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  1. Article ; Online: Magnetic solid-phase extraction based on restricted-access molecularly imprinted polymers for ultrarapid determination of ractopamine residues from food samples by capillary electrophoresis.

    Vidal, Daniel Ferreira / Pires, Bruna Carneiro / Borges, Marcella Matos Cordeiro / de Oliveira, Hanna Leijoto / Silva, Camilla Fonseca / Borges, Keyller Bastos

    Journal of chromatography. A

    2024  Volume 1720, Page(s) 464809

    Abstract: An ultrafast, efficient, and eco-friendly method combining magnetic solid phase extraction and capillary electrophoresis with diode array detection have been developed to determine ractopamine residues in food samples. A restricted access material based ... ...

    Abstract An ultrafast, efficient, and eco-friendly method combining magnetic solid phase extraction and capillary electrophoresis with diode array detection have been developed to determine ractopamine residues in food samples. A restricted access material based on magnetic and mesoporous molecularly imprinted polymer has been properly synthesized and characterized, demonstrating excellent selectivity and high adsorbent capacity. Short-end injection capillary electrophoresis method was optimized: 75 mM triethylamine pH 7 as BGE, -20 kV, 50 mbar by hydrodynamic injection during 8 s, and capillary temperature at 25 °C; reaching ultrafast ractopamine analysis (∼0.6 min) with good peak asymmetry, and free from interfering and/or baseline noise. After sample preparation optimization, the conditions were: 1000 µL of sample at pH 6, 20 mg of adsorbent, stirring time of 120 s, 250 µL of ultrapure water as washing solvent, 1000 µL of methanol: acetic acid (7: 3, v/v) as eluent, and the adsorbent can be reused four times. In these conditions, the analytical method showed recoveries around to 100 %, linearity ranged from 9.74 to 974.0 µg kg
    MeSH term(s) Animals ; Swine ; Molecularly Imprinted Polymers ; Solid Phase Extraction/methods ; Electrophoresis, Capillary/methods ; Magnetic Phenomena ; Molecular Imprinting/methods ; Chromatography, High Pressure Liquid/methods ; Phenethylamines
    Chemical Substances ractopamine (57370OZ3P1) ; Molecularly Imprinted Polymers ; Phenethylamines
    Language English
    Publishing date 2024-03-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1171488-8
    ISSN 1873-3778 ; 0021-9673
    ISSN (online) 1873-3778
    ISSN 0021-9673
    DOI 10.1016/j.chroma.2024.464809
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 813: Show issues Location:
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  2. Article ; Online: Magnetic and mesoporous molecularly imprinted polymer synthesized by rational computation design: Sample preparation and analysis of ractopamine.

    Vidal, Daniel Ferreira / Silva, Camilla Fonseca / Borges, Marcella Matos Cordeiro / Nascimento, Clebio Soares / Borges, Keyller Bastos

    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

    2023  Volume 1227, Page(s) 123843

    Abstract: Through density functional theory calculations was studied theoretically the formation process of a magnetic and mesoporous molecularly imprinted polymer for ractopamine (RAC), evaluating the molecular electrostatic potential map, functional monomers, ... ...

    Abstract Through density functional theory calculations was studied theoretically the formation process of a magnetic and mesoporous molecularly imprinted polymer for ractopamine (RAC), evaluating the molecular electrostatic potential map, functional monomers, functional monomer / template stoichiometry and crosslink agents. The results revealed that the best conditions for the synthesis were established with acrylic acid as functional monomer in a 1: 4 stoichiometry using acetonitrile as the solvent and ethylene glycol dimethacrylate as crosslink agent. It was observed that nine hydrogen bonds established between the RAC and acrylic acid play a key role on the pre-polymerization complex. In addition, three analytical methods using HPLC, UHPLC and CE instruments were optimized for rapid analysis. The adsorbent was experimentally synthesized considering the best conditions found at the molecular level and characterized by FTIR, DRX, TGA, SEM, TEM, surface analysis, and wettability. After that, the synthesized material was used in magnetic solid phase extraction combined with capillary electrophoresis in a preliminary RAC recovery study from milk samples. Finally, greenness metric with a score of 0.55 have been obtained for the sample preparation procedure using the online AGREEprep metric.
    MeSH term(s) Molecularly Imprinted Polymers ; Molecular Imprinting/methods ; Adsorption ; Solid Phase Extraction/methods ; Chromatography, High Pressure Liquid/methods ; Magnetic Phenomena
    Chemical Substances Molecularly Imprinted Polymers ; acrylic acid (J94PBK7X8S) ; ractopamine (57370OZ3P1)
    Language English
    Publishing date 2023-07-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1180823-8
    ISSN 1873-376X ; 0378-4347 ; 1570-0232 ; 1387-2273
    ISSN (online) 1873-376X
    ISSN 0378-4347 ; 1570-0232 ; 1387-2273
    DOI 10.1016/j.jchromb.2023.123843
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Short-End Injection Capillary Electrophoresis and Multivariate Analysis for Simultaneous Determination of Heavy Metals in

    Klassen, Aline / Fernandes, Rafael Ferreira / de Oliveira, Débora Cristina / do Nascimento, Maria Patrícia / Borges, Marcella Matos Cordeiro / de Oliveira, Marcone Augusto Leal / Calixto, Leandro Augusto / Borges, Keyller Bastos

    International journal of environmental research and public health

    2022  Volume 19, Issue 23

    Abstract: An ultra-fast method for the simultaneous determination of heavy metals in Passiflora incarnata tea by capillary electrophoresis (CE) using a short-end injection combined with multivariate analysis was proposed. Separation was conducted by hydrodynamic ... ...

    Abstract An ultra-fast method for the simultaneous determination of heavy metals in Passiflora incarnata tea by capillary electrophoresis (CE) using a short-end injection combined with multivariate analysis was proposed. Separation was conducted by hydrodynamic injection (5 s at 0.5 psi) using the short-end injection procedure in a fused uncoated silica capillary (50 cm total length, 10.2 cm effective length, 50 µm i.d.) with separation time less than 2 min. An indirect UV detection at 214 nm was employed by using imidazole as a chromophore. The buffer used was 6 mmol/L hydroxybutyric acid (HIBA). The optimum conditions by full factorial with a central point were achieved by 18-crown-6 concentration (23.3 mmol L−1), voltage (+11.4 kV), methanol concentration (3.8%), and temperature (20 °C). The method showed good linearity (R2 > 0.998) for both Cd and Pb, inter-day precision of less than 14.49%, and an adequate limit of quantification only for Cd (LOQ < 0.5 µg mL−1 for Cd) based on the US Pharmacopeial Convention limit requirements for elemental impurities. After method validation, the method was applied to Passiflora incarnata tea samples from a local market. Furthermore, the developed method showed great potential for the determination of metals in other samples with proper sample preparation procedures.
    MeSH term(s) Passiflora ; Cadmium ; Electrophoresis, Capillary/methods ; Multivariate Analysis
    Chemical Substances Cadmium (00BH33GNGH)
    Language English
    Publishing date 2022-11-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph192315994
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  4. Article ; Online: Assessment of the Performance of Solid Phase Extraction Based on Pipette Tip Employing a Hybrid Molecularly Imprinted Polymer as an Adsorbent for Enantioselective Determination of Albendazole Sulfoxide.

    Anacleto, Sara da Silva / de Oliveira, Hanna Leijoto / da Silva, Anny Talita Maria / do Nascimento, Tienne Aparecida / Borges, Marcella Matos Cordeiro / Silva, Ricky Cássio Dos Santos / Pereira, Arnaldo César / Borges, Keyller Bastos

    Journal of chromatographic science

    2019  Volume 57, Issue 7, Page(s) 671–678

    Abstract: Herein, an organic-inorganic hybrid molecularly imprinted polymer (MIP) was successfully synthesized with albendazole sulfoxide (ABZSO) as a template and 3-(trimethoxysilyl)propyl methacrylate, a bifunctional group compound, as a single cross-linking ... ...

    Abstract Herein, an organic-inorganic hybrid molecularly imprinted polymer (MIP) was successfully synthesized with albendazole sulfoxide (ABZSO) as a template and 3-(trimethoxysilyl)propyl methacrylate, a bifunctional group compound, as a single cross-linking agent. In this study, a simple method using HPLC-DAD was developed for the determination of ABZSO enantiomers in human urine using pipette tip-based molecularly imprinted polymer solid phase extraction (PT-MIP-SPE). Enantioseparation with satisfactory retention times (5.17 and 7.09 min), acceptable theoretical plates (N = 4,535 and 5,091) and strong resolution (Rs = 5.45) was performed with an Agilent® Eclipse Plus C18 (100 mm × 4.6 mm, 3.5 μm) coupled with a Chiralpak® IA column (100 mm × 4.6 mm, 3 μm), a mixture with ethanol:water (50:50, v/v) as the mobile phase, temperature at 40°C, flow rate at 0.9 mL min-1 and λ = 230 nm. Thereafter, certain parameters affecting the PT-MIP-SPE were investigated in detail and the better conditions were: 300 μL of water as washing solvent, 500 μL of ethanol:acetic acid (9:1, v/v) as eluting solvent, 20 mg of MIP, 500 μL of human urine at pH 9 and no addition of NaCl. Recoveries/relative standard deviation (RSD%) for (R)-(+)-ABZSO and (S)-(-)-ABZSO were 78.2 ± 0.2% and 69.7 ± 1.7%, respectively.
    Language English
    Publishing date 2019-06-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80141-0
    ISSN 1945-239X ; 0021-9665
    ISSN (online) 1945-239X
    ISSN 0021-9665
    DOI 10.1093/chromsci/bmz036
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 895: Show issues Location:
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  5. Article ; Online: Evaluation of physicochemical properties as supporting information on quality control of raw materials and veterinary pharmaceutical formulations.

    Anacleto, Sara da Silva / Borges, Marcella Matos Cordeiro / de Oliveira, Hanna Leijoto / Vicente, Andressa Reis / de Figueiredo, Eduardo Costa / de Oliveira, Marcone Augusto Leal / Borges, Bárbara Juliana Pinheiro / de Oliveira, Marcelo Antonio / Borges, Warley de Souza / Borges, Keyller Bastos

    Journal of pharmaceutical analysis

    2018  Volume 8, Issue 3, Page(s) 168–175

    Abstract: This study aimed to show that the physicochemical proprieties obtained by Fourier transform infrared spectroscopy (FTIR), thermogravimetry (TG), and scanning electronic microscopy (SEM) can be useful tools for evaluating the quality of active ... ...

    Abstract This study aimed to show that the physicochemical proprieties obtained by Fourier transform infrared spectroscopy (FTIR), thermogravimetry (TG), and scanning electronic microscopy (SEM) can be useful tools for evaluating the quality of active pharmaceutical ingredients (APIs) and pharmaceutical products. In addition, a simple, sensitive, and efficient method employing HPLC-DAD was developed for simultaneous determination of lidocaine (LID), ciprofloxacin (CFX) and enrofloxacin (EFX) in raw materials and in veterinary pharmaceutical formulations. Compounds were separated using a Gemini C
    Language English
    Publishing date 2018-01-17
    Publishing country China
    Document type Journal Article
    ISSN 2214-0883
    ISSN (online) 2214-0883
    DOI 10.1016/j.jpha.2018.01.001
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  6. Article ; Online: Desomorphine (Krokodil): An overview of its chemistry, pharmacology, metabolism, toxicology and analysis.

    Florez, Diego Hernando Ângulo / Dos Santos Moreira, Ana Maria / da Silva, Pedro Rafael / Brandão, Ricardo / Borges, Marcella Matos Cordeiro / de Santana, Fernando José Malagueño / Borges, Keyller Bastos

    Drug and alcohol dependence

    2017  Volume 173, Page(s) 59–68

    Abstract: Background: "Krokodil" or "Crocodile" is an illegal homemade desomorphine drug obtained from chemical reactions of commercial codeine drugs with several other powerful and highly toxic chemical agents increasing its addiction and hallucinogenic effects ... ...

    Abstract Background: "Krokodil" or "Crocodile" is an illegal homemade desomorphine drug obtained from chemical reactions of commercial codeine drugs with several other powerful and highly toxic chemical agents increasing its addiction and hallucinogenic effects when compared with other morphine analogues.
    Methods: This paper summarizes a complete review about an old drug called desomorphine (Krokodil), presenting its chemistry, pharmacology, metabolism, toxicology and analysis.
    Results: It is of particular interest and concern because this cheaper injectable semisynthetic opioid drug has been largely used in recent years for recreational purposes in several Eastern European as well as North and South American countries, despite known damage to health that continuous use might induce. These injuries are much stronger and more aggressive than morphine's, infecting and rotting skin and soft tissue to the bone of addicts at the point of injection in less than three years, which, in most cases, evolves to death. On this basis, it is imperative that literature reviews focus on the chemistry, pharmacology, toxicology and analysis of dangerous Krokodil to find strategies for rapid and effective determination to mitigate its adverse effects on addicts and prevent consumption.
    Conclusions: It is crucial to know the symptoms and consequences of the use of Krokodil, as well as METHODS: for identification and quantification of desomorphine, contaminants and metabolites, which can help the forensic work of diagnosis and propose actions to control and eradicate this great danger to public health around the world.
    MeSH term(s) Analgesics, Opioid/adverse effects ; Analgesics, Opioid/pharmacokinetics ; Analgesics, Opioid/pharmacology ; Analgesics, Opioid/toxicity ; Behavior, Addictive ; Codeine/adverse effects ; Codeine/analogs & derivatives ; Codeine/pharmacokinetics ; Codeine/pharmacology ; Codeine/toxicity ; Humans ; Infection/chemically induced ; Opioid-Related Disorders ; Street Drugs/adverse effects ; Street Drugs/pharmacokinetics ; Street Drugs/pharmacology ; Street Drugs/toxicity
    Chemical Substances Analgesics, Opioid ; Street Drugs ; desomorphine (7OP86J5E33) ; Codeine (Q830PW7520)
    Language English
    Publishing date 2017-01-31
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 519918-9
    ISSN 1879-0046 ; 0376-8716
    ISSN (online) 1879-0046
    ISSN 0376-8716
    DOI 10.1016/j.drugalcdep.2016.12.021
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    Zs.A 1310: Show issues Location:
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