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Article ; Online: Beneficial effects of a program of Mindfulness by remote during COVID-19 lockdown.

Borghi, S / Nisticò, A / Marano, G / Janiri, L / Sani, G / Mazza, M

European review for medical and pharmacological sciences

2022 Volume 26, Issue 15, Page(s) 5562–5567

Abstract: Objective: In the emergency context of COVID-19 pandemic and lockdown, mindfulness relaxation techniques can provide a safe and effective strategy to obtain in a reasonably short time some degree of relief from suffering and to guarantee a greater ... ...

Abstract	Objective: In the emergency context of COVID-19 pandemic and lockdown, mindfulness relaxation techniques can provide a safe and effective strategy to obtain in a reasonably short time some degree of relief from suffering and to guarantee a greater confidence with emotional reactions in the general population. Subjects and methods: The Mindfulness-Based Stress Reduction program for coping with COVID-19 emergency was designed as an 8-week program during the early phase of lockdown consisting in practice meditation exercises at least once a day guided and structured by certified instructors entered on a free online platform. At the end of the program all participants completed a survey. Results: A total of 108 surveys were completed (67.6% male; 32.4% female). Despite the difficult moment of lockdown and the fear linked to the pandemic, 61.9% of interviewed subjects declared a state of general well-being from fair to good linked to the practice of mindfulness. Female subjects (p=0.001), married subjects (p=0.05) and people taking pharmacologic therapy demonstrated (p=0.009) significant improvement in daily management of emotions and practical requests during the early phase of the COVID-19 outbreak. Conclusions: Mindfulness meditation may be effective in helping people to regulate emotions and to support their mental health during this period of worry and uncertainty.
MeSH term(s)	COVID-19 ; Communicable Disease Control ; Female ; Humans ; Male ; Meditation/methods ; Mindfulness/methods ; Pandemics
Language	English
Publishing date	2022-08-22
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202208_29427
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Article ; Online: Effect of a mattress on lumbar spine alignment in supine position in healthy subjects: an MRI study.

Vitale, Jacopo Antonino / Borghi, Stefano / Bassani, Tito / Messina, Carmelo / Sconfienza, Luca Maria / Galbusera, Fabio

European radiology experimental

2023 Volume 7, Issue 1, Page(s) 47

Abstract: Background: Humans should sleep for about a third of their lifetime and the choice of the mattress is very important from a quality-of-life perspective. Therefore, the primary aim of this study was to assess the changes of lumbar angles, evaluated in a ... ...

Abstract	Background: Humans should sleep for about a third of their lifetime and the choice of the mattress is very important from a quality-of-life perspective. Therefore, the primary aim of this study was to assess the changes of lumbar angles, evaluated in a supine position using magnetic resonance imaging (MRI), on a mattress versus a rigid surface. Methods: Twenty healthy subjects (10 females, 10 males), aged 32.3 ± 6.5 (mean ± standard deviation), with body mass index 22.4 ± 2.9, completed three evaluations: (i) spine MRI in supine position on a mattress (MAT); (ii) spine MRI in supine position on rigid surface (CON); and (iii) biplanar radiographic imaging in standing position. The following indexes were calculated for both MAT and CON: lumbar lordosis angles L1-L5, L1-S1, L5-S1, and the sacral slope (SS). Further, pelvic incidence (PI) was calculated from the biplanar radiographic images. Results: Main findings were (i) L1-L5 and SS were greater in MAT than CON (L1:L5: +2.9°; SS: +2.0°); (ii) L5-S1 was lower in MAT than CON (-1.6°); (iii) L1-S1 was greater in MAT than CON only for male subjects (+2.0°); (iv) significant and positive correlations between PI and L1-L5, L1-S1 and SS were observed in both CON and MAT. Conclusions: The use of a mattress determined small but statistically significant changes in lumbar angles. Relevance statement: The use of a mattress determines small but statistically significant changes in radiological angles describing the sagittal alignment of the lumbar spine when lying in the supine position. Key points: • Lordosis angle L1-L5 was greater in MAT than in CON condition (+2.9°). • Sacral slope was greater in MAT than in CON condition (+2.0°). • Lordosis angle L5-S1 was lower in MAT than in CON condition (-1.6°).
MeSH term(s)	Female ; Animals ; Male ; Humans ; Lumbar Vertebrae/diagnostic imaging ; Lordosis ; Healthy Volunteers ; Supine Position ; Magnetic Resonance Imaging
Language	English
Publishing date	2023-09-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2509-9280
ISSN (online)	2509-9280
DOI	10.1186/s41747-023-00361-w
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Article ; Online: To Sleep Dreaming Medals: Sleep Characteristics, Napping Behavior, and Sleep-Hygiene Strategies in Elite Track-and-Field Athletes Facing the Olympic Games of Tokyo 2021.

Vitale, Jacopo A / Borghi, Stefano / Piacentini, Maria Francesca / Banfi, Giuseppe / La Torre, Antonio

International journal of sports physiology and performance

2023 Volume 18, Issue 12, Page(s) 1412–1419

Abstract: Purpose: Few data are available on sleep characteristics of elite track-and-field athletes. Our study aimed to assess (1) differences in sleep between sexes and among different track-and-field disciplines, (2) the effect of individualized sleep-hygiene ... ...

Abstract	Purpose: Few data are available on sleep characteristics of elite track-and-field athletes. Our study aimed to assess (1) differences in sleep between sexes and among different track-and-field disciplines, (2) the effect of individualized sleep-hygiene strategies on athletes' sleep parameters, and (3) daytime nap characteristics in track-and-field athletes. Methods: Sleep characteristics of 16 elite Olympic-level track-and-field athletes (male: n = 8; female: n = 8) were assessed during the preseason period, at baseline (T0), and during the in-season period, after the adoption of individualized sleep-hygiene strategies (T1). Sleep parameters were objectively monitored by actigraphy for a minimum of 10 days, for each athlete, at both T0 and T1. A total of 702 nights were analyzed (T0 = 425; T1 = 277). Results: Female athletes displayed better sleep efficiency (88.69 [87.69-89.68] vs 91.72 [90.99-92.45]; P = .003, effect size [ES]: 0.44), lower sleep latency (18.99 [15.97-22.00] vs 6.99 [5.65-8.32]; P < .001, ES: 0.65), higher total sleep time (07:03 [06:56-07:11] vs 07:18 [07:10-07:26]; P = .030, ES: 0.26), earlier bedtime (00:24 [00:16-00:32] vs 00:13 [00:04-00:22]; P = .027, ES: 0.18), and lower nap frequency (P < .001) than male athletes. Long-distance runners had earlier bedtime (00:10 [00:03-00:38] vs 00:36 [00:26-00:46]; P < .001, ES: 0.41) and wake-up time (07:41 [07:36-07:46] vs 08:18 [08:07-08:30]; P < .001, ES: 0.61), higher nap frequency, but lower sleep efficiency (88.79 [87.80-89.77] vs 91.67 [90.95-92.38]; P = .013, ES: 0.44), and longer sleep latency (18.89 [15.94-21.84] vs 6.69 [5.33-8.06]; P < .001, ES: 0.67) than athletes of short-term disciplines. Furthermore, sleep-hygiene strategies had a positive impact on athletes' total sleep time (429.2 [423.5-434.8] vs 451.4 [444.2-458.6]; P < .001, ES: 0.37) and sleep latency (14.33 [12.34-16.32] vs 10.67 [8.66-12.68]; P = .017, ES: 0.19). Conclusions: Sleep quality and quantity were suboptimal at baseline in Olympic-level track-and-field athletes. Large differences were observed in sleep characteristics between sexes and among different track-and-field disciplines. Given the positive effect of individualized sleep-hygiene strategies on athlete's sleep, coaches should implement sleep education sessions in the daily routine of top-level athletes.
MeSH term(s)	Humans ; Male ; Female ; Tokyo ; Sleep ; Athletes ; Track and Field ; Hygiene ; Awards and Prizes
Language	English
Publishing date	2023-09-20
Publishing country	United States
Document type	Journal Article
ISSN	1555-0273
ISSN (online)	1555-0273
DOI	10.1123/ijspp.2023-0144
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Article ; Online: Abundance and distribution of marine litter on the beaches of Okinawa Island, Japan.

Ilechukwu, Ifenna / Das, Rocktim Ramen / Jamodiong, Emmeline A / Borghi, Stefano / Manzano, Geminne G / Hakim, Agus Alim / Reimer, James Davis

Marine pollution bulletin

2024 Volume 200, Page(s) 116036

Abstract: This study evaluated the distribution and abundance of marine litter on 30 beaches around Okinawa Island, Japan. Beach quality indices and multivariate statistical analyses were used to assess the quality of the beaches and their pollution patterns. A ... ...

Abstract	This study evaluated the distribution and abundance of marine litter on 30 beaches around Okinawa Island, Japan. Beach quality indices and multivariate statistical analyses were used to assess the quality of the beaches and their pollution patterns. A total of 11,626 items weighing 513.49 kg with an average density of 0.13 ± 0.10 items/m
MeSH term(s)	Environmental Monitoring ; Japan ; Waste Products/analysis ; Bathing Beaches ; Plastics/analysis
Chemical Substances	Waste Products ; Plastics
Language	English
Publishing date	2024-01-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2001296-2
ISSN	1879-3363 ; 0025-326X
ISSN (online)	1879-3363
ISSN	0025-326X
DOI	10.1016/j.marpolbul.2024.116036
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Article ; Online: Interrelationship among thigh intermuscular adipose tissue, cross-sectional area, muscle strength, and functional mobility in older subjects.

Borghi, Stefano / Bonato, Matteo / La Torre, Antonio / Banfi, Giuseppe / Vitale, Jacopo Antonino

Medicine

2022 Volume 101, Issue 26, Page(s) e29744

Abstract: The aim of this cross-sectional study was to investigate the association between lower limb strength, muscle mass and composition, and balance ability in elders. Thirthy-four older participants (Age: 65.6 ± 4.73 years; male = 10 and female = 24) were ... ...

Abstract	The aim of this cross-sectional study was to investigate the association between lower limb strength, muscle mass and composition, and balance ability in elders. Thirthy-four older participants (Age: 65.6 ± 4.73 years; male = 10 and female = 24) were assessed for muscle strength (maximal isometric strength of knee extensors and one repetition maximum by leg press, the one repetition maximum [1RM]), balance and gait capacity (Mini-BESTest), body composition by whole-body dual energy x-ray absorptiometry (obtaining Appendicular Skeletal Muscle Mass Index, ASMMI), and magnetic resonance imaging of thigh to evaluate Intermuscular Adipose Tissue (IMAT) and muscle Cross Sectional Area (CSA). Positive correlations between 1RM and ASMMI (rs = 0.64, P < .0001) and thigh CSA (rs = 0.52, P = .0017), but not with thigh IMAT, were found. In addition, significant correlations between knee extensors strength and ASMMI (rs = 0.48, P = .004) and thigh CSA (rs = 0.49, P = .0033) and IMAT (rs = -0.35, P = .043) were observed, whereas no significant correlations between the Mini-BESTest with ASMMI, thigh CSA, and IMAT were observed. Lower limb strength positively correlated with appendicular muscle mass. Further, the maximal isometric strength of knee extensors negatively correlated with thigh IMAT in elderly patients, whereas the dynamic balance ability did not correlate with any of the morphological variables of the muscle (i.e., ASMMI, CSA, and IMAT). A reduced muscle size and strength could affect movement and reduce physical function in older patients. Improving the composition and size of muscle in elder subjects could reduce frailty and risk of falls.
MeSH term(s)	Adipose Tissue/diagnostic imaging ; Aged ; Body Composition ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Muscle Strength/physiology ; Thigh
Language	English
Publishing date	2022-07-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000029744
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Article: Oxidative Stress and Redox-Dependent Pathways in Cholangiocarcinoma.

Caligiuri, Alessandra / Becatti, Matteo / Porro, Nunzia / Borghi, Serena / Marra, Fabio / Pastore, Mirella / Taddei, Niccolò / Fiorillo, Claudia / Gentilini, Alessandra

Antioxidants (Basel, Switzerland)

2023 Volume 13, Issue 1

Abstract: Cholangiocarcinoma (CCA) is a primary liver tumor that accounts for 2% of all cancer-related deaths worldwide yearly. It can arise from cholangiocytes of biliary tracts, peribiliary glands, and possibly from progenitor cells or even hepatocytes. CCA is ... ...

Abstract	Cholangiocarcinoma (CCA) is a primary liver tumor that accounts for 2% of all cancer-related deaths worldwide yearly. It can arise from cholangiocytes of biliary tracts, peribiliary glands, and possibly from progenitor cells or even hepatocytes. CCA is characterized by high chemoresistance, aggressiveness, and poor prognosis. Potentially curative surgical therapy is restricted to a small number of patients with early-stage disease (up to 35%). Accumulating evidence indicates that CCA is an oxidative stress-driven carcinoma resulting from chronic inflammation. Oxidative stress, due to enhanced reactive oxygen species (ROS) production and/or decreased antioxidants, has been recently suggested as a key factor in cholangiocyte oncogenesis through gene expression alterations and molecular damage. However, due to different experimental models and conditions, contradictory results regarding oxidative stress in cholangiocarcinoma have been reported. The role of ROS and antioxidants in cancer is controversial due to their context-dependent ability to stimulate tumorigenesis and support cancer cell proliferation or promote cell death. On these bases, the present narrative review is focused on illustrating the role of oxidative stress in cholangiocarcinoma and the main ROS-driven intracellular pathways. Heterogeneous data about antioxidant effects on cancer development are also discussed.
Language	English
Publishing date	2023-12-22
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox13010028
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Article: SIRT1 and thrombosis.

Bettiol, Alessandra / Urban, Maria Letizia / Emmi, Giacomo / Galora, Silvia / Argento, Flavia Rita / Fini, Eleonora / Borghi, Serena / Bagni, Giacomo / Mattioli, Irene / Prisco, Domenico / Fiorillo, Claudia / Becatti, Matteo

Frontiers in molecular biosciences

2024 Volume 10, Page(s) 1325002

Abstract: Thrombosis is a major cause of morbidity and mortality worldwide, with a complex and multifactorial pathogenesis. Recent studies have shown that SIRT1, a member of the sirtuin family of NAD + -dependent deacetylases, plays a crucial role in regulating ... ...

Abstract	Thrombosis is a major cause of morbidity and mortality worldwide, with a complex and multifactorial pathogenesis. Recent studies have shown that SIRT1, a member of the sirtuin family of NAD + -dependent deacetylases, plays a crucial role in regulating thrombosis, modulating key pathways including endothelial activation, platelet aggregation, and coagulation. Furthermore, SIRT1 displays anti-inflammatory activity both
Language	English
Publishing date	2024-01-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2814330-9
ISSN	2296-889X
ISSN	2296-889X
DOI	10.3389/fmolb.2023.1325002
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Article ; Online: Effects of mental fatigue on soccer-specific performance in young players.

Filipas, Luca / Borghi, Stefano / La Torre, Antonio / Smith, Mitchell R

Science & medicine in football

2020 Volume 5, Issue 2, Page(s) 150–157

Abstract: Objective: To investigate the effects of mental fatigue on soccer-specific physical and technical performance in young players.: Methods: Twelve under-14 (U14), twelve under-16 (U16) and twelve under-18 (U18) soccer players completed the two parts of ...

Abstract	Objective: To investigate the effects of mental fatigue on soccer-specific physical and technical performance in young players. Methods: Twelve under-14 (U14), twelve under-16 (U16) and twelve under-18 (U18) soccer players completed the two parts of the investigation. Part one assessed the soccer-specific physical performance using the Yo-Yo Intermittent Recovery Test, Level 1 (Yo-Yo IR1). Part two assessed the soccer-specific technical performance using the Loughborough Soccer Passing and Shooting Tests (LSPT, LSST). Each part was preceded by 30 min of Stroop task or 15 min of control task performed in a randomised and counterbalanced order. Results: Subjective ratings of mental fatigue were higher after the Stroop task compared to the control in U14, U16 and U18 in both parts. Mental fatigue significantly reduced Yo-Yo IR1 distance, alongside an increase in heart rate and ratings of perceived exertion, and this effect was moderated by age as older players showed greater declines in performance. Soccer-specific technical performance was negatively affected by mental fatigue condition only in U18 in the LSPT..
MeSH term(s)	Athletic Performance/physiology ; Heart Rate/physiology ; Humans ; Mental Fatigue ; Physical Endurance/physiology ; Soccer/physiology
Language	English
Publishing date	2020-09-16
Publishing country	England
Document type	Journal Article
ISSN	2473-4446
ISSN (online)	2473-4446
DOI	10.1080/24733938.2020.1823012
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Article ; Online: Rest-activity daily rhythm and physical activity levels after hip and knee joint replacement: the role of actigraphy in orthopedic clinical practice.

Vitale, Jacopo Antonino / Banfi, Giuseppe / Tivolesi, Valentina / Pelosi, Catia / Borghi, Stefano / Negrini, Francesco

Chronobiology international

2021 Volume 38, Issue 12, Page(s) 1692–1701

Abstract: Elective hip and knee joint replacement for osteoarthritis are cost-effective surgical procedures requiring specific rehabilitation programs. Actigraphy is widely used in both research and clinical practice to study activity patterns with great accuracy ... ...

Abstract	Elective hip and knee joint replacement for osteoarthritis are cost-effective surgical procedures requiring specific rehabilitation programs. Actigraphy is widely used in both research and clinical practice to study activity patterns with great accuracy and validity but it has never been utilized in orthopedic patients. Therefore, the aim of this study was to objectively assess, through actigraphy, physical activity (PA) levels and rest-activity daily rhythm (RAR) in patients undergoing hip or knee joint replacement and hospitalized for ten days after surgery. Twenty subjects (11 males and 9 females; age: 62.68 ± 10.39 years old; BMI: 29.03 ± 3.92 kg/m
MeSH term(s)	Actigraphy ; Aged ; Arthroplasty, Replacement ; Circadian Rhythm ; Exercise ; Female ; Humans ; Male ; Middle Aged ; Sleep
Language	English
Publishing date	2021-06-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	998996-1
ISSN	1525-6073 ; 0742-0528
ISSN (online)	1525-6073
ISSN	0742-0528
DOI	10.1080/07420528.2021.1939365
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Article: Multilayer Regulation of

Borghi, Sara / Antunes, Ana / Haag, Andreas F / Spinsanti, Marco / Brignoli, Tarcisio / Ndoni, Enea / Scarlato, Vincenzo / Delany, Isabel

Microorganisms

2022 Volume 10, Issue 4

Abstract: Neisseria meningitidis colonizes the nasopharynx of humans, and pathogenic strains can disseminate into the bloodstream, causing septicemia and meningitis. NHBA is a surface-exposed lipoprotein expressed by all N. meningitidis strains in different ... ...

Abstract	Neisseria meningitidis colonizes the nasopharynx of humans, and pathogenic strains can disseminate into the bloodstream, causing septicemia and meningitis. NHBA is a surface-exposed lipoprotein expressed by all N. meningitidis strains in different isoforms. Diverse roles have been reported for NHBA in heparin-mediated serum resistance, biofilm formation, and adherence to host tissues. We determined that temperature controls the expression of NHBA in all strains tested, with increased levels at 30−32 °C compared to 37 °C. Higher NHBA expression at lower temperatures was measurable both at mRNA and protein levels, resulting in higher surface exposure. Detailed molecular analysis indicated that multiple molecular mechanisms are responsible for the thermoregulated NHBA expression. The comparison of mRNA steady-state levels and half-lives at 30 °C and 37 °C demonstrated an increased mRNA stability/translatability at lower temperatures. Protein stability was also impacted, resulting in higher NHBA stability at lower temperatures. Ultimately, increased NHBA expression resulted in higher susceptibility to complement-mediated killing. We propose that NHBA regulation in response to temperature downshift might be physiologically relevant during transmission and the initial step(s) of interaction within the host nasopharynx. Together these data describe the importance of NHBA both as a virulence factor and as a vaccine antigen during neisserial colonization and invasion.
Language	English
Publishing date	2022-04-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms10040834
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