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  1. Article: Determination of butyric acid dosage based on clinical and experimental studies - a literature review.

    Banasiewicz, Tomasz / Domagalska, Dorota / Borycka-Kiciak, Katarzyna / Rydzewska, Grażyna

    Przeglad gastroenterologiczny

    2020  Volume 15, Issue 2, Page(s) 119–125

    Abstract: Short-chain fatty acids produced by bacteria living in the large intestine are the main energy substrate for the colonocytes. Butyric acid is used for the treatment and prevention of exacerbations of various gastrointestinal diseases: diarrhoea, ... ...

    Abstract Short-chain fatty acids produced by bacteria living in the large intestine are the main energy substrate for the colonocytes. Butyric acid is used for the treatment and prevention of exacerbations of various gastrointestinal diseases: diarrhoea, intestinal inflammations, functional disorders, dysbiosis, and post-surgery or post-chemotherapy conditions. The current standard doses of butyric acid (150-300 mg) range between 1.5-3% and 15-30% of the reported daily demand. Increased metabolism of the colonocytes in conditions involving intestine damage or inflammation, increased energy expenditure during a disease, stimulation of intestine growth in 'stress' conditions with accelerated intestinal passage and increased intestinal excretion, and decreased production of endogenous butyrate due to changes in bacterial flora in different pathological conditions require a significant increase of the supply of this acid. Physiological high demand for butyrate and known mechanisms of pathological conditions indicate that current supplementation doses do not cover the demand and their increase should be considered.
    Language English
    Publishing date 2020-06-08
    Publishing country Poland
    Document type Journal Article ; Review
    ZDB-ID 2596134-2
    ISSN 1897-4317 ; 1895-5770
    ISSN (online) 1897-4317
    ISSN 1895-5770
    DOI 10.5114/pg.2020.95556
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Mesenchymal stem cells for the treatment of complex perianal fistulas in patients with Crohn disease.

    Borycka-Kiciak, Katarzyna / Pietrzak, Anna / Kielar, Maciej / Tarnowski, Wiesław

    Polski przeglad chirurgiczny

    2020  Volume 92, Issue 1, Page(s) 38–47

    Abstract: Treatment of perianal fistulizing Crohn's disease is demanding and burdened with a high percentage of failures, which forces clinicians to search for new, more effective therapeutic options. One of these options is the use of adipose-derived mesenchymal ... ...

    Abstract Treatment of perianal fistulizing Crohn's disease is demanding and burdened with a high percentage of failures, which forces clinicians to search for new, more effective therapeutic options. One of these options is the use of adipose-derived mesenchymal stem cells in local administration. Due to their multipotentiality and complex mechanism of action, stem cells are the promising new therapeutic approach for the treatment-refractory complex perianal fistulas - demonstrating both high efficacy and a favorable safety profile. The paper presents current knowledge on the mechanisms of action and manner of administration of mesenchymal stem cells, as well as the effectiveness and safety of their use in the treatment of perianal Crohn's disease based on available literature.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Crohn Disease/complications ; Female ; Humans ; Male ; Mesenchymal Stem Cell Transplantation/methods ; Middle Aged ; Rectal Fistula/etiology ; Rectal Fistula/therapy
    Language English
    Publishing date 2020-04-20
    Publishing country Poland
    Document type Journal Article ; Review
    ZDB-ID 128732-1
    ISSN 2299-2847 ; 0032-373X
    ISSN (online) 2299-2847
    ISSN 0032-373X
    DOI 10.5604/01.3001.0013.2390
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Diagnosis and Treatment of Obstetric Anal Sphincter Injuries: New Evidence and Perspectives.

    Spinelli, Antonino / Laurenti, Virginia / Carrano, Francesco Maria / Gonzalez-Díaz, Enrique / Borycka-Kiciak, Katarzyna

    Journal of clinical medicine

    2021  Volume 10, Issue 15

    Abstract: Perineal injury during childbirth is a common event with important morbidity associated in particular with third-and-fourth degree perineal tears (also referred to as obstetric anal sphincter injuries-OASIS). Early diagnosis of these damages is mandatory ...

    Abstract Perineal injury during childbirth is a common event with important morbidity associated in particular with third-and-fourth degree perineal tears (also referred to as obstetric anal sphincter injuries-OASIS). Early diagnosis of these damages is mandatory to define a prompt therapeutic strategy and thus avoid the development of late-onset consequences, such as faecal incontinence. For this purpose, various diagnostic exams can be performed after a thorough clinical examination. The management of OASIS includes several measures and should be individualized according to the timing and features of the clinical presentation.
    Language English
    Publishing date 2021-07-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm10153261
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  4. Article: Butyric acid - a well-known molecule revisited.

    Borycka-Kiciak, Katarzyna / Banasiewicz, Tomasz / Rydzewska, Grażyna

    Przeglad gastroenterologiczny

    2017  Volume 12, Issue 2, Page(s) 83–89

    Abstract: The properties of butyric acid, and the role it plays in the gastrointestinal tract, have been known for many years. However, the newest research shows that butyric acid still remains a molecule with a potential that has not as yet been fully exploited. ... ...

    Abstract The properties of butyric acid, and the role it plays in the gastrointestinal tract, have been known for many years. However, the newest research shows that butyric acid still remains a molecule with a potential that has not as yet been fully exploited. The article provides an outline of relevant up-to-date knowledge about butyric acid, and presents the expert position on the clinical benefits of using butyric acid products in the therapy of gastrointestinal diseases.
    Language English
    Publishing date 2017-06-13
    Publishing country Poland
    Document type Journal Article ; Review
    ZDB-ID 2596134-2
    ISSN 1897-4317 ; 1895-5770
    ISSN (online) 1897-4317
    ISSN 1895-5770
    DOI 10.5114/pg.2017.68342
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Non-invasive obstetric anal sphincter injury diagnostics using impedance spectroscopy.

    Borycka-Kiciak, Katarzyna / Młyńczak, Marcel / Kiciak, Adam / Pietrzak, Piotr / Dziki, Adam

    Scientific reports

    2019  Volume 9, Issue 1, Page(s) 7097

    Abstract: Obstetric anal sphincter injuries are the most common cause of fecal incontinence in women yet remain under-diagnosed. The aim of this study was to assess the suitability of impedance spectroscopy for diagnosing sphincter injuries arising during delivery. ...

    Abstract Obstetric anal sphincter injuries are the most common cause of fecal incontinence in women yet remain under-diagnosed. The aim of this study was to assess the suitability of impedance spectroscopy for diagnosing sphincter injuries arising during delivery. This was a prospective single-center study. 22 female patients were included: 10 with symptoms of sphincter dysfunction, in the early postpartum period, and 12 unaffected, in the distant period of more than 2 years after natural delivery. The presence, extent and severity of anal sphincters injury was assessed by measuring the sphincter parameters in physical examination, the degree of sphincter damage in endoanal ultrasound imaging and the sphincters function parameters in anorectal manometry. All measurements were used as references and compared with the outcomes from the impedance spectroscopy models. Impedance spectroscopy showed the highest precision (with mean accuracy of 83.9%) in relation to transanal ultrasonography. 74.1% of its results corresponded to the results of rectal physical examination and 76.7% - to those of anorectal manometry. The method showed the highest accuracy in the assessment of the sphincter's parameters, both anatomically and functionally. New impedance spectroscopy techniques hold promise for detecting obstetric anal sphincter injuries.
    MeSH term(s) Adult ; Anal Canal/diagnostic imaging ; Anal Canal/injuries ; Data Accuracy ; Delivery, Obstetric/adverse effects ; Dielectric Spectroscopy/instrumentation ; Dielectric Spectroscopy/methods ; Fecal Incontinence/diagnosis ; Fecal Incontinence/etiology ; Female ; Humans ; Manometry/methods ; Middle Aged ; Postpartum Period ; Prospective Studies ; Rectum/physiopathology ; Ultrasonography/methods
    Language English
    Publishing date 2019-05-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-019-43637-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Role of electromyography and functional electrical stimulation in the treatment of anorectal diseases

    Borycka-Kiciak Katarzyna / Wawiernia Karolina / Namysł Jan / Garstka-Namysł Krystyna / Tarnowski Wiesław

    Polish Journal of Surgery, Vol 87, Iss 4, Pp 194-

    2015  Volume 202

    Keywords Medicine (General) ; R5-920 ; Medicine ; R
    Language English
    Publishing date 2015-04-01T00:00:00Z
    Publisher Versita
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Role of electromyography and functional electrical stimulation in the treatment of anorectal diseases.

    Borycka-Kiciak, Katarzyna / Wawiernia, Karolina / Namysł, Jan / Garstka-Namysł, Krystyna / Tarnowski, Wiesław

    Polski przeglad chirurgiczny

    2015  Volume 87, Issue 4, Page(s) 194–202

    MeSH term(s) Anal Canal/physiology ; Electric Stimulation ; Electrodes ; Electronics, Medical ; Rectal Diseases/diagnosis ; Rectal Diseases/therapy ; Sympathetic Nervous System/physiopathology
    Language English
    Publishing date 2015-04
    Publishing country Poland
    Document type Journal Article ; Review
    ZDB-ID 128732-1
    ISSN 2299-2847 ; 0032-373X
    ISSN (online) 2299-2847
    ISSN 0032-373X
    DOI 10.1515/pjs-2015-0044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  8. Article: Perianal infection of highly oncogenic human papilloma virus: how to prevent from cancer? Case report.

    Borycka-Kiciak, Katarzyna / Białas, Agnieszka / Wejman, Jarosław / Uchman-Musielak, Małgorzata / Tarnowski, Wiesław

    Wiadomosci lekarskie (Warsaw, Poland : 1960)

    2015  Volume 68, Issue 2, Page(s) 215–217

    Abstract: The presence of oncogenic types of human papilloma virus (HPV) in location of the anus is related to anal carcinoma. However, there is little knowledge about the natural history of such infections in patients outside risk groups, its relation to cervical ...

    Abstract The presence of oncogenic types of human papilloma virus (HPV) in location of the anus is related to anal carcinoma. However, there is little knowledge about the natural history of such infections in patients outside risk groups, its relation to cervical cancer, the risk of anal cancer development as well as any way to prevent it. There are no standard procedures in the case of finding of HPV-associated anal intraepithelial neoplasia in the perianal area. Case report describes an incidental finding of a highly oncogenic type of HPV discovered in a histopathological assessment of a 48-year old woman after a haemorrhoidectomy. This paper presents the approach taken for this patient in terms of diagnosis, treatment and methods of prevention of anal and cervical cancer development.
    MeSH term(s) Anal Canal/pathology ; Anal Canal/virology ; Anus Neoplasms/etiology ; Anus Neoplasms/prevention & control ; Drug Administration Schedule ; Female ; Fluorouracil/administration & dosage ; Hemorrhoidectomy ; Hemorrhoids/complications ; Hemorrhoids/surgery ; Humans ; Incidental Findings ; Middle Aged ; Papillomaviridae/isolation & purification ; Papillomavirus Infections/complications ; Papillomavirus Infections/pathology ; Precancerous Conditions/prevention & control ; Uterine Cervical Neoplasms/etiology ; Uterine Cervical Neoplasms/prevention & control
    Chemical Substances Fluorouracil (U3P01618RT)
    Language English
    Publishing date 2015
    Publishing country Poland
    Document type Case Reports ; Journal Article
    ZDB-ID 414731-5
    ISSN 0043-5147 ; 1895-0485 ; 0860-8865
    ISSN 0043-5147 ; 1895-0485 ; 0860-8865
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 646: Show issues Location:
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  9. Article ; Online: Laparoscopically assisted ileo-colonic resection in patients with Crohn's disease--preliminary report.

    Borycka-Kiciak, Katarzyna / Dib, Naser / Janaszek, Łukasz / Sołtysiak, Łukasz / Bukowicka, Barbara / Tarnowski, Wiesław

    Polski przeglad chirurgiczny

    2013  Volume 85, Issue 9, Page(s) 505–510

    Abstract: Unlabelled: Despite increasing number of reports indicating good treatment outcomes, laparoscopic treatment of Crohn's disease remains controversial. The aim of the study was to compare outcomes of laparoscopically assisted and open ileo-colonic ... ...

    Abstract Unlabelled: Despite increasing number of reports indicating good treatment outcomes, laparoscopic treatment of Crohn's disease remains controversial. The aim of the study was to compare outcomes of laparoscopically assisted and open ileo-colonic resection in patients with active Crohn's disease.
    Material and methods: 82 patients who underwent surgical treatment (44 laparoscopic and 38 open procedures) at the Department of General, Oncological and Gastrointestinal Surgery in Warsaw were enrolled to the study. The following perioperative parameters were compared in both these groups: duration of hospitalization and presence of postoperative complications in at least 12 months of follow-up.
    Results: The conversion rate in the laparoscopy group was 29.5%. There were no statistically significant differences between the study groups with regard to duration of the surgical procedure, requirement for perioperative transfusions and total number of postoperative complications (19.3% in the laparoscopy group versus 28.9% in the open surgery group). However, amount of analgesic drugs required in the postoperative period was significantly lower (25 ± 6 vs 43 ± 9, p < 0.01) and duration of hospitalization was significantly shorter (9.0 vs 11.3 days, p = 0.021) after laparoscopic versus open procedures procedures. Most of the patients with complicated Crohn's disease who were qualified to laparoscopic treatment, underwent successful treatment using this method. Patients in whom conversion was done, were more likely to be on long term preoperative immunosuppressive therapy versus other patients.
    Conclusions: Laparoscopy is a demanding procedure from the technical point of view, but provides valuable benefits to patients with Crohn's disease, including those with a complicated disease. However, this method requires ongoing improvement of technical aspects and thorough analysis of failures to identify factors that could accurately select patients with indications and contraindications to this procedure.
    MeSH term(s) Adult ; Colon/surgery ; Conversion to Open Surgery/statistics & numerical data ; Crohn Disease/surgery ; Digestive System Surgical Procedures/methods ; Female ; Humans ; Ileum/surgery ; Laparoscopy/methods ; Length of Stay ; Male ; Middle Aged ; Postoperative Complications ; Treatment Outcome
    Language English
    Publishing date 2013-09
    Publishing country Poland
    Document type Comparative Study ; Journal Article
    ZDB-ID 128732-1
    ISSN 2299-2847 ; 0032-373X
    ISSN (online) 2299-2847
    ISSN 0032-373X
    DOI 10.2478/pjs-2013-0078
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    In stock of ZB MED Cologne/Königswinter

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  10. Article ; Online: Early treatment and prevention of the radiation proctitis--composite enemas containing sodium butyrate.

    Stojcev, Zoran / Krokowicz, Łukasz / Krokowicz, Piotr / Szczepkowski, Marek / Borycka-Kiciak, Katarzyna / Kiciak, Adam / Walkowiak, Jarosław / Drews, Michał / Banasiewicz, Tomasz

    International journal of colorectal disease

    2013  Volume 28, Issue 12, Page(s) 1731–1732

    MeSH term(s) Butyric Acid/therapeutic use ; Enema ; Humans ; Proctitis/diagnosis ; Proctitis/drug therapy ; Proctitis/prevention & control ; Radiation Injuries/diagnosis ; Radiation Injuries/drug therapy ; Radiation Injuries/prevention & control
    Chemical Substances Butyric Acid (107-92-6)
    Language English
    Publishing date 2013-03-21
    Publishing country Germany
    Document type Letter ; Randomized Controlled Trial
    ZDB-ID 84975-3
    ISSN 1432-1262 ; 0179-1958
    ISSN (online) 1432-1262
    ISSN 0179-1958
    DOI 10.1007/s00384-013-1682-0
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