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  1. AU="Bortz, Cole"
  2. AU="Clarke, Julia R"
  3. AU=Jordan William D Jr
  4. AU="Frangaj, Brulinda"
  5. AU="Oostindjer, Andrew"
  6. AU="Diarra, Zoumana"
  7. AU="Saragoni, V G"

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  1. Artikel ; Online: Critical incidents in Colorado's opioid treatment programs: A comparison of the COVID-19 pandemic to previous years.

    Bortz, Cole / Armistead, Isaac / Bonaguidi, Angela / Coyle, D Tyler

    Journal of substance use and addiction treatment

    2024  Band 161, Seite(n) 209342

    Abstract: Introduction: In response to the COVID-19 pandemic, Substance Abuse and Mental Health Services Administration (SAMHSA) guidance allowed opioid treatment programs (OTPs) greater flexibility to provide take-home medication doses to patients. This study ... ...

    Abstract Introduction: In response to the COVID-19 pandemic, Substance Abuse and Mental Health Services Administration (SAMHSA) guidance allowed opioid treatment programs (OTPs) greater flexibility to provide take-home medication doses to patients. This study aims to characterize trends in the rates of critical incidents-safety events occurring in OTPs that are reportable to regulatory entities-across all Colorado OTPs during the COVID-19 pandemic.
    Methods: This study is a retrospective review of critical incidents (CIs) for patients enrolled in Colorado OTPs between the years 2017 to 2022, as recorded in Colorado Behavioral Health Administration's (BHA) Opioid Treatment Program Critical Incident Repository Dataset. March 15, 2020 was considered the start of the COVID-19 pandemic in Colorado, so only incidents which occurred from March 15-December 31 of each year were included. CI rate per 100 patients was calculated by dividing CI annual count between March 15-December 31 by the census of enrolled patients at the calendar midpoint of this period, which is August 7. Means comparison tests assessed differences in CI rates.
    Results: OTP patient enrollment in Colorado increased from 4377 in 2017 to 7327 in 2022. Overall, Medication Diversion accounted for 70 % of CIs, followed by Death (14 %), and Other (5 %). There was a significant increase in the overall rate of CIs from 2017 to 2022 (1.1 % to 3.4 %). The average post-COVID CI rate was higher than pre-COVID (4.0 % vs. 2.4 %). There was no difference, however, in the post-COVID rate of CIs when exclusively compared to 2019 (4.0 % vs. 4.1 %). Post-pandemic years had significantly more CIs per month than pre-pandemic years (27.6 ± 5.6 vs 15.8 ± 3.5). There was no difference in mean monthly CIs between 2019 and post-pandemic (28.5 ± 5.3 vs 27.6 ± 5.6).
    Conclusions: There was no increase in the rate of reportable CIs in Colorado OTPs following the SAMHSA COVID-19 guidance increasing take-home doses when comparing 2019 to post-pandemic years. The notable increase in CI incidence occurred from 2018 to 2019, predating the pandemic. These data offer a measure of reassurance for the safety of increased take-home methadone doses. There should be further consideration of how a greater number of take-home doses might benefit both patients and OTPs.
    Mesh-Begriff(e) Humans ; Colorado/epidemiology ; COVID-19/epidemiology ; Retrospective Studies ; Opioid-Related Disorders/epidemiology ; Male ; Female ; Adult ; Opiate Substitution Treatment ; Middle Aged ; Analgesics, Opioid/therapeutic use ; Analgesics, Opioid/adverse effects ; Substance Abuse Treatment Centers ; Pandemics
    Chemische Substanzen Analgesics, Opioid
    Sprache Englisch
    Erscheinungsdatum 2024-03-20
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Comparative Study
    ISSN 2949-8759
    ISSN (online) 2949-8759
    DOI 10.1016/j.josat.2024.209342
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Buprenorphine Prescribing and Dosing Limits: Evidence and Policy Goals.

    Coyle, David Tyler / Stewart, Stephanie / Bortz, Cole / Manalo, Jane / Ritvo, Alexis / Krsak, Martin

    Substance abuse

    2023  Band 44, Heft 1, Seite(n) 17–23

    Abstract: The opioid misuse epidemic is a serious public health crisis. Opioid-involved deaths continue to rise and the potency of illicitly manufactured synthetic opioids has increased, creating challenges for the healthcare system to provide multifaceted ... ...

    Abstract The opioid misuse epidemic is a serious public health crisis. Opioid-involved deaths continue to rise and the potency of illicitly manufactured synthetic opioids has increased, creating challenges for the healthcare system to provide multifaceted specialized care. Elements of the regulation around buprenorphine, 1 of 3 drugs approved to treat opioid use disorder (OUD), constrain treatment options for patients and providers alike. Updates to this regulatory framework, particularly around dosing and access to care, would enable providers to better treat the changing landscape of opioid misuse. Specific actions to this end are to: (1) Increase buprenorphine dosing flexibility based on FDA labeling which drives payor policies; (2) Restrict local government and institutional impositions of arbitrary access and dosing limits for buprenorphine; and (3) Liberalize buprenorphine initiation and maintenance via telemedicine for OUD.
    Mesh-Begriff(e) Humans ; Buprenorphine/therapeutic use ; Goals ; Analgesics, Opioid/therapeutic use ; Opioid-Related Disorders/drug therapy ; Policy
    Chemische Substanzen Buprenorphine (40D3SCR4GZ) ; Analgesics, Opioid
    Sprache Englisch
    Erscheinungsdatum 2023-04-26
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1458030-5
    ISSN 1547-0164 ; 0889-7077
    ISSN (online) 1547-0164
    ISSN 0889-7077
    DOI 10.1177/08897077231165619
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: 20-year-old male college basketball prospect • wrist pain after falling on wrist • normal ROM • pain with active/passive wrist extension • Dx?

    Bortz, Cole / Khodaee, Morteza

    The Journal of family practice

    2019  Band 68, Heft 8, Seite(n) 462;464;467

    Abstract: Right wrist pain 4 days after falling on wrist while playing basketball. Normal range of motion of wrist and hand. Pain with active and passive wrist extension. ...

    Abstract Right wrist pain 4 days after falling on wrist while playing basketball. Normal range of motion of wrist and hand. Pain with active and passive wrist extension.
    Mesh-Begriff(e) Accidental Falls ; Arthralgia/diagnostic imaging ; Arthralgia/etiology ; Basketball/injuries ; Fractures, Bone/complications ; Fractures, Bone/diagnostic imaging ; Fractures, Bone/therapy ; Humans ; Male ; Range of Motion, Articular ; Triquetrum Bone/injuries ; Wrist Joint ; Young Adult
    Sprache Englisch
    Erscheinungsdatum 2019-10-08
    Erscheinungsland United States
    Dokumenttyp Case Reports
    ZDB-ID 197883-4
    ISSN 1533-7294 ; 0094-3509
    ISSN (online) 1533-7294
    ISSN 0094-3509
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: How Do Colorado Public Libraries Respond to Patron Queries about Opioid Use Disorder? A Secret Shopper Study.

    Kuehl, Carly / Bortz, Cole / Fussner, Holly / Olson, Courtney / Russell, Nicole / Sumner, Robert Andrew / Coyle, D Tyler

    Substance use & misuse

    2022  Band 58, Heft 2, Seite(n) 198–203

    Abstract: ... ...

    Abstract Background
    Mesh-Begriff(e) Humans ; Colorado ; Cross-Sectional Studies ; Opioid-Related Disorders/drug therapy ; Naloxone/therapeutic use ; Opiate Overdose/drug therapy ; Analgesics, Opioid/therapeutic use ; Narcotic Antagonists/therapeutic use ; Drug Overdose
    Chemische Substanzen Naloxone (36B82AMQ7N) ; Analgesics, Opioid ; Narcotic Antagonists
    Sprache Englisch
    Erscheinungsdatum 2022-11-28
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1310358-1
    ISSN 1532-2491 ; 1082-6084
    ISSN (online) 1532-2491
    ISSN 1082-6084
    DOI 10.1080/10826084.2022.2151825
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Pyogenic Vertebral Column Osteomyelitis in Adults: Analysis of Risk Factors for 30-Day and 1-Year Mortality in a Single Center Cohort Study.

    Vettivel, Jeevan / Bortz, Cole / Passias, Peter Gust / Baker, Joseph Frederick

    Asian spine journal

    2019  Band 13, Heft 4, Seite(n) 608–614

    Abstract: Study design: Retrospective cohort study.: Purpose: To describe our experience in the management and outcomes of vertebral column osteomyelitis (VCO), particularly focusing on the risk factors of early and late mortality.: Overview of literature: ... ...

    Abstract Study design: Retrospective cohort study.
    Purpose: To describe our experience in the management and outcomes of vertebral column osteomyelitis (VCO), particularly focusing on the risk factors of early and late mortality.
    Overview of literature: Previous reports suggest a global increase in spinal column infections highlighting significant morbidity and mortality. To date, there have been no reports from our local population, and no previous report has assessed the potential relationship of frailty with mortality in a cohort of patients with VCO.
    Methods: We reviewed 76 consecutive patients with VCO between 2009 and 2016 in Waikato Hospital, New Zealand. Demographic, clinical, microbiological, and treatment data were collected. Comorbidities were noted to calculate the modified Frailty Index (mFI). Mortality at 30 days and 1 year was recorded. Univariate and multivariate analyses were used to identify the predictors of mortality.
    Results: The mean age of patients was 64.1 years, with 77.6% being male. Most patients presented with axial back pain (71.1%), with the lumbar spine most commonly affected (46%). A mean of 2.1 vertebral bodies was involved. Methicillin-sensitive Staphylococcus aureus was the most common organism of infection (35.5%), and 15.8% of patients exhibited polymicrobial infection. Twenty patients (26.3%) underwent surgical intervention, which was more likely in patients with concomitant spinal epidural abscess (odds ratio [OR], 4.88) or spondylodiscitis (OR, 3.81). Mortality rate was 5.2% at 30 days and 22.3% at 1 year. The presence of frailty (OR, 13.62) and chronic renal failure (OR, 13.40) elevated the 30-day mortality risk only in univariate analysis. An increase in age (OR, 1.07) and the number of vertebral levels (OR, 2.30) elevated the 1-year mortality risk in both univariate and multivariate analyses.
    Conclusions: Although the mFI correlated with 30-day mortality in univariate analysis, it was not a significant predictor in multivariate analysis. An increase in age and the number of levels involved elevated the 1-year mortality risk.
    Sprache Englisch
    Erscheinungsdatum 2019-03-15
    Erscheinungsland Korea (South)
    Dokumenttyp Journal Article
    ZDB-ID 2559763-2
    ISSN 1976-7846 ; 1976-1902
    ISSN (online) 1976-7846
    ISSN 1976-1902
    DOI 10.31616/asj.2018.0295
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Epidural Steroid Injections for Management of Degenerative Spondylolisthesis: Little Effect on Clinical Outcomes in Operatively and Nonoperatively Treated Patients.

    Gerling, Michael C / Bortz, Cole / Pierce, Katherine E / Lurie, Jon D / Zhao, Wenyan / Passias, Peter G

    The Journal of bone and joint surgery. American volume

    2020  Band 102, Heft 15, Seite(n) 1297–1304

    Abstract: Background: Although epidural steroid injection (ESI) may provide pain relief for patients with degenerative spondylolisthesis in treatment regimens of up to 4 months, it remains unclear whether ESI affects crossover from nonoperative to operative ... ...

    Abstract Background: Although epidural steroid injection (ESI) may provide pain relief for patients with degenerative spondylolisthesis in treatment regimens of up to 4 months, it remains unclear whether ESI affects crossover from nonoperative to operative management.
    Methods: This retrospective cohort study analyzed 2 groups of surgical candidates with degenerative spondylolisthesis: those who received ESI within 3 months after enrollment (ESI group) and those who did not (no-ESI group). Annual outcomes following enrollment were assessed within operative and nonoperative groups (patients who initially chose or were assigned to surgery or nonoperative treatment) by using longitudinal mixed-effect models with a random subject intercept term accounting for correlations between repeated measurements. Treatment comparisons were performed at follow-up intervals. Area-under-the-curve analysis for all time points assessed the global significance of treatment.
    Results: The study included 192 patients in the no-ESI group and 74 in the ESI group. The no-ESI group had greater baseline Short Form-36 (SF-36) Bodily Pain scores (median, 35 versus 32) and self-reported preference for surgery (38% versus 11%). There were no differences in surgical rates within 4 years after enrollment between the no-ESI and ESI groups (61% versus 62%). The surgical ESI and no-ESI groups also showed no differences in changes in patient-reported outcomes at any follow-up interval or in the 4-year average. Compared with the nonoperative ESI group, the nonoperative no-ESI group showed greater improvements in SF-36 scores for Bodily Pain (p = 0.004) and Physical Function (p = 0.005) at 4 years, Bodily Pain at 1 year (p = 0.002) and 3 years (p = 0.005), and Physical Function at 1 year (p = 0.030) and 2 years (p = 0.002). Of the patients who were initially treated nonsurgically, those who received ESI and those who did not receive ESI did not differ with regard to surgical crossover rates. The rates of crossover to nonoperative treatment by patients who initially chose or were assigned to surgery also did not differ between the ESI and no-ESI groups.
    Conclusions: There was no relationship between ESI and improved clinical outcomes over a 4-year study period for patients who chose or were assigned to receive surgery for degenerative spondylolisthesis. In the nonsurgical group, ESI was associated with inferior pain reduction through 3 years, although this was confounded by greater baseline pain. ESI showed little relationship with surgical crossover.
    Level of evidence: Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
    Mesh-Begriff(e) Aged ; Female ; Glucocorticoids/administration & dosage ; Glucocorticoids/therapeutic use ; Humans ; Injections, Epidural ; Laminectomy ; Low Back Pain/drug therapy ; Low Back Pain/etiology ; Low Back Pain/surgery ; Lumbar Vertebrae ; Male ; Middle Aged ; Retrospective Studies ; Spinal Stenosis/complications ; Spinal Stenosis/etiology ; Spondylolisthesis/complications ; Spondylolisthesis/surgery ; Treatment Outcome
    Chemische Substanzen Glucocorticoids
    Sprache Englisch
    Erscheinungsdatum 2020-08-07
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Multicenter Study ; Observational Study ; Randomized Controlled Trial
    ZDB-ID 220625-0
    ISSN 1535-1386 ; 0021-9355
    ISSN (online) 1535-1386
    ISSN 0021-9355
    DOI 10.2106/JBJS.19.00596
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Defining age-adjusted spinopelvic alignment thresholds: should we integrate BMI?

    Passias, Peter G / Segreto, Frank A / Imbo, Bailey / Williamson, Tyler / Joujon-Roche, Rachel / Tretiakov, Peter / Krol, Oscar / Naessig, Sara / Bortz, Cole A / Horn, Samantha R / Ahmad, Waleed / Pierce, Katherine / Ihejirika, Yael U / Lafage, Virginie

    Spine deformity

    2022  Band 10, Heft 5, Seite(n) 1077–1084

    Abstract: Purpose: To develop age- and BMI-adjusted alignment targets to improve patient-specific management and operative treatment outcomes.: Methods: Retrospective review of a single-center stereographic database. ASD patients receiving operative or non- ... ...

    Abstract Purpose: To develop age- and BMI-adjusted alignment targets to improve patient-specific management and operative treatment outcomes.
    Methods: Retrospective review of a single-center stereographic database. ASD patients receiving operative or non-operative treatment, ≥ 18y/o with complete baseline (BL) ODI scores and radiographic parameters (PT, SVA, PILL, TPA) were included. Patients were stratified by age consistent with US-Normative values (norms) of SF-36(< 35, 35-55, 45-54, 55-64, 65-74, ≥ 75y/o), and dichotomized by BMI (Non-Obese < 30; Obese ≥ 30). Linear regression analysis established normative age- and BMI-specific radiographic thresholds, utilizing previously published age-specific US-Normative ODI values converted from SF-36 PCS (Lafage et al.), in conjunction with BL age and BMI means.
    Results: 486 patients were included (Age: 52.5, Gender: 68.7%F, mean BMI: 26.2, mean ODI: 32.7), 135 of which were obese. Linear regression analysis developed age- and BMI-specific alignment thresholds, indicating PT, SVA, PILL, and TPA to increase with both increased age and increased BMI (all R > 0.5, p < 0.001). For non-obese patients, PT, SVA, PILL, and TPA ranged from 10.0, - 25.8, - 9.0, 3.1 in patients < 35y/o to 27.8, 53.4, 17.7, 25.8 in patients ≥ 75 y/o. Obese patients' PT, SVA, PILL, and TPA ranged from 10.5, - 7.6, - 7.1, 5.8 in patients < 35 y/o to 28.3, 67.0, 19.15, 27.7 in patients ≥ 75y/o. Normative SVA values in obese patients were consistently ≥ 10 mm greater compared to non-obese values, at all ages.
    Conclusion: Significant associations exist between age, BMI, and sagittal alignment. While BMI influenced age-adjusted alignment norms for PT, SVA, PILL, and TPA at all ages, obesity most greatly influenced SVA, with normative values similar to non-obese patients who were 10 years older. Age-adjusted alignment thresholds should take BMI into account, calling for less rigorous alignment objectives in older and obese patients.
    Mesh-Begriff(e) Aged ; Body Mass Index ; Child ; Humans ; Middle Aged ; Obesity/complications ; Quality of Life ; Retrospective Studies ; Treatment Outcome
    Sprache Englisch
    Erscheinungsdatum 2022-06-03
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2717704-X
    ISSN 2212-1358 ; 2212-134X ; 2212-1358
    ISSN (online) 2212-1358 ; 2212-134X
    ISSN 2212-1358
    DOI 10.1007/s43390-022-00522-8
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Predicting 30-Day Perioperative Outcomes in Adult Spinal Deformity Patients With Baseline Paralysis or Functional Dependence.

    Alas, Haddy / Ihejirika, Rivka C / Kummer, Nicholas / Passfall, Lara / Krol, Oscar / Bortz, Cole / Pierce, Katherine E / Brown, Avery / Vasquez-Montes, Dennis / Diebo, Bassel G / Paulino, Carl B / De la Garza Ramos, Rafael / Janjua, Muhammad B / Gerling, Michael C / Passias, Peter G

    International journal of spine surgery

    2022  Band 16, Heft 3, Seite(n) 427–434

    Sprache Englisch
    Erscheinungsdatum 2022-06-20
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ISSN 2211-4599
    ISSN 2211-4599
    DOI 10.14444/8261
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  9. Artikel: Predictors of Complication Severity Following Adult Spinal Deformity Surgery: Smoking Rate, Diabetes, and Osteotomy Increase Risk of Severe Adverse Events.

    Bortz, Cole A / Pierce, Katherine E / Krol, Oscar / Kummer, Nicholas / Passfall, Lara / Egers, Max / Oh, Cheongeun / Horn, Samantha R / Segreto, Frank A / Vasquez-Montes, Dennis / Frangella, Nicholas J / Buza, John A / Raman, Tina / Kuprys, Tomas / Lafage, Renaud / Jankowski, Pawel P / Hassanzadeh, Hamid / Vira, Shaleen N / Diebo, Bassel G /
    Gerling, Michael C / Passias, Peter G

    International journal of spine surgery

    2023  Band 17, Heft 1, Seite(n) 103–111

    Sprache Englisch
    Erscheinungsdatum 2023-02-07
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ISSN 2211-4599
    ISSN 2211-4599
    DOI 10.14444/8393
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  10. Artikel: The Prevalence of Hip Pathologies in Adolescent Idiopathic Scoliosis.

    Bortz, Cole / Williamson, Tyler K / Adenwalla, Ammar / Naessig, Sara / Imbo, Bailey / Passfall, Lara / Krol, Oscar / Tretiakov, Peter / Joujon-Roche, Rachel / Moattari, Kevin / Sagoo, Navraj / Ahmad, Salman / Singh, Vivek / Owusu-Sarpong, Stephane / Vira, Shaleen / Diebo, Bassel / Passias, Peter G

    Journal of orthopaedics

    2022  Band 31, Seite(n) 29–32

    Abstract: Background: Adolescent idiopathic scoliosis (AIS) is the most common form of abnormal spine curvature observed in patients age 10 to 18. Typically characterized by shoulder height and waistline asymmetry, AIS may drive uneven distribution of force in ... ...

    Abstract Background: Adolescent idiopathic scoliosis (AIS) is the most common form of abnormal spine curvature observed in patients age 10 to 18. Typically characterized by shoulder height and waistline asymmetry, AIS may drive uneven distribution of force in the hips, leading to increased rates of concurrent hip diagnoses. The relationship between AIS and concurrent hip diagnoses is underexplored in the literature, and to date, there has been little research comparing rates of hip diagnoses between patients with AIS and those unaffected.
    Purpose: Assess differences in rates and clusters of hip diagnoses between patients with AIS and those unaffected.
    Study design: Retrospective review of Healthcare Cost and Utilization Project's (HCUP) Nationwide Inpatient Sample (NIS).
    Patient sample: 224,504 weighted inpatient discharges.
    Outcome measures: Rates of hip diagnoses.
    Methods: Patients in the NIS database (2005-2013) ages 10-18 years were isolated. Patients were grouped by those diagnosed with AIS (ICD-9: 737.30) and those unaffected. Patient groups were propensity score matched (PSM) for age. Means comparison tests assessed differences in demographic, comorbidity, and diagnosis profiles between patient groups for corresponding age categories. ICD-9 codes were used to identify specific hip diagnoses.
    Results: Following PSM, 24,656 AIS and 24,656 unaffected patients were included. The AIS patient group was comprised of more females (66% vs 59%) and had lower rates of obesity (2.4% vs 3.5%, both p < 0.001). Overall, 1.1% of patients had at least one hip diagnosis: congenital deformity (0.31%), developmental dysplasia (0.24%), recurrent dislocation (0.18%), isolated dislocation (0.09%), osteonecrosis (0.08%), osteochondrosis (0.07%), acquired deformity (0.03%), and osteoarthritis (0.02%). AIS patients had lower rates of osteonecrosis (0.04% vs 0.12%, p = 0.003), but higher rates of all other hip diagnoses, including dysplasia (0.41% vs 0.07%, p < 0.001), recurrent dislocation (0.32% vs 0.03%, p < 0.001), isolated dislocation (0.13% vs 0.06%, p < 0.001), and osteoarthritis (0.04% vs 0.01%, p = 0.084. Co-occurrences of hip diagnoses were relatively rare, with 0.03% patients having more than one hip diagnosis. Rates of co-occurring hip diagnoses did not differ between AIS and unaffected groups (0.04% vs 0.02%, p = 0.225).
    Conclusions: Compared to unaffected patients of similar ages, patients with AIS had higher overall rates of hip diagnoses, including dysplasia and recurrent dislocation. A higher trend of precocious osteoarthritis was also observed at a higher rate in AIS patients, although this difference was not statistically significant. Our results present an argument for surgical realignment in the coronal and sagittal planes to neutralize asymmetrical forces in the hips, and suggest the need for increased awareness and clinical screening for hip-related disorders in AIS patients.
    Level of evidence: III.
    Sprache Englisch
    Erscheinungsdatum 2022-03-10
    Erscheinungsland India
    Dokumenttyp Journal Article
    ZDB-ID 2240839-3
    ISSN 0972-978X
    ISSN 0972-978X
    DOI 10.1016/j.jor.2022.02.017
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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