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  1. Article ; Online: Multifunctional polydopamine - Zn

    Bhattacharjee, Arjak / Bose, Susmita

    Biomaterials advances

    2023  Volume 153, Page(s) 213487

    Abstract: The lack of site-specific chemotherapeutic agents after osteosarcoma surgeries often induces severe side effects. We propose the utilization of curcumin as an alternative natural chemo-preventive drug for tumor-specific delivery systems with 3D printed ... ...

    Abstract The lack of site-specific chemotherapeutic agents after osteosarcoma surgeries often induces severe side effects. We propose the utilization of curcumin as an alternative natural chemo-preventive drug for tumor-specific delivery systems with 3D printed tricalcium phosphate (TCP) based artificial bone grafts. The poor bioavailability and hydrophobic nature of curcumin restrict its clinical use. We have used polydopamine (PDA) coating with Zn
    MeSH term(s) Zinc/chemistry ; Curcumin/chemistry ; Ceramics/chemistry ; Bone Transplantation ; Humans ; Cells, Cultured ; Cell Survival
    Chemical Substances polydopamine ; Zinc (J41CSQ7QDS) ; Curcumin (IT942ZTH98)
    Language English
    Publishing date 2023-06-02
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2772-9508
    ISSN (online) 2772-9508
    DOI 10.1016/j.bioadv.2023.213487
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  2. Article ; Online: Vitamin D3 Release from MgO Doped 3D Printed TCP Scaffolds for Bone Regeneration.

    Jo, Yongdeok / Majumdar, Ujjayan / Bose, Susmita

    ACS biomaterials science & engineering

    2024  Volume 10, Issue 3, Page(s) 1676–1685

    Abstract: Regenerating bone tissue in critical-sized craniofacial bone defects remains challenging and requires the implementation of innovative bone implants with early stage osteogenesis and blood vessel formation. Vitamin D3 is incorporated into MgO-doped 3D- ... ...

    Abstract Regenerating bone tissue in critical-sized craniofacial bone defects remains challenging and requires the implementation of innovative bone implants with early stage osteogenesis and blood vessel formation. Vitamin D3 is incorporated into MgO-doped 3D-printed scaffolds for defect-specific and patient-specific implants in low load-bearing areas. This novel bone implant also promotes early stage osteogenesis and blood vessel development. Our results show that vitamin D3-loaded MgO-doped 3D-printed scaffolds enhance osteoblast cell proliferation 1.3-fold after being cultured for 7 days. Coculture studies on osteoblasts derived from human mesenchymal stem cells (hMSCs) and osteoclasts derived from monocytes show the upregulation of genes related to osteoblastogenesis and the downregulation of RANK-L, which is essential for osteoclastogenesis. Release of vitamin D3 also inhibits osteoclast differentiation by 1.9-fold after a 21-day culture. After 6 weeks, vitamin D3 release from MgO-doped 3D-printed scaffolds enhances the new bone formation, mineralization, and angiogenic potential. The multifunctional 3D-printed scaffolds can improve early stage osteogenesis and blood vessel formation in craniofacial bone defects.
    MeSH term(s) Humans ; Tissue Scaffolds ; Magnesium Oxide/pharmacology ; Cholecalciferol/pharmacology ; Printing, Three-Dimensional ; Bone Regeneration
    Chemical Substances Magnesium Oxide (3A3U0GI71G) ; Cholecalciferol (1C6V77QF41)
    Language English
    Publishing date 2024-02-22
    Publishing country United States
    Document type Journal Article
    ISSN 2373-9878
    ISSN (online) 2373-9878
    DOI 10.1021/acsbiomaterials.3c01779
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  3. Article ; Online: Extrusion 3D-printed tricalcium phosphate-polycaprolactone biocomposites for quercetin-KCl delivery in bone tissue engineering.

    Toulou, Connor / Chaudhari, Vishal Sharad / Bose, Susmita

    Journal of biomedical materials research. Part A

    2024  

    Abstract: Critical-sized bone defects pose a significant challenge in advanced healthcare due to limited bone tissue regenerative capacity. The complex interplay of numerous overlapping variables hinders the development of multifunctional biocomposites. ... ...

    Abstract Critical-sized bone defects pose a significant challenge in advanced healthcare due to limited bone tissue regenerative capacity. The complex interplay of numerous overlapping variables hinders the development of multifunctional biocomposites. Phytochemicals show promise in promoting bone growth, but their dose-dependent nature and physicochemical properties halt clinical use. To develop a comprehensive solution, a 3D-printed (3DP) extrusion-based tricalcium phosphate-polycaprolactone (TCP-PCL) scaffold is augmented with quercetin and potassium chloride (KCl). This composite material demonstrates a compressive strength of 30 MPa showing promising stability for low load-bearing applications. Quercetin release from the scaffold follows a biphasic pattern that persists for up to 28 days, driven via diffusion-mediated kinetics. The incorporation of KCl allows for tunable degradation rates of scaffolds and prevents the initial rapid release. Functionalization of scaffolds facilitates the attachment and proliferation of human fetal osteoblasts (hfOB), resulting in a 2.1-fold increase in cell viability. Treated scaffolds exhibit a 3-fold reduction in osteosarcoma (MG-63) cell viability as compared to untreated substrates. Ruptured cell morphology and decreased mitochondrial membrane potential indicate the antitumorigenic potential. Scaffolds loaded with quercetin and quercetin-KCl (Q-KCl) demonstrate 76% and 89% reduction in bacterial colonies of Staphylococcus aureus, respectively. This study provides valuable insights as a promising strategy for bone tissue engineering (BTE) in orthopedic repair.
    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2099989-6
    ISSN 1552-4965 ; 1549-3296 ; 0021-9304
    ISSN (online) 1552-4965
    ISSN 1549-3296 ; 0021-9304
    DOI 10.1002/jbm.a.37692
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  4. Article: 3D printed hydroxyapatite - Zn

    Bhattacharjee, Arjak / Bose, Susmita

    Materials & design

    2022  Volume 221

    Abstract: Hydroxyapatite (HA) - polymer composite based 3D printed bone grafts require extensive mechanical and biological property optimization for specific clinical needs. This fuels the need to develop innovative methods of optimization. Using an in-house ... ...

    Abstract Hydroxyapatite (HA) - polymer composite based 3D printed bone grafts require extensive mechanical and biological property optimization for specific clinical needs. This fuels the need to develop innovative methods of optimization. Using an in-house extrusion-based 3D printer, we show the feasibility of fabricating hydroxyapatite- Zn
    Language English
    Publishing date 2022-06-27
    Publishing country England
    Document type Journal Article
    ISSN 0264-1275
    ISSN 0264-1275
    DOI 10.1016/j.matdes.2022.110903
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  5. Article: Zinc curcumin complex on fluoride doped hydroxyapatite with enhanced biological properties for dental and orthopedic applications.

    Bhattacharjee, Arjak / Bose, Susmita

    Journal of materials research

    2022  Volume 37, Issue 12, Page(s) 2009–2020

    Abstract: Since antiquity, curcumin, from turmeric is utilized in traditional Indian medicine ( ...

    Abstract Since antiquity, curcumin, from turmeric is utilized in traditional Indian medicine (
    Language English
    Publishing date 2022-06-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2015297-8
    ISSN 2044-5326 ; 0884-2914
    ISSN (online) 2044-5326
    ISSN 0884-2914
    DOI 10.1557/s43578-022-00595-1
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  6. Article ; Online: In vitro

    Jo, Yongdeok / Sarkar, Naboneeta / Bose, Susmita

    Journal of materials chemistry. B

    2023  Volume 11, Issue 24, Page(s) 5503–5513

    Abstract: Three-dimensional printed (3DP) tricalcium phosphate (TCP) scaffolds can guide bone regeneration, especially for patient-specific defect repair applications in low-load bearing sites. Epigallocatechin gallate (EGCG), a green tea compound, has gained ... ...

    Abstract Three-dimensional printed (3DP) tricalcium phosphate (TCP) scaffolds can guide bone regeneration, especially for patient-specific defect repair applications in low-load bearing sites. Epigallocatechin gallate (EGCG), a green tea compound, has gained attention as a safer alternative treatment for bone disorders. The 3DP TCP scaffold is designed for localized EGCG delivery, which can enhance
    MeSH term(s) Humans ; Osteogenesis ; Bone and Bones ; Calcium Phosphates/pharmacology ; Human Umbilical Vein Endothelial Cells
    Chemical Substances epigallocatechin gallate (BQM438CTEL) ; calcium phosphate (97Z1WI3NDX) ; tricalcium phosphate (K4C08XP666) ; Calcium Phosphates
    Language English
    Publishing date 2023-06-21
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2702241-9
    ISSN 2050-7518 ; 2050-750X
    ISSN (online) 2050-7518
    ISSN 2050-750X
    DOI 10.1039/d2tb02210a
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  7. Article ; Online: In vivo

    Bhattacharjee, Arjak / Jo, Yongdeok / Bose, Susmita

    Journal of materials chemistry. B

    2023  Volume 11, Issue 21, Page(s) 4725–4739

    Abstract: The lack of site-specific chemotherapeutic agents to treat bone malignancy throws a significant challenge in the design of a delivery vehicle. The major scientific question posed in this study is, can we utilize curcumin-loaded magnesium oxide (MgO) ... ...

    Abstract The lack of site-specific chemotherapeutic agents to treat bone malignancy throws a significant challenge in the design of a delivery vehicle. The major scientific question posed in this study is, can we utilize curcumin-loaded magnesium oxide (MgO) doped 3D printed tricalcium phosphate (TCP) bone grafts as a localized delivery system that improves early stage
    MeSH term(s) Rats ; Animals ; Magnesium Oxide/pharmacology ; Tissue Scaffolds/chemistry ; Tissue Engineering/methods ; Curcumin/pharmacology ; Curcumin/chemistry ; Staphylococcus aureus ; Printing, Three-Dimensional ; Osteosarcoma/drug therapy ; Bone Neoplasms
    Chemical Substances Magnesium Oxide (3A3U0GI71G) ; tricalcium phosphate (K4C08XP666) ; Curcumin (IT942ZTH98)
    Language English
    Publishing date 2023-05-31
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2702241-9
    ISSN 2050-7518 ; 2050-750X
    ISSN (online) 2050-7518
    ISSN 2050-750X
    DOI 10.1039/d2tb02547g
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  8. Article ; Online: Hydroxyapatite coated titanium with curcumin and epigallocatechin gallate for orthopedic and dental applications.

    Kushram, Priya / Majumdar, Ujjayan / Bose, Susmita

    Biomaterials advances

    2023  Volume 155, Page(s) 213667

    Abstract: Titanium and its alloy are clinically used as an implant material for load-bearing applications to treat bone defects. However, the lack of biological interaction between bone tissue and implant and the risk of infection are still critical challenges in ... ...

    Abstract Titanium and its alloy are clinically used as an implant material for load-bearing applications to treat bone defects. However, the lack of biological interaction between bone tissue and implant and the risk of infection are still critical challenges in clinical orthopedics. In the current work, we have developed a novel approach by first 1) modifying the implant surface using hydroxyapatite (HA) coating to enhance bioactivity and 2) integrating curcumin and epigallocatechin gallate (EGCG) in the coating that would induce chemopreventive and osteogenic potential and impart antibacterial properties to the implant. The study shows that curcumin and EGCG exhibit controlled and sustained release profiles in acidic and physiological environments. Curcumin and EGCG also show in vitro cytotoxicity toward osteosarcoma cells after 11 days, and the dual system shows a ~94 % reduction in bacterial growth, indicating their in vitro chemopreventive potential and antibacterial efficacy. The release of both curcumin and EGCG was found to be compatible with osteoblast cells and further promotes their growth. It shows a 3-fold enhancement in cellular viability in the dual drug-loaded implant compared to the untreated samples. These findings suggest that multifunctional HA-coated Ti6Al4V implants integrated with curcumin and EGCG could be a promising strategy for osteosarcoma inhibition and osteoblast cell growth while preventing infection.
    MeSH term(s) Humans ; Curcumin/pharmacology ; Titanium/pharmacology ; Durapatite/pharmacology ; Anti-Bacterial Agents/pharmacology ; Osteosarcoma/drug therapy ; Bone Neoplasms
    Chemical Substances Curcumin (IT942ZTH98) ; Titanium (D1JT611TNE) ; Durapatite (91D9GV0Z28) ; epigallocatechin gallate (BQM438CTEL) ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-10-31
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2772-9508
    ISSN (online) 2772-9508
    DOI 10.1016/j.bioadv.2023.213667
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  9. Article ; Online: Garlic extract enhances bioceramic bone scaffolds through upregulating ALP & BGLAP expression in hMSC-monocyte co-culture.

    Bose, Susmita / Robertson, Samuel F / Vu, Ashley A

    Biomaterials advances

    2023  Volume 154, Page(s) 213622

    Abstract: Bone homeostasis is predicated by osteoblast and osteoclast cell cycles where gene expressions are responsible for their differentiation from human mesenchymal stem cells (hMSC) and monocytes, respectively. The pro-osteogenic potential of an hMSC- ... ...

    Abstract Bone homeostasis is predicated by osteoblast and osteoclast cell cycles where gene expressions are responsible for their differentiation from human mesenchymal stem cells (hMSC) and monocytes, respectively. The pro-osteogenic potential of an hMSC-monocyte co-culture can be measured through complementary DNA (mRNA synthesis) within the nucleus, known as quantitative polymerase chain reaction (qPCR). Through this technique, the effects of garlic extract (allicin) release from calcium phosphate bone scaffolds on gene expression of bone forming and bone remodeling cells was explored. Results show this complex biomaterial system enhances hMSC differentiation through the upregulation of bone-forming proteins. Osteoblastic gene markers alkaline phosphatase (ALP) and osteocalcin (BGLAP), are respectively upregulated by 3-fold and 1.6-fold by day 14. These mature osteoblasts then upregulate the receptor activator of nuclear factor-kB ligand (RANKL) which recruits osteoclast cells, as captured by a nearly 2-fold higher osteoclast expression of tartrate-resistance acid-phosphatase (ACP5). This also activates antagonist osteoprotegerin (OPG) expression in osteoblasts, decreasing osteoclast resorption potential and ACP5 expression by day 21. The pro-osteogenic environment with garlic extract release is further quantified by a 4× increase in phosphatase activity and visibly captured in immunofluorescent tagged confocal images. Also corroborated by enhanced collagen formation in a preliminary in vivo rat distal femur model, this work collectively reveals how garlic extract can enhance bioceramic scaffolds for bone tissue regenerative applications.
    MeSH term(s) Rats ; Animals ; Humans ; Alkaline Phosphatase/genetics ; Monocytes/metabolism ; Coculture Techniques ; Garlic/metabolism ; Bone and Bones/metabolism
    Chemical Substances Alkaline Phosphatase (EC 3.1.3.1)
    Language English
    Publishing date 2023-09-09
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2772-9508
    ISSN (online) 2772-9508
    DOI 10.1016/j.bioadv.2023.213622
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  10. Article ; Online: Micelle encapsulated curcumin and piperine-laden 3D printed calcium phosphate scaffolds enhance in vitro biological properties.

    Bose, Susmita / Sarkar, Naboneeta / Majumdar, Ujjayan

    Colloids and surfaces. B, Biointerfaces

    2023  Volume 231, Page(s) 113563

    Abstract: Limitations in the current clinical management of critical-sized osseous defects have driven the need for multifunctional bone constructs. The ideal bone scaffold should possess advanced microarchitecture, well-defined pore interconnectivity, and supply ... ...

    Abstract Limitations in the current clinical management of critical-sized osseous defects have driven the need for multifunctional bone constructs. The ideal bone scaffold should possess advanced microarchitecture, well-defined pore interconnectivity, and supply biological signals, which actively guide and control tissue regeneration while simultaneously preventing post-implantation complications. Here, a natural medicine-based localized drug delivery from 3D printed scaffold is presented, which offers controlled release of curcumin, piperine from nano-sized polymeric micelles, and burst release of antibacterial carvacrol from the coating endowing the scaffold with their distinct, individual biological properties. This functionalized scaffold exhibits improved osteoblast (hFOB) cell attachment, 4-folds higher hFOB proliferation, and 73% increased hFOB differentiation while simultaneously providing cytotoxicity towards osteosarcoma cells with 61% lesser viability compared to control. In vitro, early tube formation (p < 0.001) indicates that the scaffolds can modulate the endothelial cellular network, critical for faster wound healing. The scaffold also exhibits 94% enhanced antibacterial efficacy (p < 0.001) against gram-positive Staphylococcus aureus, the main causative bacteria for osteomyelitis. Together, the multifunctional scaffolds provide controlled delivery of natural biomolecules from the nano-sized micelle-loaded 3D printed matrix for significant improvement in osteoblast proliferation, endothelial formation, osteosarcoma, and bacterial inhibition, guiding better bone regeneration for post-traumatic defect repair.
    MeSH term(s) Humans ; Tissue Scaffolds ; Micelles ; Curcumin/pharmacology ; Printing, Three-Dimensional ; Bone Regeneration ; Osteosarcoma ; Bone Neoplasms ; Calcium Phosphates/pharmacology ; Anti-Bacterial Agents/pharmacology ; Osteogenesis ; Tissue Engineering
    Chemical Substances Micelles ; piperine (U71XL721QK) ; Curcumin (IT942ZTH98) ; Calcium Phosphates ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-09-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1500523-9
    ISSN 1873-4367 ; 0927-7765
    ISSN (online) 1873-4367
    ISSN 0927-7765
    DOI 10.1016/j.colsurfb.2023.113563
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