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  1. Article ; Online: SARS-CoV-2 PCR negativization in respiratory sample in patients with need for recurring assistance.

    Bassets-Bosch, Alba / Raya-Muñoz, Judith / Wörner-Tomasa, Núria / Melendo-Pérez, Susana / González-Peris, Sebastià

    Anales de pediatria

    2022  Volume 96, Issue 4, Page(s) 357–359

    MeSH term(s) COVID-19/diagnosis ; Humans ; Polymerase Chain Reaction ; Recurrence ; SARS-CoV-2
    Language English
    Publishing date 2022-03-03
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 2830901-7
    ISSN 2341-2879 ; 2341-2879
    ISSN (online) 2341-2879
    ISSN 2341-2879
    DOI 10.1016/j.anpede.2021.01.008
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  2. Article ; Online: Negativización de PCR a SARS-CoV-2 en muestra respiratoria en pacientes con necesidad de asistencia recurrente.

    Bassets-Bosch, Alba / Raya-Muñoz, Judith / Wörner-Tomasa, Núria / Melendo-Pérez, Susana / González-Peris, Sebastià

    Anales de pediatria

    2021  

    Title translation SARS-CoV-2 PCR negativization in respiratory sample in patients with need for recurring assistance.
    Language Spanish
    Publishing date 2021-01-27
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 2830901-7
    ISSN 2341-2879 ; 2341-2879
    ISSN (online) 2341-2879
    ISSN 2341-2879
    DOI 10.1016/j.anpedi.2021.01.006
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  3. Article ; Online: Influence of the mother's lifestyles on the initiation of breastfeeding: A case-control study.

    Del Campo Giménez, María / López-Torres Hidalgo, Jesús / Fernández Bosch, Alba / Martínez de la Torre, Carlos / Minuesa García, María / Córcoles García, Sara / Párraga Martínez, Ignacio

    Anales de pediatria

    2022  Volume 97, Issue 5, Page(s) 342–350

    Abstract: Introduction: Breast milk is the optimal food during the first months of life. The main objective was to analyse the factors associated with not initiating breastfeeding in terms of maternal lifestyles, epidemiological characteristics and information on ...

    Abstract Introduction: Breast milk is the optimal food during the first months of life. The main objective was to analyse the factors associated with not initiating breastfeeding in terms of maternal lifestyles, epidemiological characteristics and information on breastfeeding.
    Material and method: Observational analytical study of cases and controls in 6 primary care centres. The sample included women with a child under 5 years, with an estimated necessary sample size of 166 cases (women who did not initiate breastfeeding) and 166 controls (women who began breastfeeding). Sociodemographic and maternal lifestyle variables were measured before and during pregnancy, such as physical activity using the BPAAT questionnaire, diet with the MEDAS-14 questionnaire, and tobacco and alcohol consumption. We assessed the information and opinions about breastfeeding as well as previous experience with it.
    Results: The study included 348 women (174 cases and 174 controls) with a mean age of 33.4 years (SD, 5.4). The variables independently associated with not initiating breastfeeding were: absence of previous experience with breastfeeding (odds ratio [OR], 12.75), making the decision during pregnancy or delivery (OR, 10.55), not being married or in a partnership (OR, 3.42) and being sedentary for periods of 2 hours or greater/day during pregnancy (OR, 1.77).
    Conclusions: In our study, the determining factors associated with not initiating breastfeeding were the lack of previous experience with breastfeeding, the timing of the decision about breastfeeding, and marital status. When it came to lifestyle, only a sedentary lifestyle was associated with not initiating breastfeeding, while dietary or other habits had no influence.
    MeSH term(s) Pregnancy ; Child ; Humans ; Female ; Adult ; Breast Feeding ; Mothers ; Case-Control Studies ; Milk, Human ; Life Style
    Language English
    Publishing date 2022-09-13
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 2830901-7
    ISSN 2341-2879 ; 2341-2879
    ISSN (online) 2341-2879
    ISSN 2341-2879
    DOI 10.1016/j.anpede.2022.09.002
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  4. Article ; Online: Transfusion for acute upper gastrointestinal bleeding.

    Villanueva, Càndid / Colomo, Alan / Bosch, Alba

    The New England journal of medicine

    2013  Volume 368, Issue 14, Page(s) 1362–1363

    MeSH term(s) Erythrocyte Transfusion/methods ; Gastrointestinal Hemorrhage/therapy ; Hemoglobins/analysis ; Humans
    Chemical Substances Hemoglobins
    Language English
    Publishing date 2013-04-04
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1301256
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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: Prevention of postoperative bleeding in hip fractures treated with prosthetic replacement: efficacy and safety of fibrin sealant and tranexamic acid. A randomised controlled clinical trial (TRANEXFER study).

    Jordan, Marcos / Aguilera, Xavier / González, José Carlos / Castillón, Pablo / Salomó, Mónica / Hernández, José Antonio / Ruiz, Leonardo / Mora, José Maria / Camacho-Carrasco, Pilar / Prat-Fabregat, Salvi / Bosch, Alba / Rodriguez-Arias, Ainhoa / Martínez-Zapata, María José

    Archives of orthopaedic and trauma surgery

    2018  Volume 139, Issue 5, Page(s) 597–604

    Abstract: Introduction: We assessed the efficacy of fibrin sealant (FS) and tranexamic acid (TXA) administered topically in patients with a hip fracture treated with prosthetic replacement.: Materials and methods: Parallel, multicentre, open label, randomised, ...

    Abstract Introduction: We assessed the efficacy of fibrin sealant (FS) and tranexamic acid (TXA) administered topically in patients with a hip fracture treated with prosthetic replacement.
    Materials and methods: Parallel, multicentre, open label, randomised, clinical trial. We compared three interventions to reduce blood loss: (1) 10 ml of FS, (2) 1 g of topical TXA, both administered at the end of the surgery, and (3) usual haemostasis (control group). The main outcome was blood loss collected in drains. Other secondary variables were total blood loss, hidden blood loss, transfusion rate, average hospital stay, complications, adverse events, and mortality.
    Results: A total of 158 patients were included, 56 in the FS group, 52 in the TXA group, and 50 in the control group. The total amount of blood collected in drains was lower in the TXA group (148.6 ml, SD 122.7 in TXA; 168.2 ml, SD 137.4 in FS; and 201.5 ml, SD 166.5 in control group) without achieving statistical significance (p = 0.178). The transfusion rate was lower in the TXA group (32.7%), compared with FS group (42.9%) and control group (44.0%), without statistical significance (p = 0.341). There were no complications or adverse effects related to the evaluated interventions.
    Conclusions: The use of TXA and FS administered topically prior to surgical closure in patients with a sub-capital femoral fracture undergoing arthroplasty did not significantly reduce either postoperative blood loss or transfusion rate, compared with a group that only received usual haemostasis.
    MeSH term(s) Administration, Topical ; Aged ; Aged, 80 and over ; Antifibrinolytic Agents/administration & dosage ; Arthroplasty, Replacement, Hip ; Blood Loss, Surgical/prevention & control ; Female ; Fibrin Tissue Adhesive/administration & dosage ; Hemostasis, Surgical/methods ; Hemostatics/administration & dosage ; Hip Fractures/complications ; Hip Fractures/surgery ; Humans ; Male ; Postoperative Hemorrhage/etiology ; Postoperative Hemorrhage/prevention & control ; Tranexamic Acid/administration & dosage ; Treatment Outcome
    Chemical Substances Antifibrinolytic Agents ; Fibrin Tissue Adhesive ; Hemostatics ; Tranexamic Acid (6T84R30KC1)
    Language English
    Publishing date 2018-12-11
    Publishing country Germany
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 80407-1
    ISSN 1434-3916 ; 0003-9330 ; 0344-8444
    ISSN (online) 1434-3916
    ISSN 0003-9330 ; 0344-8444
    DOI 10.1007/s00402-018-3089-4
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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.58: Show issues Location:
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  6. Article: Efficacy of autologous platelet-rich plasma for the treatment of muscle rupture with haematoma: a multicentre, randomised, double-blind, placebo-controlled clinical trial.

    Martinez-Zapata, Ma José / Orozco, Lluís / Balius, Ramon / Soler, Robert / Bosch, Alba / Rodas, Gil / Til, Lluís / Peirau, Xavier / Urrútia, Gerard / Gich, Ignasi / Bonfill, Xavier

    Blood transfusion = Trasfusione del sangue

    2016  Volume 14, Issue 2, Page(s) 245–254

    Abstract: Background: The goals of the treatment of muscle injuries are to shorten the time of healing and to avoid relapses. The aim of this study was to assess the efficacy of autologous platelet-rich plasma (PRP) in the healing of muscle injuries.: Materials ...

    Abstract Background: The goals of the treatment of muscle injuries are to shorten the time of healing and to avoid relapses. The aim of this study was to assess the efficacy of autologous platelet-rich plasma (PRP) in the healing of muscle injuries.
    Materials and methods: A multicentre, randomised, double-blind, parallel, controlled clinical trial was conducted in 71 patients (81.8% males) aged 45.6 (SD=10.0) years with muscle tears in the legs and haematoma. The haematoma was evacuated in all patients. Thirty-three patients were randomised to a single dose of autologous PRP and 38 patients to simulation of PRP administration. The primary end-point was time to complete recovery of muscle injury. Secondary end-points were pain, relapses, ultrasound parameters, and adverse events. The total follow-up per patient was 12 months.
    Results: Time to complete recovery after the treatment was 31.63 days (SD=15.38) in the PRP group, and 38.43 days (SD=18.58) in the control group (p=0.261). Pain decreased over time in both groups without statistical differences between them. Eight patients relapsed (seven in the control group, and one in the PRP group). There were no adverse effects related to the interventions.
    Discussion: Autologous PRP did not significantly improve the time to healing compared to that in the control group.
    MeSH term(s) Double-Blind Method ; Hematoma ; Humans ; Platelet Transfusion ; Platelet-Rich Plasma ; Tendinopathy/therapy ; Treatment Outcome
    Language English
    Publishing date 2016
    Publishing country Italy
    Document type Journal Article ; Comment
    ZDB-ID 2135732-8
    ISSN 1723-2007 ; 0041-1787
    ISSN 1723-2007 ; 0041-1787
    DOI 10.2450/2015.0099-15
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 798: Show issues Location:
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  7. Article ; Online: Transfusion strategies for acute upper gastrointestinal bleeding.

    Villanueva, Càndid / Colomo, Alan / Bosch, Alba / Concepción, Mar / Hernandez-Gea, Virginia / Aracil, Carles / Graupera, Isabel / Poca, María / Alvarez-Urturi, Cristina / Gordillo, Jordi / Guarner-Argente, Carlos / Santaló, Miquel / Muñiz, Eduardo / Guarner, Carlos

    The New England journal of medicine

    2013  Volume 368, Issue 1, Page(s) 11–21

    Abstract: Background: The hemoglobin threshold for transfusion of red cells in patients with acute gastrointestinal bleeding is controversial. We compared the efficacy and safety of a restrictive transfusion strategy with those of a liberal transfusion strategy.!# ...

    Abstract Background: The hemoglobin threshold for transfusion of red cells in patients with acute gastrointestinal bleeding is controversial. We compared the efficacy and safety of a restrictive transfusion strategy with those of a liberal transfusion strategy.
    Methods: We enrolled 921 patients with severe acute upper gastrointestinal bleeding and randomly assigned 461 of them to a restrictive strategy (transfusion when the hemoglobin level fell below 7 g per deciliter) and 460 to a liberal strategy (transfusion when the hemoglobin fell below 9 g per deciliter). Randomization was stratified according to the presence or absence of liver cirrhosis.
    Results: A total of 225 patients assigned to the restrictive strategy (51%), as compared with 61 assigned to the liberal strategy (14%), did not receive transfusions (P<0.001) [corrected].The probability of survival at 6 weeks was higher in the restrictive-strategy group than in the liberal-strategy group (95% vs. 91%; hazard ratio for death with restrictive strategy, 0.55; 95% confidence interval [CI], 0.33 to 0.92; P=0.02). Further bleeding occurred in 10% of the patients in the restrictive-strategy group as compared with 16% of the patients in the liberal-strategy group (P=0.01), and adverse events occurred in 40% as compared with 48% (P=0.02). The probability of survival was slightly higher with the restrictive strategy than with the liberal strategy in the subgroup of patients who had bleeding associated with a peptic ulcer (hazard ratio, 0.70; 95% CI, 0.26 to 1.25) and was significantly higher in the subgroup of patients with cirrhosis and Child-Pugh class A or B disease (hazard ratio, 0.30; 95% CI, 0.11 to 0.85), but not in those with cirrhosis and Child-Pugh class C disease (hazard ratio, 1.04; 95% CI, 0.45 to 2.37). Within the first 5 days, the portal-pressure gradient increased significantly in patients assigned to the liberal strategy (P=0.03) but not in those assigned to the restrictive strategy.
    Conclusions: As compared with a liberal transfusion strategy, a restrictive strategy significantly improved outcomes in patients with acute upper gastrointestinal bleeding. (Funded by Fundació Investigació Sant Pau; ClinicalTrials.gov number, NCT00414713.).
    MeSH term(s) Acute Disease ; Adult ; Erythrocyte Transfusion/adverse effects ; Erythrocyte Transfusion/methods ; Esophageal and Gastric Varices/therapy ; Gastrointestinal Hemorrhage/blood ; Gastrointestinal Hemorrhage/therapy ; Gastroscopy ; Hematemesis/therapy ; Hemoglobins/analysis ; Humans ; Kaplan-Meier Estimate ; Melena/therapy
    Chemical Substances Hemoglobins
    Language English
    Publishing date 2013-01-03
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMoa1211801
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  8. Article ; Online: Convalescent Plasma for COVID-19: A multicenter, randomized clinical trial

    Avendano-Sola, Cristina / Ramos-Martinez, Antonio / Munez-Rubio, Elena / Ruiz-Antoran, Belen / Malo de Molina, Rosa / Torres, Ferran / Fernandez-Cruz, Ana / Callejas-Diaz, Alejandro / Calderon, Jorge / Payares-Herrera, Concepcion / Salcedo, Isabel / Romera, Irene / Lora-Tamayo, Jaime / Mancheno-Losa, Mikel / Paciello, Maria Liz / Villegas, Carolina / Estrada, Vicente / Saez-Serrano, Isabel / Porras-Leal, Maria Lourdes /
    Jarilla-Fernandez, Maria del Castillo / Pano-Pardo, Jose Ramon / Moreno-Chulilla, Jose Antonio / Arrieta-Aldea, Itziar / Bosch, Alba / Belhassen-Garcia, Moncef / Lopez-Villar, Olga / Ramos-Garrido, Ascension / Blanco, Lydia / Madrigal, Maria Elena / Contreras, Enric / Muniz-Diaz, Eduard / Domingo-Morera, Jose Maria / Casas-Flecha, Inmaculada / Perez-Olmeda, Mayte / Garcia-Perez, Javier / Alcami, Jose / Bueno, Jose Luis / Duarte, Rafael F

    medRxiv

    Abstract: Background: Passive immunotherapy with convalescent plasma (CP) is a potential treatment for COVID-19 for which evidence from controlled clinical trials is lacking. Methods: We conducted a multi-center, randomized clinical trial in patients hospitalized ... ...

    Abstract Background: Passive immunotherapy with convalescent plasma (CP) is a potential treatment for COVID-19 for which evidence from controlled clinical trials is lacking. Methods: We conducted a multi-center, randomized clinical trial in patients hospitalized for COVID-19. All patients received standard of care treatment, including off-label use of marketed medicines, and were randomized 1:1 to receive one dose (250-300 mL) of CP from donors with IgG anti-SARS-CoV-2. The primary endpoint was the proportion of patients in categories 5, 6 or 7 of the COVID-19 ordinal scale at day 15. Results: The trial was stopped after first interim analysis due to the fall in recruitment related to pandemic control. With 81 patients randomized, there were no patients progressing to mechanical ventilation or death among the 38 patients assigned to receive plasma (0%) versus 6 out of 43 patients (14%) progressing in control arm. Mortality rates were 0% vs 9.3% at days 15 and 29 for the active and control groups, respectively. No significant differences were found in secondary endpoints. At inclusion, patients had a median time of 8 days (IQR, 6-9) of symptoms and 49,4% of them were positive for anti-SARS-CoV-2 IgG antibodies. Conclusions: Convalescent plasma could be superior to standard of care in avoiding progression to mechanical ventilation or death in hospitalized patients with COVID-19. The strong dependence of results on a limited number of events in the control group prevents drawing firm conclusions about CP efficacy from this trial. (Funded by Instituto de Salud Carlos III; NCT04345523).
    Keywords covid19
    Language English
    Publishing date 2020-09-01
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2020.08.26.20182444
    Database COVID19

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