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Article ; Online: Pain perception in paediatric patients: evaluation of computerised anaesthesia delivery system vs conventional infiltration anaesthesia in paediatric patients.

Ludovichetti, F S / Zuccon, A / Zambon, G / Pellegrino, G / Signoriello, A G / Milia, E / Bortone, A / Gracco, A / Mazzoleni, S

European journal of paediatric dentistry

2022 Volume 23, Issue 2, Page(s) 153–156

Abstract: Aim: The aim of the present study is to compare the effectiveness of a computerised system (QuickSleeper) compared to traditional syringe in injection of local anaesthetic focusing on the perception of anxiety and pain in paediatric patients.: Methods! ...

Abstract	Aim: The aim of the present study is to compare the effectiveness of a computerised system (QuickSleeper) compared to traditional syringe in injection of local anaesthetic focusing on the perception of anxiety and pain in paediatric patients. Methods: Study design: 100 children aged between 3 and 15 years in need of two dental treatments that required local anaesthesia were selected and treated randomly but alternately with computerised and traditional local anaesthesia. After each anaesthetic injection, patient's anxiety was measured using the Venham test. Results: Electronic anaesthesia showed statistically significant better results than traditional anaesthesia according to the Venham pain scale, in both mandibular and maxillary sites. Statistics: Data were analysed using the paired Wilcoxon test. Conclusion: The computer-assisted anaesthesia system resulted in a significantly lower pain perception score and yielded to helpful, cooperative behaviour. For this reason, it is an advantageous alternative to traditional injection anaesthesia and can avoid invasive treatments and trauma for young patients.
MeSH term(s)	Adolescent ; Anesthesia, Dental/methods ; Anesthesia, Local/methods ; Anesthetics, Local ; Child ; Child, Preschool ; Humans ; Pain/etiology ; Pain Perception
Chemical Substances	Anesthetics, Local
Language	English
Publishing date	2022-07-15
Publishing country	Italy
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2035588-9
ISSN	2035-648X ; 1591-996X
ISSN (online)	2035-648X
ISSN	1591-996X
DOI	10.23804/ejpd.2022.23.02.06
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Zs.A 5002: Show issues

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Article ; Online: Xerostomia: From Pharmacological Treatments to Traditional Medicine-An Overview on the Possible Clinical Management and Prevention Using Systemic Approaches.

Sardellitti, Luigi / Bortone, Antonella / Filigheddu, Enrica / Serralutzu, Francesca / Milia, Egle Patrizia

Current oncology (Toronto, Ont.)

2023 Volume 30, Issue 5, Page(s) 4412–4426

Abstract: Despite high incidence rates and severe complications, the management of xerostomia lacks clinical guidelines. The aim of this overview was to summarize the clinical experience derived from the last 10 years of treatments and prevention using systemic ... ...

Abstract	Despite high incidence rates and severe complications, the management of xerostomia lacks clinical guidelines. The aim of this overview was to summarize the clinical experience derived from the last 10 years of treatments and prevention using systemic compounds. Results showed that the cytoprotective drug amifostine, and its antioxidant agents, are the most discussed as preventive agents of xerostomia in head and neck cancer (HNC) patients. In the presence of the disease, the pharmacological treatments have been mainly directed to stimulate secretion of the damaged salivary glands, or to counteract a decreased capacity of the antioxidant system, in view of an increasing of reactive oxygen species (ROS). However, the data demonstrated low ability of the drugs, together with a great number of side effects, which strongly limit their use. Concerning traditional medicine (TM), valid clinical trials are so limited that neither the efficacy nor the absence of interferences to concomitant chemical therapies can be validated. Consequently, the management of xerostomia and its devastating complications remain a very significant void in daily clinical practice.
MeSH term(s)	Humans ; Radiation-Protective Agents/adverse effects ; Antioxidants ; Xerostomia/drug therapy ; Xerostomia/etiology ; Amifostine/adverse effects ; Medicine, Traditional/adverse effects
Chemical Substances	Radiation-Protective Agents ; Antioxidants ; Amifostine (M487QF2F4V)
Language	English
Publishing date	2023-04-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1236972-x
ISSN	1718-7729 ; 1198-0052
ISSN (online)	1718-7729
ISSN	1198-0052
DOI	10.3390/curroncol30050336
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Zs.A 4305: Show issues

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Article ; Online: Left ventricular summit premature ventricular contractions treated by venous ethanol infusion: Scar assessment by magnetic resonance imaging.

Limite, Luca Rosario / Laborie, Guillaume / Constantin, Justine / Maubon, Antoine / Arcari, Luca / Hebert, Caroline / Bortone, Agustín

Pacing and clinical electrophysiology : PACE

2023 Volume 46, Issue 10, Page(s) 1235–1238

Abstract: Left ventricular (LV) summit premature ventricular contractions (PVCs) are often unresponsive to radiofrequency (RF) ablation. Retrograde venous ethanol infusion (RVEI) can be a valuable alternative in this scenario. A 43-year-old woman without ... ...

Abstract	Left ventricular (LV) summit premature ventricular contractions (PVCs) are often unresponsive to radiofrequency (RF) ablation. Retrograde venous ethanol infusion (RVEI) can be a valuable alternative in this scenario. A 43-year-old woman without structural heart disease presented with LV summit PVCs unresponsive to RF ablation because of their deep-seated origin. Unipolar pace mapping performed through a wire inserted into a branch of the distal great cardiac vein (GCV) demonstrated 12/12 concordance with the clinical PVCs thus indicating close proximity to PVCs' origin. RVEI abolished the PVCs without complications. Subsequently, magnetic resonance imaging (MRI) evidenced an intramural myocardial scar produced by ethanol ablation. In conclusion, RVEI effectively and safely treated PVC arising from a deep site in the LVS. The scar provoked by chemical damage was well characterized by MRI imaging.
MeSH term(s)	Female ; Humans ; Adult ; Ventricular Premature Complexes/surgery ; Cicatrix/surgery ; Ethanol ; Catheter Ablation/methods ; Magnetic Resonance Imaging ; Treatment Outcome
Chemical Substances	Ethanol (3K9958V90M)
Language	English
Publishing date	2023-03-12
Publishing country	United States
Document type	Case Reports
ZDB-ID	424437-0
ISSN	1540-8159 ; 0147-8389
ISSN (online)	1540-8159
ISSN	0147-8389
DOI	10.1111/pace.14680
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Zs.A 1466: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 399: Show issues

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Article ; Online: Double trouble within the coronary sinus: What is the mechanism?

Laborie, Guillaume / Jebberi, Zeynab / Marra, Céline / Bortone, Agustín

Journal of cardiovascular electrophysiology

2019 Volume 30, Issue 5, Page(s) 785–788

MeSH term(s)	Action Potentials ; Aged ; Catheter Ablation ; Coronary Sinus/physiopathology ; Electrophysiologic Techniques, Cardiac ; Heart Rate ; Humans ; Male ; Predictive Value of Tests ; Tachycardia, Supraventricular/diagnosis ; Tachycardia, Supraventricular/etiology ; Tachycardia, Supraventricular/physiopathology ; Tachycardia, Supraventricular/surgery ; Time Factors ; Treatment Outcome
Language	English
Publishing date	2019-02-13
Publishing country	United States
Document type	Case Reports ; Video-Audio Media
ZDB-ID	1025989-2
ISSN	1540-8167 ; 1045-3873
ISSN (online)	1540-8167
ISSN	1045-3873
DOI	10.1111/jce.13870
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Zs.A 2863: Show issues

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Article ; Online: Transcatheter closure of atrial septal defect using intracardiac echocardiography: a two-center, retrospective study.

Lucarelli, Katya / Acquaviva, Tommaso / Ferrero, Paolo / De Cillis, Emanuela / Casamassima, Vito / Basile, Eloisa / Cacciapaglia, Erasmo / Iorio, Elia / Martimucci, Marcello / Cecere, Giacomo / Petti, Pierpaolo / Caruso, Rosa / Langialonga, Tommaso / Bortone, Alessandro / Grimaldi, Massimo / Chessa, Massimo

Journal of cardiovascular medicine (Hagerstown, Md.)

2024 Volume 25, Issue 4, Page(s) 311–317

Abstract: Aims: We present the experience and long-term results of intracardiac echocardiography (ICE)-guided closure of ostium secundum atrial septal defects (ASDs) in two Italian centers and investigate its systematic applicability as the gold standard in ... ...

Abstract	Aims: We present the experience and long-term results of intracardiac echocardiography (ICE)-guided closure of ostium secundum atrial septal defects (ASDs) in two Italian centers and investigate its systematic applicability as the gold standard in routine clinical practice. Methods: We retrospectively evaluated all consecutive patients who underwent an ASD percutaneous closure procedure from March 2008 to February 2020. All patients underwent a preprocedural transesophageal echocardiography (TEE) evaluation. The closures were carried out under fluoroscopic and ICE guidance. A follow-up visit was performed at 1, 3 and 12 months, followed by telephone evaluations approximately every 2 years. Results: Sixty-six patients (29% male individuals), mean age 43 ± 16 years, were treated. In 15 cases, the TEE defect diameter was less than 10 mm, and in 8 of these patients, the ICE intraprocedural sizing increased the maximum diameter by more than 5 mm. Sizing balloon of the defect was performed in 51 cases; 2 patients received an ASD 38 mm device. Eight patients had multiple defects; in three of these, it was necessary to apply two devices. Four patients showed nonsignificant residual shunt; no complications related to the use of ICE were observed. One patient presented the migration of the ASD device into the abdominal aorta, percutaneously retrieved with a snare. No major complications were recorded during the entire follow-up period. Conclusion: This study confirms that ICE monitoring during ASD percutaneous closure is well tolerated and effective; it might be achievable as a routine gold standard by operators willing to use ICE systematically in all transcatheter closure interventions of interatrial communications.
MeSH term(s)	Humans ; Male ; Adult ; Middle Aged ; Female ; Retrospective Studies ; Cardiac Catheterization/adverse effects ; Cardiac Catheterization/methods ; Heart Septal Defects, Atrial/diagnostic imaging ; Heart Septal Defects, Atrial/therapy ; Echocardiography, Transesophageal ; Fluoroscopy ; Treatment Outcome
Language	English
Publishing date	2024-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2223461-5
ISSN	1558-2035 ; 1558-2027
ISSN (online)	1558-2035
ISSN	1558-2027
DOI	10.2459/JCM.0000000000001603
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Zs.A 5210: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 559: Show issues

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Article: Leaves and Fruits Preparations of

Milia, Egle / Bullitta, Simonetta Maria / Mastandrea, Giorgio / Szotáková, Barbora / Schoubben, Aurélie / Langhansová, Lenka / Quartu, Marina / Bortone, Antonella / Eick, Sigrun

Antibiotics (Basel, Switzerland)

2021 Volume 10, Issue 4

Abstract: There is an increasing interest in revisiting plants for drug discovery, proving scientifically their role as remedies. The aim of this review was to give an overview of the ethnopharmacological uses ... ...

Abstract	There is an increasing interest in revisiting plants for drug discovery, proving scientifically their role as remedies. The aim of this review was to give an overview of the ethnopharmacological uses of
Language	English
Publishing date	2021-04-12
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics10040425
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Article ; Online: Clinical evaluation of the efficacy of one self-adhesive composite in dental hypersensitivity.

Pinna, R / Bortone, A / Sotgiu, G / Dore, S / Usai, P / Milia, E

Clinical oral investigations

2015 Volume 19, Issue 7, Page(s) 1663–1672

Abstract: Objectives: The aim of the present study was to investigate the clinical effectiveness over 12 weeks of Vertise Flow(™), a self-adhering composite, in dental hypersensitivity (DH).: Material and methods: The study was conducted as a split-mouth ... ...

Abstract	Objectives: The aim of the present study was to investigate the clinical effectiveness over 12 weeks of Vertise Flow(™), a self-adhering composite, in dental hypersensitivity (DH). Material and methods: The study was conducted as a split-mouth randomized clinical trial. Vertise Flow™ was compared to the following: (1) Universal Dentine Sealant, (2) Clearfil Protect Bond, and (3) Flor-Opal® Varnish. A total of 46 patients with 116 hypersensitive teeth were studied. Pain experience was generated by a cold stimulus and assessed using the visual analog scale (VAS) of pain. The response was recorded before the application of the materials (pre-1), immediately after (post-1), at 1- (post-2), 2- (post-3), and 12-week controls (post-4). Statistical differences in VAS were performed using the Kruskal-Wallis analysis at the different time-points (P < 0.05), adjusting statistical significances for multiple comparisons (Bonferroni correction). Results: All the materials showed any statistically significant differences at the baseline. After the application of each material, a VAS decrease was demonstrated at every post-control. VF showed significant hypersensitivity reduction in post-1. Statistically significant relief was also observed in post-2 while no significant differences were detected in post-3 and post-4. Conclusions: After 12-week controls, there was no statistically significant hypersensitivity reduction using VF in respect to the other materials. On the other hand, any significant differences were detected in the decrease of the VAS irrespective of the desensitizing agent employed at the 12-week controls. Clinical relevance: The significant increase in VAS scores within the 12-weeks of environment suggested there is instability of VF when used as desensitizing agent.
MeSH term(s)	Dental Cements/therapeutic use ; Dentin Sensitivity/etiology ; Female ; Humans ; Male ; Treatment Outcome
Chemical Substances	Dental Cements
Language	English
Publishing date	2015-09
Publishing country	Germany
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	1364490-7
ISSN	1436-3771 ; 1432-6981
ISSN (online)	1436-3771
ISSN	1432-6981
DOI	10.1007/s00784-014-1390-3
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Zs.A 4788: Show issues

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Article ; Online: 90 vs 50-Watt Radiofrequency Applications for Pulmonary Vein Isolation: Experimental and Clinical Findings.

Bortone, Agustín / Albenque, Jean-Paul / Ramirez, F Daniel / Haïssaguerre, Michel / Combes, Stéphane / Constantin, Marion / Laborie, Guillaume / Brault-Noble, Guillaume / Marijon, Éloi / Jaïs, Pierre / Pambrun, Thomas

Circulation. Arrhythmia and electrophysiology

2022 Volume 15, Issue 4, Page(s) e010663

Abstract: Background: Fifty-watt radiofrequency applications have proven to be safe and efficient for pulmonary vein isolation (PVI). However, as PV reconnection still occurs and ablation catheter instability significantly contributes to suboptimal lesion ... ...

Abstract	Background: Fifty-watt radiofrequency applications have proven to be safe and efficient for pulmonary vein isolation (PVI). However, as PV reconnection still occurs and ablation catheter instability significantly contributes to suboptimal lesion formation, a new ablation catheter capable of delivering 90 W for 4 seconds only has been developed with the aim of improving PVI outcomes. In this setting, we sought to determine whether 90 W applications create transmural lesions without collateral damage experimentally and whether they can safely improve PVI procedures clinically compared with 50 W settings. Methods: Experimentally, individual lesions were created in vivo in the right atrium of 6 swine with 90 W-4 seconds applications using the SmartTouch-SF catheter in a power-controlled mode (3 animals) or the QDOT-MICRO catheter in a temperature-controlled mode (3 animals). Clinically, PVI was performed in a homogenous population of 150 consecutive paroxysmal atrial fibrillation patients using CARTO and the QDOT-MICRO catheter in a temperature-controlled mode (75 patients 50 W-ablation index-guided and 75 patients 90 W-4 seconds). Results: Mostly, (94.9%) experimental lesions were transmural in the thin-walled right atrium of swine. However, collateral damage was observed with both catheters in 17.9% of lesions. Clinically, 90 W procedures had a lower first-pass PVI rate (49% versus 81%, Conclusions: Experimentally, using the QDOT-MICRO catheter, 90 W-4 seconds lesions are mostly transmural in the thin-walled right atrium of swine (median depth 1.87 mm) with a moderate lesion diameter of 6.62 mm but retain the potential for collateral damage. Clinically, 90 W-4 seconds applications are associated with a lower first-pass PVI rate and a higher acute PV reconnection rate than 50 W applications but similar safety outcomes and effectiveness at 1 year.
MeSH term(s)	Animals ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/surgery ; Catheter Ablation/adverse effects ; Catheter Ablation/methods ; Catheters ; Heart Atria/surgery ; Humans ; Pulmonary Veins/surgery ; Recurrence ; Swine ; Treatment Outcome
Language	English
Publishing date	2022-04-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2426129-4
ISSN	1941-3084 ; 1941-3149
ISSN (online)	1941-3084
ISSN	1941-3149
DOI	10.1161/CIRCEP.121.010663
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Zs.A 6667: Show issues

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Article ; Online: Radiofrequency ablation of an atrial tachycardia emanating from the non-coronary aortic Cusp guided by an electroanatomic navigation system.

Bortone, Agustin / Maupas, Eric

Indian pacing and electrophysiology journal

2010 Volume 10, Issue 2, Page(s) 99–103

Abstract: We report on an atrial tachycardia (AT), emanating from the non-coronary (NC) aortic cusp, ablated with the aid of an electro-anatomical navigation system. In this setting, the electrocardiographic, electrophysiologic (EP), anatomical, and ablative ... ...

Abstract	We report on an atrial tachycardia (AT), emanating from the non-coronary (NC) aortic cusp, ablated with the aid of an electro-anatomical navigation system. In this setting, the electrocardiographic, electrophysiologic (EP), anatomical, and ablative considerations are discussed.Although NC aortic cusp focal ATs are an uncommon EP finding, their ablation is effective and safe, especially from an atrio-ventricular (AV) conductive point of view. This origin of AT must be invoked and systematically disclosed when a peri-AV nodal AT origin is suspected, in order to avoid a potentially harmful energy application at the vicinity of the AV conductive tissue.
Language	English
Publishing date	2010-02-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2123606-9
ISSN	0972-6292 ; 0972-6292
ISSN (online)	0972-6292
ISSN	0972-6292
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Article ; Online: Successful radiofrequency ablation of persistent atrial fibrillation in a patient with mechanical mitral valve prosthesis: utility of merging computed tomography of the left atrium with its electroanatomic mapping reconstruction.

Bortone, Agustín / Appetiti, Anthony

Heart rhythm

2009 Volume 6, Issue 9, Page(s) 1388–1389

MeSH term(s)	Atrial Fibrillation/diagnosis ; Atrial Fibrillation/surgery ; Body Surface Potential Mapping ; Catheter Ablation ; Chronic Disease ; Female ; Heart Atria/pathology ; Heart Valve Prosthesis ; Humans ; Middle Aged ; Mitral Valve ; Time Factors ; Tomography, X-Ray Computed ; Treatment Outcome
Language	English
Publishing date	2009-09
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2229357-7
ISSN	1556-3871 ; 1547-5271
ISSN (online)	1556-3871
ISSN	1547-5271
DOI	10.1016/j.hrthm.2008.12.001
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