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Article ; Online: The necessity of immediate cardio-thoracic surgical cover for high-risk transvenous lead extraction procedures: the Art of lead extraction.

Rinaldi, Christopher A / Bosco, Paolo

2019 Volume 286, Page(s) 85–86

MeSH term(s)	Defibrillators, Implantable ; Device Removal ; Humans ; Shoulder ; Surgeons ; Thoracic Surgical Procedures
Language	English
Publishing date	2019-04-03
Publishing country	Netherlands
Document type	Editorial ; Comment
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2019.04.005
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Article ; Online: Predictors of Outcome in Patients with Pulmonary Hypertension Undergoing Mitral and Tricuspid Valve Surgery.

Kew, Ee Phui / Caruso, Vincenzo / Grapsa, Julia / Bosco, Paolo / Lucchese, Gianluca

Medicina (Kaunas, Lithuania)

2023 Volume 59, Issue 6

Abstract: Background and ... ...

Abstract	Background and Objectives
MeSH term(s)	Humans ; Hypertension, Pulmonary/complications ; Tricuspid Valve/surgery ; Mitral Valve/surgery ; Heart Diseases/surgery ; Retrospective Studies ; Length of Stay ; Mortality ; Ventricular Function, Left ; Treatment Outcome ; Echocardiography ; Male ; Female ; Middle Aged ; Aged ; Survival Analysis ; Renal Insufficiency/complications ; Respiratory Tract Diseases/complications
Language	English
Publishing date	2023-06-07
Publishing country	Switzerland
Document type	Observational Study ; Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina59061103
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Zs.A 6270: Show issues

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Article: Distribution Indices of Magnetic Susceptibility Values in the Primary Motor Cortex Enable to Classify Patients with Amyotrophic Lateral Sclerosis.

Costagli, Mauro / Donatelli, Graziella / Cecchi, Paolo / Bosco, Paolo / Migaleddu, Gianmichele / Siciliano, Gabriele / Cosottini, Mirco

Brain sciences

2022 Volume 12, Issue 7

Abstract: Quantitative Susceptibility Mapping (QSM) can measure iron concentration increase in the primary motor cortex (M1) of patients with Amyotrophic Lateral Sclerosis (ALS). However, such alteration is confined to only specific regions interested by upper ... ...

Abstract	Quantitative Susceptibility Mapping (QSM) can measure iron concentration increase in the primary motor cortex (M1) of patients with Amyotrophic Lateral Sclerosis (ALS). However, such alteration is confined to only specific regions interested by upper motor neuron pathology; therefore, mean QSM values in the entire M1 have limited diagnostic accuracy in discriminating between ALS patients and control subjects. This study investigates the diagnostic accuracy of a broader set of M1 QSM distribution indices in classifying ALS patients and controls. Mean, standard deviation, skewness and kurtosis of M1 QSM values were used either individually or as combined predictors in support vector machines. The classification performance was compared to that obtained by the radiological assessment of T2* signal hypo-intensity of M1 in susceptibility-weighted MRI. The least informative index for the classification of ALS patients and controls was the subject's mean QSM value in M1. The highest diagnostic performance was obtained when all the distribution indices of positive QSM values in M1 were considered, which yielded a diagnostic accuracy of 0.90, with sensitivity = 0.89 and specificity = 1. The radiological assessment of M1 yielded a diagnostic accuracy of 0.79, with sensitivity = 0.76 and specificity = 0.90. The joint evaluation of QSM distribution indices could support the clinical examination in ALS diagnosis and patient monitoring.
Language	English
Publishing date	2022-07-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci12070942
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Article ; Online: Correction: Neutralization of tumor necrosis factor-related apoptosis-inducing ligand reduces spinal cord injury damage in mice.

Cantarella, Giuseppina / Di Benedetto, Giulia / Scollo, Mimmo / Paterniti, Irene / Cuzzocrea, Salvatore / Bosco, Paolo / Nocentini, Giuseppe / Riccardi, Carlo / Bernardini, Renato

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

2023 Volume 49, Issue 6, Page(s) 1061–1062

Language	English
Publishing date	2023-11-29
Publishing country	England
Document type	Published Erratum
ZDB-ID	639471-1
ISSN	1740-634X ; 0893-133X
ISSN (online)	1740-634X
ISSN	0893-133X
DOI	10.1038/s41386-023-01768-0
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Zs.A 2379: Show issues

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Article: Relationship among Connectivity of the Frontal Aslant Tract, Executive Functions, and Speech and Language Impairment in Children with Childhood Apraxia of Speech.

Bombonato, Clara / Cipriano, Emilio / Pecini, Chiara / Casalini, Claudia / Bosco, Paolo / Podda, Irina / Tosetti, Michela / Biagi, Laura / Chilosi, Anna Maria

Brain sciences

2022 Volume 13, Issue 1

Abstract: Childhood apraxia of speech (CAS) is a subtype of motor speech disorder usually co-occurring with language impairment. A supramodal processing difficulty, involving executive functions (EFs), might contribute to the cognitive endophenotypes and ... ...

Abstract	Childhood apraxia of speech (CAS) is a subtype of motor speech disorder usually co-occurring with language impairment. A supramodal processing difficulty, involving executive functions (EFs), might contribute to the cognitive endophenotypes and behavioral manifestations. The present study aimed to profile the EFs in CAS, investigating the relationship between EFs, speech and language severity, and the connectivity of the frontal aslant tract (FAT), a white matter tract involved in both speech and EFs. A total of 30 preschool children with CAS underwent speech, language, and EF assessments and brain MRIs. Their FAT connectivity metrics were compared to those of 30 children without other neurodevelopmental disorders (NoNDs), who also underwent brain MRIs. Alterations in some basic EF components were found. Inhibition and working memory correlated with speech and language severity. Compared to NoND children, a weak, significant reduction in fractional anisotropy (FA) in the left presupplementary motor area (preSMA) FAT component was found. Only speech severity correlated and predicted FA values along with the FAT in both of its components, and visual-spatial working memory moderated the relationship between speech severity and FA in the left SMA. Our study supports the conceptualization of a composite and complex picture of CAS, not limited to the speech core deficit, but also involving high-order cognitive skills.
Language	English
Publishing date	2022-12-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci13010078
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Article ; Online: "Thunderball": Oscillating ball thrombus within a giant sinus of Valsalva aneurysm.

Gossios, Thomas D / Silva, Daniela / Bosco, Paolo / Grapsa, Julia / Rajani, Ronak

Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese

2020 Volume 62, Issue 3, Page(s) 241–243

MeSH term(s)	Aortic Aneurysm/complications ; Aortic Aneurysm/diagnostic imaging ; Aortic Aneurysm/surgery ; Echocardiography ; Humans ; Sinus of Valsalva/diagnostic imaging ; Sinus of Valsalva/surgery ; Thrombosis/diagnostic imaging ; Thrombosis/etiology
Language	English
Publishing date	2020-07-28
Publishing country	Netherlands
Document type	Letter
ZDB-ID	2215027-4
ISSN	2241-5955 ; 1109-9666
ISSN (online)	2241-5955
ISSN	1109-9666
DOI	10.1016/j.hjc.2020.07.002
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Zs.A 6187: Show issues

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Article ; Online: Simulated and experimental phantom data for multi-center quality assurance of quantitative susceptibility maps at 3 T, 7 T and 9.4 T.

Gustavo Cuña, Enrique / Schulz, Hildegard / Tuzzi, Elisa / Biagi, Laura / Bosco, Paolo / García-Fontes, Margarita / Mattos, Javier / Tosetti, Michela / Engelmann, Jörn / Scheffler, Klaus / Hagberg, Gisela E

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)

2023 Volume 110, Page(s) 102590

Abstract: Purpose: To develop methods for quality assurance of quantitative susceptibility mapping (QSM) using MRI at different magnetic field strengths, and scanners, using different MR-sequence protocols, and post-processing pipelines.: Methods: We built a ... ...

Abstract	Purpose: To develop methods for quality assurance of quantitative susceptibility mapping (QSM) using MRI at different magnetic field strengths, and scanners, using different MR-sequence protocols, and post-processing pipelines. Methods: We built a custom phantom based on iron in two forms: homogeneous susceptibility ('free iron') and with fine-scaled variations in susceptibility ('clustered iron') at different iron concentrations. The phantom was measured at 3.0 T (two scanners), 7.0 T and 9.4 T using multi-echo, gradient echo acquisition sequences. A digital phantom analogue to the iron-phantom, tailored to obtain similar results as in experimentation was developed, with similar geometry and susceptibility values. Morphology enabled dipole inversion was applied to the phase images to obtain QSM for experimental and simulated data using the MEDI + 0 approach for background regularization. Results: Across all scanners, QSM-values showed a linear increase with iron concentrations. The QSM-relaxivity was 0.231 ± 0.047 ppm/mM for free and 0.054 ± 0.013 ppm/mM for clustered iron, with adjusted determination coefficients (DoC) ≥ 0.87. Similarly, the simulations yielded linear increases (DoC ≥ 0.99). In both the experimental and digital phantoms, the estimated molar susceptibility was lower with clustered iron, because clustering led to highly localized field effects. Conclusion: Our iron phantom can be used to evaluate the capability of QSM to detect local variations in susceptibility across different field strengths, when using different MR-sequence protocols. The devised simulation method captures the effect of iron clustering in QSM as seen experimentally and could be used in the future to optimize QSM processing pipelines and achieve higher accuracy for local field effects, as also seen in Alzheimer's beta-amyloid plaques.
MeSH term(s)	Iron ; Phantoms, Imaging ; Magnetic Resonance Imaging/methods ; Computer Simulation ; Brain ; Image Processing, Computer-Assisted/methods ; Brain Mapping/methods
Chemical Substances	Iron (E1UOL152H7)
Language	English
Publishing date	2023-04-26
Publishing country	Italy
Document type	Journal Article
ZDB-ID	1122650-x
ISSN	1724-191X ; 1120-1797
ISSN (online)	1724-191X
ISSN	1120-1797
DOI	10.1016/j.ejmp.2023.102590
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Zs.B 2941: Show issues

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Article ; Online: Cost-effectiveness analysis of leadless cardiac resynchronization therapy.

Wijesuriya, Nadeev / Mehta, Vishal / Vere, Felicity De / Howell, Sandra / Behar, Jonathan M / Shute, Andrew / Lee, Michael / Bosco, Paolo / Niederer, Steven A / Rinaldi, Christopher A

Journal of cardiovascular electrophysiology

2023 Volume 34, Issue 12, Page(s) 2590–2598

Abstract: Background: The Wireless Stimulation Endocardially for CRT (WiSE-CRT) system is a novel technology used to treat patients with dyssynchronous heart failure (HF) by providing leadless cardiac resynchronization therapy (CRT). Observational studies have ... ...

Abstract	Background: The Wireless Stimulation Endocardially for CRT (WiSE-CRT) system is a novel technology used to treat patients with dyssynchronous heart failure (HF) by providing leadless cardiac resynchronization therapy (CRT). Observational studies have demonstrated its safety and efficacy profile, however, the treatment cost-effectiveness has not previously been examined. Methods: A cost-effectiveness evaluation of the WiSE-CRT System was performed using a cohort-based economic model adopting a "proportion in state" structure. In addition to the primary analysis, scenario analyses and sensitivity analyses were performed to test for uncertainty in input parameters. Outcomes were quantified in terms of quality-adjusted life year (QALY) differences. Results: The primary analysis demonstrated that treatment with the WiSE-CRT system is likely to be cost-effective over a lifetime horizon at a QALY reimbursement threshold of £20 000, with a net monetary benefit (NMB) of £3781 per QALY. Cost-effectiveness declines at time horizons shorter than 10 years. Sensitivity analyses demonstrated that average system battery life had the largest impact on potential cost-effectiveness. Conclusion: Within the model limitations, these findings support the use of WiSE-CRT in indicated patients from an economic standpoint. However, improving battery technology should be prioritized to maximize cost-effectiveness in times when health services are under significant financial pressures.
MeSH term(s)	Humans ; Cardiac Resynchronization Therapy/economics ; Cost-Effectiveness Analysis ; Heart Failure/therapy ; Treatment Outcome
Language	English
Publishing date	2023-10-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1025989-2
ISSN	1540-8167 ; 1045-3873
ISSN (online)	1540-8167
ISSN	1045-3873
DOI	10.1111/jce.16102
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Zs.A 2863: Show issues

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Article ; Online: Probing the Role of a Regional Quantitative Assessment of Amyloid PET.

Peira, Enrico / Grazzini, Matteo / Bauckneht, Matteo / Sensi, Francesco / Bosco, Paolo / Arnaldi, Dario / Morbelli, Silvia / Chincarini, Andrea / Pardini, Matteo / Nobili, Flavio

Journal of Alzheimer's disease : JAD

2021 Volume 80, Issue 1, Page(s) 383–396

Abstract: Background: In clinical practice, the amy-PET is globally inspected to provide a binary outcome, but the role of a regional assessment has not been fully investigated yet.: Objective: To deepen the role of regional amyloid burden and its implication ... ...

Abstract	Background: In clinical practice, the amy-PET is globally inspected to provide a binary outcome, but the role of a regional assessment has not been fully investigated yet. Objective: To deepen the role of regional amyloid burden and its implication on clinical-neuropsychological features. Materials: Amy-PET and a complete neuropsychological assessment (Trail Making Test, Rey Auditory Verbal Learning Test, semantic verbal fluency, Symbol Digit, Stroop, visuoconstruction) were available in 109 patients with clinical suspicion of Alzheimer's disease. By averaging the standardized uptake value ratio and ELBA, a regional quantification was calculated for each scan. Patients were grouped according to their overall amyloid load: correlation maps, based on regional quantification, were calculated and compared. A regression analysis between neuropsychological assessment and the regional amyloid-β (Aβ) load was carried out. Results: Significant differences were observed between the correlation maps of patients at increasing levels of Aβ and the overall dataset. The Aβ uptake of the subcortical gray matter resulted not related to other brain regions independently of the global Aβ level. A significant association of semantic verbal fluency was observed with ratios of cortical and subcortical distribution of Aβ which represent a coarse measure of differences in regional distribution of Aβ. Conclusion: Our observations confirmed the different susceptibility to Aβ accumulation among brain regions. The association between cognition and Aβ distribution deserves further investigations: it is possibly due to a direct local effect or it represents a proxy marker of a more aggressive disease subtype. Regional Aβ assessment represents an available resource on amy-PET scan with possibly clinical and prognostic implications.
MeSH term(s)	Aged ; Aged, 80 and over ; Alzheimer Disease/diagnosis ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/psychology ; Amyloid/metabolism ; Amyloidosis/diagnostic imaging ; Amyloidosis/metabolism ; Amyloidosis/psychology ; Brain Mapping ; Female ; Gray Matter/diagnostic imaging ; Humans ; Image Processing, Computer-Assisted ; Male ; Middle Aged ; Neuropsychological Tests ; Positron-Emission Tomography/methods ; Stroop Test ; Trail Making Test ; Verbal Behavior ; Verbal Learning
Chemical Substances	Amyloid
Language	English
Publishing date	2021-02-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1440127-7
ISSN	1875-8908 ; 1387-2877
ISSN (online)	1875-8908
ISSN	1387-2877
DOI	10.3233/JAD-201156
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Zs.A 6084: Show issues

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Article: Iatrogenic Supravalvular Aortic Stenosis.

Bosco, Paolo / Ferrara, Antonella / Nashef, Samer A M

Aorta (Stamford, Conn.)

2016 Volume 4, Issue 5, Page(s) 172–174

Abstract: We describe a case of hemolytic anemia and proximal anastomotic site stenosis following emergency repair of a Type A aortic dissection. This rare complication led to a reoperation to correct the iatrogenic aortic stenosis and cure the consequent ... ...

Abstract	We describe a case of hemolytic anemia and proximal anastomotic site stenosis following emergency repair of a Type A aortic dissection. This rare complication led to a reoperation to correct the iatrogenic aortic stenosis and cure the consequent hemolysis. A "sandwich" technique (with two Teflon strips on the outside and inside of the aortic wall) was used in the initial repair to reinforce the suture line and prevent bleeding from the aortic anastomoses. At the time of reoperation, the inner Teflon strip at the proximal aortic anastomosis was found to have inverted into the aortic lumen, as suggested by the preoperative magnetic resonance imaging. Surgical treatment consisted of resecting the portion of inner Teflon that had turned in and tacking the remaining part back onto the aortic wall. The observed hemolysis was likely due to the turbulent flow associated with the supra-aortic stenosis and the collision of red cells with the internal Teflon strip. The patient made an uncomplicated recovery with no further hemolysis and was discharged on postoperative day 8.
Language	English
Publishing date	2016-10-01
Publishing country	Germany
Document type	Case Reports
ISSN	2325-4637
ISSN	2325-4637
DOI	10.12945/j.aorta.2016.16.008
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