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Article ; Online: Relationship between elimination disorders and internalizing-externalizing problems in children: A systematic review and meta-analysis.

Aymerich, Claudia / Pedruzo, Borja / Pacho, Malein / Herrero, Jon / Laborda, María / Bordenave, Marta / Salazar de Pablo, Gonzalo / Sesma, Eva / Fernández-Rivas, Aranzazu / Catalan, Ana / González-Torres, Miguel Ángel

JCPP advances

2023 Volume 3, Issue 3, Page(s) e12185

Abstract: Background: Elimination disorders are highly prevalent in childhood and often associated with clinically relevant comorbid psychological disorders. The aim of this study is to determine if, and to what extent, children with elimination disorders show ... ...

Abstract	Background: Elimination disorders are highly prevalent in childhood and often associated with clinically relevant comorbid psychological disorders. The aim of this study is to determine if, and to what extent, children with elimination disorders show higher internalizing and externalizing problems than their healthy peers. Methods: A multistep literature search was performed from database inception until May 1st, 2022. PRISMA/MOOSE-compliant systematic review (PROSPERO: CRD42022303555) were used to identify studies reporting on internalizing and/or externalizing symptoms in children with an elimination disorder and a healthy control (HC) group. First, a systematic review was provided. Second, where data allowed for it, a quantitative meta-analysis with random effects model was conducted to analyze the differences between the elimination disorder and the HC groups for internalizing and externalizing symptoms. Effect size was standardized mean difference. Meta-regression analyses were conducted to examine the effect of sex, age, and study quality. Funnel plots were used to detect a publication bias. Where found, the trim and fill method was used to correct it. Results: 36 articles were included, 32 of them reporting on enuresis ( Conclusions: Children with an elimination disorder may have significant internalizing and externalizing problems, as well as impaired self-concept. It is recommendable to screen for them in children with enuresis or encopresis and provide appropriate interventions.
Language	English
Publishing date	2023-07-27
Publishing country	United States
Document type	Journal Article
ISSN	2692-9384
ISSN (online)	2692-9384
DOI	10.1002/jcv2.12185
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Article: Substance use during pregnancy and risk of postpartum depression: a systematic review and meta-analysis.

Pacho, Malein / Aymerich, Claudia / Pedruzo, Borja / Salazar de Pablo, Gonzalo / Sesma, Eva / Bordenave, Marta / Dieguez, Rodrigo / Lopez-Zorroza, Itziar / Herrero, Jon / Laborda, Maria / Fernandez-Rivas, Aranzazu / Garcia-Rizo, Clemente / Gonzalez-Torres, Miguel Angel / Catalan, Ana

Frontiers in psychiatry

2023 Volume 14, Page(s) 1264998

Abstract: Introduction: Postpartum depression (PPD) is a prevalent mental health condition affecting women globally within the first year following childbirth. Substance use during pregnancy has been associated with an increased risk of developing PPD, but the ... ...

Abstract	Introduction: Postpartum depression (PPD) is a prevalent mental health condition affecting women globally within the first year following childbirth. Substance use during pregnancy has been associated with an increased risk of developing PPD, but the evidence remains inconclusive. This meta-analysis aims to comprehensively assess the effects of different substances on PPD risk, exploring potential modifiers and confounding factors. Objectives: To examine the proportion of PPD among substance users during pregnancy, compared to non-users, and investigate the specific risk associated with different substances (tobacco, alcohol, and non-specified substance use/multiple substance use). Methods: A systematic literature search was conducted from inception to November 2022 using the Web of Science database (Clarivate Analytics), incorporating Web of Science Core Collection, the BIOSIS Citation Index, the KCI-Korean Journal Database, MEDLINE Results: Among the 26 included studies, encompassing 514,441 women, the pooled prevalence of PPD among substance users during pregnancy was 29% (95% CI 25-33). Meta-analyzes revealed an overall odds ratio (OR) of 3.67 (95% CI 2.31-5.85, Conclusion: This meta-analysis provides evidence of an increased risk of PPD among pregnant substance users, particularly those using multiple substances or tobacco. However, caution is needed in interpreting the association with alcohol use due to its non-significant result. Systematic review registration: This study protocol was registered at PROSPERO (registration number: CCRD42022375500).
Language	English
Publishing date	2023-11-09
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2023.1264998
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Article ; Online: Longitudinal change in neurocognitive functioning in children and adolescents at clinical high risk for psychosis: a systematic review.

Pedruzo, Borja / Aymerich, Claudia / Pacho, Malein / Herrero, Jon / Laborda, María / Bordenave, Marta / Giuliano, Anthony J / McCutcheon, Robert A / Gutiérrez-Rojas, Luis / McGuire, Philip / Stone, William S / Fusar-Poli, Paolo / González-Torres, Miguel Ángel / Catalan, Ana

European child & adolescent psychiatry

2023

Abstract: Clinical high risk of psychosis (CHR-P) population has become an attractive area of interest in preventing transitions to psychosis. The consequences of developing a psychotic disorder may be worse in cases of early onset. Thus, childhood and adolescence ...

Abstract	Clinical high risk of psychosis (CHR-P) population has become an attractive area of interest in preventing transitions to psychosis. The consequences of developing a psychotic disorder may be worse in cases of early onset. Thus, childhood and adolescence represent a critical developmental window, where opportunities to gain social and adaptive abilities depend on the individuals' neurocognitive performance. There have been previous syntheses of the evidence regarding neurocognitive functioning in CHR-P individuals and its longitudinal changes. However, there has been less focus on children and adolescents at CHR-P. A multistep literature search was performed from database inception until July 15th, 2022. PRIMSA/MOOSE compliant systematic review and PROSPERO protocol were used to identify studies reporting on longitudinal changes in neurocognitive functioning in children and adolescents (mean age of sample ≤ 18 years) at CHR-P and matched healthy control (HC) group. A systematic review of identified studies was then undertaken. Three articles were included, resulting in a total sample size of 151 CHR-P patients [mean (SD) age, 16.48 (2.41) years; 32.45% female] and 64 HC individuals [mean (SD) age, 16.79 (2.38) years; 42.18% female]. CHR-P individuals had worse outcomes in verbal learning, sustained attention and executive functioning domains compared to HC. Individuals taking antidepressants had better outcomes in verbal learning in contrast with those taking antipsychotics. In children and adolescents, neurocognition may be already impaired before the psychosis onset, and remains stable during the transition to psychosis. Further study should be performed to obtain more robust evidence.
Language	English
Publishing date	2023-05-18
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1118299-4
ISSN	1435-165X ; 1018-8827 ; 1433-5719
ISSN (online)	1435-165X
ISSN	1018-8827 ; 1433-5719
DOI	10.1007/s00787-023-02221-9
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Article ; Online: Prolactin and morning cortisol concentrations in antipsychotic naïve first episode psychosis: A systematic review and meta-analysis.

Aymerich, Claudia / Pedruzo, Borja / Pacho, Malein / Laborda, María / Herrero, Jon / Pillinger, Toby / McCutcheon, Robert A / Alonso-Alconada, Daniel / Bordenave, Marta / Martínez-Querol, Maria / Arnaiz, Ainara / Labad, Javier / Fusar-Poli, Paolo / González-Torres, Miguel Ángel / Catalan, Ana

Psychoneuroendocrinology

2023 Volume 150, Page(s) 106049

Abstract: Importance: Alterations in prolactin and cortisol levels have been reported in antipsychotic naïve patients with first episode psychosis (FEP). However, it has been studied in very small samples, and inter-group variability has never been studied before. ...

Abstract	Importance: Alterations in prolactin and cortisol levels have been reported in antipsychotic naïve patients with first episode psychosis (FEP). However, it has been studied in very small samples, and inter-group variability has never been studied before. Objective: To provide estimates of standardized mean differences (SMD) and inter-group variability for prolactin, cortisol awakening response (CAR) and morning cortisol concentrations in antipsychotic naïve FEP (AN-FEP) patients and healthy controls (HC). Data sources: BIOSIS, KCI, MEDLINE, Russian Science Citation Index, SciELO, Cochrane, PsycINFO, Web of Science were searched from inception to February 28, 2022. Study selection: Peer-reviewed cohort studies that reported on prolactin or cortisol blood concentrations in AN- FEP patients and HC were included. Data extraction and synthesis: Study characteristics, means and standard deviations (SD) were extracted from each article. Inter group differences in magnitude of effect were estimated using Hedges g. Inter-group variability was estimated with the coefficient of variation ratio (CVR). In both cases estimates were pooled using random-effects meta-analysis. Differences by study-level characteristics were estimated using meta-regression. PRISMA guideline was followed (No. CRD42022303555). Main outcomes and measures: Prolactin, CAR and morning cortisol blood concentrations in AN-FEP group in relation to HC group. Results: Fourteen studies for prolactin (N = 761 for AN-FEP group, N = 687 for HC group) and twelve studies for morning cortisol (N = 434 for AN-FEP group, N = 528 for HC group) were included. No studies were found in CAR in AN-FEP patients. Mean SMD for prolactin blood concentration was 0.88 (95% CI 0.57, 1.20) for male and 0.56 (95% CI 0.26, 0.87) for female. As a group, AN-FEP presented greater inter-group variability for prolactin levels than HC (CVR=1.28, 95% CI 1.02, 1.62). SMD for morning cortisol concentrations was non-significant: 0.34 (95% CI -0.01, 0.69) and no inter-group variability significant differences were detected: CVR= 1.05 (95% CI 0.91, 1.20). Meta-regression analyses for age and quality were non-significant. Funnel plots did not suggest a publication bias. Conclusions and relevance: Increased prolactin levels were found in AN-FEP patients. A greater inter-group variability in the AN-FEP group suggests the existence of patient subgroups with different prolactin levels. No significant abnormalities were found in morning cortisol levels. Further research is needed to clarify whether prolactin concentrations could be used as an illness biomarker.
MeSH term(s)	Humans ; Male ; Female ; Prolactin ; Schizophrenia ; Antipsychotic Agents ; Hydrocortisone ; Psychotic Disorders
Chemical Substances	Prolactin (9002-62-4) ; Antipsychotic Agents ; Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2023-02-04
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	197636-9
ISSN	1873-3360 ; 0306-4530
ISSN (online)	1873-3360
ISSN	0306-4530
DOI	10.1016/j.psyneuen.2023.106049
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Article ; Online: Psychological impact of COVID-19 lockdown on a population with serious mental illness. A prospective cohort study.

Pedruzo, Borja / Catalan, Ana / Aymerich, Claudia / Bordenave, Marta / Estevez, Olatz / Gómez, Diego Aurofio / Herrero, Jon / Laborda, María / Mancebo, Gonzalo / Martínez, Ania / Pacho, Malein / Paniagua, Ana / Pérez, José Luis / González-Torres, Miguel Ángel

Revista de psiquiatria y salud mental

2022 Volume 16, Page(s) 59–67

Abstract: Introduction: COVID-19 has spread worldwide since its appearance at the end of 2019. In Spain, 99-day long home confinement was set from March 15th 2020. Previous studies about events requiring situations of isolation suggested that mental health ... ...

Abstract	Introduction: COVID-19 has spread worldwide since its appearance at the end of 2019. In Spain, 99-day long home confinement was set from March 15th 2020. Previous studies about events requiring situations of isolation suggested that mental health problems may occur among the general population and, more specifically, vulnerable groups such as individuals with serious mental illness (SMI). This study aims to assess the psychological effect of confinement in patients with mental illness admitted to an inpatient psychiatric unit. Method: In this longitudinal study, IDER (State-Trait Depression Inventory) and STAI (State-Trait Anxiety Inventory) questionnaires were used at two different times (at the beginning and after the lockdown) of the pandemic to evaluate the depression and anxiety symptoms, respectively, in a population of patients who had been previously admitted to the Psychiatry Unit of the Basurto University Hospital. Results: 95 participants completed the IDER questionnaire in the first measurement, with a mean score of 24.56 (SD = 8.18) for state and 23.57 (SD = 8.14) for trait. In the case of STAI, the mean score was 27.86 (SD = 15.19) for the state and 30.49 (SD = 14.71) for the trait. No differences between the first and the second time were found in anxiety and depression levels. People with personality disorders presented high levels of anxiety. Conclusions: Individuals with a personality disorder showed the highest scores in anxiety and depression. Nevertheless, strict confinement did not affect this population, despite the literature that evidences that the pandemic has worsened people's mental health with SMI.
Language	English
Publishing date	2022-06-17
Publishing country	Spain
Document type	Journal Article
ISSN	1989-4600
ISSN (online)	1989-4600
DOI	10.1016/j.rpsm.2022.04.004
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Article ; Online: Effects of exogenous nitric oxide on growth, proline accumulation and antioxidant capacity in Cakile maritima seedlings subjected to water deficit stress.

Jday, Asma / Ben Rejeb, Kilani / Slama, Ines / Saadallah, Kaouthar / Bordenave, Marianne / Planchais, Séverine / Savouré, Arnould / Abdelly, Chedly

Functional plant biology : FPB

2020 Volume 43, Issue 10, Page(s) 939–948

Abstract: Nitric oxide (NO) - an endogenous signalling molecule in plants and animals - mediates responses to biotic and abiotic stresses. In the present study, we examined the role of exogenous application of NO in mediating stress responses in Cakile maritima ... ...

Abstract	Nitric oxide (NO) - an endogenous signalling molecule in plants and animals - mediates responses to biotic and abiotic stresses. In the present study, we examined the role of exogenous application of NO in mediating stress responses in Cakile maritima Scop. seedlings under water deficit stress using sodium nitroprusside (SNP) as NO donor and as a pre-treatment before the application of stress. Water deficit stress was applied by withholding water for 14 days. Growth, leaf water content (LWC), osmotic potential (ψs), chlorophyll, malondialdehyde (MDA), electrolyte leakage (EL), proline and Δ1-pyrroline-5-carboxylate synthetase (P5CS) and proline dehydrogenase (ProDH) protein levels were determined. Enzyme activities involved in antioxidant activities (superoxide dismutase (SOD) and catalase (CAT)) were measured upon withholding water. The results showed that shoot biomass production was significantly decreased in plants subjected to water deficit stress alone. However, in water deficit stressed plants pre-treated with SNP, growth activity was improved and proline accumulation was significantly increased. Proline accumulation was concomitant with the stimulation of its biosynthesis as shown by the accumulation of P5CS proteins. Nevertheless, no significant change in ProDH protein levels was observed. Besides plants showed lower water deficit-induced lipid membrane degradation and oxidative stress after the pretreatment with 100µM SNP. This behaviour was related to the increased activity of SOD and CAT. Thus, we concluded that NO increased C. maritima drought tolerance and mitigated damage associated with water deficit stress by the regulation of proline metabolism and the reduction of oxidative damage.
Language	English
Publishing date	2020-06-02
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2071582-1
ISSN	1445-4416 ; 1445-4408
ISSN (online)	1445-4416
ISSN	1445-4408
DOI	10.1071/FP15363
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Article: Analysis of pectin methyl esterases

Bordenave, M

Linskens, H. F. Plant cell wall analysis /

1996

Keywords	pectinesterase ; enzyme activity ; quantitative analysis ; purification ; physicochemical properties ; cell wall components
Language	English
Size	p. 165-180.
Publisher	Springer, c1996.
Publishing place	Berlin ; New York
Document type	Article
ISBN	354059406X ; 9783540594062
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Immobilized and Free Apoplastic Pectinmethylesterases in Mung Bean Hypocotyl.

Bordenave, M. / Goldberg, R.

Plant physiology

2002 Volume 106, Issue 3, Page(s) 1151–1156

Abstract: The nature and the action pattern of apoplastic pectinmethylesterase (PME) isoforms were investigated in mung bean [Vigna radiata (L.) Wilzeck] hypocotyls. Successive extractions of neutral and alkaline PME isoforms present in hypocotyl native cell walls ...

Abstract	The nature and the action pattern of apoplastic pectinmethylesterase (PME) isoforms were investigated in mung bean [Vigna radiata (L.) Wilzeck] hypocotyls. Successive extractions of neutral and alkaline PME isoforms present in hypocotyl native cell walls (referred to as PE1, PE2, PE3, PE4, with increasingly basic isoelectric points) revealed that solubilization of PE1, PE2, and PE4 did not induce any significant decrease in the cell-wall-bound PME activity. The in vitro de-esterification occurring when isolated cell walls were incubated with pectin resulted, then, from the activity of PE3. In addition, pH control of PME activity was shown to be much stronger for enzymes bound to cell walls, in their native state or reintroduced after solubilization, than for enzymes in solution. Mature cell walls showed much more activity than young cell walls, and were relatively enriched in two acidic PME isoforms missing in young cell walls. One acidic PME was also detected in the extracellular fluid. The acidic and neutral isoforms that could be easily transferred from their binding sites to their substrate might be those involved in the demethylation process developing along the mung bean hypocotyl.
Language	English
Publishing date	2002-01-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	208914-2
ISSN	1532-2548 ; 0032-0889
ISSN (online)	1532-2548
ISSN	0032-0889
DOI	10.1104/pp.106.3.1151
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Article ; Online: Biochemical characterization of proline dehydrogenase in Arabidopsis mitochondria.

Schertl, Peter / Cabassa, Cécile / Saadallah, Kaouthar / Bordenave, Marianne / Savouré, Arnould / Braun, Hans-Peter

The FEBS journal

2014 Volume 281, Issue 12, Page(s) 2794–2804

Abstract: Proline has multiple functions in plants. Besides being a building block for protein biosynthesis proline plays a central role in the plant stress response and in further cellular processes. Here, we report an analysis on the integration of proline ... ...

Abstract	Proline has multiple functions in plants. Besides being a building block for protein biosynthesis proline plays a central role in the plant stress response and in further cellular processes. Here, we report an analysis on the integration of proline dehydrogenase (ProDH) into mitochondrial metabolism in Arabidopsis thaliana. An experimental system to induce ProDH activity was established using cell cultures. Induction of ProDH was measured by novel photometric activity assays and by a ProDH in gel activity assay. Effects of increased ProDH activity on other mitochondrial enzymes were systematically investigated. Activities of the protein complexes of the respiratory chain were not significantly altered. In contrast, some mitochondrial dehydrogenases had markedly changed activities. Activity of glutamate dehydrogenase substantially increased, indicating upregulation of the entire proline catabolic pathway, which was confirmed by co-expression analyses of the corresponding genes. Furthermore, activity of d-lactate dehydrogenase was increased. d-lactate was identified to be a competitive inhibitor of ProDH in plants. We suggest that induction of d-lactate dehydrogenase activity allows rapid upregulation of ProDH activity during the short-term stress response in plants.
MeSH term(s)	Arabidopsis/enzymology ; Blotting, Western ; Cells, Cultured ; Electrophoresis, Polyacrylamide Gel ; Glutamate Dehydrogenase/metabolism ; Lactic Acid/pharmacology ; Mitochondria/enzymology ; Proline Oxidase/antagonists & inhibitors ; Proline Oxidase/metabolism ; Stereoisomerism ; Up-Regulation
Chemical Substances	Lactic Acid (33X04XA5AT) ; Glutamate Dehydrogenase (EC 1.4.1.2) ; Proline Oxidase (EC 1.5.3.-)
Language	English
Publishing date	2014-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2173655-8
ISSN	1742-4658 ; 1742-464X
ISSN (online)	1742-4658
ISSN	1742-464X
DOI	10.1111/febs.12821
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Article: Résultats à long terme du traitement de l'incontinence urinaire masculine par implantation de sphincter artificiel urinaire (AMS 800) en position bulbaire: expérience monocentrique.

Bordenave, M / Rouprêt, M / Taksin, L / Parra, J / Cour, F / Richard, F / Bitker, M-O / Chartier-Kastler, E

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie

2011 Volume 21, Issue 4, Page(s) 277–282

Abstract: Objective: To report the functional results and morbidity after implantation of bulbar artificial urinary sphincter (AUS) in incontinent men with at least 5 years of follow-up.: Patients and methods: The files of patients treated between 1984 and ... ...

Title translation	Long-term results of the treatment of urinary incontinence with bulbar implantation of artificial urinary sphincter in men: a single-center experience.
Abstract	Objective: To report the functional results and morbidity after implantation of bulbar artificial urinary sphincter (AUS) in incontinent men with at least 5 years of follow-up. Patients and methods: The files of patients treated between 1984 and 2003 by setting up a SAU at bulbar location were reviewed. The following data were recorded: age, etiology of incontinence, intra-operative complications. To evaluate the results on continence, patients were seen at 1, 3, 6 and 12 months, and yearly thereafter. Results: Overall, 159 men implanted with an AUS were included. The median age was 68.4 years and the median follow-up was 69 months. The etiology of incontinence was a prostate surgery in 83% of cases. The five-year rates of continence and satisfaction were 74.2% (n=118) and 92% (n=140), respectively. The five-year rates of infections and erosions were 4.4% and 9.4%, respectively. In case of previous radiotherapy, the rate of erosion at 5 years was 22.2%. The rate of atrophy and urethral mechanical failure at 5 years was 7.5% and 23.6%, respectively. The rate of reoperation at 5 years was 41.5%. Conclusion: Our results confirm that the AUS is still the standard treatment for male with urinary incontinence due to intrinsic sphincter deficiency. Minimally invasive therapies are being developed that could overcome the mechanical failures and offer an alternative in case of primary or even secondary failure of the AUS.
MeSH term(s)	Aged ; Follow-Up Studies ; Humans ; Male ; Treatment Outcome ; Urinary Incontinence/surgery ; Urinary Sphincter, Artificial
Language	French
Publishing date	2011-04
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	1186190-3
ISSN	1166-7087
ISSN	1166-7087
DOI	10.1016/j.purol.2010.07.007
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