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  1. Book: Tumors of the serosal membranes

    Nicholson, Andrew / Husain, Aliya N. / Borczuk, Alain C.

    (AFIP atlas of tumor and non-tumor pathology ; fifth series, fasc. 11)

    2022  

    Author's details by Andrew G. Nicholson, Aliya N. Husain, Alain C. Borczuk
    Series title AFIP atlas of tumor and non-tumor pathology ; fifth series, fasc. 11
    AFIP atlases of tumor and non-tumor pathology
    Collection AFIP atlases of tumor and non-tumor pathology
    Keywords Neoplasms, Mesothelial / pathology ; Serous fluids/Pathology ; Membranes (Biology)/Tumors
    Subject code 612.01522
    Language English
    Size xiii, 183 Seiten
    Publisher American Registry of Pathology
    Publishing place Arlington, Virgiia
    Publishing country United States
    Document type Book
    HBZ-ID HT021579046
    ISBN 978-1-933-47719-0 ; 1-933-47719-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 A 164 available for loan (reading room) Lesesaal EG

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  2. Book ; Online ; E-Book: Frozen section pathology

    Borczuk, Alain C. / Yantiss, Rhonda K. / Robinson, Brian D. / Scognamiglio, Theresa / D'Alfonso, Timothy M.

    diagnostic challenges

    2021  

    Author's details Alain C. Borczuk, Rhonda K. Yantiss, Brian D. Robinson, Theresa Scognamiglio, Timothy M. D'Alfonso
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (x, 453 Seiten), Illustrationen, Diagramme
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020935385
    ISBN 978-3-030-71308-9 ; 9783030713072 ; 3-030-71308-3 ; 3030713075
    DOI 10.1007/978-3-030-71308-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Thoracic Pathology-Learning from the Past to Inform the Future.

    Borczuk, Alain C

    Surgical pathology clinics

    2023  Volume 17, Issue 2, Page(s) xi–xii

    MeSH term(s) Humans ; Pathology, Surgical
    Language English
    Publishing date 2023-12-09
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ISSN 1875-9157
    ISSN (online) 1875-9157
    DOI 10.1016/j.path.2023.11.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Molecular Testing in Lung Cancer: Recommendations and Update.

    Borczuk, Alain C

    Surgical pathology clinics

    2023  Volume 17, Issue 2, Page(s) 307–320

    Abstract: Adoption of molecular testing in lung cancer is increasing. Molecular testing for staging and prediction of response for targeted therapy remain the main indications, and although utilization of blood-based testing for tumor is growing, the use of the ... ...

    Abstract Adoption of molecular testing in lung cancer is increasing. Molecular testing for staging and prediction of response for targeted therapy remain the main indications, and although utilization of blood-based testing for tumor is growing, the use of the diagnostic cytology and tissue specimens is equally important. The pathologist needs to optimize reflex testing, incorporate stage-based algorithms, and understand types of tests for timely and complete assessment in the majority of cases. When tissue is limited, testing should capture the most frequent alterations to maximize the yield of what are largely mutually exclusive alterations, avoiding the need for repeat biopsy.
    MeSH term(s) Humans ; Lung Neoplasms/pathology ; Lung Neoplasms/genetics ; Lung Neoplasms/diagnosis ; Biomarkers, Tumor/genetics ; Molecular Diagnostic Techniques ; Neoplasm Staging ; Practice Guidelines as Topic ; Mutation ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; Carcinoma, Non-Small-Cell Lung/diagnosis
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2023-12-16
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1875-9157
    ISSN (online) 1875-9157
    DOI 10.1016/j.path.2023.11.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Invasive Size in Lung Adenocarcinoma-Reproducible Criteria, More Accurate Staging.

    Borczuk, Alain C

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

    2023  Volume 19, Issue 3, Page(s) 360–362

    MeSH term(s) Humans ; Lung Neoplasms/pathology ; Adenocarcinoma of Lung ; Adenocarcinoma/pathology ; Neoplasm Staging ; Retrospective Studies ; Prognosis ; Neoplasm Invasiveness
    Language English
    Publishing date 2023-11-22
    Publishing country United States
    Document type Editorial
    ZDB-ID 2432037-7
    ISSN 1556-1380 ; 1556-0864
    ISSN (online) 1556-1380
    ISSN 1556-0864
    DOI 10.1016/j.jtho.2023.11.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6664: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 652: Show issues

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  6. Article ; Online: Pathogenesis of Pulmonary Long COVID-19.

    Borczuk, Alain C

    Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

    2023  Volume 37, Issue 2, Page(s) 100378

    Abstract: COVID-19 is characterized by an acute respiratory illness that, in some patients, progresses to respiratory failure, largely demonstrating a pattern of acute respiratory distress syndrome. Excluding fatal cases, the outcome of this severe illness ranges ... ...

    Abstract COVID-19 is characterized by an acute respiratory illness that, in some patients, progresses to respiratory failure, largely demonstrating a pattern of acute respiratory distress syndrome. Excluding fatal cases, the outcome of this severe illness ranges from complete resolution to persistent respiratory dysfunction. This subacute-to-chronic respiratory illness has different manifestations and is collectively termed as "long COVID." The pathogenesis of organ dysfunction in acute injury stems from exaggerated innate immune response, complement activation, and monocyte influx, with a shift toward an organ injury state with abnormalities in cellular maturation. Although the increased rate of thrombosis observed in acute COVID-19 does not appear to persist, interestingly, ongoing symptomatic COVID-19 and post-COVID pathogeneses appear to reflect the persistence of immune and cellular disturbances triggered by the acute and subacute periods.
    MeSH term(s) Humans ; COVID-19 ; Post-Acute COVID-19 Syndrome ; SARS-CoV-2 ; Lung ; Complement Activation
    Language English
    Publishing date 2023-11-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645073-8
    ISSN 1530-0285 ; 0893-3952
    ISSN (online) 1530-0285
    ISSN 0893-3952
    DOI 10.1016/j.modpat.2023.100378
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2450: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Pathology of COVID-19 Lung Disease.

    Borczuk, Alain C

    Surgical pathology clinics

    2023  Volume 17, Issue 2, Page(s) 203–214

    Abstract: The pathology of severe COVID-19 lung injury is predominantly diffuse alveolar damage, with other reported patterns including acute fibrinous organizing pneumonia, organizing pneumonia, and bronchiolitis. Lung injury was caused by primary viral injury, ... ...

    Abstract The pathology of severe COVID-19 lung injury is predominantly diffuse alveolar damage, with other reported patterns including acute fibrinous organizing pneumonia, organizing pneumonia, and bronchiolitis. Lung injury was caused by primary viral injury, exaggerated immune responses, and superinfection with bacteria and fungi. Although fatality rates have decreased from the early phases of the pandemic, persistent pulmonary dysfunction occurs and its pathogenesis remains to be fully elucidated.
    MeSH term(s) Humans ; COVID-19/pathology ; COVID-19/complications ; Lung/pathology ; SARS-CoV-2 ; Lung Diseases/pathology
    Language English
    Publishing date 2023-12-20
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1875-9157
    ISSN (online) 1875-9157
    DOI 10.1016/j.path.2023.11.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Pulmonary pathology of COVID-19: a review of autopsy studies.

    Borczuk, Alain C

    Current opinion in pulmonary medicine

    2021  Volume 27, Issue 3, Page(s) 184–192

    Abstract: Purpose of review: COVID-19 lung injury is a common manifestation of severe illness. Lung tissue examination has been largely derived from autopsy - a combination of case reports, small and moderately sized series with international scope. Common and ... ...

    Abstract Purpose of review: COVID-19 lung injury is a common manifestation of severe illness. Lung tissue examination has been largely derived from autopsy - a combination of case reports, small and moderately sized series with international scope. Common and uncommon histopathology provides insight into the progression of severe, fatal disease.
    Recent findings: COVID-19 lung histology is most commonly diffuse alveolar damage as part of acute respiratory distress syndrome. Lung injury can be temporally heterogeneous, with patterns of healing alongside new injury. Viral studies, including immunohistochemistry, RNA in-situ hybridization, and tissue-based Polymerase chain reaction (PCR) assist in discerning complications of therapy (e.g. ventilator-associated pneumonia) from primary viral-induced injury. Response to viral infection produces systemic effects, and one major manifestation is thrombosis of micro-circulation and larger vessels. Less common patterns include neutrophil-rich inflammation, raising speculation that neutrophil extra-cellular traps may play a role in both viral control and exaggerated immune response.
    Summary: The heterogeneity of fatal cases- persistence of viral infection in lung, clearance of virus but severe lung injury, thrombosis, and exaggerated immune response - suggest that antiviral, antithrombotic, anti-inflammatory, and supportive therapy play a role in treatment, but that the patient-specific cause and timing of the lung injury is important in choosing intervention.
    MeSH term(s) Autopsy/methods ; COVID-19/immunology ; COVID-19/mortality ; COVID-19/pathology ; COVID-19/therapy ; Disease Management ; Humans ; Immunity ; Lung/pathology ; SARS-CoV-2/pathogenicity ; Thrombosis/drug therapy ; Thrombosis/etiology ; Thrombosis/pathology
    Language English
    Publishing date 2021-01-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1285505-4
    ISSN 1531-6971 ; 1070-5287 ; 1078-1641
    ISSN (online) 1531-6971
    ISSN 1070-5287 ; 1078-1641
    DOI 10.1097/MCP.0000000000000761
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4900: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Updates in grading and invasion assessment in lung adenocarcinoma.

    Borczuk, Alain C

    Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

    2021  Volume 35, Issue Suppl 1, Page(s) 28–35

    Abstract: The pathologic evaluation of lung adenocarcinoma, because of greater understanding of disease progression and prognosis, has become more complex. It is clear that histologic growth patterns reflect indolent and aggressive disease, resulting in clearer ... ...

    Abstract The pathologic evaluation of lung adenocarcinoma, because of greater understanding of disease progression and prognosis, has become more complex. It is clear that histologic growth patterns reflect indolent and aggressive disease, resulting in clearer morphologic groups that can be the underpinning of a grading system. In addition, the progression of adenocarcinoma from a tumor that preserves alveolar architecture to one that remodels and effaces lung structure has led to criteria that reflect invasive rather than in-situ growth. While some of these are based on tumor cell growth pattern, aspects of this remodeling from desmoplasia to artifacts of lung collapse and sectioning, can lead to difficult to interpret patterns with lower reproducibility between observers. Such scenarios are examined to provide updates on new histologic concepts and to highlight ongoing problem areas.
    MeSH term(s) Adenocarcinoma of Lung/pathology ; Humans ; Lung/pathology ; Lung Neoplasms/pathology ; Neoplasm Grading ; Neoplasm Invasiveness/pathology
    Language English
    Publishing date 2021-10-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645073-8
    ISSN 1530-0285 ; 0893-3952
    ISSN (online) 1530-0285
    ISSN 0893-3952
    DOI 10.1038/s41379-021-00934-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2450: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Therapeutic Interception of Early Lung Adenocarcinoma Progression: Not Just How, but When?

    Borczuk, Alain C

    American journal of respiratory and critical care medicine

    2020  Volume 203, Issue 1, Page(s) 8–9

    MeSH term(s) Adenocarcinoma ; Adenocarcinoma of Lung ; Disease Progression ; Humans ; Lipocalin-2 ; Lung Neoplasms ; Pulmonary Disease, Chronic Obstructive
    Chemical Substances Lipocalin-2
    Language English
    Publishing date 2020-08-26
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202008-3087ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh II Zs.80: Show issues Location:
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