krautwurst, Sven / Gerilowski, Konstantin / Lindauer, Matthias / Kubistin, Dagmar / Burrows, John P.

eISSN: 1867-8548

2020

Abstract: A reduction of the anthropogenic emissions of CO 2 (carbon dioxide) is necessary to stop or slow down man-made climate change. To verify mitigation strategies, a global monitoring system such as the envisaged European Copernicus anthropogenic CO 2 ... ...

Abstract	A reduction of the anthropogenic emissions of CO 2 (carbon dioxide) is necessary to stop or slow down man-made climate change. To verify mitigation strategies, a global monitoring system such as the envisaged European Copernicus anthropogenic CO 2 monitoring mission (CO2M) is required. Those satellite data are going to be complemented and validated with airborne measurements. UAV (unmanned aerial vehicle) based measurements can provide a cost-effective way to contribute to this activities. Here we present the development of a sUAS (small unmanned aircraft system) to quantify the CO 2 emissions of a nearby point source from its downwind mass flux without the need for any ancillary data. Specifically, CO 2 is measured by a NDIR (non-dispersive infrared) detector and the wind speed and direction is measured with a 2D ultrasonic acoustic resonance anemometer. By means of laboratory measurements and an in-flight validation at the ICOS (Integrated Carbon Observation System) atmospheric station Steinkimmen (STE) near Bremen, Germany, we estimate that the individual CO 2 measurements have a precision of 3 ppm and that CO 2 enhancements can be determined with an accuracy of 1.3 % or 0.9 ppm, whichever is larger. We introduce an anemometer calibration method to minimize the effect of rotor downwash on the wind measurements. This method derives the fit parameters of a linear calibration model accounting for scaling, rotation, and a potential constant bias. For this purpose it analyzes wind measurements taken while following a suitable flight pattern and assuming stationary wind conditions. From the calibration and validation experiments, we estimate the single measurement precision of the horizontal wind speed to be 0.40 m s −1 and the accuracy to be 0.33 m s −1 . By means of two flights downwind of the ExxonMobil natural gas processing facility in Großenkneten about 40 km east of Bremen, Germany, we demonstrate how the measurements of elevated CO 2 concentrations can be used to infer mass fluxes of atmospheric CO 2 related to the emissions of the facility.
Subject code	551
Language	English
Publishing date	2020-08-04
Publishing country	de
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Thesis: Entwicklung der Resistenzhäufigkeit und Risikofaktoren für Resistenz bei Mycobacterium tuberculosis

Borchardt, Jakob

The European Respiratory Journal ; 8.1995 u.d.T.: Borchardt, J. [ u.a.] : Drug-resistant tuberculosis in Northern Germany

eine retrospektive Untersuchung von 1055 Patienten eines Fachkrankenhauses von 1984 bis 1993

1997

Title variant	Drug-resistant tuberculosis in Northern Germany
Author's details	vorgelegt von Jakob Borchardt
Language	English
Size	S. 1076 - 1083, graph. Darst
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Univ., FB Medizin, Diss.--Hamburg, 1997
Note	Text in englischer Sprache
Database	Former special subject collection: coastal and deep sea fishing

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Book ; Online: Evaluation of simulated CO2 power plant plumes from six high-resolution atmospheric transport models

Brunner, Dominik / Kuhlmann, Gerrit / Henne, Stephan / Koene, Erik / Kern, Bastian / Wolff, Sebastian / Voigt, Christiane / Jöckel, Patrick / Kiemle, Christoph / Roiger, Anke / Fiehn, Alina / Krautwurst, Sven / Gerilowski, Konstantin / Bovensmann, Heinrich / Borchardt, Jakob / Galkowski, Michal / Gerbig, Christoph / Marshall, Julia / Klonecki, Andrzej /

Prunet, Pascal / Hanfland, Robert / Pattantyús-Ábrahám, Margit / Wyszogrodzki, Andrzej / Fix, Andreas

eISSN: 1680-7324

2023

Abstract: Power plants and large industrial facilities contribute more than half of global anthropogenic CO 2 emissions. Quantifying the emissions of these point sources is therefore one of the main goals of the planned constellation of anthropogenic CO 2 ... ...

Abstract	Power plants and large industrial facilities contribute more than half of global anthropogenic CO 2 emissions. Quantifying the emissions of these point sources is therefore one of the main goals of the planned constellation of anthropogenic CO 2 monitoring satellites (CO2M) of the European Copernicus program. Atmospheric transport models may be used to study the capabilities of such satellites through observing system simulation experiments and to quantify emissions in an inverse modeling framework. How realistically the CO 2 plumes of power plants can be simulated and how strongly the results may depend on model type and resolution, however, is not well known due to a lack of observations available for benchmarking. Here, we use the unique data set of aircraft in situ and remote sensing observations collected during the CoMet (Carbon Dioxide and Methane Mission) measurement campaign downwind of the coal-fired power plants at Bełchatów in Poland and Jänschwalde in Germany in 2018 to evaluate the simulations of six different atmospheric transport models. The models include three large-eddy simulation (LES) models, two mesoscale numerical weather prediction (NWP) models extended for atmospheric tracer transport, and one Lagrangian particle dispersion model (LPDM) and cover a wide range of model resolutions from 200 m to 2 km horizontal grid spacing. At the time of the aircraft measurements between late morning and early afternoon, the simulated plumes were slightly (at Jänschwalde) to highly (at Bełchatów) turbulent, consistent with the observations, and extended over the whole depth of the atmospheric boundary layer (ABL; up to 1800 m a.s.l. (above sea level) in the case of Bełchatów). The stochastic nature of turbulent plumes puts fundamental limitations on a point-by-point comparison between simulations and observations. Therefore, the evaluation focused on statistical properties such as plume amplitude and width as a function of distance from the source. LES and NWP models showed similar performance and ...
Subject code	551
Language	English
Publishing date	2023-02-27
Publishing country	de
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Treating hepatic hydrothorax.

Borchardt, Jakob / Smirnov, Alona / Metchnik, Lora / Malnick, Stephen

BMJ (Clinical research ed.)

2003 Volume 326, Issue 7392, Page(s) 751–752

MeSH term(s)	Aged ; Anti-Bacterial Agents/therapeutic use ; Bacterial Infections/complications ; Chest Tubes ; Drainage/instrumentation ; Fatal Outcome ; Hepatitis B/complications ; Humans ; Hydrothorax/drug therapy ; Hydrothorax/etiology ; Hydrothorax/surgery ; Liver Cirrhosis/complications ; Male ; Middle Aged ; Penicillins/therapeutic use ; Pleurodesis/methods ; Portasystemic Shunt, Transjugular Intrahepatic/methods
Chemical Substances	Anti-Bacterial Agents ; Penicillins
Language	English
Publishing date	2003-04-05
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1362901-3
ISSN	1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
ISSN (online)	1756-1833
ISSN	0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
DOI	10.1136/bmj.326.7392.751
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Article ; Online: Airborne methane remote measurements reveal heavy-tail flux distribution in Four Corners region.

Frankenberg, Christian / Thorpe, Andrew K / Thompson, David R / Hulley, Glynn / Kort, Eric Adam / Vance, Nick / Borchardt, Jakob / Krings, Thomas / Gerilowski, Konstantin / Sweeney, Colm / Conley, Stephen / Bue, Brian D / Aubrey, Andrew D / Hook, Simon / Green, Robert O

Proceedings of the National Academy of Sciences of the United States of America

2016 Volume 113, Issue 35, Page(s) 9734–9739

Abstract: Methane (CH4) impacts climate as the second strongest anthropogenic greenhouse gas and air quality by influencing tropospheric ozone levels. Space-based observations have identified the Four Corners region in the Southwest United States as an area of ... ...

Abstract	Methane (CH4) impacts climate as the second strongest anthropogenic greenhouse gas and air quality by influencing tropospheric ozone levels. Space-based observations have identified the Four Corners region in the Southwest United States as an area of large CH4 enhancements. We conducted an airborne campaign in Four Corners during April 2015 with the next-generation Airborne Visible/Infrared Imaging Spectrometer (near-infrared) and Hyperspectral Thermal Emission Spectrometer (thermal infrared) imaging spectrometers to better understand the source of methane by measuring methane plumes at 1- to 3-m spatial resolution. Our analysis detected more than 250 individual methane plumes from fossil fuel harvesting, processing, and distributing infrastructures, spanning an emission range from the detection limit [Formula: see text] 2 kg/h to 5 kg/h through [Formula: see text] 5,000 kg/h. Observed sources include gas processing facilities, storage tanks, pipeline leaks, and well pads, as well as a coal mine venting shaft. Overall, plume enhancements and inferred fluxes follow a lognormal distribution, with the top 10% emitters contributing 49 to 66% to the inferred total point source flux of 0.23 Tg/y to 0.39 Tg/y. With the observed confirmation of a lognormal emission distribution, this airborne observing strategy and its ability to locate previously unknown point sources in real time provides an efficient and effective method to identify and mitigate major emissions contributors over a wide geographic area. With improved instrumentation, this capability scales to spaceborne applications [Thompson DR, et al. (2016) Geophys Res Lett 43(12):6571-6578]. Further illustration of this potential is demonstrated with two detected, confirmed, and repaired pipeline leaks during the campaign.
Language	English
Publishing date	2016-08-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.1605617113
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Zs.A 1148: Show issues

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Book ; Online: Methane emissions from a Californian landfill, determined from airborne remote sensing and in situ measurements

Krautwurst, Sven / Gerilowski, Konstantin / Jonsson, Haflidi H. / Thompson, David R. / Kolyer, Richard W. / Iraci, Laura T. / Thorpe, Andrew K. / Horstjann, Markus / Eastwood, Michael / Leifer, Ira / Vigil, Samuel A. / Krings, Thomas / Borchardt, Jakob / Buchwitz, Michael / Fladeland, Matthew M. / Burrows, John P. / Bovensmann, Heinrich

eISSN: 1867-8548

2018

Abstract: Fugitive emissions from waste disposal sites are important anthropogenic sources of the greenhouse gas methane (CH 4 ). As a result of the growing world population and the recognition of the need to control greenhouse gas emissions, this anthropogenic ... ...

Abstract	Fugitive emissions from waste disposal sites are important anthropogenic sources of the greenhouse gas methane (CH 4 ). As a result of the growing world population and the recognition of the need to control greenhouse gas emissions, this anthropogenic source of CH 4 has received much recent attention. However, the accurate assessment of the CH 4 emissions from landfills by modeling and existing measurement techniques is challenging. This is because of inaccurate knowledge of the model parameters and the extent of and limited accessibility to landfill sites. This results in a large uncertainty in our knowledge of the emissions of CH 4 from landfills and waste management. In this study, we present results derived from data collected during the research campaign COMEX (CO 2 and MEthane eXperiment) in late summer 2014 in the Los Angeles (LA) Basin. One objective of COMEX, which comprised aircraft observations of methane by the remote sensing Methane Airborne MAPper (MAMAP) instrument and a Picarro greenhouse gas in situ analyzer, was the quantitative investigation of CH 4 emissions. Enhanced CH 4 concentrations or <q>CH 4 plumes</q> were detected downwind of landfills by remote sensing aircraft surveys. Subsequent to each remote sensing survey, the detected plume was sampled within the atmospheric boundary layer by in situ measurements of atmospheric parameters such as wind information and dry gas mixing ratios of CH 4 and carbon dioxide (CO 2 ) from the same aircraft. This was undertaken to facilitate the independent estimation of the surface fluxes for the validation of the remote sensing estimates. During the COMEX campaign, four landfills in the LA Basin were surveyed. One landfill repeatedly showed a clear emission plume. This landfill, the Olinda Alpha Landfill, was investigated on 4 days during the last week of August and first days of September 2014. Emissions were estimated for all days using a mass balance approach. The derived emissions vary between 11.6 and 17.8 kt CH 4 yr −1 with related uncertainties in the range of 14 to 45 %. The comparison of the remote sensing and in situ based CH 4 emission rate estimates reveals good agreement within the error bars with an average of the absolute differences of around 2.4 kt CH 4 yr −1 (±2. 8 kt CH 4 yr −1 ). The US Environmental Protection Agency (EPA) reported inventory value is 11.5 kt CH 4 yr −1 for 2014, on average 2.8 kt CH 4 yr −1 (±1. 6 kt CH 4 yr −1 ) lower than our estimates acquired in the afternoon in late summer 2014. This difference may in part be explained by a possible leak located on the southwestern slope of the landfill, which we identified in the observations of the Airborne Visible/Infrared Imaging Spectrometer – Next Generation (AVIRIS-NG) instrument, flown contemporaneously aboard a second aircraft on 1 day.
Subject code	333
Language	English
Publishing date	2018-09-14
Publishing country	de
Document type	Book ; Online
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Article: Acute cholestatic hepatitis after exposure to isoflurane.

Malnick, Stephen D H / Mahlab, Keren / Borchardt, Jakob / Sokolowski, Nadia / Attali, Malka

The Annals of pharmacotherapy

2002 Volume 36, Issue 2, Page(s) 261–263

Abstract: Objective: To report a case of acute cholestatic hepatitis following exposure to the inhalational anesthetic isoflurane.: Case summary: A 70-year-old healthy woman from Iraq developed acute cholestatic hepatitis 3 weeks following repair of the right ... ...

Abstract	Objective: To report a case of acute cholestatic hepatitis following exposure to the inhalational anesthetic isoflurane. Case summary: A 70-year-old healthy woman from Iraq developed acute cholestatic hepatitis 3 weeks following repair of the right rotator cuff under general anesthesia. There was no evidence for viral, autoimmune, or metabolic causes of hepatitis. No other medications were involved except for dipyrone for analgesia. The alanine aminotransferase was elevated to a peak concentration of 1533 U/L and the serum bilirubin reached a peak of 17.0 mg/dL. There was slow improvement over 4 months. Accidental reexposure by the patient to dipyrone was uneventful. Discussion: The clinical and histologic picture of this case resembles halothane hepatitis, which has a significant mortality rate. Conclusions: Isoflurane, a common anesthetic agent, can cause severe cholestatic hepatitis.
MeSH term(s)	Acetylcysteine/therapeutic use ; Acute Disease ; Aged ; Anesthetics, Inhalation/administration & dosage ; Anesthetics, Inhalation/adverse effects ; Biopsy ; Chemical and Drug Induced Liver Injury/drug therapy ; Chemical and Drug Induced Liver Injury/pathology ; Cholestasis/chemically induced ; Cholestasis/pathology ; Female ; Humans ; Isoflurane/administration & dosage ; Isoflurane/adverse effects ; Liver/pathology ; Liver Function Tests ; Ursodeoxycholic Acid/therapeutic use
Chemical Substances	Anesthetics, Inhalation ; Ursodeoxycholic Acid (724L30Y2QR) ; Isoflurane (CYS9AKD70P) ; Acetylcysteine (WYQ7N0BPYC)
Language	English
Publishing date	2002-02
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1101370-9
ISSN	1542-6270 ; 1060-0280
ISSN (online)	1542-6270
ISSN	1060-0280
DOI	10.1345/aph.1A009
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