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  1. Article ; Online: Visible-light and near-infrared fluorescence and surface-enhanced Raman scattering point-of-care sensing and bio-imaging: a review.

    Hang, Yingjie / Boryczka, Jennifer / Wu, Nianqiang

    Chemical Society reviews

    2022  Volume 51, Issue 1, Page(s) 329–375

    Abstract: This review article deals with the concepts, principles and applications of visible-light and near-infrared (NIR) fluorescence and surface-enhanced Raman scattering (SERS) ... ...

    Abstract This review article deals with the concepts, principles and applications of visible-light and near-infrared (NIR) fluorescence and surface-enhanced Raman scattering (SERS) in
    MeSH term(s) COVID-19 ; Humans ; Nucleic Acids ; Point-of-Care Systems ; SARS-CoV-2 ; Spectrum Analysis, Raman
    Chemical Substances Nucleic Acids
    Language English
    Publishing date 2022-01-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1472875-8
    ISSN 1460-4744 ; 0306-0012
    ISSN (online) 1460-4744
    ISSN 0306-0012
    DOI 10.1039/c9cs00621d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Visible-light and near-infrared fluorescence and surface-enhanced Raman scattering point-of-care sensing and bio-imaging: a review

    Hang, Yingjie / Boryczka, Jennifer / Wu, Nianqiang

    Chemical Society reviews. 2022 Jan. 4, v. 51, no. 1

    2022  

    Abstract: This review article deals with the concepts, principles and applications of visible-light and near-infrared (NIR) fluorescence and surface-enhanced Raman scattering (SERS) in in vitro point-of-care testing (POCT) and in vivo bio-imaging. It has discussed ...

    Abstract This review article deals with the concepts, principles and applications of visible-light and near-infrared (NIR) fluorescence and surface-enhanced Raman scattering (SERS) in in vitro point-of-care testing (POCT) and in vivo bio-imaging. It has discussed how to utilize the biological transparency windows to improve the penetration depth and signal-to-noise ratio, and how to use surface plasmon resonance (SPR) to amplify fluorescence and SERS signals. This article has highlighted some plasmonic fluorescence and SERS probes. It has also reviewed the design strategies of fluorescent and SERS sensors in the detection of metal ions, small molecules, proteins and nucleic acids. Particularly, it has provided perspectives on the integration of fluorescent and SERS sensors into microfluidic chips as lab-on-chips to realize point-of-care testing. It has also discussed the design of active microfluidic devices and non-paper- or paper-based lateral flow assays for in vitro diagnostics. In addition, this article has discussed the strategies to design in vivo NIR fluorescence and SERS bio-imaging platforms for monitoring physiological processes and disease progression in live cells and tissues. Moreover, it has highlighted the applications of POCT and bio-imaging in testing toxins, heavy metals, illicit drugs, cancers, traumatic brain injuries, and infectious diseases such as COVID-19, influenza, HIV and sepsis.
    Keywords COVID-19 infection ; bioimaging ; brain ; diagnostic techniques ; disease progression ; fluorescence ; influenza ; signal-to-noise ratio ; surface plasmon resonance
    Language English
    Dates of publication 2022-0104
    Size p. 329-375.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 1472875-8
    ISSN 1460-4744 ; 0306-0012
    ISSN (online) 1460-4744
    ISSN 0306-0012
    DOI 10.1039/c9cs00621d
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Enabling Direct Protein Detection in a Drop of Whole Blood with an "On-Strip" Plasma Separation Unit in a Paper-Based Lateral Flow Strip.

    Gao, Xuefei / Boryczka, Jennifer / Kasani, Sujan / Wu, Nianqiang

    Analytical chemistry

    2020  Volume 93, Issue 3, Page(s) 1326–1332

    Abstract: Conventional paper lateral flow assays have low sensitivity and suffer from severe interference from complex human fluid sample matrices, which prevents their practical application in the testing of whole blood samples in the point-of-care settings. To ... ...

    Abstract Conventional paper lateral flow assays have low sensitivity and suffer from severe interference from complex human fluid sample matrices, which prevents their practical application in the testing of whole blood samples in the point-of-care settings. To solve this problem, gold nanostar@Raman reporter@silica-sandwiched nanoparticles have been developed as the surface-enhanced Raman scattering (SERS) probes for sensing transduction; and a functionalized filter membrane assembly has been designed and constructed in the paper-based lateral flow strip (PLFS) as a built-in plasma separation unit. In this "on-strip" plasma separation unit, three layers of filter membranes are stacked and surface-modified to maximize the separation efficiency and the plasma yield. As a result, the integrated PLFS has been successfully used for the detection of carcinoembryonic antigen (CEA) in 30 μL of whole blood with the assistance of a portable Raman reader, achieving a limit of detection of 1.0 ng mL
    MeSH term(s) Carcinoembryonic Antigen/blood ; Gold/chemistry ; Humans ; Metal Nanoparticles/chemistry ; Paper ; Reagent Strips/chemistry ; Silicon Dioxide/chemistry ; Spectrum Analysis, Raman
    Chemical Substances Carcinoembryonic Antigen ; Reagent Strips ; Gold (7440-57-5) ; Silicon Dioxide (7631-86-9)
    Language English
    Publishing date 2020-12-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.0c02555
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4033: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Plasmon-enhanced near-infrared fluorescence detection of traumatic brain injury biomarker glial fibrillary acidic protein in blood plasma.

    Zheng, Peng / Kasani, Sujan / Tan, Weirui / Boryczka, Jennifer / Gao, Xuefei / Yang, Feng / Wu, Nianqiang

    Analytica chimica acta

    2022  Volume 1203, Page(s) 339721

    Abstract: An ultrasensitive plasmonic near-infrared fluorescent biosensor substrate has been developed for detection of glial fibrillary acidic protein (GFAP) biomarker in blood plasma, an important protein biomarker of traumatic brain injury (TBI). To minimize ... ...

    Abstract An ultrasensitive plasmonic near-infrared fluorescent biosensor substrate has been developed for detection of glial fibrillary acidic protein (GFAP) biomarker in blood plasma, an important protein biomarker of traumatic brain injury (TBI). To minimize the interference from blood plasma sample matrix, a near-infrared fluorophore in the first biological transparency window is used in the biosensor. To amplify the fluorescence signals, a plasmonic gold nanopyramid array has been coupled to the fluorophore. Finite-difference time-domain simulation reveals that the excitation enhancement is primarily responsible for the fluorescence enhancement owing to the intense local electric field excited on the corners and edges. As a result, this biosensor exhibits a lower limit of detection of 0.6 pg/mL toward detection of GFAP in blood plasma.
    MeSH term(s) Biomarkers/blood ; Biosensing Techniques ; Brain Injuries, Traumatic/diagnostic imaging ; Fluorescence ; Glial Fibrillary Acidic Protein/blood ; Humans
    Chemical Substances Biomarkers ; Glial Fibrillary Acidic Protein
    Language English
    Publishing date 2022-03-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1483436-4
    ISSN 1873-4324 ; 0003-2670
    ISSN (online) 1873-4324
    ISSN 0003-2670
    DOI 10.1016/j.aca.2022.339721
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A "hot Spot"-Enhanced paper lateral flow assay for ultrasensitive detection of traumatic brain injury biomarker S-100β in blood plasma.

    Gao, Xuefei / Boryczka, Jennifer / Zheng, Peng / Kasani, Sujan / Yang, Feng / Engler-Chiurazzi, Elizabeth B / Simpkins, James W / Wigginton, Jane G / Wu, Nianqiang

    Biosensors & bioelectronics

    2021  Volume 177, Page(s) 112967

    Abstract: Currently colorimetric paper lateral flow strips (PLFS) encounter two major limitations, that is, low sensitivity and severe interference from complex sample matrices such as blood. These shortcomings limit their application in detection of low- ... ...

    Abstract Currently colorimetric paper lateral flow strips (PLFS) encounter two major limitations, that is, low sensitivity and severe interference from complex sample matrices such as blood. These shortcomings limit their application in detection of low-concentration analytes in complex samples. To solve these problems, a PLFS has been developed by utilizing surface-enhanced Raman scattering (SERS) for sensing signal transduction. In particular, a hierarchical three-dimensional nanostructure has been designed to create "hot spots", which can significantly amplify the SERS sensing signal, leading to high sensitivity. As a result, this PLFS has demonstrated a limit of detection (LOD) of 5.0 pg mL
    MeSH term(s) Biomarkers ; Biosensing Techniques ; Brain Injuries, Traumatic ; Humans ; Plasma ; S100 Calcium Binding Protein beta Subunit ; Spectrum Analysis, Raman
    Chemical Substances Biomarkers ; S100 Calcium Binding Protein beta Subunit ; S100B protein, human
    Language English
    Publishing date 2021-01-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 1011023-9
    ISSN 1873-4235 ; 0956-5663
    ISSN (online) 1873-4235
    ISSN 0956-5663
    DOI 10.1016/j.bios.2021.112967
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2275: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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