LIVIVO - Search results -

Search results

Result 1 - 10 of total 62

Search options

Article ; Online: Tipping the Balance: A Criticality Perspective.

Bose, Indrani

2022 Volume 24, Issue 3

Abstract: Cell populations are often characterised by phenotypic heterogeneity in the form of two distinct subpopulations. We consider a model of tumour cells consisting of two subpopulations: non-cancer promoting (NCP) and cancer-promoting (CP). Under steady ... ...

Abstract	Cell populations are often characterised by phenotypic heterogeneity in the form of two distinct subpopulations. We consider a model of tumour cells consisting of two subpopulations: non-cancer promoting (NCP) and cancer-promoting (CP). Under steady state conditions, the model has similarities with a well-known model of population genetics which exhibits a purely noise-induced transition from unimodality to bimodality at a critical value of the noise intensity σ2. The noise is associated with the parameter
Language	English
Publishing date	2022-03-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2014734-X
ISSN	1099-4300 ; 1099-4300
ISSN (online)	1099-4300
ISSN	1099-4300
DOI	10.3390/e24030405
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Emergent phenomena in living systems:A statistical mechanical perspective.

Bose, Indrani

Journal of biosciences

2022 Volume 47

Abstract: A natural phenomenon occurring in a living system is an outcome of the dynamics of the specific biological network underlying the phenomenon. The collective dynamics have both deterministic and stochastic components. The stochastic nature of the key ... ...

Abstract	A natural phenomenon occurring in a living system is an outcome of the dynamics of the specific biological network underlying the phenomenon. The collective dynamics have both deterministic and stochastic components. The stochastic nature of the key processes like gene expression and cell differentiation give rise to fluctuations (noise) at the levels of the biomolecules, and this combined with nonlinear interactions gives rise to a number of emergent phenomena. In this review, we describe and discuss some of these phenomena which have the character of phase transitions in physical systems. We specifically focus on noise-induced transitions in a stochastic model of gene expression and in a population genetics model which have no analogs when the dynamics are solely deterministic in nature. Some of these transitions exhibit critical-point phenomena belonging to the mean-field Ising universality class of equilibrium phase transitions. A number of other examples, ranging from biofilms to homeostasis in adult tissues, are also discussed, which exhibit behaviour similar to critical phenomena in equilibrium and nonequilbrium phase transitions. The examples illustrate how the subject of statistical mechanics provides a bridge between theoretical models and experimental observations.
MeSH term(s)	Cell Differentiation ; Stochastic Processes
Language	English
Publishing date	2022-09-09
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	756157-x
ISSN	0973-7138 ; 0250-5991
ISSN (online)	0973-7138
ISSN	0250-5991
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1907: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Book ; Online: Emergent phenomena in living systems

Bose, Indrani

a statistical mechanical perspective

2023

Abstract	A natural phenomenon occurring in a living system is an outcome of the dynamics of the specific biological network underlying the phenomenon. The collective dynamics have both deterministic and stochastic components. The stochastic nature of the key processes like gene expression and cell differentiation give rise to fluctuations (noise) in the levels of the biomolecules and this combined with nonlinear interactions give rise to a number of emergent phenomena. In this review, we describe and discuss some of these phenomena which have the character of phase transitions in physical systems. We specifically focus on noise-induced transitions in a stochastic model of gene expression and in a population genetics model which have no analogs when the dynamics are solely deterministic in nature. Some of these transitions exhibit critical-point phenomena belonging to the mean-field Ising universality class of equilibrium phase transitions. A number of other examples, ranging from biofilms to homeostasis in adult tissues, are also discussed which exhibit behavior similar to critical phenomena in equilibrium and nonequilbrium phase transitions. The examples illustrate how the subject of statistical mechanics provides a bridge between theoretical models and experimental observations. Comment: 29 pages, 4 figures
Keywords	Condensed Matter - Statistical Mechanics ; Physics - Biological Physics ; Quantitative Biology - Quantitative Methods
Subject code	612
Publishing date	2023-08-31
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Book ; Online: Growth, Poverty Trap and Escape

Bose, Indrani

2023

Abstract: The well-known Solow growth model is the workhorse model of the theory of economic growth, which studies capital accumulation in a model economy as a function of time with capital stock, labour and technology efiiciency as the basic ingredients. The ... ...

Abstract	The well-known Solow growth model is the workhorse model of the theory of economic growth, which studies capital accumulation in a model economy as a function of time with capital stock, labour and technology efiiciency as the basic ingredients. The capital is assumed to be in the form of manufacturing equipments and materials. Two important parameters of the model are: the saving fraction $s$ of the output of a production function and the technology efficiency parameter $A$, appearing in the production function. The saved fraction of the output is fully invested in the generation of new capital and the rest is consumed. The capital stock also depreciates as a function of time due to the wearing out of old capital and the increase in the size of the labour population. We propose a stochastic Solow growth model assuming the saving fraction to be a sigmoidal function of the per capita capital $k_p$. We derive analytically the steady state probability distribution $P(k_p)$ and demonstrate the existence of a poverty trap, of central concern in development economics. In a parameter regime, $P(k_p)$ is bimodal with the twin peaks corresponding to states of poverty and well-being respectively. The associated potential landscape has two valleys with fluctuation-driven transitions between them. The mean exit times from the valleys are computed and one finds that the escape from a poverty trap is more favourable at higher values of $A$. We identify a critical value of $A_c$ below (above) which the state of poverty (well-being) dominates and propose two early signatures of the regime shift occurring at $A_c$. The economic model, with conceptual foundation in nonlinear dynamics and statistical mechanics, share universal features with dynamical models from diverse disciplines like ecology and cell biology.
Keywords	Physics - Physics and Society ; Quantitative Finance - General Finance
Subject code	612
Publishing date	2023-10-13
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Emergent phenomena in living systems: A statistical mechanical perspective

Bose, Indrani

Journal of biosciences. 2022 June, v. 47, no. 2

2022

Abstract	A natural phenomenon occurring in a living system is an outcome of the dynamics of the specific biological network underlying the phenomenon. The collective dynamics have both deterministic and stochastic components. The stochastic nature of the key processes like gene expression and cell differentiation give rise to fluctuations (noise) at the levels of the biomolecules, and this combined with nonlinear interactions gives rise to a number of emergent phenomena. In this review, we describe and discuss some of these phenomena which have the character of phase transitions in physical systems. We specifically focus on noise-induced transitions in a stochastic model of gene expression and in a population genetics model which have no analogs when the dynamics are solely deterministic in nature. Some of these transitions exhibit critical-point phenomena belonging to the mean-field Ising universality class of equilibrium phase transitions. A number of other examples, ranging from biofilms to homeostasis in adult tissues, are also discussed, which exhibit behaviour similar to critical phenomena in equilibrium and nonequilbrium phase transitions. The examples illustrate how the subject of statistical mechanics provides a bridge between theoretical models and experimental observations.
Keywords	adults ; biochemical compounds ; biofilm ; cell differentiation ; gene expression ; homeostasis ; mechanics ; population genetics ; stochastic processes
Language	English
Dates of publication	2022-06
Size	p. 22.
Publishing place	Springer India
Document type	Article
Note	Review
ZDB-ID	756157-x
ISSN	0973-7138 ; 0250-5991
ISSN (online)	0973-7138
ISSN	0250-5991
DOI	10.1007/s12038-021-00247-2
Database	NAL-Catalogue (AGRICOLA)

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 5290: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Molecular Pathogenesis of Nipah Virus.

Talukdar, Pratik / Dutta, Debankita / Ghosh, Elija / Bose, Indrani / Bhattacharjee, Sourish

Applied biochemistry and biotechnology

2023 Volume 195, Issue 4, Page(s) 2451–2462

Abstract: Viral diseases are causing mayhem throughout the world. One of the zoonotic viruses that have emerged as a potent threat to community health in the past few decades is Nipah virus. Nipah viral sickness is a zoonotic disease whose main carrier is bat. ... ...

Abstract	Viral diseases are causing mayhem throughout the world. One of the zoonotic viruses that have emerged as a potent threat to community health in the past few decades is Nipah virus. Nipah viral sickness is a zoonotic disease whose main carrier is bat. This disease is caused by Nipah virus (NiV). It belongs to the henipavirous group and of the family paramyxoviridae. Predominantly Pteropus spp. is the carrier of this virus. It was first reported from the Kampung Sungai Nipah town of Malaysia in 1998. Human-to-human transmission can also occur. Several repeated outbreaks were reported from South and Southeast Asia in the recent past. In humans, the disease is responsible for rapid development of acute illness, which can result in severe respiratory illness and serious encephalitis. Therefore, this calls for an urgent need for health authorities to conduct clinical trials to establish possible treatment regimens to prevent any further outbreaks.
MeSH term(s)	Animals ; Humans ; Nipah Virus/genetics ; Henipavirus Infections/epidemiology ; Henipavirus Infections/prevention & control ; Zoonoses/epidemiology ; Zoonoses/prevention & control ; Disease Outbreaks ; Chiroptera
Language	English
Publishing date	2023-01-19
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	392344-7
ISSN	1559-0291 ; 0273-2289
ISSN (online)	1559-0291
ISSN	0273-2289
DOI	10.1007/s12010-022-04300-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 3053: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Molecular Pathogenesis of Nipah Virus

Talukdar, Pratik / Dutta, Debankita / Ghosh, Elija / Bose, Indrani / Bhattacharjee, Sourish

Appl Biochem Biotechnol. 2023 Apr., v. 195, no. 4 p.2451-2462

2023

Abstract	Viral diseases are causing mayhem throughout the world. One of the zoonotic viruses that have emerged as a potent threat to community health in the past few decades is Nipah virus. Nipah viral sickness is a zoonotic disease whose main carrier is bat. This disease is caused by Nipah virus (NiV). It belongs to the henipavirous group and of the family paramyxoviridae. Predominantly Pteropus spp. is the carrier of this virus. It was first reported from the Kampung Sungai Nipah town of Malaysia in 1998. Human-to-human transmission can also occur. Several repeated outbreaks were reported from South and Southeast Asia in the recent past. In humans, the disease is responsible for rapid development of acute illness, which can result in severe respiratory illness and serious encephalitis. Therefore, this calls for an urgent need for health authorities to conduct clinical trials to establish possible treatment regimens to prevent any further outbreaks.
Keywords	Nipah henipavirus ; Pteropus ; community health ; encephalitis ; pathogenesis ; respiratory tract diseases ; viruses ; zoonoses ; Malaysia
Language	English
Dates of publication	2023-04
Size	p. 2451-2462.
Publishing place	Springer US
Document type	Article ; Online
Note	Review
ZDB-ID	392344-7
ISSN	0273-2289
ISSN	0273-2289
DOI	10.1007/s12010-022-04300-0
Database	NAL-Catalogue (AGRICOLA)

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 80/718: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Criticality in cell differentiation.

Bose, Indrani / Pal, Mainak

Journal of biosciences

2017 Volume 42, Issue 4, Page(s) 683–693

Abstract: Cell differentiation is an important process in living organisms. Differentiation is mostly based on binary decisions with the progenitor cells choosing between two specific lineages. The differentiation dynamics have both deterministic and stochastic ... ...

Abstract	Cell differentiation is an important process in living organisms. Differentiation is mostly based on binary decisions with the progenitor cells choosing between two specific lineages. The differentiation dynamics have both deterministic and stochastic components. Several theoretical studies suggest that cell differentiation is a bifurcation phenomenon, well-known in dynamical systems theory. The bifurcation point has the character of a critical point with the system dynamics exhibiting specific features in its vicinity. These include the critical slowing down, rising variance and lag-1 autocorrelation function, strong correlations between the fluctuations of key variables and non-Gaussianity in the distribution of fluctuations. Recent experimental studies provide considerable support to the idea of criticality in cell differentiation and in other biological processes like the development of the fruit fly embryo. In this review, an elementary introduction is given to the concept of criticality in cell differentiation. The correspondence between the signatures of criticality and experimental observations on blood cell differentiation in mice is further highlighted.
MeSH term(s)	Animals ; Cell Differentiation/genetics ; Cell Lineage/genetics ; Drosophila melanogaster/cytology ; Drosophila melanogaster/growth & development ; Drosophila melanogaster/metabolism ; Gene Regulatory Networks ; Humans ; Mice ; Models, Genetic ; Models, Statistical ; Stem Cells/cytology ; Stem Cells/metabolism ; Stochastic Processes ; Systems Theory
Language	English
Publishing date	2017-12-29
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	756157-x
ISSN	0973-7138 ; 0250-5991
ISSN (online)	0973-7138
ISSN	0250-5991
DOI	10.1007/s12038-017-9721-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1907: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Book ; Online: Bifurcation and Criticality

Bose, Indrani / Ghosh, Sayantari

2019

Abstract: Equilibrium and nonequilibrium systems exhibit power-law singularities close to their critical and bifurcation points respectively. A recent study has shown that biochemical nonequilibrium models with positive feedback belong to the universality class of ...

Abstract	Equilibrium and nonequilibrium systems exhibit power-law singularities close to their critical and bifurcation points respectively. A recent study has shown that biochemical nonequilibrium models with positive feedback belong to the universality class of the mean-field Ising model. Through a mapping between the two systems, effective thermodynamic quantities like temperature, magnetic field and order parameter can be expressed in terms of biochemical parameters. In this paper, we demonstrate the equivalence using a simple deterministic approach. As an illustration we consider a model of population dynamics exhibiting the Allee effect for which we determine the exact phase diagram. We further consider a two-variable model of positive feedback, the genetic toggle, and discuss the conditions under which the model belongs to the mean-field Ising universality class. In the biochemical models, the supercritical pitchfork bifurcation point serves as the critical point. The dynamical behaviour predicted by the two models is in qualitative agreement with experimental observations and opens up the possibility of exploring critical point phenomena in laboratory populations and synthetic biological circuits. Comment: 13 Pages, 5 Figures
Keywords	Quantitative Biology - Quantitative Methods ; Condensed Matter - Statistical Mechanics ; Nonlinear Sciences - Adaptation and Self-Organizing Systems
Subject code	612
Publishing date	2019-06-03
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Criticality in cell differentiation

Bose, Indrani / Mainak Pal

Journal of biosciences. 2017 Dec., v. 42, no. 4

2017

Abstract	Cell differentiation is an important process in living organisms. Differentiation is mostly based on binary decisions with the progenitor cells choosing between two specific lineages. The differentiation dynamics have both deterministic and stochastic components. Several theoretical studies suggest that cell differentiation is a bifurcation phenomenon, well-known in dynamical systems theory. The bifurcation point has the character of a critical point with the system dynamics exhibiting specific features in its vicinity. These include the critical slowing down, rising variance and lag-1 autocorrelation function, strong correlations between the fluctuations of key variables and non-Gaussianity in the distribution of fluctuations. Recent experimental studies provide considerable support to the idea of criticality in cell differentiation and in other biological processes like the development of the fruit fly embryo. In this review, an elementary introduction is given to the concept of criticality in cell differentiation. The correspondence between the signatures of criticality and experimental observations on blood cell differentiation in mice is further highlighted.
Keywords	autocorrelation ; cell differentiation ; fruit flies ; mice ; stem cells ; variance
Language	English
Dates of publication	2017-12
Size	p. 683-693.
Publishing place	Springer India
Document type	Article
Note	Review
ZDB-ID	756157-x
ISSN	0973-7138 ; 0250-5991
ISSN (online)	0973-7138
ISSN	0250-5991
DOI	10.1007/s12038-017-9721-6
Database	NAL-Catalogue (AGRICOLA)

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 5290: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

To top

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED