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  1. Article ; Online: Model-based comparison of subcutaneous versus sublingual apomorphine administration in the treatment of motor fluctuations in Parkinson's disease.

    Nasser, Azmi / Gomeni, Roberto / Ceresoli-Borroni, Gianpiera / Xie, Lanyi / Busse, Gregory D / Melyan, Zare / Rubin, Jonathan

    Journal of pharmacokinetics and pharmacodynamics

    2024  

    Abstract: The objective of this study was to compare the effectiveness of subcutaneous (SC) and sublingual (SL) formulations of apomorphine for the treatment of motor fluctuations in Parkinson's disease using a pharmacokinetics (PK)/pharmacodynamics (PD) modeling ... ...

    Abstract The objective of this study was to compare the effectiveness of subcutaneous (SC) and sublingual (SL) formulations of apomorphine for the treatment of motor fluctuations in Parkinson's disease using a pharmacokinetics (PK)/pharmacodynamics (PD) modeling approach. The PK of SC and SL apomorphine are best described by a one-compartment model with first-order absorption and a two-compartment model with delayed absorption, respectively. The PK/PD model relating apomorphine plasma concentrations to the Unified Parkinson's Disease Rating Scale (UPDRS) motor scores was described by a sigmoidal E
    Language English
    Publishing date 2024-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2041601-5
    ISSN 1573-8744 ; 1567-567X
    ISSN (online) 1573-8744
    ISSN 1567-567X
    DOI 10.1007/s10928-024-09914-x
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  2. Article ; Online: Charting connections: A systematic review of colorectal surgery research networks.

    Crippa, Jacopo / Magistro, Carmelo / Montroni, Isacco / Borroni, Giacomo / Ziccarelli, Antonio / Spinelli, Antonino / Mari, Giulio Maria

    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

    2024  Volume 50, Issue 6, Page(s) 108322

    Abstract: Research in surgery faces intrinsic difficulties such as the lack of reproducibility of surgical operations, self-referring surgeons, decentralized data. Establishing a community of qualified researchers across surgeons is crucial. Clinical networks have ...

    Abstract Research in surgery faces intrinsic difficulties such as the lack of reproducibility of surgical operations, self-referring surgeons, decentralized data. Establishing a community of qualified researchers across surgeons is crucial. Clinical networks have been proposed as solutions to many challenges in surgical research, yet their implementation remains uncommon, especially for surgical trialists. The extent of literature produced by networks remains unclear, but fostering such collaborations could enhance the overall quality of surgical research. We conducted review focusing on research networks in colorectal surgery to assess their workload and impact in the literature and identify factors contributing to their durability. Following PRISMA guidelines, we searched for articles published through research networks. Networks were categorized by subspecialty, and specific items were retrieved for further classification. A survey was administered to twenty experts in colorectal surgery or research networking. A total of 2490 manuscripts were screened, and 397 networks identified. Of these, 96 were colorectal networks contributing to 492 publications, with 28 networks having five or more publications. Seventeen networks were affiliated with International or National societies, and only 5 conducted both prospective trials and RCTs. Twenty networks reported national or population-based data, and 26 networks lasted for more than 5 years. Sixteen experts participated in the survey, with an 80 % compliance rate, and 12 of them have been involved in creating a surgical network. The large majority of experts advocate the establishment of guidelines for networks creation in the surgical community.
    Language English
    Publishing date 2024-04-17
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 632519-1
    ISSN 1532-2157 ; 0748-7983
    ISSN (online) 1532-2157
    ISSN 0748-7983
    DOI 10.1016/j.ejso.2024.108322
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  3. Article: Why a monograph on cutaneous drug-induced reactions seen in histopathological perspective.

    Borroni, G / Tomasini, C

    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia

    2014  Volume 149, Issue 2, Page(s) 205

    MeSH term(s) Drug Eruptions/pathology ; Humans
    Language English
    Publishing date 2014-04
    Publishing country Italy
    Document type Introductory Journal Article
    ZDB-ID 604114-0
    ISSN 1827-1820 ; 0392-0488 ; 0026-4741
    ISSN (online) 1827-1820
    ISSN 0392-0488 ; 0026-4741
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  4. Article: The "raison d'être" of a monograph on panniculitides.

    Borroni, G / Tomasini, C F

    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia

    2013  Volume 148, Issue 4, Page(s) 313–314

    MeSH term(s) Humans ; Panniculitis
    Language English
    Publishing date 2013-08
    Publishing country Italy
    Document type Introductory Journal Article
    ZDB-ID 604114-0
    ISSN 1827-1820 ; 0392-0488 ; 0026-4741
    ISSN (online) 1827-1820
    ISSN 0392-0488 ; 0026-4741
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  5. Article ; Online: Risk factors for recurrence and complications after laparoscopic repair of incisional hernia using a double-layered ePTFE/PP mesh: results of a retrospective study.

    Chiari, Damiano / Jovanovic, Slobodan / Borroni, Giacomo / Morenghi, Emanuela / Moroni, Maurizio R / Zuliani, Walter

    Minerva surgery

    2022  Volume 78, Issue 3, Page(s) 247–253

    Abstract: Background: The objective was to analyse, risk factors for recurrence (primary outcome) and complications (secondary outome) after the implantation of a double layer ePTFE (expanded PolytTetraFluoroEthylene) / PP (PolyPropylene) mesh to treat incisional ...

    Abstract Background: The objective was to analyse, risk factors for recurrence (primary outcome) and complications (secondary outome) after the implantation of a double layer ePTFE (expanded PolytTetraFluoroEthylene) / PP (PolyPropylene) mesh to treat incisional hernias (IH) using the Intraperitoneal Onlay Mesh (IPOM) technique.
    Methods: We included all elective laparoscopic IH repairs with intraperitoneal placement of a ePTFE / PP mesh (Relimesh
    Results: A total of 284 patients were enrolled. According to the European Hernia Society (EHS) hernias were classified as: W1 (<4 cm) 60.29%, W2 (≥4-10 cm) 35.02% and W3 (≥10 cm) 4.69%; medial 90.85%, lateral 6.69%, both medial and lateral 2.11%. Average follow-up was 48 (11-110) months. The 30-days complication rate was 4.23%. Hernia recurrence rate was 3.36%. Long-term complication rate was 6.34%. At multivariable analysis, an increased risk of short-term complications was associated to chronic obstructive pulmonary disease (COPD) (OR 7.59 [2.23-25.83], P=0.001); an increased risk of long-term complications was associated to diabetes (OR 6.21 [1.80-21.42], P=0.004), an increased risk of recurrence was correlated to COPD (OR 13.40 [1.36-131.9], P=0.026) and hernia defects larger than 6 cm (OR 19.2 [1.12-329.9], P=0.042).
    Conclusions: Elective laparoscopic IH repair with a double-layered ePTFE/PP mesh is safe and effective. Compliance with indications and preoperative patients evaluation are essential to improve outcomes.
    MeSH term(s) Humans ; Incisional Hernia/epidemiology ; Incisional Hernia/surgery ; Incisional Hernia/etiology ; Retrospective Studies ; Hernia, Ventral/surgery ; Hernia, Ventral/etiology ; Surgical Mesh ; Herniorrhaphy/adverse effects ; Herniorrhaphy/methods ; Neoplasm Recurrence, Local/etiology ; Neoplasm Recurrence, Local/surgery ; Laparoscopy/adverse effects ; Laparoscopy/methods ; Risk Factors
    Language English
    Publishing date 2022-12-16
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3067899-7
    ISSN 2724-5438
    ISSN (online) 2724-5438
    DOI 10.23736/S2724-5691.22.09740-4
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    Zs.A 25: Show issues Location:
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  6. Article ; Online: Effectiveness of surgical treatment of severe macrocheilia in a patient with orofacial granulomatosis.

    Vassallo, C / Rivetti, N / Merlino, M / Borroni, G / Brazzelli, V

    Clinical and experimental dermatology

    2017  Volume 42, Issue 8, Page(s) 887–889

    Abstract: Orofacial granulomatosis (OFG) is the term given to a group of diseases characterized by the presence of non-necrotizing granulomatous inflammation affecting the soft tissues of the orofacial region. Treatment of OFG is often challenging and ... ...

    Abstract Orofacial granulomatosis (OFG) is the term given to a group of diseases characterized by the presence of non-necrotizing granulomatous inflammation affecting the soft tissues of the orofacial region. Treatment of OFG is often challenging and unsatisfactory. We report on a 32-year-old man with a 2-year history of oedema and swelling of the upper lip without systemic symptoms. The history, clinical features and histopathological findings led to the diagnosis of cheilitis granulomatosa (CG), a disease included in the spectrum of OFG. The patient was treated with oral diaminodiphenyl sulfone (DDS) and clofazimine without success. Oral doxycycline led to a slight improvement of the disease. Because the volume of the upper lip was twice normal size, surgical reduction was performed, followed by administration of oral doxycycline for 3 months. This therapeutic approach led to complete remission, with no recurrence after 3 years.
    Language English
    Publishing date 2017-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 195504-4
    ISSN 1365-2230 ; 0307-6938
    ISSN (online) 1365-2230
    ISSN 0307-6938
    DOI 10.1111/ced.13201
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  7. Article: Vasculitides with cutaneous expression in children: clinico-pathological correlations.

    Borroni, G / Grassi, S / Carugno, A

    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia

    2015  Volume 150, Issue 1, Page(s) 51–71

    Abstract: The most recent pediatric vasculitis classifications (EULAR/PRINTO/PRES) have proposed the use of an integration of clinical signs and symptoms, laboratory data, imaging and pathologic data. Pediatric vasculitis represent a peculiar clinical-diagnostic ... ...

    Abstract The most recent pediatric vasculitis classifications (EULAR/PRINTO/PRES) have proposed the use of an integration of clinical signs and symptoms, laboratory data, imaging and pathologic data. Pediatric vasculitis represent a peculiar clinical-diagnostic model, compared to the corresponding adult pathology chapter, and in particular, dermatopathologic aspects of these diseases identify more specific issues, made contingent by crucial variables such as duration of vasculitis lesion, site of the biopsy, proper biopsy depth, and possibility to correlate histopathological findings with immunopathological results. Possible additional diagnostic difficulties may arise from the fact that, in children, the same systemic disease, such as lupus erythematosus, may present with different clinical manifestations, with histopathological features of a precise type of vasculitis specific for that type of clinical manifestation. Examples are provided by hypocomplementemic urticarial vasculitis, cryoglobulinemic purpura, lymphocytic vasculitis of livedoid lesions. This paper describes the cutaneous histopathological findings of some vasculitis related pediatric diseases, be they pertaining to a systemic vasculitis with corresponding cutaneous vasculitis, to a systemic vasculitis with sporadic cutaneous vasculitic involvement, and to a systemic vasculitis without cutaneous vasculitic involvement. Type and level of histopathological vasculitic involvement, caliber of the vessel, type of vasculitis associated infiltrate, are likewise reliable integration in the complex diagnostic path of vasculitis in childhood. On the basis of these criteria dermatopathologists should be confident in identifying the type of the vasculitis and relate them to a specific pediatric disease.
    MeSH term(s) Age Factors ; Biopsy ; Child ; Humans ; Skin Diseases, Vascular/classification ; Skin Diseases, Vascular/diagnosis ; Skin Diseases, Vascular/pathology ; Systemic Vasculitis/classification ; Systemic Vasculitis/diagnosis ; Systemic Vasculitis/pathology ; Vasculitis/classification ; Vasculitis/diagnosis ; Vasculitis/pathology
    Language English
    Publishing date 2015-02
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 604114-0
    ISSN 1827-1820 ; 0392-0488 ; 0026-4741
    ISSN (online) 1827-1820
    ISSN 0392-0488 ; 0026-4741
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  8. Article: To classify or to discern? That's the problem.

    Borroni, G / Tomasini, C / Berti, E

    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia

    2015  Volume 150, Issue 1, Page(s) 27–28

    MeSH term(s) Humans ; Skin Diseases, Vascular/classification ; Skin Diseases, Vascular/diagnosis ; Skin Diseases, Vascular/pathology ; Vasculitis/classification ; Vasculitis/diagnosis ; Vasculitis/pathology
    Language English
    Publishing date 2015-02
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 604114-0
    ISSN 1827-1820 ; 0392-0488 ; 0026-4741
    ISSN (online) 1827-1820
    ISSN 0392-0488 ; 0026-4741
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  9. Article ; Online: Bright Red Papules in a HIV-Positive 20-Year-Old Man: Challenge and Answer.

    Borroni, Giovanni / Barruscotti, Stefania / Vassallo, Camilla

    The American Journal of dermatopathology

    2019  Volume 41, Issue 8, Page(s) 621

    MeSH term(s) Adult ; Erythema ; HIV Infections ; HIV Seropositivity ; Humans ; Male ; Skin Abnormalities ; Young Adult
    Language English
    Publishing date 2019-07-04
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 448469-1
    ISSN 1533-0311 ; 0193-1091
    ISSN (online) 1533-0311
    ISSN 0193-1091
    DOI 10.1097/DAD.0000000000000565
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  10. Article: The roots of dermatologic thought originated in a botanic garden.

    Borroni, G

    Archives of dermatology

    2000  Volume 136, Issue 1, Page(s) 28–29

    MeSH term(s) Botany/history ; Dermatology/history ; History, 17th Century ; History, 18th Century ; History, 19th Century ; Humans ; Skin Diseases/classification ; Skin Diseases/history
    Language English
    Publishing date 2000-01
    Publishing country United States
    Document type Historical Article ; Journal Article
    ZDB-ID 212139-6
    ISSN 1538-3652 ; 0003-987X
    ISSN (online) 1538-3652
    ISSN 0003-987X
    DOI 10.1001/archderm.136.1.28
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