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  1. AU="Bortoleti, Bruna Taciane da Silva"
  2. AU="Ehrbar, Martin"
  3. AU="Lepre, Davide"
  4. AU="Olszewska, Zuzanna"
  5. AU="Vojta, Leslie"
  6. AU=Wickstrom Eric AU=Wickstrom Eric
  7. AU="Gangavarapu, Sridevi"
  8. AU="Hussein, Hazem Abdelwaheb"
  9. AU=Cai Yixin AU=Cai Yixin
  10. AU="Hüls, Anke"
  11. AU="Poondru, Srinivasu"
  12. AU="Coca, Daniel"
  13. AU="Lebeau, Paul"
  14. AU="Dehghani, Sedigheh"
  15. AU="Ishibashi, Kenji"
  16. AU="Xu, Yanhua"
  17. AU="Matera, Katarzyna"
  18. AU="Ait-Ouarab, Slimane"
  19. AU="Nicola, Coppede"
  20. AU="Dewitt, John M"
  21. AU="Sorin M. Dudea"
  22. AU="Tanusha D. Ramdin"
  23. AU="Hao, Zehui"
  24. AU="Chauhan, Aman"

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  1. Artikel ; Online: Leishmania amazonensis infection regulates oxidate stress in hyperglycemia and diabetes impairing macrophage's function and immune response.

    Silva, Taylon Felipe / Detoni, Mariana Barbosa / Concato-Lopes, Virgínia Márcia / Tomiotto-Pellissier, Fernanda / Miranda-Sapla, Milena Menegazzo / Bortoleti, Bruna Taciane da Silva / Gonçalves, Manoela Daiele / Rodrigues, Ana Carolina Jacob / Sanfelice, Raquel Arruda / Cruz, Ellen Mayara Souza / Silva, Maria Stacy Dos Santos / Carloto, Amanda Cristina Machado / Bidoia, Danielle Lazarin / Costa, Idessania Nazareth / Pavanelli, Wander Rogério / Conchon-Costa, Ivete

    Biochimica et biophysica acta. Molecular basis of disease

    2024  Band 1870, Heft 4, Seite(n) 167078

    Abstract: Leishmaniasis is a group of infectious diseases caused by protozoa of the Leishmania genus and its immunopathogenesis results from an unbalanced immune response during the infection. Diabetes is a chronic disease resulting from dysfunction of the body's ... ...

    Abstract Leishmaniasis is a group of infectious diseases caused by protozoa of the Leishmania genus and its immunopathogenesis results from an unbalanced immune response during the infection. Diabetes is a chronic disease resulting from dysfunction of the body's production of insulin or the ability to use it properly, leading to hyperglycemia causing tissue damage and impairing the immune system.
    Aims: The objective of this work was to evaluate the effects of hyperglycemia and diabetes during Leishmania amazonensis infection and how these conditions alter the immune response to the parasite.
    Methods: An in vitro hyperglycemic stimulus model using THP-1-derived macrophages and an in vivo experimental diabetes with streptozotocin (STZ) in C57BL/6 mice was employed to investigate the impact of diabetes and hyperglicemia in Leishmania amazonensis infection.
    Results: We observed that hyperglycemia impair the leishmanicidal capacity of macrophages derived from THP-1 cells and reverse the resistance profile that C57BL/6 mice have against infection by L. amazonensis, inducing more exacerbated lesions compared to non-diabetic animals. In addition, the hyperglycemic stimulus favored the increase of markers related to the phenotype of M2 macrophages. The induction of experimental diabetes in C57BL/6 mice resulted in a failure in the production of nitric oxide (NO) in the face of infection and macrophages from diabetic animals failed to process and present Leishmania antigens, being unable to activate and induce proliferation of antigen-specific lymphocytes.
    Conclusion: Together, these data demonstrate that diabetes and hyperglycemia can impair the cellular immune response, mainly of macrophages, against infection by parasites of the genus Leishmania.
    Mesh-Begriff(e) Animals ; Mice ; Mice, Inbred C57BL ; Leishmaniasis/complications ; Leishmaniasis/parasitology ; Leishmania/physiology ; Macrophages ; Hyperglycemia/complications ; Immunity ; Diabetes Mellitus
    Sprache Englisch
    Erscheinungsdatum 2024-02-15
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 60-7
    ISSN 1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbadis.2024.167078
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Trilobolide-6-O-isobutyrate from Sphagneticola trilobata acts by inducing oxidative stress, metabolic changes and apoptosis-like processes by caspase 3/7 activation of human lung cancer cell lines.

    Concato-Lopes, Virginia Marcia / Gonçalves-Lens, Manoela Daiele / Tomiotto-Pellissier, Fernanda / Detoni, Mariana Barbosa / Cruz, Ellen Mayara Souza / Bortoleti, Bruna Taciane da Silva / Carloto, Amanda Cristina Machado / Rodrigues, Ana Carolina Jacob / Silva, Taylon Felipe / Siqueira, Elaine da Silva / de Matos, Ricardo Luís Nascimento / Alves Cardoso, Ian Lucas / Conchon-Costa, Ivete / Lazarin-Bidóia, Danielle / Arakawa, Nilton Syogo / Dekker, Robert F H / Mantovani, Mário Sérgio / Pavanelli, Wander Rogério

    Phytomedicine : international journal of phytotherapy and phytopharmacology

    2024  Band 128, Seite(n) 155536

    Abstract: Background: Lung cancer, a chronic and heterogeneous disease, is the leading cause of cancer-related death on a global scale. Presently, despite a variety of available treatments, their effectiveness is limited, often resulting in considerable toxicity ... ...

    Abstract Background: Lung cancer, a chronic and heterogeneous disease, is the leading cause of cancer-related death on a global scale. Presently, despite a variety of available treatments, their effectiveness is limited, often resulting in considerable toxicity and adverse effects. Additionally, the development of chemoresistance in cancer cells poses a challenge. Trilobolide-6-O-isobutyrate (TBB), a natural sesquiterpene lactone extracted from Sphagneticola trilobata, has exhibited antitumor effects. Its pharmacological properties in NSCLC lung cancer, however, have not been explored.
    Purpose: This study evaluated the impact of TBB on the A549 and NCI-H460 tumor cell lines in vitro, examining its antiproliferative properties and initial mechanisms of cell death.
    Methods: TBB, obtained at 98 % purity from S. trilobata leaves, was characterized using chromatographic techniques. Subsequently, its impact on inhibiting tumor cell proliferation in vitro, TBB-induced cytotoxicity in LLC-MK2, THP-1, AMJ2-C11 cells, as well as its effects on sheep erythrocytes, and the underlying mechanisms of cell death, were assessed.
    Results: In silico predictions have shown promising drug-likeness potential for TBB, indicating high oral bioavailability and intestinal absorption. Treatment of A549 and NCI-H460 human tumor cells with TBB demonstrated a direct impact, inducing significant morphological and structural alterations. TBB also reduced migratory capacity without causing toxicity at lower concentrations to LLC-MK2, THP-1 and AMJ2-C11 cell lines. This antiproliferative effect correlated with elevated oxidative stress, characterized by increased levels of ROS, superoxide anion radicals and NO, accompanied by a decrease in antioxidant markers: SOD and GSH. TBB-stress-induced led to changes in cell metabolism, fostering the accumulation of lipid droplets and autophagic vacuoles. Stress also resulted in compromised mitochondrial integrity, a crucial aspect of cellular function. Additionally, TBB prompted apoptosis-like cell death through activation of caspase 3/7 stressors.
    Conclusion: These findings underscore the potential of TBB as a promising candidate for future studies and suggest its viability as an additional component in the development of novel anticancer drugs prototypes.
    Mesh-Begriff(e) Humans ; Oxidative Stress/drug effects ; Apoptosis/drug effects ; Lung Neoplasms/drug therapy ; Caspase 3/metabolism ; Cell Line, Tumor ; Caspase 7/metabolism ; Asteraceae/chemistry ; Lactones/pharmacology ; A549 Cells ; Cell Proliferation/drug effects ; Sesquiterpenes/pharmacology ; Antineoplastic Agents, Phytogenic/pharmacology ; Plant Leaves/chemistry ; Animals ; Reactive Oxygen Species/metabolism ; Plant Extracts/pharmacology
    Chemische Substanzen Caspase 3 (EC 3.4.22.-) ; Caspase 7 (EC 3.4.22.-) ; Lactones ; Sesquiterpenes ; Antineoplastic Agents, Phytogenic ; Reactive Oxygen Species ; Plant Extracts ; CASP7 protein, human (EC 3.4.22.-)
    Sprache Englisch
    Erscheinungsdatum 2024-03-13
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2024.155536
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  3. Artikel ; Online: Nanomedicine in leishmaniasis: A promising tool for diagnosis, treatment and prevention of disease - An update overview.

    Assolini, João Paulo / Carloto, Amanda Cristina Machado / Bortoleti, Bruna Taciane da Silva / Gonçalves, Manoela Daiele / Tomiotto Pellissier, Fernanda / Feuser, Paulo Emilio / Cordeiro, Arthur Poester / Hermes de Araújo, Pedro Henrique / Sayer, Claudia / Miranda Sapla, Milena Menegazzo / Pavanelli, Wander Rogério

    European journal of pharmacology

    2022  Band 923, Seite(n) 174934

    Abstract: Leishmaniasis is a neglected tropical disease that has a wide spectrum of clinical manifestations, ranging from visceral to cutaneous, with millions of new cases and thousands of deaths notified every year. The severity of the disease and its various ... ...

    Abstract Leishmaniasis is a neglected tropical disease that has a wide spectrum of clinical manifestations, ranging from visceral to cutaneous, with millions of new cases and thousands of deaths notified every year. The severity of the disease and its various clinical forms are determined by the species of the causative agent, Leishmania, as well as the host's immune response. Major challenges still exist in the diagnosis and treatment of leishmaniasis, and there is no vaccine available to prevent this disease in humans. Nanotechnology has emerged as a promising tool in a variety of fields. In this review, we highlight the main and most recent advances in nanomedicine to improve the diagnosis and treatment, as well as for the development of vaccines, for leishmaniasis. Nanomaterials are nanometric in size and can be produced by a variety of materials, including lipids, polymers, ceramics, and metals, with varying structures and morphologies. Nanotechnology can be used as biosensors to detect antibodies or antigens, thus improving the sensitivity and specificity of such immunological and molecular diagnostic tests. While in treatment, nanomaterials can act as drug carriers or, be used directly, to reduce any toxic effects of drug compounds to the host and to be more selective towards the parasite. Furthermore, preclinical studies show that different nanomaterials can carry different Leishmania antigens, or even act as adjuvants to improve a Th1 immune response in an attempt to produce an effective vaccine.
    Mesh-Begriff(e) Drug Carriers ; Humans ; Leishmania ; Leishmaniasis/diagnosis ; Leishmaniasis/drug therapy ; Leishmaniasis/prevention & control ; Nanomedicine ; Nanotechnology ; Vaccines/pharmacology
    Chemische Substanzen Drug Carriers ; Vaccines
    Sprache Englisch
    Erscheinungsdatum 2022-03-31
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review
    ZDB-ID 80121-5
    ISSN 1879-0712 ; 0014-2999
    ISSN (online) 1879-0712
    ISSN 0014-2999
    DOI 10.1016/j.ejphar.2022.174934
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Corrigendum: Murine Susceptibility to

    Tomiotto-Pellissier, Fernanda / Miranda-Sapla, Milena Menegazzo / Silva, Taylon Felipe / Bortoleti, Bruna Taciane da Silva / Gonçalves, Manoela Daiele / Concato, Virginia Márcia / Rodrigues, Ana Carolina Jacob / Detoni, Mariana Barbosa / Staurengo-Ferrari, Larissa / Verri, Waldiceu Aparecido / Costa, Idessania Nazareth / Panis, Carolina / Conchon-Costa, Ivete / Bordignon, Juliano / Pavanelli, Wander Rogério

    Frontiers in cellular and infection microbiology

    2022  Band 11, Seite(n) 804809

    Abstract: This corrects the article DOI: 10.3389/fcimb.2021.687633.]. ...

    Abstract [This corrects the article DOI: 10.3389/fcimb.2021.687633.].
    Sprache Englisch
    Erscheinungsdatum 2022-02-24
    Erscheinungsland Switzerland
    Dokumenttyp Published Erratum
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2021.804809
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  5. Artikel ; Online: Exploring the antileishmanial activity of

    Santiago-Silva, Kaio Maciel de / Bortoleti, Bruna Taciane da Silva / Brito, Tiago de Oliveira / Costa, Ivete Conchon / Lima, Camilo Henrique da Silva / Macedo, Fernando / Miranda-Sapla, Milena Menegazzo / Pavanelli, Wander Rogério / Bispo, Marcelle de Lima Ferreira

    Journal of biomolecular structure & dynamics

    2021  Band 40, Heft 22, Seite(n) 11495–11510

    Abstract: In this report, we describe the synthesis and evaluation of ... ...

    Abstract In this report, we describe the synthesis and evaluation of nine
    Mesh-Begriff(e) Leishmania ; Molecular Docking Simulation ; Macrophages, Peritoneal ; Macrophages ; Antiprotozoal Agents/pharmacology
    Chemische Substanzen Antiprotozoal Agents
    Sprache Englisch
    Erscheinungsdatum 2021-08-06
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2021.1959403
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  6. Artikel ; Online: Biogenic silver nanoparticles reduce Toxoplasma gondii infection and proliferation in RAW 264.7 macrophages by inducing tumor necrosis factor-alpha and reactive oxygen species production in the cells.

    Arruda da Silva Sanfelice, Raquel / Silva, Taylon Felipe / Tomiotto-Pellissier, Fernanda / Bortoleti, Bruna Taciane da Silva / Lazarin-Bidóia, Danielle / Scandorieiro, Sara / Nakazato, Gerson / de Barros, Luiz Daniel / Garcia, João Luis / Verri, Waldiceu Aparecido / Conchon-Costa, Ivete / Pavanelli, Wander Rogério / Costa, Idessania Nazareth

    Microbes and infection

    2022  Band 24, Heft 5, Seite(n) 104971

    Abstract: Owing to the serious adverse effects caused by pyrimethamine and sulfadiazine, the drugs commonly used to treat toxoplasmosis, there is a need for treatment alternatives for this disease. Nanotechnology has enabled significant advances toward this goal. ... ...

    Abstract Owing to the serious adverse effects caused by pyrimethamine and sulfadiazine, the drugs commonly used to treat toxoplasmosis, there is a need for treatment alternatives for this disease. Nanotechnology has enabled significant advances toward this goal. This study was conducted to evaluate the activity of biogenic silver nanoparticles (AgNp-Bio) in RAW 264.7 murine macrophages infected with the RH strain of Toxoplasma gondii. The macrophages were infected with T. gondii tachyzoites and then treated with various concentrations of AgNp-Bio. The cells were evaluated by microscopy, and culture supernatants were collected for ELISA determination of their cytokine concentration. Treatment with 6 μM AgNp-Bio reduced the infection and parasite load in infected RAW 264.7 macrophages without being toxic to the cells. The treatment also induced the synthesis of reactive oxygen species and tumor necrosis factor-alpha (both pro-inflammatory mediators), which resulted in ultrastructural changes in the tachyzoites and their intramacrophagic destruction. Our findings suggest that AgNp-Bio affect T. gondii tachyzoites by activating microbicidal and pro-inflammatory mechanisms and may be a potential alternative treatment for toxoplasmosis.
    Mesh-Begriff(e) Animals ; Cell Proliferation ; Macrophages/drug effects ; Macrophages/parasitology ; Metal Nanoparticles ; Mice ; RAW 264.7 Cells ; Reactive Oxygen Species/metabolism ; Silver/pharmacology ; Toxoplasma ; Toxoplasmosis/drug therapy ; Tumor Necrosis Factor-alpha/metabolism
    Chemische Substanzen Reactive Oxygen Species ; Tumor Necrosis Factor-alpha ; Silver (3M4G523W1G)
    Sprache Englisch
    Erscheinungsdatum 2022-03-25
    Erscheinungsland France
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1465093-9
    ISSN 1769-714X ; 1286-4579
    ISSN (online) 1769-714X
    ISSN 1286-4579
    DOI 10.1016/j.micinf.2022.104971
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  7. Artikel ; Online: The cytotoxic and anti-leishmanial activity of Oregano (Origanum vulgare) essential oil: An in vitro, in vivo, and in silico study

    Tomiotto-Pellissier, Fernanda / Bortoleti, Bruna Taciane da Silva / Concato, Virgínia Márcia / Ganaza, Ana Flávia Marques / Quasne, Ana Carolina / Ricci, Beatriz / Dolce e Carvalho, Pedro Vinicius / Della Colleta, Gustavo Henrique / Lazarin-Bidóia, Danielle / Silva, Taylon Felipe / Gonçalves, Manoela Daiele / Kobayashi, Renata Katsuko Takayama / Nakazato, Gerson / Costa, Idessania Nazareth / Conchon-Costa, Ivete / Miranda-Sapla, Milena Menegazzo / Pavanelli, Wander Rogério

    Industrial Crops & Products. 2022 Nov., v. 187 p.115367-

    2022  

    Abstract: This study was aimed at investigating the leishmanicidal and immunomodulatory of oregano essential oil (OEO) from Origanum vulgare on experimental Leishmania amazonensis-model through in silico, in vitro, and in vivo approaches. For this purpose, drug- ... ...

    Abstract This study was aimed at investigating the leishmanicidal and immunomodulatory of oregano essential oil (OEO) from Origanum vulgare on experimental Leishmania amazonensis-model through in silico, in vitro, and in vivo approaches. For this purpose, drug-likeness prediction of OEO main components in silico was assessed, the leishmanicidal activity against promastigotes and amastigote-infected macrophages, as well its microbicide and immunomodulatory mechanisms in vitro, and the in vivo treatment on L. amazonensis-infected mice. It was demonstrated that OEO containing carvacrol, thymol, γ-terpinene, p-cymene, and β-caryophyllene as the main components is a good candidate for oral and topical drug development according to the in silico study, acting against L. amazonensis in vitro and in vivo in murine model. OEO acted on promastigote forms, triggering a combination of autophagic, apoptotic, and necrotic events, as well as in intramacrophagic amastigote forms, without triggering a pro-inflammatory response, showing reduced TNF-α, reactive oxygen species, and nitric oxide levels with high arginase-1/iNOS ratio. The in vivo study confirmed the OEO anti-leishmanial potential, reducing the lesions of infected mice. Computational docking analysis suggested the arginase-carvacrol interactions by spontaneous binding proposing probable antileishmanial targets of OEO. The study provided new perspectives to the OEO treatment, showing its effect against L. amazonensis, providing support for further studies of antileishmanial drugs.
    Schlagwörter Leishmania ; Origanum vulgare ; animal models ; antileishmanial properties ; apoptosis ; carvacrol ; computer simulation ; cytotoxicity ; disinfectants ; drug development ; inflammation ; macrophages ; nitric oxide ; oregano ; oregano oil ; p-cymene ; prediction ; promastigotes ; reactive oxygen species ; thymol ; CCR2 ; CCL2 ; CCR5 ; TLC ; Antiprotozoal ; Lamiaceae ; TNF-α
    Sprache Englisch
    Erscheinungsverlauf 2022-11
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel ; Online
    ZDB-ID 1132158-1
    ISSN 1872-633X ; 0926-6690
    ISSN (online) 1872-633X
    ISSN 0926-6690
    DOI 10.1016/j.indcrop.2022.115367
    Datenquelle NAL Katalog (AGRICOLA)

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  8. Artikel ; Online: Thiohydantoins as anti-leishmanial agents:

    Camargo, Priscila Goes / Bortoleti, Bruna Taciane da Silva / Fabris, Marcieli / Gonçalves, Manoela Daiele / Tomiotto-Pellissier, Fernanda / Costa, Idessania Nazareth / Conchon-Costa, Ivete / Lima, Camilo Henrique da Silva / Pavanelli, Wander Rogério / Bispo, Marcelle de Lima Ferreira / Macedo, Fernando

    Journal of biomolecular structure & dynamics

    2020  Band 40, Heft 7, Seite(n) 3213–3222

    Abstract: Leishmaniasis is a neglected tropical disease caused by protozoa of the ... ...

    Abstract Leishmaniasis is a neglected tropical disease caused by protozoa of the genus
    Mesh-Begriff(e) Antiprotozoal Agents/chemistry ; Antiprotozoal Agents/pharmacology ; Humans ; Leishmania ; Leishmaniasis/drug therapy ; Molecular Docking Simulation ; Thiohydantoins/pharmacology
    Chemische Substanzen Antiprotozoal Agents ; Thiohydantoins
    Sprache Englisch
    Erscheinungsdatum 2020-11-13
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2020.1845979
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  9. Artikel ; Online: Murine Susceptibility to

    Tomiotto-Pellissier, Fernanda / Miranda-Sapla, Milena Menegazzo / Silva, Taylon Felipe / Bortoleti, Bruna Taciane da Silva / Gonçalves, Manoela Daiele / Concato, Virginia Márcia / Rodrigues, Ana Carolina Jacob / Detoni, Mariana Barbosa / Costa, Idessania Nazareth / Panis, Carolina / Conchon-Costa, Ivete / Bordignon, Juliano / Pavanelli, Wander Rogério

    Frontiers in cellular and infection microbiology

    2021  Band 11, Seite(n) 687633

    Abstract: Cutaneous leishmaniasis is a zoonotic infectious disease broadly distributed worldwide, causing a range of diseases with clinical outcomes ranging from self-healing infections to chronic disfiguring disease. The effective immune response to this ... ...

    Abstract Cutaneous leishmaniasis is a zoonotic infectious disease broadly distributed worldwide, causing a range of diseases with clinical outcomes ranging from self-healing infections to chronic disfiguring disease. The effective immune response to this infection is yet to be more comprehensively understood and is fundamental for developing drugs and vaccines. Thus, we used experimental models of susceptibility (BALB/c) and partial resistance (C57BL/6) to
    Mesh-Begriff(e) Animals ; Arginase ; Leishmania ; Leishmaniasis, Cutaneous ; Macrophages ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL
    Chemische Substanzen Arg1 protein, mouse (EC 3.5.3.1) ; Arginase (EC 3.5.3.1)
    Sprache Englisch
    Erscheinungsdatum 2021-10-01
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2021.687633
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Caryocar coriaceum

    Tomiotto-Pellissier, Fernanda / Alves, Daniela Ribeiro / Morais, Selene Maia de / Bortoleti, Bruna Taciane da Silva / Gonçalves, Manoela Daiele / Silva, Taylon Felipe / Tavares, Eliandro Reis / Yamauchi, Lucy Megumi / Costa, Idessania Nazareth / Marinho, Emmanuel Silva / Marinho, Marcia Machado / Conchon-Costa, Ivete / Miranda-Sapla, Milena Menegazzo / Pavanelli, Wander Rogério

    Journal of biomolecular structure & dynamics

    2021  Band 40, Heft 17, Seite(n) 8040–8055

    Abstract: Leishmaniasis is a group of neglected diseases caused by parasites of ... ...

    Abstract Leishmaniasis is a group of neglected diseases caused by parasites of the
    Mesh-Begriff(e) Animals ; Antioxidants/pharmacology ; Antiprotozoal Agents/pharmacology ; Ferritins/metabolism ; Ferritins/pharmacology ; Ferritins/therapeutic use ; Flavonoids/pharmacology ; Fruit ; Humans ; Iron/metabolism ; Leishmania ; Leishmaniasis/drug therapy ; Malpighiales/metabolism ; Mice ; Mice, Inbred BALB C ; NF-E2-Related Factor 2/metabolism ; Phosphatidylserines/metabolism ; Phosphatidylserines/pharmacology ; Phosphatidylserines/therapeutic use ; Reactive Oxygen Species/metabolism ; Rutin/pharmacology ; Rutin/therapeutic use
    Chemische Substanzen Antioxidants ; Antiprotozoal Agents ; Flavonoids ; NF-E2-Related Factor 2 ; Phosphatidylserines ; Reactive Oxygen Species ; Rutin (5G06TVY3R7) ; Ferritins (9007-73-2) ; Iron (E1UOL152H7)
    Sprache Englisch
    Erscheinungsdatum 2021-03-26
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2021.1905557
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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