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Article ; Online: Metabolome-Driven Regulation of Adenovirus-Induced Cell Death.

Laevskaya, Anastasia / Borovjagin, Anton / Timashev, Peter S / Lesniak, Maciej S / Ulasov, Ilya

International journal of molecular sciences

2021 Volume 22, Issue 1

Abstract: A viral infection that involves virus invasion, protein synthesis, and virion assembly is typically accompanied by sharp fluctuations in the intracellular levels of metabolites. Under certain conditions, dramatic metabolic shifts can result in various ... ...

Abstract	A viral infection that involves virus invasion, protein synthesis, and virion assembly is typically accompanied by sharp fluctuations in the intracellular levels of metabolites. Under certain conditions, dramatic metabolic shifts can result in various types of cell death. Here, we review different types of adenovirus-induced cell death associated with changes in metabolic profiles of the infected cells. As evidenced by experimental data, in most cases changes in the metabolome precede cell death rather than represent its consequence. In our previous study, the induction of autophagic cell death was observed following adenovirus-mediated lactate production, acetyl-CoA accumulation, and ATP release, while apoptosis was demonstrated to be modulated by alterations in acetate and asparagine metabolism. On the other hand, adenovirus-induced ROS production and ATP depletion were demonstrated to play a significant role in the process of necrotic cell death. Interestingly, the accumulation of ceramide compounds was found to contribute to the induction of all the three types of cell death mentioned above. Eventually, the characterization of metabolite analysis could help in uncovering the molecular mechanism of adenovirus-mediated cell death induction and contribute to the development of efficacious oncolytic adenoviral vectors.
MeSH term(s)	Adenoviridae/genetics ; Adenoviridae/physiology ; Apoptosis/genetics ; Apoptosis/physiology ; Cell Death/genetics ; Cell Death/physiology ; Genetic Vectors/genetics ; Genetic Vectors/physiology ; Humans ; Metabolome/genetics ; Metabolome/physiology
Language	English
Publishing date	2021-01-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22010464
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The IL13α 2R paves the way for anti-glioma nanotherapy.

Ulasov, Ilya V / Borovjagin, Anton / Laevskaya, Anastasia / Kamynina, Margarita / Timashev, Peter / Cerchia, Laura / Rozhkova, Elena A

Genes & diseases

2021 Volume 10, Issue 1, Page(s) 89–100

Abstract: Glioblastoma (GBM) is one of the most aggressive (grade IV) gliomas characterized by a high rate of recurrence, resistance to therapy and a grim survival prognosis. The long-awaited improvement in GBM patients' survival rates essentially depends on ... ...

Abstract	Glioblastoma (GBM) is one of the most aggressive (grade IV) gliomas characterized by a high rate of recurrence, resistance to therapy and a grim survival prognosis. The long-awaited improvement in GBM patients' survival rates essentially depends on advances in the development of new therapeutic approaches. Recent preclinical studies show that nanoscale materials could greatly contribute to the improvement of diagnosis and management of brain cancers. In the current review, we will discuss how specific features of glioma pathobiology can be employed for designing efficient targeting approaches. Moreover, we will summarize the main evidence for the potential of the IL-13R alpha 2 receptor (IL13α2R) targeting in GBM early diagnosis and experimental therapy.
Language	English
Publishing date	2021-09-15
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2821806-1
ISSN	2352-3042 ; 2352-3042
ISSN (online)	2352-3042
ISSN	2352-3042
DOI	10.1016/j.gendis.2021.08.006
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Article: Individualized Surgical Reconstruction of the Right Ventricle Outflow Tract in Double Outlet Right Ventricle With Mirror Image-Dextrocardia.

Chen, Wangping / Iroegbu, Chukwuemeka Daniel / Xie, Xia / Zhou, Wenwu / Wu, Ming / Wu, Xun / Fan, Chengming / Borovjagin, Anton V / Yang, Jinfu

Frontiers in pediatrics

2021 Volume 9, Page(s) 611007

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2021-02-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2021.611007
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Article ; Online: Successful Surgical Treatment of a Giant Left Coronary Artery Aneurysm with Fistula.

Li, Huadong / Yu, Hong / Song, Yu / Tong, Lu / Zhao, Meng / Borovjagin, Anton V / Dong, Nianguo / Wu, Long

The heart surgery forum

2021 Volume 24, Issue 5, Page(s) E868–E869

Abstract: Coronary artery aneurysm (CAA) is an aortic catastrophe with low prevalence. Giant CAA is even more uncommon, requiring surgical intervention. Giant CAA usually originates from the proximal segments of the right coronary and the anterior descending ... ...

Abstract	Coronary artery aneurysm (CAA) is an aortic catastrophe with low prevalence. Giant CAA is even more uncommon, requiring surgical intervention. Giant CAA usually originates from the proximal segments of the right coronary and the anterior descending arteries. Here we report a rare case of giant left CAA with fistula formation treated with successful surgery.
MeSH term(s)	Computed Tomography Angiography ; Coronary Aneurysm/complications ; Coronary Aneurysm/diagnosis ; Coronary Aneurysm/surgery ; Coronary Angiography ; Coronary Vessels/diagnostic imaging ; Coronary Vessels/surgery ; Echocardiography ; Female ; Humans ; Magnetic Resonance Imaging, Cine ; Middle Aged ; Treatment Outcome ; Vascular Fistula/diagnosis ; Vascular Fistula/etiology ; Vascular Fistula/surgery ; Vascular Surgical Procedures/methods
Language	English
Publishing date	2021-10-07
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2069188-9
ISSN	1522-6662 ; 1098-3511
ISSN (online)	1522-6662
ISSN	1098-3511
DOI	10.1532/hsf.3877
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Zs.A 5745: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
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Article ; Online: Reabsorbable Pins can Reinforce an Early Sternal Stability After Median Sternotomy in Young Children with Congenital Heart Disease.

Fan, Chengming / Tang, Mi / Wu, Sijie / Yuan, Shuwen / Borovjagin, Anton V / Yang, Jinfu

Pediatric cardiology

2019 Volume 40, Issue 8, Page(s) 1728–1734

Abstract: We evaluated the efficacy of bioresorbable sternal reinforcement device (poly-L-lactide sternal pins) on sternal healing after median sternotomy in young children (with body weight less than 10 kg) with congenital heart disease (CHD). Data from 85 ... ...

Abstract	We evaluated the efficacy of bioresorbable sternal reinforcement device (poly-L-lactide sternal pins) on sternal healing after median sternotomy in young children (with body weight less than 10 kg) with congenital heart disease (CHD). Data from 85 patients, who underwent CHD surgery through median sternotomy from October 2016 to May 2018, were collected and analyzed. Sternal pins were utilized in 85 patients (10 mm × 1 mm × 1 mm for patients with body weights less than 5 kg and 15 mm × 2 mm × 2 mm for those weighing between 5 and 10 kg) in addition to sternum closure with Ethicon PDS
MeSH term(s)	Bone Nails ; Case-Control Studies ; Female ; Heart Defects, Congenital/surgery ; Humans ; Imaging, Three-Dimensional ; Infant ; Male ; Polyesters/therapeutic use ; Sternotomy/methods ; Sternotomy/statistics & numerical data ; Sternum/surgery ; Surgical Wound Dehiscence/prevention & control ; Tomography, X-Ray Computed ; Treatment Outcome
Chemical Substances	Polyesters ; poly(lactide) (459TN2L5F5)
Language	English
Publishing date	2019-09-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	800857-7
ISSN	1432-1971 ; 0172-0643
ISSN (online)	1432-1971
ISSN	0172-0643
DOI	10.1007/s00246-019-02212-1
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Zs.A 1528: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
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Article ; Online: KISS1 in breast cancer progression and autophagy.

Ulasov, Ilya V / Borovjagin, Anton V / Timashev, Peter / Cristofanili, Massimo / Welch, Danny R

Cancer metastasis reviews

2019 Volume 38, Issue 3, Page(s) 493–506

Abstract: Tumor suppressors are cellular proteins typically expressed in normal (non-cancer) cells that not only regulate such cellular functions as proliferation, migration and adhesion, but can also be secreted into extracellular space and serve as biomarkers ... ...

Abstract	Tumor suppressors are cellular proteins typically expressed in normal (non-cancer) cells that not only regulate such cellular functions as proliferation, migration and adhesion, but can also be secreted into extracellular space and serve as biomarkers for pathological conditions or tumor progression. KISS1, a precursor for several shorter peptides, known as metastin (Kisspeptin-54), Kisspeptin-14, Kisspeptin-13 and Kisspeptin-10, is one of those metastasis suppressor proteins, whose expression is commonly downregulated in the metastatic tumors of various origins. The commonly accepted role of KISS1 in metastatic tumor progression mechanism is the ability of this protein to suppress colonization of disseminated cancer cells in distant organs critical for the formation of the secondary tumor foci. Besides, recent evidence suggests involvement of KISS1 in the mechanisms of tumor angiogenesis, autophagy and apoptosis regulation, suggesting a possible role in both restricting and promoting cancer cell invasion. Here, we discuss the role of KISS1 in regulating metastases, the link between KISS1 expression and the autophagy-related biology of cancer cells and the perspectives of using KISS1 as a potential diagnostic marker for cancer progression as well as a new anti-cancer therapeutics.
MeSH term(s)	Animals ; Autophagy/physiology ; Biomarkers, Tumor/metabolism ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Female ; Humans ; Kisspeptins/metabolism
Chemical Substances	Biomarkers, Tumor ; Kisspeptins
Language	English
Publishing date	2019-11-08
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	604857-2
ISSN	1573-7233 ; 0167-7659
ISSN (online)	1573-7233
ISSN	0167-7659
DOI	10.1007/s10555-019-09814-4
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Zs.A 1812: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: From Microscale Devices to 3D Printing: Advances in Fabrication of 3D Cardiovascular Tissues.

Borovjagin, Anton V / Ogle, Brenda M / Berry, Joel L / Zhang, Jianyi

Circulation research

2017 Volume 120, Issue 1, Page(s) 150–165

Abstract: Current strategies for engineering cardiovascular cells and tissues have yielded a variety of sophisticated tools for studying disease mechanisms, for development of drug therapies, and for fabrication of tissue equivalents that may have application in ... ...

Abstract	Current strategies for engineering cardiovascular cells and tissues have yielded a variety of sophisticated tools for studying disease mechanisms, for development of drug therapies, and for fabrication of tissue equivalents that may have application in future clinical use. These efforts are motivated by the need to extend traditional 2-dimensional (2D) cell culture systems into 3D to more accurately replicate in vivo cell and tissue function of cardiovascular structures. Developments in microscale devices and bioprinted 3D tissues are beginning to supplant traditional 2D cell cultures and preclinical animal studies that have historically been the standard for drug and tissue development. These new approaches lend themselves to patient-specific diagnostics, therapeutics, and tissue regeneration. The emergence of these technologies also carries technical challenges to be met before traditional cell culture and animal testing become obsolete. Successful development and validation of 3D human tissue constructs will provide powerful new paradigms for more cost effective and timely translation of cardiovascular tissue equivalents.
MeSH term(s)	Animals ; Cardiovascular System/cytology ; Cell Culture Techniques/methods ; Humans ; Myocytes, Cardiac/physiology ; Printing, Three-Dimensional ; Tissue Engineering/methods ; Tissue Scaffolds
Language	English
Publishing date	2017-01-03
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	80100-8
ISSN	1524-4571 ; 0009-7330 ; 0931-6876
ISSN (online)	1524-4571
ISSN	0009-7330 ; 0931-6876
DOI	10.1161/CIRCRESAHA.116.308538
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Ui IV Zs.70: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Ui IV Zs.60: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Evaluating antitumor activity of Escherichia coli purine nucleoside phosphorylase against head and neck patient-derived xenografts.

Rab, Regina / Ehrhardt, Annette / Achyut, Bhagelu R / Joshi, Disha / Gilbert-Ross, Melissa / Huang, Chunzi / Floyd, Katharine / Borovjagin, Anton V / Parker, William B / Sorscher, Eric J / Hong, Jeong S

Cancer reports (Hoboken, N.J.)

2022 Volume 6, Issue 2, Page(s) e1708

Abstract: Background: Purine nucleoside phosphorylase (PNP) gene transfer represents a promising approach to treatment of head and neck malignancies. We tested recombinant adenovirus already in phase I/II clinical testing and leading-edge patient-derived ... ...

Abstract	Background: Purine nucleoside phosphorylase (PNP) gene transfer represents a promising approach to treatment of head and neck malignancies. We tested recombinant adenovirus already in phase I/II clinical testing and leading-edge patient-derived xenografts (PDX) as a means to optimize this therapeutic strategy. Methods: Our experiments investigated purine base cytotoxicity, PNP enzyme activity following treatment of malignant tissue, tumor mass regression, viral receptor studies, and transduction by tropism-modified adenovirus. Results: Replication deficient vector efficiently transduced PDX cells and mediated significant anticancer effect following treatment with fludarabine phosphate in vivo. Either 6-methylpurine or 2-fluoroadenine (toxic molecules generated by the PNP approach) ablated head and neck cancer cell proliferation. High levels of adenovirus-3 specific receptors were detected in human tumor models, and vector was evaluated that utilizes this pathway. Conclusions: Our studies provide the scientific foundation necessary to improve PNP prodrug cleavage and advance a new treatment for head and neck cancer.
MeSH term(s)	Humans ; Purine-Nucleoside Phosphorylase/genetics ; Purine-Nucleoside Phosphorylase/metabolism ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Heterografts ; Genetic Vectors ; Genetic Therapy ; Head and Neck Neoplasms ; Adenoviridae/genetics
Chemical Substances	Purine-Nucleoside Phosphorylase (EC 2.4.2.1)
Language	English
Publishing date	2022-10-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2573-8348
ISSN (online)	2573-8348
DOI	10.1002/cnr2.1708
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Article ; Online: Calreticulin is important for the development of renal fibrosis and dysfunction in diabetic nephropathy.

Lu, Ailing / Pallero, Manuel A / Owusu, Benjamin Y / Borovjagin, Anton V / Lei, Weiqi / Sanders, Paul W / Murphy-Ullrich, Joanne E

Matrix biology plus

2020 Volume 8, Page(s) 100034

Abstract: Previously, our lab showed that the endoplasmic reticulum (ER) and calcium regulatory protein, calreticulin (CRT), is important for collagen transcription, secretion, and assembly into the extracellular matrix (ECM) and that ER CRT is critical for TGF-β ... ...

Abstract	Previously, our lab showed that the endoplasmic reticulum (ER) and calcium regulatory protein, calreticulin (CRT), is important for collagen transcription, secretion, and assembly into the extracellular matrix (ECM) and that ER CRT is critical for TGF-β stimulation of type I collagen transcription through stimulation of ER calcium release and NFAT activation. Diabetes is the leading cause of end stage renal disease. TGF-β is a key factor in the pathogenesis of diabetic nephropathy. However, the role of calreticulin (
Language	English
Publishing date	2020-04-03
Publishing country	Netherlands
Document type	Journal Article
ISSN	2590-0285
ISSN (online)	2590-0285
DOI	10.1016/j.mbplus.2020.100034
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Article ; Online: Battling Neurodegenerative Diseases with Adeno-Associated Virus-Based Approaches.

Mijanović, Olja / Branković, Ana / Borovjagin, Anton / Butnaru, Denis V / Bezrukov, Evgeny A / Sukhanov, Roman B / Shpichka, Anastasia / Timashev, Peter / Ulasov, Ilya

Viruses

2020 Volume 12, Issue 4

Abstract: Neurodegenerative diseases (NDDs) are most commonly found in adults and remain essentially incurable. Gene therapy using AAV vectors is a rapidly-growing field of experimental medicine that holds promise for the treatment of NDDs. To date, the delivery ... ...

Abstract	Neurodegenerative diseases (NDDs) are most commonly found in adults and remain essentially incurable. Gene therapy using AAV vectors is a rapidly-growing field of experimental medicine that holds promise for the treatment of NDDs. To date, the delivery of a therapeutic gene into target cells via AAV represents a major obstacle in the field. Ideally, transgenes should be delivered into the target cells specifically and efficiently, while promiscuous or off-target gene delivery should be minimized to avoid toxicity. In the pursuit of an ideal vehicle for NDD gene therapy, a broad variety of vector systems have been explored. Here we specifically outline the advantages of adeno-associated virus (AAV)-based vector systems for NDD therapy application. In contrast to many reviews on NDDs that can be found in the literature, this review is rather focused on AAV vector selection and their preclinical testing in experimental and preclinical NDD models. Preclinical and in vitro data reveal the strong potential of AAV for NDD-related diagnostics and therapeutic strategies.
MeSH term(s)	Animals ; Central Nervous System/metabolism ; Central Nervous System/pathology ; Dependovirus/genetics ; Disease Models, Animal ; Environment ; Gene Targeting ; Gene Transfer Techniques ; Genetic Therapy/adverse effects ; Genetic Therapy/methods ; Genetic Vectors/genetics ; Humans ; Neurodegenerative Diseases/diagnosis ; Neurodegenerative Diseases/etiology ; Neurodegenerative Diseases/therapy ; Transgenes
Language	English
Publishing date	2020-04-18
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v12040460
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