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  1. Book ; Thesis: Identifikation und Analyse polymorpher Bereiche auf Chromosom 19p 13.3 und ihre möglichen Assoziationen mit der Wegenerschen Granulomatose

    Borgmann, Stefan

    2000  

    Author's details vorgelegt von Stefan Borgmann
    Language German
    Size 61, X S., Ill., graph. Darst., 21 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis München, Univ., Diss., 2000
    HBZ-ID HT012891405
    Database Catalogue ZB MED Medicine, Health

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    2001 D 120 order for loan Magazin

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  2. Book ; Thesis: Elektronenstrahlmikroanalyse intrazellulärer Elemente in kultivierten Epithelien

    Borgmann, Stefan

    1996  

    Author's details vorgelegt von Stefan Borgmann
    Language German
    Size 124 S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis München, Univ., Diss., 1996
    HBZ-ID HT007368551
    Database Catalogue ZB MED Medicine, Health

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  3. Article: A Comparison of Germany and the United Kingdom Indicates That More SARS-CoV-2 Circulation and Less Restrictions in the Warm Season Might Reduce Overall COVID-19 Burden.

    Meintrup, David / Nowak-Machen, Martina / Borgmann, Stefan

    Life (Basel, Switzerland)

    2022  Volume 12, Issue 7

    Abstract: 1) Background: Between March 2020 and January 2022 severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) caused five infection waves in Europe. The first and the second wave was caused by wildtype SARS-CoV-2, while the following waves were ... ...

    Abstract (1) Background: Between March 2020 and January 2022 severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) caused five infection waves in Europe. The first and the second wave was caused by wildtype SARS-CoV-2, while the following waves were caused by the variants of concern Alpha, Delta, and Omicron respectively. (2) Methods: In the present analysis, the first four waves were compared in Germany and the UK, in order to examine the COVID-19 epidemiology and its modulation by non-pharmaceutical interventions (NPI). (3) Results: The number of COVID-19 patients on intensive care units and the case fatality rate were used to estimate disease burden, the excess mortality to assess the net effect of NPI and other measures on the population. The UK was more severely affected by the first and the third wave while Germany was more affected by the second wave. The UK had a higher excess mortality during the first wave, afterwards the excess mortality in both countries was nearly identical. While most NPI were lifted in the UK in July 2021, the measures were kept and even aggravated in Germany. Nevertheless, in autumn 2021 Germany was much more affected, nearly resulting in a balanced sum of infections and deaths compared to the UK. Within the whole observation period, in Germany the number of COVID-19 patients on ICUs was up to four times higher than in the UK. Our results show that NPI have a limited effect on COVID-19 burden, seasonality plays a crucial role, and a higher virus circulation in a pre-wave situation could be beneficial. (4) Conclusions: Although Germany put much more effort and resources to fight the pandemic, the net balance of both countries was nearly identical, questioning the benefit of excessive ICU treatments and of the implementation of NPI, especially during the warm season.
    Language English
    Publishing date 2022-06-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life12070953
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Epidemiological and Clinical Features of

    Itzek, Andreas / Weißbach, Victoria / Meintrup, David / Rieß, Beate / van der Linden, Mark / Borgmann, Stefan

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 4

    Abstract: 1) Background: ...

    Abstract (1) Background:
    Language English
    Publishing date 2023-04-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12040589
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  5. Article ; Online: Nine Months of COVID-19 Pandemic in Europe: A Comparative Time Series Analysis of Cases and Fatalities in 35 Countries.

    Meintrup, David / Nowak-Machen, Martina / Borgmann, Stefan

    International journal of environmental research and public health

    2021  Volume 18, Issue 12

    Abstract: 1) Background: to describe the dynamic of the pandemic across 35 European countries over a period of 9 months. (2) Methods: a three-phase time series model was fitted for 35 European countries, predicting deaths based on SARS-CoV-2 incidences. ... ...

    Abstract (1) Background: to describe the dynamic of the pandemic across 35 European countries over a period of 9 months. (2) Methods: a three-phase time series model was fitted for 35 European countries, predicting deaths based on SARS-CoV-2 incidences. Hierarchical clustering resulted in three clusters of countries. A multiple regression model was developed predicting thresholds for COVID-19 incidences, coupled to death numbers. (3) Results: The model showed strongly connected deaths and incidences during the waves in spring and fall. The corrected case-fatality rates ranged from 2% to 20.7% in the first wave, and from 0.5% to 4.2% in the second wave. If the incidences stay below a threshold, predicted by the regression model (R2=85.0%), COVID-19 related deaths and incidences were not necessarily coupled. The clusters represented different regions in Europe, and the corrected case-fatality rates in each cluster flipped from high to low or vice versa. Severely and less severely affected countries flipped between the first and second wave. (4) Conclusions: COVID-19 incidences and related deaths were uncoupled during the summer but coupled during two waves. Once a country-specific threshold of infections is reached, death numbers will start to rise, allowing health care systems and countries to prepare.
    MeSH term(s) COVID-19 ; Europe/epidemiology ; Humans ; Incidence ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2021-06-21
    Publishing country Switzerland
    Document type Journal Article
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph18126680
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  6. Article ; Online: Editorial: New frontiers in immunology and infectious diseases.

    Borgmann, Stefan

    Current pharmaceutical biotechnology

    2012  Volume 13, Issue 8, Page(s) 1377

    MeSH term(s) Biological Products/therapeutic use ; Communicable Diseases/immunology ; Humans ; Immune System Phenomena ; Neoplasms/therapy
    Chemical Substances Biological Products
    Language English
    Publishing date 2012-02-14
    Publishing country Netherlands
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2132197-8
    ISSN 1873-4316 ; 1389-2010
    ISSN (online) 1873-4316
    ISSN 1389-2010
    DOI 10.2174/138920112800784934
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: Mumps in the Vaccination Age: Global Epidemiology and the Situation in Germany.

    Beleni, Andrea-Ioana / Borgmann, Stefan

    International journal of environmental research and public health

    2018  Volume 15, Issue 8

    Abstract: Vaccination against mumps virus (MuV) (mostly measles-mumps-rubella) is routinely performed in more than 120 countries and has resulted in a distinct decrease of mumps incidence. However, alteration of mumps epidemiology has been observed in several ... ...

    Abstract Vaccination against mumps virus (MuV) (mostly measles-mumps-rubella) is routinely performed in more than 120 countries and has resulted in a distinct decrease of mumps incidence. However, alteration of mumps epidemiology has been observed in several countries after implementation of the vaccine but is sparsely documented. Moreover, outbreaks have occurred after starting vaccination, even in highly vaccinated populations. In the former German Democratic Republic (DDR) mumps was a notifiable disease but vaccination against mumps was not implemented. In the five eastern German states forming the DDR until 1990, mumps was not notifiable until 2001. Except for the lack of reporting between 1990⁻2000, data from Eastern Germany allow analysis of mumps epidemiology after initiating the vaccination campaign. For the period from 2001 to 2016 the data show that the incidence of mumps dropped notably after initiating vaccines, and was accompanied by an increase of the median age of patients with mumps. In Eastern Germany, no outbreaks were noted, while several outbreaks occurred in Western Germany, possibly due to a lower vaccination rate. Further literature analysis revealed that outbreaks were facilitated by waning immunity and crowding. Nevertheless, although vaccination prevented infection, the course of illness, once infected, was sometimes more complicated. In comparison to non-vaccinated populations, high rates of complicated courses occurred and were marked by orchitis, due to higher age of mumps patients. Therefore, refusing vaccination against mumps increases the risk of severe courses when living in a vaccinated population.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Disease Outbreaks/prevention & control ; Female ; Germany/epidemiology ; Humans ; Immunization Programs/organization & administration ; Incidence ; Infant ; Male ; Measles/epidemiology ; Measles/prevention & control ; Measles-Mumps-Rubella Vaccine/therapeutic use ; Middle Aged ; Mumps/epidemiology ; Mumps/prevention & control ; Vaccination/statistics & numerical data ; Young Adult
    Chemical Substances Measles-Mumps-Rubella Vaccine
    Language English
    Publishing date 2018-07-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph15081618
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Long-Lasting Decrease of the Acquisition of

    Borgmann, Stefan / Rieß, Beate / Meintrup, David / Klare, Ingo / Werner, Guido

    International journal of environmental research and public health

    2020  Volume 17, Issue 17

    Abstract: Previously it was shown that application of probiotics stopped the acquisition of vancomycin- ... ...

    Abstract Previously it was shown that application of probiotics stopped the acquisition of vancomycin-resistant
    MeSH term(s) Anti-Bacterial Agents ; Enterococcus faecium/drug effects ; Enterococcus faecium/isolation & purification ; Gram-Negative Bacteria/drug effects ; Gram-Negative Bacteria/isolation & purification ; Gram-Positive Bacterial Infections/prevention & control ; Humans ; Probiotics/pharmacology ; Vancomycin ; beta-Lactamases
    Chemical Substances Anti-Bacterial Agents ; Vancomycin (6Q205EH1VU) ; beta-Lactamases (EC 3.5.2.6)
    Language English
    Publishing date 2020-08-21
    Publishing country Switzerland
    Document type Journal Article
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph17176100
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Incidence and Death Rates from COVID-19 Are Not Always Coupled: An Analysis of Temporal Data on Local, Federal, and National Levels.

    Borgmann, Stefan / Meintrup, David / Reimer, Kerstin / Schels, Helmut / Nowak-Machen, Martina

    Healthcare (Basel, Switzerland)

    2021  Volume 9, Issue 3

    Abstract: SARS-CoV-2 has caused a deadly pandemic worldwide, placing a burden on local health care systems and economies. Infection rates with SARS-CoV-2 and the related mortality of COVID-19 are not equal among countries or even neighboring regions. Based on data ...

    Abstract SARS-CoV-2 has caused a deadly pandemic worldwide, placing a burden on local health care systems and economies. Infection rates with SARS-CoV-2 and the related mortality of COVID-19 are not equal among countries or even neighboring regions. Based on data from official German health authorities since the beginning of the pandemic, we developed a case-fatality prediction model that correctly predicts COVID-19-related death rates based on local geographical developments of infection rates in Germany, Bavaria, and a local community district city within Upper Bavaria. Our data point towards the proposal that local individual infection thresholds, when reached, could lead to increasing mortality. Restrictive measures to minimize the spread of the virus could be applied locally based on the risk of reaching the individual threshold. Being able to predict the necessity for increasing hospitalization of COVID-19 patients could help local health care authorities to prepare for increasing patient numbers.
    Language English
    Publishing date 2021-03-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare9030338
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  10. Article: Treatment with

    Borgmann, Stefan / Rieß, Beate / Siegmund, Rabea / Werner, Guido / Klare, Ingo

    Therapeutics and clinical risk management

    2019  Volume 15, Page(s) 343–354

    Abstract: Purpose: According to the WHO vancomycin-resistant : Patients and methods: Rectal screening swabs were taken at admission and once per week on the early rehabilitation ward of Ingolstadt Hospital (ERWIN) but not at other wards. The number of VRE ... ...

    Abstract Purpose: According to the WHO vancomycin-resistant
    Patients and methods: Rectal screening swabs were taken at admission and once per week on the early rehabilitation ward of Ingolstadt Hospital (ERWIN) but not at other wards. The number of VRE colonized patients was evaluated by using appropriate computer software (LabCentre, Hybase). The Hybase program was also used to find out the number of
    Results: Between 2013 and 2015 the number of VRE increased from 30 to 78 per year whereas in 2016 and 2017 the number declined to 51. Systematic analysis of the laboratory data revealed that this increase was driven by oligoclonal transmission of
    Conclusion: Application of
    Language English
    Publishing date 2019-02-27
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2186560-7
    ISSN 1178-203X ; 1176-6336
    ISSN (online) 1178-203X
    ISSN 1176-6336
    DOI 10.2147/TCRM.S179208
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6067: Show issues Location:
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