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  1. Article ; Online: An update on stem cell therapy for stroke patients: Where are we now?

    Gordon, Jonah / Borlongan, Cesar V

    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

    2024  , Page(s) 271678X241227022

    Abstract: With a foundation built upon initial work from the 1980s demonstrating graft viability in cerebral ischemia, stem cell transplantation has shown immense promise in promoting survival, enhancing neuroprotection and inducing neuroregeneration, while ... ...

    Abstract With a foundation built upon initial work from the 1980s demonstrating graft viability in cerebral ischemia, stem cell transplantation has shown immense promise in promoting survival, enhancing neuroprotection and inducing neuroregeneration, while mitigating both histological and behavioral deficits that frequently accompany ischemic stroke. These findings have led to a number of clinical trials that have thoroughly supported a strong safety profile for stem cell therapy in patients but have generated variable efficacy. As preclinical evidence continues to expand through the investigation of new cell lines and optimization of stem cell delivery, it remains critical for translational models to adhere to the protocols established through basic scientific research. With the recent shift in approach towards utilization of stem cells as a conjunctive therapy alongside standard thrombolytic treatments, key issues including timing, route of administration, and stem cell type must each be appropriately translated from the laboratory in order to resolve the question of stem cell efficacy for cerebral ischemia that ultimately will enhance therapeutics for stroke patients towards improving quality of life.
    Language English
    Publishing date 2024-04-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604628-9
    ISSN 1559-7016 ; 0271-678X
    ISSN (online) 1559-7016
    ISSN 0271-678X
    DOI 10.1177/0271678X241227022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1663: Show issues Location:
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  2. Article: Going straight for the gut: gut-brain axis pathology and treatment of Parkinson's disease.

    Ebedes, Dominique / Borlongan, Cesar V

    Neural regeneration research

    2024  Volume 19, Issue 10, Page(s) 2111–2112

    Language English
    Publishing date 2024-01-08
    Publishing country India
    Document type Journal Article
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.392885
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Neurovascular unit permeability in neuroinflammatory diseases: a common pathologic and therapeutic target?

    Monsour, Molly / Borlongan, Cesar V

    Neural regeneration research

    2023  Volume 18, Issue 8, Page(s) 1715–1716

    Language English
    Publishing date 2023-02-07
    Publishing country India
    Document type Journal Article
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.363197
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The central role of peripheral inflammation in ischemic stroke.

    Monsour, Molly / Borlongan, Cesar V

    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

    2023  Volume 43, Issue 5, Page(s) 622–641

    Abstract: Stroke pathology and its treatments conventionally focus on the brain. Probing inflammation, a critical secondary cell death mechanism in stroke, has been largely relegated to the brain. To this end, peripheral inflammation has emerged as an equally ... ...

    Abstract Stroke pathology and its treatments conventionally focus on the brain. Probing inflammation, a critical secondary cell death mechanism in stroke, has been largely relegated to the brain. To this end, peripheral inflammation has emerged as an equally potent contributor to the onset and progression of stroke secondary cell death. Here, we review novel concepts on peripheral organs displaying robust inflammatory response to stroke. These inflammation-plagued organs include the spleen, cervical lymph nodes, thymus, bone marrow, gastrointestinal system, and adrenal glands, likely converging their inflammatory effects through B and T-cells. Recognizing the significant impact of this systemic inflammation, we also discuss innovative stroke therapeutics directed at sequestration of peripheral inflammation. This review paper challenges the paradigm of a brain-centered disease pathology and treatment and offers a peripheral approach to our stroke understanding.
    MeSH term(s) Humans ; Ischemic Stroke/pathology ; Stroke/pathology ; Brain/metabolism ; Spleen/metabolism ; Inflammation/pathology ; Brain Ischemia/pathology
    Language English
    Publishing date 2023-01-05
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 604628-9
    ISSN 1559-7016 ; 0271-678X
    ISSN (online) 1559-7016
    ISSN 0271-678X
    DOI 10.1177/0271678X221149509
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  5. Article: Quite amusing stem cells: Muse cells.

    Monsour, Molly / Borlongan, Cesar V

    Neural regeneration research

    2023  Volume 18, Issue 11, Page(s) 2377–2378

    Language English
    Publishing date 2023-06-06
    Publishing country India
    Document type Journal Article
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.371351
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Traumatic brain injury treatment using a rodent model of homelessness.

    Monsour, Molly / Borlongan, Cesar V

    Neural regeneration research

    2023  Volume 19, Issue 9, Page(s) 1873–1874

    Language English
    Publishing date 2023-12-21
    Publishing country India
    Document type Journal Article
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.391186
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Message from the Editor-in-Chief.

    Borlongan, Cesar V

    CNS & neurological disorders drug targets

    2019  Volume 18, Issue 1, Page(s) 2

    Language English
    Publishing date 2019-02-28
    Publishing country United Arab Emirates
    Document type Editorial
    ZDB-ID 2228394-8
    ISSN 1996-3181 ; 1871-5273
    ISSN (online) 1996-3181
    ISSN 1871-5273
    DOI 10.2174/187152731801181220123413
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5892: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article ; Online: Fatty acid chemical mediator provides insights into the pathology and treatment of Parkinson's disease.

    Borlongan, Cesar V

    Proceedings of the National Academy of Sciences of the United States of America

    2018  Volume 115, Issue 25, Page(s) 6322–6324

    MeSH term(s) Fatty Acids ; Humans ; Mitochondria ; Parkinson Disease
    Chemical Substances Fatty Acids
    Language English
    Publishing date 2018-05-30
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1807276115
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1148: Show issues Location:
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  9. Article ; Online: Recent advances in cell therapy for stroke.

    Park, You Jeong / Borlongan, Cesar V

    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

    2021  Volume 41, Issue 10, Page(s) 2797–2799

    Abstract: The last 50 years have witnessed the translation of stem cell therapy from the laboratory to the clinic for treating brain disorders, in particular stroke. From the focal stereotaxic transplantation to the minimally invasive intravenous and intraarterial ...

    Abstract The last 50 years have witnessed the translation of stem cell therapy from the laboratory to the clinic for treating brain disorders, in particular stroke. From the focal stereotaxic transplantation to the minimally invasive intravenous and intraarterial delivery, stem cells display the ability to replenish injured cells and to secrete therapeutic molecules, altogether promoting brain repair. The increased stroke incidence in COVID-19 survivors poses as a new disease indication for cell therapy, owing in part to the cells' robust anti-inflammatory properties. Optimization of the cell transplant regimen will ensure the safe and effective clinical application of cell therapy in stroke and relevant neurological disorders.
    MeSH term(s) Animals ; Brain/pathology ; COVID-19/complications ; COVID-19/diagnosis ; Humans ; Incidence ; Regenerative Medicine/methods ; SARS-CoV-2/isolation & purification ; Stem Cell Transplantation/methods ; Stroke/etiology ; Stroke/pathology ; Stroke/therapy
    Language English
    Publishing date 2021-06-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604628-9
    ISSN 1559-7016 ; 0271-678X
    ISSN (online) 1559-7016
    ISSN 0271-678X
    DOI 10.1177/0271678X211026507
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  10. Article: Editorial: Stem Cells and Aging.

    Borlongan, Cesar V / Steinberg, Gary K

    Frontiers in aging neuroscience

    2021  Volume 13, Page(s) 690613

    Language English
    Publishing date 2021-05-17
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2021.690613
    Database MEDical Literature Analysis and Retrieval System OnLINE

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