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  1. Book ; Audio / Video ; Thesis: Einflüsse von Cadmium (Cd_1hn2_1hn+) auf zelluläre Kontakte, mitochondriale Funktion und Zellzyklusregulation in kultivierten Nierenzellen des proximalen Tubulus

    Bork, Ulrich

    Bedeutung für "Zelltod und -überleben"

    2011  

    Author's details vorgelegt von: Ulrich Bork
    Language German
    Size 1 CD-ROM, 12 cm
    Publishing country Germany
    Document type Book ; Audio / Video ; Thesis
    Thesis / German Habilitation thesis Witten, Herdecke, Univ., Diss., 2011
    HBZ-ID HT017084358
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2012 MO 9 order for loan Magazin

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  2. Book ; Thesis: Evaluation und Validierung prädikativer Marker für Pankreasfisteln infolge von Pankreasteilresektionen

    Kühne, Theo / Bork, Ulrich / Schimmack, Simon

    2021  

    Institution Klinik und Poliklinik für Viszeral-, Thorax- und Gefäßchirurgie
    Author's details von Theo Kühne aus Dresden ; Klinik und Poliklinik für Viszeral-, Thorax- und Gefäßchirurgie [Dresden]
    Language German
    Size 100 Blätter, Illustrationen, Diagramme
    Publishing place Dresden
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Technische Universität Dresden, Medizinische Fakultät, 2021
    HBZ-ID HT021268846
    Database Catalogue ZB MED Medicine, Health

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    2022 E 299 order for loan Magazin

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  3. Book ; Thesis: Einfluss der patienteneigenen Dauermedikation sowie klinischer und demografischer Merkmale auf das perioperative Outcome nach Leberresektion

    Bruß, Elene Mariella / Bork, Ulrich / Hüttner, Felix

    2021  

    Institution Klinik und Poliklinik für Viszeral-, Thorax- und Gefäßchirurgie
    Author's details von Elene Mariella Bruß aus Ulm ; Klinik und Poliklinik für Viszeral-, Thorax- und Gefäßchirurgie [Dresden]
    Language German
    Size 116 Blätter, Illustrationen, Diagramme
    Publishing place Dresden
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Technische Universität Dresden, Medizinische Fakultät, 2021
    HBZ-ID HT021268838
    Database Catalogue ZB MED Medicine, Health

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  4. Article ; Online: The Interactions of the 70 kDa Fragment of Cell Adhesion Molecule L1 with Topoisomerase 1, Peroxisome Proliferator-Activated Receptor γ and NADH Dehydrogenase (Ubiquinone) Flavoprotein 2 Are Involved in Gene Expression and Neuronal L1-Dependent Functions.

    Loers, Gabriele / Kleene, Ralf / Bork, Ute / Schachner, Melitta

    International journal of molecular sciences

    2023  Volume 24, Issue 3

    Abstract: The cell adhesion molecule L1 is essential not only for neural development, but also for synaptic functions and regeneration after trauma in adulthood. Abnormalities in L1 functions cause developmental and degenerative disorders. L1's functions ... ...

    Abstract The cell adhesion molecule L1 is essential not only for neural development, but also for synaptic functions and regeneration after trauma in adulthood. Abnormalities in L1 functions cause developmental and degenerative disorders. L1's functions critically depend on proteolysis which underlies dynamic cell interactions and signal transduction. We showed that a 70 kDa fragment (L1-70) supports mitochondrial functions and gene transcription. To gain further insights into L1-70's functions, we investigated several binding partners. Here we show that L1-70 interacts with topoisomerase 1 (TOP1), peroxisome proliferator-activated receptor γ (PPARγ) and NADH dehydrogenase (ubiquinone) flavoprotein 2 (NDUFV2). TOP1, PPARγ and NDUFV2 siRNAs reduced L1-dependent neurite outgrowth, and the topoisomerase inhibitors topotecan and irinotecan inhibited L1-dependent neurite outgrowth, neuronal survival and migration. In cultured neurons, L1 siRNA reduces the expression levels of the long autism genes neurexin-1 (Nrxn1) and neuroligin-1 (Nlgn1) and of the mitochondrially encoded gene NADH:ubiquinone oxidoreductase core subunit 2 (ND2). In mutant mice lacking L1-70, Nrxn1 and Nlgn1, but not ND2, mRNA levels are reduced. Since L1-70's interactions with TOP1, PPARγ and NDUFV2 contribute to the expression of two essential long autism genes and regulate important neuronal functions, we propose that L1 may not only ameliorate neurological problems, but also psychiatric dysfunctions.
    MeSH term(s) Animals ; Mice ; Electron Transport Complex I/metabolism ; Flavoproteins/metabolism ; Gene Expression ; NADH Dehydrogenase/genetics ; NADH Dehydrogenase/metabolism ; Neural Cell Adhesion Molecule L1/metabolism ; Neurites/metabolism ; Neurons/metabolism ; PPAR gamma/genetics ; PPAR gamma/metabolism ; Ubiquinone/metabolism ; DNA Topoisomerases, Type I/metabolism
    Chemical Substances Electron Transport Complex I (EC 7.1.1.2) ; Flavoproteins ; NADH Dehydrogenase (EC 1.6.99.3) ; Neural Cell Adhesion Molecule L1 ; PPAR gamma ; Ubiquinone (1339-63-5) ; DNA Topoisomerases, Type I (EC 5.99.1.2)
    Language English
    Publishing date 2023-01-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24032097
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Interaction of L1CAM with LC3 Is Required for L1-Dependent Neurite Outgrowth and Neuronal Survival.

    Loers, Gabriele / Kleene, Ralf / Granato, Viviana / Bork, Ute / Schachner, Melitta

    International journal of molecular sciences

    2023  Volume 24, Issue 15

    Abstract: The neural cell adhesion molecule L1 (also called L1CAM or CD171) functions not only in cell migration, but also in cell survival, differentiation, myelination, neurite outgrowth, and signaling during nervous system development and in adults. The ... ...

    Abstract The neural cell adhesion molecule L1 (also called L1CAM or CD171) functions not only in cell migration, but also in cell survival, differentiation, myelination, neurite outgrowth, and signaling during nervous system development and in adults. The proteolytic cleavage of L1 in its extracellular domain generates soluble fragments which are shed into the extracellular space and transmembrane fragments that are internalized into the cell and transported to various organelles to regulate cellular functions. To identify novel intracellular interaction partners of L1, we searched for protein-protein interaction motifs and found two potential microtubule-associated protein 1 light-chain 3 (LC3)-interacting region (LIR) motifs within L1, one in its extracellular domain and one in its intracellular domain. By ELISA, immunoprecipitation, and proximity ligation assay using L1 mutant mice lacking the 70 kDa L1 fragment (L1-70), we showed that L1-70 interacts with LC3 via the extracellular LIR motif in the fourth fibronectin type III domain, but not by the motif in the intracellular domain. The disruption of the L1-LC3 interaction reduces L1-mediated neurite outgrowth and neuronal survival.
    Language English
    Publishing date 2023-08-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241512531
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Interdisciplinary Collaborations in Digital Health Research: Mixed Methods Case Study.

    Krause-Jüttler, Grit / Weitz, Jürgen / Bork, Ulrich

    JMIR human factors

    2022  Volume 9, Issue 2, Page(s) e36579

    Abstract: Background: Digital innovations in medicine are disruptive technologies that can change the way diagnostic procedures and treatments are delivered. Such innovations are typically designed in teams with different disciplinary backgrounds. This paper ... ...

    Abstract Background: Digital innovations in medicine are disruptive technologies that can change the way diagnostic procedures and treatments are delivered. Such innovations are typically designed in teams with different disciplinary backgrounds. This paper concentrates on 2 interdisciplinary research teams with 20 members from the medicine and engineering sciences working jointly on digital health solutions.
    Objective: The aim of this paper was to identify factors on the individual, team, and organizational levels that influence the implementation of interdisciplinary research projects elaborating on digital applications for medicine and, based on the results, to draw conclusions for the proactive design of the interdisciplinary research process to make these projects successful.
    Methods: To achieve this aim, 2 interdisciplinary research teams were observed, and a small case study (response rate: 15/20, 75%) was conducted using a web-based questionnaire containing both closed and open self-report questions. The Spearman rank correlation coefficient was calculated to analyze the quantitative data. The answers to the open-ended questions were subjected to qualitative content analysis.
    Results: With regard to the interdisciplinary research projects investigated, the influencing factors of the three levels presented (individual, team, and organization) have proven to be relevant for interdisciplinary research cooperation.
    Conclusions: With regard to recommendations for the future design of interdisciplinary cooperation, management aspects are addressed, that is, the installation of a coordinator, systematic definition of goals, required resources, and necessary efforts on the part of the involved interdisciplinary research partners. As only small groups were investigated, further research in this field is necessary to derive more general recommendations for interdisciplinary research teams.
    Trial registration: German Clinical Trials Register, DRKS00023909, https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00023909 ; German Clinical Trials Register, DRKS00025077, https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00025077.
    Language English
    Publishing date 2022-05-04
    Publishing country Canada
    Document type Journal Article
    ISSN 2292-9495
    ISSN (online) 2292-9495
    DOI 10.2196/36579
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Impact of the COVID-19 Pandemic on Student and Resident Teaching and Training in Surgical Oncology

    Hau, H. M. / Weitz, J. / Bork, U.

    J Clin Med

    Abstract: The COVID-19 pandemic has tremendously changed private and professional interactions and behaviors worldwide The effects of this pandemic and the actions taken have changed our healthcare systems, which consequently has affected medical education and ... ...

    Abstract The COVID-19 pandemic has tremendously changed private and professional interactions and behaviors worldwide The effects of this pandemic and the actions taken have changed our healthcare systems, which consequently has affected medical education and surgical training In the face of constant disruptions of surgical education and training during this pandemic outbreak, structured and innovative concepts and adapted educational curricula are important to ensure a high quality of medical treatment While efforts were undertaken to prevent viral spreading, it is important to analyze and assess the effects of this crisis on medical education, surgical training and teaching at large and certainly in the field of surgical oncology Against this background, in this paper we introduce practical and creative recommendations for the continuity of students' and residents' medical and surgical training and teaching This includes virtual educational curricula, skills development classes, video-based feedback and simulation in the specialty field of surgical oncology In conclusion, the effects of COVID 19 on Surgical Training and Teaching, certainly in the field of Surgical Oncology, are challenging
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #895376
    Database COVID19

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  8. Article: Kompetenzvermittlung in der Chirurgischen Onkologie

    Bork, U. / Hau, H. M. / Weitz, J.

    Krebs im Focus

    2020  Volume 11, Issue Juli, Page(s) 12

    Language German
    Document type Article
    ZDB-ID 2761631-9
    Database Current Contents Medicine

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    Zs.A 7047: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Conference proceedings: Oncological outcome and quality of life after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC)

    Oehme, F / Weiß, J / Bork, U / Schweipert, J / Weitz, J / Riediger, C

    Zeitschrift für Gastroenterologie

    2022  Volume 60, Issue 08

    Event/congress Viszeralmedizin 2022 76. Jahrestagung der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten mit Sektion Endoskopie 13. Herbsttagung der Deutschen Gesellschaft für Allgemein- und Viszeralchirurgie gemeinsam mit den Arbeitsgemeinschaften der DGAV, Erst online. Dann Hamburg., 2022-09-12
    Language German
    Publishing date 2022-08-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 201387-3
    ISSN 1439-7803 ; 0044-2771 ; 0172-8504
    ISSN (online) 1439-7803
    ISSN 0044-2771 ; 0172-8504
    DOI 10.1055/s-0042-1754912
    Database Thieme publisher's database

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    Zs.A 111: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.A 111/X: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: eHealth Literacy of German Physicians in the Pre-COVID-19 Era: Questionnaire Study.

    Kirchberg, Johanna / Fritzmann, Johannes / Weitz, Jürgen / Bork, Ulrich

    JMIR mHealth and uHealth

    2020  Volume 8, Issue 10, Page(s) e20099

    Abstract: Background: Digitalization is a disruptive technology that changes the way we deliver diagnostic procedures and treatments in medicine. Different stakeholders have varying interests in and expectations of the digitalization of modern medicine. Many ... ...

    Abstract Background: Digitalization is a disruptive technology that changes the way we deliver diagnostic procedures and treatments in medicine. Different stakeholders have varying interests in and expectations of the digitalization of modern medicine. Many recent digital advances in the medical field, such as the implementation of electronic health records, telemedical services, and mobile health apps, are increasingly used by medical professionals and patients. During the current pandemic outbreak of a novel coronavirus-caused respiratory disease (COVID-19), many modern information and communication technologies (ICT) have been used to overcome the physical barriers and limitations caused by government-issued curfews and workforce shortages. Therefore, the COVID-19 pandemic has led to a surge in the usage of modern ICT in medicine. At the same time, the eHealth literacy of physicians working with these technologies has probably not improved since our study.
    Objective: This paper describes a representative cohort of German physicians before the COVID-19 pandemic and their eHealth literacy and attitude towards modern ICT.
    Methods: A structured, self-developed questionnaire about user behavior and attitudes towards eHealth applications was administered to a representative cohort of 93 German physicians.
    Results: Of the 93 German physicians who participated in the study, 97% (90/93) use a mobile phone. Medical apps are used by 42% (39/93). Half of the surveyed physicians (47/93, 50%) use their private mobile phones for official purposes on a daily basis. Telemedicine is part of the daily routine for more than one-third (31/93, 33%) of all participants. More than 80% (76/93, 82%) of the trial participants state that their knowledge regarding the legal aspects and data safety of medical apps and cloud computing is insufficient.
    Conclusions: Modern ICT is frequently used and mostly welcomed by German physicians. However, there is a tremendous lack of eHealth literacy and knowledge about the safe and secure implementation of these technologies in routine clinical practice.
    MeSH term(s) Adult ; Attitude of Health Personnel ; COVID-19 ; Cohort Studies ; Coronavirus Infections/epidemiology ; Female ; Germany/epidemiology ; Health Literacy ; Humans ; Male ; Middle Aged ; Pandemics ; Physicians/psychology ; Physicians/statistics & numerical data ; Pneumonia, Viral/epidemiology ; Surveys and Questionnaires ; Telemedicine
    Keywords covid19
    Language English
    Publishing date 2020-10-16
    Publishing country Canada
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2719220-9
    ISSN 2291-5222 ; 2291-5222
    ISSN (online) 2291-5222
    ISSN 2291-5222
    DOI 10.2196/20099
    Database MEDical Literature Analysis and Retrieval System OnLINE

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