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  1. Artikel ; Online: Osteoporosis treatment: the battle to be won.

    Borges, Joao Lindolfo C

    Archives of endocrinology and metabolism

    2020  Band 64, Heft 4, Seite(n) 327–328

    Mesh-Begriff(e) Humans ; Osteoporosis/drug therapy
    Sprache Englisch
    Erscheinungsdatum 2020-08-12
    Erscheinungsland Brazil
    Dokumenttyp Editorial
    ISSN 2359-4292
    ISSN (online) 2359-4292
    DOI 10.20945/2359-3997000000276
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Accelerated fracture healing with teriparatide.

    Borges, João Lindolfo C

    Archives of endocrinology and metabolism

    2015  Band 59, Heft 1, Seite(n) 89

    Mesh-Begriff(e) Bone Density Conservation Agents/therapeutic use ; Female ; Femoral Neck Fractures/drug therapy ; Fracture Healing/drug effects ; Humans ; Osteoporotic Fractures/drug therapy ; Teriparatide/therapeutic use
    Chemische Substanzen Bone Density Conservation Agents ; Teriparatide (10T9CSU89I)
    Sprache Englisch
    Erscheinungsdatum 2015-02
    Erscheinungsland Brazil
    Dokumenttyp Comment ; Letter
    ISSN 2359-4292
    ISSN (online) 2359-4292
    DOI 10.1590/2359-3997000000016
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: The Clinical Utility of Vertebral Fracture Assessment in Predicting Fractures.

    Borges, Joao Lindolfo C / de M Miranda, Isabella Santiago / Lewiecki, E Michael

    Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry

    2017  Band 20, Heft 3, Seite(n) 304–308

    Abstract: Vertebral fracture (VF) is the most common type of osteoporotic fracture. VFs are associated with diminished quality of life and high morbidity and mortality. The presence of a VF, especially a recent one, is an important risk factor for developing ... ...

    Abstract Vertebral fracture (VF) is the most common type of osteoporotic fracture. VFs are associated with diminished quality of life and high morbidity and mortality. The presence of a VF, especially a recent one, is an important risk factor for developing another fracture. However, most VFs are not clinically recognized. VF assessment by dual-energy X-ray absorptiometry is a convenient, low-cost, low-radiation, reliable method to identify VFs during bone mineral density measurement. The finding of a previously unrecognized VF may change the diagnostic classification, assessment of fracture risk, and treatment strategies. This paper focuses on the utility of VF assessment in clinical practice.
    Mesh-Begriff(e) Absorptiometry, Photon ; Algorithms ; Arthritis, Rheumatoid/diagnostic imaging ; Female ; Humans ; Male ; Osteoporotic Fractures/diagnostic imaging ; Postmenopause ; Predictive Value of Tests ; Recurrence ; Risk Assessment ; Spinal Fractures/diagnostic imaging
    Sprache Englisch
    Erscheinungsdatum 2017-07
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2040951-5
    ISSN 1094-6950
    ISSN 1094-6950
    DOI 10.1016/j.jocd.2017.06.016
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Accelerated fracture healing with teriparatide.

    Borges, João Lindolfo C / Freitas, Anderson / Bilezikian, John P

    Arquivos brasileiros de endocrinologia e metabologia

    2013  Band 57, Heft 2, Seite(n) 153–156

    Abstract: Satisfactory healing of the osteoporotic fracture is critically important to functional recovery, morbidity, and quality of life. Some therapies for osteoporosis may affect the processes associated with bone repair. For example, bisphosphonates in ... ...

    Abstract Satisfactory healing of the osteoporotic fracture is critically important to functional recovery, morbidity, and quality of life. Some therapies for osteoporosis may affect the processes associated with bone repair. For example, bisphosphonates in experimental models are associated with increased callus size and mineralization, reduced callus remodeling, and improved mechanical strength. Local and systemic bisphosphonate treatment may improve implant fixation. No negative impact on fracture healing has been observed, even after major surgery or when administered immediately after fracture. For the osteoanabolic agent teriparatide, case reports and a randomized trial have produced mixed results, but they are consistent with a positive impact of teriparatide on fracture healing. Some of the agents currently being developed for osteoporosis, notably sclerostin and DKK1 antibodies have shown a beneficial effect on fracture healing. At this point, therefore, there is no evidence that osteoporosis therapies are detrimental to fracture healing with some promising experimental evidence for positive effects on healing, notably for those agents whose actions are primarily anabolic.
    Mesh-Begriff(e) Aged, 80 and over ; Bone Density ; Bone Density Conservation Agents/therapeutic use ; Female ; Femoral Neck Fractures/drug therapy ; Fracture Healing/drug effects ; Humans ; Osteoporotic Fractures/drug therapy ; Randomized Controlled Trials as Topic ; Teriparatide/therapeutic use ; Treatment Outcome
    Chemische Substanzen Bone Density Conservation Agents ; Teriparatide (10T9CSU89I)
    Sprache Englisch
    Erscheinungsdatum 2013-02-05
    Erscheinungsland Brazil
    Dokumenttyp Case Reports ; Journal Article ; Review
    ZDB-ID 603919-4
    ISSN 1677-9487 ; 0004-2730
    ISSN (online) 1677-9487
    ISSN 0004-2730
    DOI 10.1590/s0004-27302013000200010
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Complicando o monitoramento da osteoporose: mas não aqui.

    Borges, João Lindolfo C

    Arquivos brasileiros de endocrinologia e metabologia

    2004  Band 48, Heft 2, Seite(n) 221–222

    Titelübersetzung Complicating the monitoring of osteoporosis: but not here.
    Mesh-Begriff(e) Bone Density ; Humans ; Osteoporosis/blood ; Osteoporosis/metabolism ; Parathyroid Hormone/blood ; Seasons ; Vitamin D/blood
    Chemische Substanzen Parathyroid Hormone ; Vitamin D (1406-16-2)
    Sprache Portugiesisch
    Erscheinungsdatum 2004-07-07
    Erscheinungsland Brazil
    Dokumenttyp Editorial
    ZDB-ID 603919-4
    ISSN 1677-9487 ; 0004-2730
    ISSN (online) 1677-9487
    ISSN 0004-2730
    DOI 10.1590/s0004-27302004000200002
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Complicando o monitoramento da osteoporose

    Borges João Lindolfo C.

    Arquivos brasileiros de Endocrinologia e Metabologia, Vol 48, Iss 2, Pp 221-

    mas não aqui

    2004  Band 222

    Schlagwörter Diseases of the endocrine glands. Clinical endocrinology ; RC648-665 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Internal medicine ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Sprache Portugiesisch
    Erscheinungsdatum 2004-01-01T00:00:00Z
    Verlag Sociedade Brasileira de Endocrinologia e Metabologia
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel: Obesity, Bariatric Surgery, and Vitamin D.

    Borges, Joao Lindolfo C / Miranda, Isabella Santiago de M / Sarquis, Marta M S / Borba, Victoria / Maeda, Sergio Setsuo / Lazaretti-Castro, Marise / Blinkey, Neil

    Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry

    2017  Band 21, Heft 2, Seite(n) 157–162

    Abstract: The high prevalence of obesity is a worldwide problem associated with multiple comorbidities, including cardiovascular diseases. Vitamin D deficiency with secondary hyperparathyroidism is common in obese individuals and can be aggravated after bariatric ... ...

    Abstract The high prevalence of obesity is a worldwide problem associated with multiple comorbidities, including cardiovascular diseases. Vitamin D deficiency with secondary hyperparathyroidism is common in obese individuals and can be aggravated after bariatric surgery. Moreover, there is no consensus on the optimal supplementation dose of vitamin D in postbariatric surgical patients. We present new data on the variability of 25(OH)D response to supplementation in postmenopausal obese women. It is important to recognize and treat vitamin D deficiency before bariatric surgery to avoid postoperative complications, such as metabolic bone disease with associated high fracture risk. The objective of this article is to discuss the bone metabolism consequences of vitamin D deficiency after bariatric surgery.
    Mesh-Begriff(e) 25-Hydroxyvitamin D 2/blood ; Bariatric Surgery/adverse effects ; Bone Density ; Bone and Bones/metabolism ; Dietary Supplements ; Humans ; Hyperparathyroidism, Secondary/etiology ; Obesity/complications ; Obesity/metabolism ; Obesity/surgery ; Postmenopause/physiology ; Postoperative Complications/prevention & control ; Risk Factors ; Vitamin D/therapeutic use ; Vitamin D Deficiency/drug therapy ; Vitamin D Deficiency/etiology ; Vitamin D Deficiency/metabolism
    Chemische Substanzen Vitamin D (1406-16-2) ; 25-Hydroxyvitamin D 2 (21343-40-8)
    Sprache Englisch
    Erscheinungsdatum 2017-04-17
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2040951-5
    ISSN 1094-6950
    ISSN 1094-6950
    DOI 10.1016/j.jocd.2017.03.001
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Low bone mass in children and adolescents.

    Borges, João Lindolfo C / Brandão, Cynthia M A

    Arquivos brasileiros de endocrinologia e metabologia

    2006  Band 50, Heft 4, Seite(n) 775–782

    Abstract: Osteoporosis is a disease characterized by low bone mass and micro architectural alterations of bone tissue leading to enhanced bone fragility and increased fracture risk. Although research in osteoporosis has focused mainly on the role of bone loss in ... ...

    Abstract Osteoporosis is a disease characterized by low bone mass and micro architectural alterations of bone tissue leading to enhanced bone fragility and increased fracture risk. Although research in osteoporosis has focused mainly on the role of bone loss in the elderly population, it is becoming increasingly clear that the amount of bone that is gained during growth is also an important determinant of future resistance to fractures. Thus, considerable interest is being placed on defining preventive strategies that optimize the gain of bone mass during childhood and adolescence. Knowledge of the determinants accounting for the physiologic and genetic variations in bone accumulation in children will provide the best means toward the early diagnosis and treatment of osteoporosis. This article reviews the techniques available for bone mass measurements in children and the major determinants and diseases influencing bone accretion during childhood and adolescence.
    Mesh-Begriff(e) Absorptiometry, Photon ; Adolescent ; Bone Density/physiology ; Bone Development/physiology ; Child ; Humans ; Osteoporosis/diagnosis ; Osteoporosis/etiology ; Osteoporosis/prevention & control ; Risk Factors
    Sprache Englisch
    Erscheinungsdatum 2006-11-07
    Erscheinungsland Brazil
    Dokumenttyp Journal Article ; Review
    ZDB-ID 603919-4
    ISSN 1677-9487 ; 0004-2730
    ISSN (online) 1677-9487
    ISSN 0004-2730
    DOI 10.1590/s0004-27302006000400022
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Update on osteoporosis therapy.

    Borges, João Lindolfo C / Bilezikian, John P

    Arquivos brasileiros de endocrinologia e metabologia

    2006  Band 50, Heft 4, Seite(n) 755–763

    Abstract: Osteoporosis is a skeletal disorder characterized by compromised bone strength that predisposes a person to increased fracture risk. Fractures are often associated with increased morbidity, higher mortality, loss of function and even psychological ... ...

    Abstract Osteoporosis is a skeletal disorder characterized by compromised bone strength that predisposes a person to increased fracture risk. Fractures are often associated with increased morbidity, higher mortality, loss of function and even psychological consequences. Pharmacotherapeutic interventions (e.g., bisphosphonates, selective estrogen receptor modulators, calcitonin, and teriparatide) in women with postmenopausal osteoporosis provide substantial reduction in fracture risk over and above risk reduction with calcium and vitamin D supplementation alone. The importance of nutritional support along with an appropriate exercise regimen, avoiding smoking and excessive alcohol use is to be emphasized along with the pharmacologic approach to osteoporosis. Despite the effectiveness of therapy with pharmacologic agents, most patients who start therapy do not remain on treatment for more than 1 year.
    Mesh-Begriff(e) Accidental Falls/prevention & control ; Bone Density/drug effects ; Bone Density Conservation Agents/pharmacology ; Bone Density Conservation Agents/therapeutic use ; Calcium, Dietary/administration & dosage ; Dietary Supplements ; Exercise ; Female ; Fractures, Bone/prevention & control ; Humans ; Long-Term Care ; Male ; Osteoporosis/drug therapy ; Osteoporosis/prevention & control ; Osteoporosis, Postmenopausal/prevention & control ; Risk Factors ; Selective Estrogen Receptor Modulators/therapeutic use ; Vitamin D/administration & dosage
    Chemische Substanzen Bone Density Conservation Agents ; Calcium, Dietary ; Selective Estrogen Receptor Modulators ; Vitamin D (1406-16-2)
    Sprache Englisch
    Erscheinungsdatum 2006-11-07
    Erscheinungsland Brazil
    Dokumenttyp Journal Article ; Review
    ZDB-ID 603919-4
    ISSN 1677-9487 ; 0004-2730
    ISSN (online) 1677-9487
    ISSN 0004-2730
    DOI 10.1590/s0004-27302006000400020
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Bone density testing in clinical practice.

    Lewiecki, E Michael / Borges, João Lindolfo C

    Arquivos brasileiros de endocrinologia e metabologia

    2006  Band 50, Heft 4, Seite(n) 586–595

    Abstract: The diagnosis of osteoporosis and monitoring of treatment is a challenge for physicians due to the large number of available tests and complexities of interpretation. Bone mineral density (BMD) testing is a non-invasive measurement to assess skeletal ... ...

    Abstract The diagnosis of osteoporosis and monitoring of treatment is a challenge for physicians due to the large number of available tests and complexities of interpretation. Bone mineral density (BMD) testing is a non-invasive measurement to assess skeletal health. The "gold-standard" technology for diagnosis and monitoring is dual-energy X-ray absorptiometry (DXA) of the spine, hip, or forearm. Fracture risk can be predicted using DXA and other technologies at many skeletal sites. Despite guidelines for selecting patients for BMD testing and identifying those most likely to benefit from treatment, many patients are not being tested or receiving therapy. Even patients with very high risk of fracture, such as those on long-term glucocorticoid therapy or with prevalent fragility fractures, are often not managed appropriately. The optimal testing strategy varies according to local availability and affordability of BMD testing. The role of BMD testing to monitor therapy is still being defined, and interpretation of serial studies requires special attention to instrument calibration, acquisition technique, analysis, and precision assessment. BMD is usually reported as a T-score, the standard deviation variance of the patient's BMD compared to a normal young-adult reference population. BMD in postmenopausal women is classified as normal, osteopenia, or osteoporosis according to criteria established by the World Health Organization. Standardized methodologies are being developed to establish cost-effective intervention thresholds for pharmacological therapy based on T-score combined with clinical risk factors for fracture.
    Mesh-Begriff(e) Absorptiometry, Photon ; Bone Density/physiology ; Bone Diseases, Metabolic/diagnosis ; Female ; Fractures, Bone/diagnostic imaging ; Fractures, Bone/etiology ; Fractures, Bone/therapy ; Humans ; Male ; Osteoporosis/complications ; Osteoporosis/diagnostic imaging ; Osteoporosis/therapy ; Osteoporosis, Postmenopausal/diagnosis ; Postmenopause ; Practice Guidelines as Topic ; Risk Assessment ; Risk Factors
    Sprache Englisch
    Erscheinungsdatum 2006-11-07
    Erscheinungsland Brazil
    Dokumenttyp Journal Article ; Review
    ZDB-ID 603919-4
    ISSN 1677-9487 ; 0004-2730
    ISSN (online) 1677-9487
    ISSN 0004-2730
    DOI 10.1590/s0004-27302006000400004
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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