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Article ; Online: Female Reproductive Factors and Risk of New-Onset Heart Failure: Findings From UK Biobank.

Zhu, Fang / Qi, Hongchao / Bos, Maxime / Boersma, Eric / Kavousi, Maryam

2023 Volume 11, Issue 9, Page(s) 1203–1212

Abstract: Background: A comprehensive evaluation of woman-specific risk factors in relation to incident heart failure (HF) is limited.: Objectives: This study sought to investigate the association of multiple female reproductive factors with the risk of HF.: ...

Abstract	Background: A comprehensive evaluation of woman-specific risk factors in relation to incident heart failure (HF) is limited. Objectives: This study sought to investigate the association of multiple female reproductive factors with the risk of HF. Methods: Between 2007 and 2010, 229,026 women (mean age: 56.5 years) without prevalent HF from the UK Biobank cohort were included and followed until December 2020. The relation between (self-reported) reproductive factors and HF was analyzed using Cox proportional hazards models with adjustment for potential confounding. Results: Menarche at age <12 years, compared to age 12-13 years, carried a 9% larger risk of HF (HR: 1.09 [95% CI: 1.01-1.18]). Younger age at menopause was associated with a higher risk of HF (HR Conclusions: The findings emphasize the importance of female reproductive history in the assessment of HF risk.
MeSH term(s)	Child ; Humans ; Female ; Middle Aged ; Adolescent ; Young Adult ; Adult ; Heart Failure/epidemiology ; Prospective Studies ; Reproductive History ; Biological Specimen Banks ; Risk Factors ; United Kingdom/epidemiology
Language	English
Publishing date	2023-04-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2705621-1
ISSN	2213-1787 ; 2213-1779
ISSN (online)	2213-1787
ISSN	2213-1779
DOI	10.1016/j.jchf.2023.02.019
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Article ; Online: Metabolic disorders mediate the relation of miscarriage with cardiovascular diseases.

Zhu, Fang / Noordermeer, Daniëlle / Aribas, Elif / Bos, Maxime / Boersma, Eric / Kavousi, Maryam

European journal of preventive cardiology

2023 Volume 31, Issue 3, Page(s) 330–336

Abstract: Aims: The extent to which the contribution of pregnancy loss to cardiovascular diseases (CVDs) can be explained by metabolic disorders is poorly elucidated but holds insights for reducing long-term cardiovascular risk. The aim of this study is to ... ...

Abstract	Aims: The extent to which the contribution of pregnancy loss to cardiovascular diseases (CVDs) can be explained by metabolic disorders is poorly elucidated but holds insights for reducing long-term cardiovascular risk. The aim of this study is to investigate the mediating effects of hypertension, diabetes mellitus (DM), and lipoprotein metabolism disorders on the association of miscarriage and stillbirth with coronary heart disease (CHD), stroke, heart failure, atrial fibrillation, and composite outcomes. Methods and results: A total of 163 283 ever-gravid women (age 55.3 ± 7.9 years) from the UK Biobank cohort without established metabolic disorders and CVDs were included and followed from 2007 to 2010 baseline until December 2020. Causal mediation analyses were used to estimate the proportion mediated. Hypertension mediated 11.1% (95% confidence interval, 3.7-18.5%) of the association between a history of miscarriage and incident CHD. Approximately, 9.5% (4.1-14.8%) of the effect of recurrent miscarriages on incident CHD was via hypertension, 8.4% (2.5-14.3%) of the effect was via lipoprotein metabolism disorders, 1.7% (0.5-2.9%) of the effect was via DM, and 10.7% (0.2-21.1%) of the effect of recurrent miscarriages on incident stroke was via hypertension. Hypertension mediated the largest proportion of effect for the atherosclerotic cardiovascular event (15.5% for a history of miscarriage and 9.4% for recurrent miscarriages), followed by lipoprotein metabolism disorders and DM. Conclusion: Hypertension, DM, and lipoprotein metabolism disorders mediated the association between miscarriage and various cardiovascular outcomes in later life. In particular, hypertension mediated a large proportion of the relationship between miscarriage and atherosclerotic CVD.
MeSH term(s)	Pregnancy ; Female ; Humans ; Middle Aged ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/complications ; Risk Factors ; Abortion, Habitual ; Hypertension/complications ; Stroke ; Coronary Disease/diagnosis ; Coronary Disease/epidemiology ; Coronary Disease/complications ; Metabolic Diseases ; Lipoproteins
Chemical Substances	Lipoproteins
Language	English
Publishing date	2023-11-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2626011-6
ISSN	2047-4881 ; 2047-4873
ISSN (online)	2047-4881
ISSN	2047-4873
DOI	10.1093/eurjpc/zwad347
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Zs.A 4686: Show issues

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Article ; Online: Association between arterial stiffness/remodeling and new-onset type 2 diabetes mellitus in general population.

Ahmadizar, Fariba / Wang, Kan / Roos, Maurits / Bos, Maxime / Mattace-Raso, Francesco / Kavousi, Maryam

Diabetes research and clinical practice

2023 Volume 196, Page(s) 110237

Abstract: Objective: We studied if large artery stiffness is involved in type 2 diabetes pathogenesis. We also investigated the effect of genetic risk for type 2 diabetes in these associations and the causality.: Research design and methods: In the prospective ...

Abstract	Objective: We studied if large artery stiffness is involved in type 2 diabetes pathogenesis. We also investigated the effect of genetic risk for type 2 diabetes in these associations and the causality. Research design and methods: In the prospective population-based Rotterdam Study (n = 3,055; mean age, 67.2 years), markers of aortic and carotid stiffnesses and measures of arterial remodeling were assessed. Cox proportional hazard regression analysis estimated the associations between arterial stiffness measures with incident type 2 diabetes. We used 403 single nucleotide polymorphisms to calculate the genetic risk score (GRS) for type 2 diabetes. We adopted Mendelian randomization (MR) analysis to evaluate the causal associations. Results: Over a median follow-up of 14.0 years, higher carotid-femoral pulse wave velocity (hazard ratio,1.18; 95 %CI: 1.04-1.35), carotid distensibility coefficient (1.17; 1.04-1.32), and carotid intima-media thickness (1.15; 1.01-1.32) were independently associated with incident diabetes. The associations were stronger among individuals with a higher GRS for type 2 diabetes. MR analysis did not support the causality of the observed associations. Conclusions: Elevated arterial stiffness is independently associated with incident type 2 diabetes. For most arterial stiffness markers, the associations with incident type 2 diabetes were more robust in individuals with a higher GRS for diabetes.
MeSH term(s)	Humans ; Aged ; Diabetes Mellitus, Type 2/complications ; Prospective Studies ; Carotid Intima-Media Thickness ; Vascular Stiffness/genetics ; Pulse Wave Analysis ; Risk Factors ; Carotid Arteries
Language	English
Publishing date	2023-01-05
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	632523-3
ISSN	1872-8227 ; 0168-8227
ISSN (online)	1872-8227
ISSN	0168-8227
DOI	10.1016/j.diabres.2023.110237
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Zs.A 2047: Show issues

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Article ; Online: Circulatory MicroRNAs in Plasma and Atrial Fibrillation in the General Population: The Rotterdam Study.

Geurts, Sven / Mens, Michelle M J / Bos, Maxime M / Ikram, M Arfan / Ghanbari, Mohsen / Kavousi, Maryam

Genes

2021 Volume 13, Issue 1

Abstract: Background: MicroRNAs (miRNAs), small non-coding RNAs regulating gene expression, have been shown to play an important role in cardiovascular disease. However, limited population-based data regarding the relationship between circulatory miRNAs in plasma ...

Abstract	Background: MicroRNAs (miRNAs), small non-coding RNAs regulating gene expression, have been shown to play an important role in cardiovascular disease. However, limited population-based data regarding the relationship between circulatory miRNAs in plasma and atrial fibrillation (AF) exist. Moreover, it remains unclear if the relationship differs by sex. We therefore aimed to determine the (sex-specific) association between plasma circulatory miRNAs and AF at the population level. Methods: Plasma levels of miRNAs were measured using a targeted next-generation sequencing method in 1999 participants from the population-based Rotterdam Study. Logistic regression and Cox proportional hazards models were used to assess the associations of 591 well-expressed miRNAs with the prevalence and incidence of AF. Models were adjusted for cardiovascular risk factors. We further examined the link between predicted target genes of the identified miRNAs. Results: The mean age was 71.7 years (57.1% women), 98 participants (58 men and 40 women) had prevalent AF at baseline. Moreover, 196 participants (96 men and 100 women) developed AF during a median follow-up of 9.0 years. After adjusting for multiple testing, miR-4798-3p was significantly associated with the odds of prevalent AF among men (odds ratio, 95% confidence interval, 0.39, 0.24-0.66, Conclusions: Plasma levels of miR-4798-3p were significantly associated with the odds of prevalent AF among men. Several target genes in relation to AF pathophysiology could potentially be regulated by miR-4798-3p that warrant further investigations in future experimental studies.
MeSH term(s)	Aged ; Atrial Fibrillation/genetics ; Circulating MicroRNA/genetics ; Female ; High-Throughput Nucleotide Sequencing/methods ; Humans ; Male ; Oxidative Stress/genetics
Chemical Substances	Circulating MicroRNA
Language	English
Publishing date	2021-12-22
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes13010011
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Article ; Online: Genetically Determined Higher TSH Is Associated With a Lower Risk of Diabetes Mellitus in Individuals With Low BMI.

Bos, Maxime M / van Vliet, Nicolien A / Mooijaart, Simon P / Noordam, Raymond / van Heemst, Diana

The Journal of clinical endocrinology and metabolism

2021 Volume 106, Issue 7, Page(s) e2502–e2511

Abstract: Context: Thyroid status is hypothesized to be causally related with the risk of diabetes mellitus (DM), but previous results were conflicting possibly because of a complex interaction between thyrotropin (TSH), body mass index (BMI) and DM.: Objective! ...

Abstract	Context: Thyroid status is hypothesized to be causally related with the risk of diabetes mellitus (DM), but previous results were conflicting possibly because of a complex interaction between thyrotropin (TSH), body mass index (BMI) and DM. Objective: This work aims to investigate the causal association between thyroid status with DM and glucose homeostasis and to what extent this association is dependent on BMI. Methods: A mendelian randomization study was conducted of European-ancestry participants from the UK Biobank population. The present study involved 408 895 individuals (mean age 57.4 years [SD 8.0], 45.9% men), of whom 19 773 had DM. Genetic variants for circulatory TSH, free thyroxine (fT4) concentrations and BMI to calculate weighted genetic risk scores. The main outcome measures included self-reported DM-stratified analyses by BMI. Analyses were repeated for nonfasting glucose and glycated hemoglobin A1c (HbA1c) among individuals without DM. Results: Genetically determined TSH and fT4 levels were not associated with risk of DM in the total UK Biobank population. However, in analyses stratified on genetically determined BMI, genetically determined higher TSH, and not fT4, was associated with a lower risk for DM only in the low BMI group (odds ratio 0.91; 95% CI, 0.85-0.98 in low BMI; P value for interaction = .06). Similar results were observed for glucose and HbA1c among individuals without DM. Conclusion: TSH, but not fT4, is a potential causal risk factor for DM in individuals with genetically determined low BMI highlighting potential protective effects of TSH only in low-risk populations.
MeSH term(s)	Adult ; Aged ; Blood Glucose/analysis ; Body Mass Index ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/genetics ; Female ; Genome-Wide Association Study ; Glycated Hemoglobin A/analysis ; Humans ; Male ; Mendelian Randomization Analysis ; Middle Aged ; Odds Ratio ; Polymorphism, Single Nucleotide ; Risk Factors ; Thyroid Function Tests ; Thyrotropin/blood ; Thyroxine/blood ; United Kingdom/epidemiology ; Whites/genetics
Chemical Substances	Blood Glucose ; Glycated Hemoglobin A ; Thyrotropin (9002-71-5) ; Thyroxine (Q51BO43MG4)
Language	English
Publishing date	2021-04-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/clinem/dgab277
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Article: Circulatory MicroRNAs in Plasma and Atrial Fibrillation in the General Population: The Rotterdam Study

Geurts, Sven / Mens, Michelle M. J. / Bos, Maxime M. / Ikram, M. Arfan / Ghanbari, Mohsen / Kavousi, Maryam

Genes. 2021 Dec. 22, v. 13, no. 1

2021

Abstract	Background: MicroRNAs (miRNAs), small non-coding RNAs regulating gene expression, have been shown to play an important role in cardiovascular disease. However, limited population-based data regarding the relationship between circulatory miRNAs in plasma and atrial fibrillation (AF) exist. Moreover, it remains unclear if the relationship differs by sex. We therefore aimed to determine the (sex-specific) association between plasma circulatory miRNAs and AF at the population level. Methods: Plasma levels of miRNAs were measured using a targeted next-generation sequencing method in 1999 participants from the population-based Rotterdam Study. Logistic regression and Cox proportional hazards models were used to assess the associations of 591 well-expressed miRNAs with the prevalence and incidence of AF. Models were adjusted for cardiovascular risk factors. We further examined the link between predicted target genes of the identified miRNAs. Results: The mean age was 71.7 years (57.1% women), 98 participants (58 men and 40 women) had prevalent AF at baseline. Moreover, 196 participants (96 men and 100 women) developed AF during a median follow-up of 9.0 years. After adjusting for multiple testing, miR-4798-3p was significantly associated with the odds of prevalent AF among men (odds ratio, 95% confidence interval, 0.39, 0.24–0.66, p-value = 0.000248). No miRNAs were significantly associated with incident AF. MiR-4798-3p could potentially regulate the expression of a number of AF-related genes, including genes involved in calcium and potassium handling in myocytes, protection of cells against oxidative stress, and cardiac fibrosis. Conclusions: Plasma levels of miR-4798-3p were significantly associated with the odds of prevalent AF among men. Several target genes in relation to AF pathophysiology could potentially be regulated by miR-4798-3p that warrant further investigations in future experimental studies.
Keywords	atrial fibrillation ; calcium ; confidence interval ; fibrosis ; gene expression ; microRNA ; myocytes ; odds ratio ; oxidative stress ; pathophysiology ; potassium ; regression analysis
Language	English
Dates of publication	2021-1222
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2527218-4
ISSN	2073-4425
ISSN	2073-4425
DOI	10.3390/genes13010011
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Apolipoprotein E genotype, lifestyle and coronary artery disease: Gene-environment interaction analyses in the UK Biobank population.

Bos, Maxime M / de Vries, Lina / Rensen, Patrick Cn / Willems van Dijk, Ko / Blauw, Gerard Jan / van Heemst, Diana / Noordam, Raymond

Atherosclerosis

2021 Volume 328, Page(s) 33–37

Abstract: Background and aims: The APOE ε4 genotype has a higher risk for developing coronary artery disease (CAD), but there is preliminary evidence that antioxidative lifestyle factors interact with APOE genotype on CAD risk. Here, we assessed the effect ... ...

Abstract	Background and aims: The APOE ε4 genotype has a higher risk for developing coronary artery disease (CAD), but there is preliminary evidence that antioxidative lifestyle factors interact with APOE genotype on CAD risk. Here, we assessed the effect modification of physical activity, oily fish and polyunsaturated fatty acid (PUFA) intake with APOE genotype on risk of incident CAD. Methods: The present study comprised 345,659 white European participants from UK Biobank (mean age: 56.5 years, 45.7% men) without a history of CAD. Information regarding physical activity, oily fish intake and PUFA intake was collected through questionnaires, and information on incident CAD through linkage with hospital admission records. Analyses were performed using Cox proportional hazard models adjusted for age and sex. Results: Higher physical activity level and oily fish intake were both associated with a lower incidence of CAD. However, these associations were similar across the different APOE genotypes (p-values for interaction > 0.05). Most notable, higher PUFA intake was associated with a lower CAD risk in APOE ε4 genotype carriers (hazard ratio: 0.76, 95% confidence interval: 0.63-0.92), and not in APOE ε3/ε3 genotype carriers (0.90; 0.79, 1.02), but without statistical evidence for effect modification (p-value Conclusions: While higher physical activity and high fish and PUFA intake were associated with a lower risk of incident CAD, no evidence for interaction of these lifestyle factors with APOE genotype was observed in UK Biobank participants. Interventions intended to reduce cardiovascular risk might therefore be similarly effective across the APOE genotype carriers.
MeSH term(s)	Animals ; Apolipoproteins E/genetics ; Biological Specimen Banks ; Coronary Artery Disease/diagnosis ; Coronary Artery Disease/epidemiology ; Coronary Artery Disease/genetics ; Female ; Gene-Environment Interaction ; Genotype ; Humans ; Life Style ; Male ; Middle Aged ; United Kingdom/epidemiology
Chemical Substances	ApoE protein, human ; Apolipoproteins E
Language	English
Publishing date	2021-05-27
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80061-2
ISSN	1879-1484 ; 0021-9150
ISSN (online)	1879-1484
ISSN	0021-9150
DOI	10.1016/j.atherosclerosis.2021.05.014
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Zs.A 226: Show issues

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Article ; Online: BMI-associated gene variants in

Ganeff, Ingeborg M M / Bos, Maxime M / van Heemst, Diana / Noordam, Raymond

Physiological genomics

2019 Volume 51, Issue 8, Page(s) 311–322

Abstract: Obesity is a causal risk factor for the development of age-related disease conditions, which includes Type 2 diabetes mellitus, cardiovascular disease, and dementia. In genome-wide association studies, genetic variation ... ...

Abstract	Obesity is a causal risk factor for the development of age-related disease conditions, which includes Type 2 diabetes mellitus, cardiovascular disease, and dementia. In genome-wide association studies, genetic variation in
MeSH term(s)	Adiposity/genetics ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO/genetics ; Body Mass Index ; Brain Diseases/genetics ; Cardiovascular Diseases/genetics ; Diabetes Mellitus, Type 2/genetics ; Eating/genetics ; Energy Metabolism/genetics ; Genetic Pleiotropy ; Humans ; Obesity/genetics ; Polymorphism, Single Nucleotide/genetics
Chemical Substances	Alpha-Ketoglutarate-Dependent Dioxygenase FTO (EC 1.14.11.33) ; FTO protein, human (EC 1.14.11.33)
Language	English
Publishing date	2019-06-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2038823-8
ISSN	1531-2267 ; 1094-8341
ISSN (online)	1531-2267
ISSN	1094-8341
DOI	10.1152/physiolgenomics.00040.2019
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Zs.A 5697: Show issues

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Article ; Online: Association Between Sex-Specific Risk Factors and Risk of New-Onset Atrial Fibrillation Among Women.

Lu, Zuolin / Aribas, Elif / Geurts, Sven / Roeters van Lennep, Jeanine E / Ikram, M Arfan / Bos, Maxime M / de Groot, Natasja M S / Kavousi, Maryam

JAMA network open

2022 Volume 5, Issue 9, Page(s) e2229716

Abstract: Importance: Atrial fibrillation (AF) is the most common cardiac arrhythmia worldwide, with different epidemiological and pathophysiological processes for women vs men and a poorer prognosis for women. Further investigation of sex-specific risk factors ... ...

Abstract	Importance: Atrial fibrillation (AF) is the most common cardiac arrhythmia worldwide, with different epidemiological and pathophysiological processes for women vs men and a poorer prognosis for women. Further investigation of sex-specific risk factors associated with AF development in women is warranted. Objective: To investigate the linear and potential nonlinear associations between sex-specific risk factors and the risk of new-onset AF in women. Design, setting, and participants: This population-based cohort study obtained data from the 2006 to 2010 UK Biobank study, a cohort of more than 500 000 participants aged 40 to 69 years. Participants were women without AF and history of hysterectomy and/or bilateral oophorectomy at baseline. Median follow-up period for AF onset was 11.6 years, and follow-up ended on October 3, 2020. Exposures: Self-reported, sex-specific risk factors, including age at menarche, history of irregular menstrual cycle, menopause status, age at menopause, years after menopause, age at first live birth, years after last birth, history of spontaneous miscarriages, history of stillbirths, number of live births, and total reproductive years. Main outcomes and measures: The primary outcome was new-onset AF, which was defined by the use of International Statistical Classification of Diseases and Related Health Problems, Tenth Revision code I48. Results: A total of 235 191 women (mean [SD] age, 55.7 [8.1] years) were included in the present study. During follow-up, 4629 (2.0%) women experienced new-onset AF. In multivariable-adjusted models, history of irregular menstrual cycle was associated with higher AF risk (hazard ratio [HR], 1.34; 95% CI, 1.01-1.79). Both early menarche (age 7-11 years; HR, 1.10 [95% CI, 1.00-1.21]) and late menarche (age 13-18 years; HR, 1.08 [95% CI, 1.00-1.17]) were associated with AF incidence. Early menopause (age 35-44 years; HR, 1.24 [95% CI, 1.10-1.39]) and delayed menopause (age ≥60 years; HR, 1.34 [95% CI, 1.10-1.78]) were associated with higher risk of AF. Compared with women with 1 to 2 live births, those with 0 live births (HR, 1.13; 95% CI, 1.04-1.24) or 7 or more live births (HR, 1.67; 95% CI, 1.03-2.70) both had significantly higher AF risk. Conclusions and relevance: Results of this study suggest that irregular menstrual cycles, nulliparity, and multiparity were associated with higher risk of new-onset AF among women. The results highlight the importance of taking into account the reproductive history of women in devising screening strategies for AF prevention.
MeSH term(s)	Atrial Fibrillation/complications ; Atrial Fibrillation/etiology ; Cohort Studies ; Female ; Humans ; Incidence ; Male ; Menopause ; Middle Aged ; Risk Factors
Language	English
Publishing date	2022-09-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2022.29716
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Article ; Online: Disentangling the association between kidney function and atrial fibrillation: a bidirectional Mendelian randomization study.

Geurts, Sven / van der Burgh, Anna C / Bos, Maxime M / Ikram, M Arfan / Stricker, Bruno H C / Deckers, Jaap W / Hoorn, Ewout J / Chaker, Layal / Kavousi, Maryam

International journal of cardiology

2022 Volume 355, Page(s) 15–22

Abstract: Background: The potential bidirectional causal association between kidney function and atrial fibrillation (AF) remains unclear.: Methods: We conducted a bidirectional two-sample Mendelian randomization (MR) analysis. From multiple genome-wide ... ...

Abstract	Background: The potential bidirectional causal association between kidney function and atrial fibrillation (AF) remains unclear. Methods: We conducted a bidirectional two-sample Mendelian randomization (MR) analysis. From multiple genome-wide association studies (GWAS), we retrieved genetic variants associated with kidney function (estimated glomerular filtration rate based on creatinine (eGFRcreat), blood urea nitrogen (BUN), chronic kidney disease (CKD stage ≥G3): n = 1,045,620, eGFR based on cystatin C: n = 24,063-32,861, urine albumin-to-creatinine ratio (UACR), and microalbuminuria: n = 564,257), and AF (n = 1,030,836). The inverse-variance weighted method was used as our main analysis. Results: MR analyses supported a causal effect of CKD (n = 9 SNPs, odds ratio (OR): 1.10, 95% confidence interval (CI): 1.04-1.17, p-value = 1.97 × 10 Conclusions: Our results supported a bidirectional causal association between kidney function and AF. The shared genetic architecture between kidney dysfunction and AF might represent potential important therapeutic targets to prevent both conditions in the general population.
MeSH term(s)	Atrial Fibrillation/diagnosis ; Atrial Fibrillation/epidemiology ; Atrial Fibrillation/genetics ; Genome-Wide Association Study ; Glomerular Filtration Rate/genetics ; Humans ; Kidney ; Mendelian Randomization Analysis ; Polymorphism, Single Nucleotide/genetics
Language	English
Publishing date	2022-03-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2022.03.004
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