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  1. Article ; Online: Ion Microscope Imaging Mass Spectrometry Using a Timepix3-Based Optical Camera.

    Wood, Daniel / Burleigh, Robert J / Smith, Natasha / Bortoletto, Daniela / Brouard, Mark / Burt, Michael / Nomerotski, Andrei / Plackett, Richard / Shipsey, Ian

    Journal of the American Society for Mass Spectrometry

    2022  Volume 33, Issue 12, Page(s) 2328–2332

    Abstract: Ion microscopy allows for high-throughput mass spectrometry imaging. In order to resolve congested mass spectra, a high degree of timing precision is required from the microscope detector. In this paper we present an ion microscope mass spectrometer that ...

    Abstract Ion microscopy allows for high-throughput mass spectrometry imaging. In order to resolve congested mass spectra, a high degree of timing precision is required from the microscope detector. In this paper we present an ion microscope mass spectrometer that uses a Timepix3 hybrid pixel readout with an optimal 1.56 ns resolution. A novel triggering technique is also employed to remove the need for an external time-to-digital converter (TDC) and allow the experiment to be performed using a low-cost and commercially available readout system. Results obtained from samples of rhodamine B demonstrate the application of multimass imaging sensors for microscope mass spectrometry imaging with high mass resolution.
    MeSH term(s) Microscopy
    Language English
    Publishing date 2022-11-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1073671-2
    ISSN 1879-1123 ; 1044-0305
    ISSN (online) 1879-1123
    ISSN 1044-0305
    DOI 10.1021/jasms.2c00223
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online: Preserving physically important variables in optimal event selections

    Windischhofer, Philipp / Zgubic, Miha / Bortoletto, Daniela

    A case study in Higgs physics

    2019  

    Abstract: Analyses of collider data, often assisted by modern Machine Learning methods, condense a number of observables into a few powerful discriminants for the separation of the targeted signal process from the contributing backgrounds. These discriminants are ... ...

    Abstract Analyses of collider data, often assisted by modern Machine Learning methods, condense a number of observables into a few powerful discriminants for the separation of the targeted signal process from the contributing backgrounds. These discriminants are highly correlated with important physical observables; using them in the event selection thus leads to the distortion of physically relevant distributions. We present a novel method based on a differentiable estimate of mutual information, a measure of non-linear dependency between variables, to construct a discriminant that is statistically independent of a number of selected observables, and so manages to preserve their distributions in the event selection. Our strategy is evaluated in a realistic setting, the analysis of the Standard Model Higgs boson decaying into a pair of bottom quarks. Using the distribution of the invariant mass of the di-b-jet system to extract the Higgs boson signal strength, our method achieves state-of-the-art performance compared to other decorrelation techniques, while significantly improving the sensitivity of a similar, cut-based, analysis published by ATLAS.
    Keywords High Energy Physics - Phenomenology ; Computer Science - Machine Learning
    Publishing date 2019-07-03
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Boosting Higgs pair production in the [Formula: see text] final state with multivariate techniques.

    Behr, J Katharina / Bortoletto, Daniela / Frost, James A / Hartland, Nathan P / Issever, Cigdem / Rojo, Juan

    The European physical journal. C, Particles and fields

    2016  Volume 76, Issue 7, Page(s) 386

    Abstract: The measurement of Higgs pair production will be a cornerstone of the LHC program in the coming years. Double Higgs production provides a crucial window upon the mechanism of electroweak symmetry breaking and has a unique sensitivity to the Higgs ... ...

    Abstract The measurement of Higgs pair production will be a cornerstone of the LHC program in the coming years. Double Higgs production provides a crucial window upon the mechanism of electroweak symmetry breaking and has a unique sensitivity to the Higgs trilinear coupling. We study the feasibility of a measurement of Higgs pair production in the [Formula: see text] final state at the LHC. Our analysis is based on a combination of traditional cut-based methods with state-of-the-art multivariate techniques. We account for all relevant backgrounds, including the contributions from light and charm jet mis-identification, which are ultimately comparable in size to the irreducible 4
    Language English
    Publishing date 2016-07-08
    Publishing country France
    Document type Journal Article
    ZDB-ID 1459069-4
    ISSN 1434-6052 ; 1434-6044
    ISSN (online) 1434-6052
    ISSN 1434-6044
    DOI 10.1140/epjc/s10052-016-4215-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Brassica aphid (Hemiptera: Aphididae) populations are conditioned by climatic variables and parasitism level: a study case of Triângulo Mineiro, Brazil.

    Sampaio, M V / Korndörfer, A P / Pujade-Villar, J / Hubaide, J E A / Ferreira, S E / Arantes, S O / Bortoletto, D M / Guimarães, C M / Sánchez-Espigares, J A / Caballero-López, B

    Bulletin of entomological research

    2017  Volume 107, Issue 3, Page(s) 410–418

    Abstract: Cosmopolitan pests such as Brevicoryne brassicae, Lipaphis pseudobrassicae, and Myzus persicae (Aphididae) cause significant damage to Brassicaceae crops. Assessment of the important biotic and abiotic factors that regulate these pests is an essential ... ...

    Abstract Cosmopolitan pests such as Brevicoryne brassicae, Lipaphis pseudobrassicae, and Myzus persicae (Aphididae) cause significant damage to Brassicaceae crops. Assessment of the important biotic and abiotic factors that regulate these pests is an essential step in the development of effective Integrated Pest Management programs for these aphids. This study evaluated the influence of leaf position, precipitation, temperature, and parasitism on populations of L. pseudobrassicae, M. persicae, and B. brassicae in collard greens fields in the Triângulo Mineiro region (Minas Gerais state), Brazil. Similar numbers of B. brassicae were found on all parts of the collard green plants, whereas M. persicae and L. pseudobrassicae were found in greatest numbers on the middle and lower parts of the plant. While temperature and precipitation were positively related to aphid population size, their effects were not accumulative, as indicated by a negative interaction term. Although Diaeretiella rapae was the main parasitoid of these aphids, hyperparasitism was dominant; the main hyperparasitoid species recovered from plant samples was Alloxysta fuscicornis. Parasitoids seem to have similar distributions on plants as their hosts. These results may help predict aphid outbreaks and gives clues for specific intra-plant locations when searching for and monitoring aphid populations.
    MeSH term(s) Animals ; Aphids/parasitology ; Aphids/physiology ; Brassicaceae/growth & development ; Brazil ; Host-Parasite Interactions ; Hymenoptera/physiology ; Plant Leaves/growth & development ; Rain ; Temperature
    Language English
    Publishing date 2017-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 280516-9
    ISSN 1475-2670 ; 0007-4853
    ISSN (online) 1475-2670
    ISSN 0007-4853
    DOI 10.1017/S0007485317000220
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Brassica aphid (Hemiptera: Aphididae) populations are conditioned by climatic variables and parasitism level: a study case of Triângulo Mineiro, Brazil

    Sampaio, M.V / Korndörfer, A.P / Pujade-Villar, J / Hubaide, J.E.A / Ferreira, S.E / Arantes, S.O / Bortoletto, D.M / Guimarães, C.M / Sánchez-Espigares, J.A / Caballero-López, B

    Bulletin of entomological research. 2017 June, v. 107, no. 3

    2017  

    Abstract: Cosmopolitan pests such as Brevicoryne brassicae, Lipaphis pseudobrassicae, and Myzus persicae (Aphididae) cause significant damage to Brassicaceae crops. Assessment of the important biotic and abiotic factors that regulate these pests is an essential ... ...

    Abstract Cosmopolitan pests such as Brevicoryne brassicae, Lipaphis pseudobrassicae, and Myzus persicae (Aphididae) cause significant damage to Brassicaceae crops. Assessment of the important biotic and abiotic factors that regulate these pests is an essential step in the development of effective Integrated Pest Management programs for these aphids. This study evaluated the influence of leaf position, precipitation, temperature, and parasitism on populations of L. pseudobrassicae, M. persicae, and B. brassicae in collard greens fields in the Triângulo Mineiro region (Minas Gerais state), Brazil. Similar numbers of B. brassicae were found on all parts of the collard green plants, whereas M. persicae and L. pseudobrassicae were found in greatest numbers on the middle and lower parts of the plant. While temperature and precipitation were positively related to aphid population size, their effects were not accumulative, as indicated by a negative interaction term. Although Diaeretiella rapae was the main parasitoid of these aphids, hyperparasitism was dominant; the main hyperparasitoid species recovered from plant samples was Alloxysta fuscicornis. Parasitoids seem to have similar distributions on plants as their hosts. These results may help predict aphid outbreaks and gives clues for specific intra-plant locations when searching for and monitoring aphid populations.
    Keywords Alloxysta ; Brassica ; Brevicoryne brassicae ; Diaeretiella rapae ; Lipaphis ; Myzus persicae ; climatic factors ; collard greens ; crops ; hosts ; hyperparasitism ; hyperparasitoids ; integrated pest management ; leaves ; monitoring ; population size ; temperature ; Brazil
    Language English
    Dates of publication 2017-06
    Size p. 410-418.
    Publishing place Cambridge University Press
    Document type Article
    ZDB-ID 280516-9
    ISSN 1475-2670 ; 0007-4853
    ISSN (online) 1475-2670
    ISSN 0007-4853
    DOI 10.1017/S0007485317000220
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Vaccine effectiveness and use of collar impregnated with insecticide for reducing incidence of Leishmania infection in dogs in an endemic region for visceral leishmaniasis, in Brazil.

    Lopes, E G / Sevá, A P / Ferreira, F / Nunes, C M / Keid, L B / Hiramoto, R M / Ferreira, H L / Oliveira, T M F S / Ovallos, F G / Galati, E A B / Villegas, T J / Bortoletto, D V / Valadas, S Y O B / Soares, R M

    Epidemiology and infection

    2018  Volume 146, Issue 3, Page(s) 401–406

    Abstract: Although a national programme for control of visceral leishmaniosis (VL) is being run in Brazil, the disease continues to spread. This programme is essentially based on culling infected dogs from endemic regions. Thus, there is an urgent need to develop ... ...

    Abstract Although a national programme for control of visceral leishmaniosis (VL) is being run in Brazil, the disease continues to spread. This programme is essentially based on culling infected dogs from endemic regions. Thus, there is an urgent need to develop other control measures against VL to deter its advance. Here, a subunit vaccine, a recombinant vaccine, an insecticide-impregnated collar and the associations between these measures were evaluated for reducing the incidence of Leishmania infection in dogs. This was through a cohort study conducted in an endemic region of Brazil, considering the incidence and time of total exposure over a period of 1 year. The incidence of VL was estimated by means of serological and molecular diagnostic tests, 180 and 360 days after the application of the control measures. The estimates of the effectiveness (EF) were not significant in any cohort. The EF of the subunit vaccine, the recombinant vaccine and the collar were 26.4%, 32.8% and 57.7% and the upper limit of the 95% confidence interval for EF were 63.7%, 67.9% and 82.5%, respectively. In conclusion, under the conditions of this study, none of the immunogens for VL control was sufficiently effective to protect dogs against infection. On the other hand, use of collars impregnated with insecticide seems to constitute a method with better prognosis, corroborating other studies in this field.
    MeSH term(s) Animals ; Brazil/epidemiology ; Cohort Studies ; Dog Diseases/epidemiology ; Dog Diseases/prevention & control ; Dogs ; Incidence ; Insecticides/therapeutic use ; Leishmania infantum/physiology ; Leishmaniasis, Visceral/epidemiology ; Leishmaniasis, Visceral/prevention & control ; Leishmaniasis, Visceral/veterinary ; Vaccination/veterinary ; Vaccines/therapeutic use
    Chemical Substances Insecticides ; Vaccines
    Language English
    Publishing date 2018-01-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632982-2
    ISSN 1469-4409 ; 0950-2688
    ISSN (online) 1469-4409
    ISSN 0950-2688
    DOI 10.1017/S0950268817003053
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Factorization test using B-bar0-->D*+ pi - and an estimate of fDs using B-->DDs-

    Bortoletto / Stone

    Physical review letters

    1990  Volume 65, Issue 24, Page(s) 2951–2954

    Language English
    Publishing date 1990-12-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.65.2951
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  8. Article ; Online: A multifaceted pharmacist intervention to improve antihypertensive adherence: a cluster-randomized, controlled trial (HAPPy trial).

    Stewart, K / George, J / Mc Namara, K P / Jackson, S L / Peterson, G M / Bereznicki, L R / Gee, P R / Hughes, J D / Bailey, M J / Hsueh, Ys A / McDowell, J M / Bortoletto, D A / Lau, R

    Journal of clinical pharmacy and therapeutics

    2014  Volume 39, Issue 5, Page(s) 527–534

    MeSH term(s) Aged ; Antihypertensive Agents/administration & dosage ; Blood Pressure Monitoring, Ambulatory ; Community Pharmacy Services ; Female ; Humans ; Hypertension/drug therapy ; Male ; Medication Adherence ; Pharmacists ; Treatment Outcome ; Victoria
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2014-10
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 639006-7
    ISSN 1365-2710 ; 0269-4727
    ISSN (online) 1365-2710
    ISSN 0269-4727
    DOI 10.1111/jcpt.12185
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: High-precision measurement of the

    Aaltonen, T / Amerio, S / Amidei, D / Anastassov, A / Annovi, A / Antos, J / Apollinari, G / Appel, J A / Arisawa, T / Artikov, A / Asaadi, J / Ashmanskas, W / Auerbach, B / Aurisano, A / Azfar, F / Badgett, W / Bae, T / Barbaro-Galtieri, A / Barnes, V E /
    Barnett, B A / Barria, P / Bartos, P / Bauce, M / Bedeschi, F / Behari, S / Bellettini, G / Bellinger, J / Benjamin, D / Beretvas, A / Bhatti, A / Bland, K R / Blumenfeld, B / Bocci, A / Bodek, A / Bortoletto, D / Boudreau, J / Boveia, A / Brigliadori, L / Bromberg, C / Brucken, E / Budagov, J / Budd, H S / Burkett, K / Busetto, G / Bussey, P / Butti, P / Buzatu, A / Calamba, A / Camarda, S / Campanelli, M / Carls, B / Carlsmith, D / Carosi, R / Carrillo, S / Casal, B / Casarsa, M / Castro, A / Catastini, P / Cauz, D / Cavaliere, V / Cerri, A / Cerrito, L / Chen, Y C / Chertok, M / Chiarelli, G / Chlachidze, G / Cho, K / Chokheli, D / Clark, A / Clarke, C / Convery, M E / Conway, J / Corbo, M / Cordelli, M / Cox, C A / Cox, D J / Cremonesi, M / Cruz, D / Cuevas, J / Culbertson, R / d'Ascenzo, N / Datta, M / de Barbaro, P / Demortier, L / Deninno, M / D'Errico, M / Devoto, F / Di Canto, A / Di Ruzza, B / Dittmann, J R / Donati, S / D'Onofrio, M / Dorigo, M / Driutti, A / Ebina, K / Edgar, R / Elagin, A / Erbacher, R / Errede, S / Esham, B / Farrington, S / Fernández Ramos, J P / Field, R / Flanagan, G / Forrest, R / Franklin, M / Freeman, J C / Frisch, H / Funakoshi, Y / Galloni, C / Garfinkel, A F / Garosi, P / Gerberich, H / Gerchtein, E / Giagu, S / Giakoumopoulou, V / Gibson, K / Ginsburg, C M / Giokaris, N / Giromini, P / Glagolev, V / Glenzinski, D / Gold, M / Goldin, D / Golossanov, A / Gomez, G / Gomez-Ceballos, G / Goncharov, M / González López, O / Gorelov, I / Goshaw, A T / Goulianos, K / Gramellini, E / Grosso-Pilcher, C / Guimaraes da Costa, J / Hahn, S R / Han, J Y / Happacher, F / Hara, K / Hare, M / Harr, R F / Harrington-Taber, T / Hatakeyama, K / Hays, C / Heinrich, J / Herndon, M / Hocker, A / Hong, Z / Hopkins, W / Hou, S / Hughes, R E / Husemann, U / Hussein, M / Huston, J / Introzzi, G / Iori, M / Ivanov, A / James, E / Jang, D / Jayatilaka, B / Jeon, E J / Jindariani, S / Jones, M / Joo, K K / Jun, S Y / Junk, T R / Kambeitz, M / Kamon, T / Karchin, P E / Kasmi, A / Kato, Y / Ketchum, W / Keung, J / Kilminster, B / Kim, D H / Kim, H S / Kim, J E / Kim, M J / Kim, S H / Kim, S B / Kim, Y J / Kim, Y K / Kimura, N / Kirby, M / Kondo, K / Kong, D J / Konigsberg, J / Kotwal, A V / Kreps, M / Kroll, J / Kruse, M / Kuhr, T / Kurata, M / Laasanen, A T / Lammel, S / Lancaster, M / Lannon, K / Latino, G / Lee, H S / Lee, J S / Leo, S / Leone, S / Lewis, J D / Limosani, A / Lipeles, E / Lister, A / Liu, Q / Liu, T / Lockwitz, S / Loginov, A / Lucchesi, D / Lucà, A / Lueck, J / Lujan, P / Lukens, P / Lungu, G / Lys, J / Lysak, R / Madrak, R / Maestro, P / Malik, S / Manca, G / Manousakis-Katsikakis, A / Marchese, L / Margaroli, F / Marino, P / Matera, K / Mattson, M E / Mazzacane, A / Mazzanti, P / McNulty, R / Mehta, A / Mehtala, P / Menzione, A / Mesropian, C / Miao, T / Michielin, E / Mietlicki, D / Mitra, A / Miyake, H / Moed, S / Moggi, N / Moon, C S / Moore, R / Morello, M J / Mukherjee, A / Muller, Th / Murat, P / Mussini, M / Nachtman, J / Nagai, Y / Naganoma, J / Nakano, I / Napier, A / Nett, J / Nigmanov, T / Nodulman, L / Noh, S Y / Norniella, O / Oakes, L / Oh, S H / Oh, Y D / Okusawa, T / Orava, R / Ortolan, L / Pagliarone, C / Palencia, E / Palni, P / Papadimitriou, V / Parker, W / Pauletta, G / Paulini, M / Paus, C / Phillips, T J / Piacentino, G / Pianori, E / Pilot, J / Pitts, K / Plager, C / Pondrom, L / Poprocki, S / Potamianos, K / Pranko, A / Prokoshin, F / Ptohos, F / Punzi, G / Redondo Fernández, I / Renton, P / Rescigno, M / Rimondi, F / Ristori, L / Robson, A / Rodriguez, T / Rolli, S / Ronzani, M / Roser, R / Rosner, J L / Ruffini, F / Ruiz, A / Russ, J / Rusu, V / Sakumoto, W K / Sakurai, Y / Santi, L / Sato, K / Saveliev, V / Savoy-Navarro, A / Schlabach, P / Schmidt, E E / Schwarz, T / Scodellaro, L / Scuri, F / Seidel, S / Seiya, Y / Semenov, A / Sforza, F / Shalhout, S Z / Shears, T / Shepard, P F / Shimojima, M / Shochet, M / Shreyber-Tecker, I / Simonenko, A / Sliwa, K / Smith, J R / Snider, F D / Song, H / Sorin, V / St Denis, R / Stancari, M / Stentz, D / Strologas, J / Sudo, Y / Sukhanov, A / Suslov, I / Takemasa, K / Takeuchi, Y / Tang, J / Tecchio, M / Teng, P K / Thom, J / Thomson, E / Thukral, V / Toback, D / Tokar, S / Tollefson, K / Tomura, T / Torre, S / Torretta, D / Totaro, P / Trovato, M / Ukegawa, F / Uozumi, S / Vázquez, F / Velev, G / Vellidis, K / Vernieri, C / Vidal, M / Vilar, R / Vizán, J / Vogel, M / Volpi, G / Wagner, P / Wallny, R / Wang, S M / Waters, D / Wester, W C / Whiteson, D / Wicklund, A B / Wilbur, S / Williams, H H / Wilson, J S / Wilson, P / Winer, B L / Wittich, P / Wolbers, S / Wolfmeister, H / Wright, T / Wu, X / Wu, Z / Yamamoto, K / Yamato, D / Yang, T / Yang, U K / Yang, Y C / Yao, W-M / Yeh, G P / Yi, K / Yoh, J / Yorita, K / Yoshida, T / Yu, G B / Yu, I / Zanetti, A M / Zeng, Y / Zhou, C / Zucchelli, S

    Science (New York, N.Y.)

    2022  Volume 376, Issue 6589, Page(s) 170–176

    Abstract: The mass of ... ...

    Abstract The mass of the
    Language English
    Publishing date 2022-04-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abk1781
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  10. Article: Inovações na assistência de enfermagem ao paciente ortopédico.

    Corrêa, S H / Bortoletto, D M / de Castro e Silva, M L / Mello, M R

    Revista brasileira de enfermagem

    1984  Volume 37, Issue 2, Page(s) 139–146

    Title translation Innovations in nursing care to orthopedic patients.
    MeSH term(s) Humans ; Orthopedic Equipment ; Orthopedic Nursing
    Language Portuguese
    Publishing date 1984-04
    Publishing country Brazil
    Document type English Abstract ; Journal Article
    ZDB-ID 731983-6
    ISSN 1984-0446 ; 0034-7167
    ISSN (online) 1984-0446
    ISSN 0034-7167
    DOI 10.1590/s0034-71671984000200009
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