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  1. Article: Himmlische Transparenz

    Bosnar, M.

    Das Dental-Labor

    2010  Volume 58, Issue 3, Page(s) 327

    Language German
    Document type Article
    ZDB-ID 212460-9
    ISSN 0011-8656
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

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  2. Article: Genetics of Marine Organisms Associated with Human Health

    Herak Bosnar, Maja / Ćetković, Helena / Harcet, Matija

    Marine drugs. 2020 Nov. 02, v. 18, no. 11

    2020  

    Abstract: The aim of this special issue was to provide insight into the field of research on genetics and genomics of marine organisms linked with human health [ ... ] ...

    Abstract The aim of this special issue was to provide insight into the field of research on genetics and genomics of marine organisms linked with human health [...]
    Keywords aquatic organisms ; drugs ; genomics ; human health ; research
    Language English
    Dates of publication 2020-1102
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-light
    ZDB-ID 2175190-0
    ISSN 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md18110548
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Rho Family of Ras-Like GTPases in Early-Branching Animals.

    Beljan, Silvestar / Herak Bosnar, Maja / Ćetković, Helena

    Cells

    2020  Volume 9, Issue 10

    Abstract: Non-bilaterian animals consist of four phyla; Porifera, Cnidaria, Ctenophora, and Placozoa. These early-diverging animals are crucial for understanding the evolution of the entire animal lineage. The Rho family of proteins make up a major branch of the ... ...

    Abstract Non-bilaterian animals consist of four phyla; Porifera, Cnidaria, Ctenophora, and Placozoa. These early-diverging animals are crucial for understanding the evolution of the entire animal lineage. The Rho family of proteins make up a major branch of the Ras superfamily of small GTPases, which function as key molecular switches that play important roles in converting and amplifying external signals into cellular responses. This review represents a compilation of the current knowledge on Rho-family GTPases in non-bilaterian animals, the available experimental data about their biochemical characteristics and functions, as well as original bioinformatics analysis, in order to gain a general insight into the evolutionary history of Rho-family GTPases in simple animals.
    MeSH term(s) Amino Acid Sequence ; Animals ; Models, Biological ; Phylogeny ; Signal Transduction ; rho GTP-Binding Proteins/chemistry ; rho GTP-Binding Proteins/metabolism
    Chemical Substances rho GTP-Binding Proteins (EC 3.6.5.2)
    Language English
    Publishing date 2020-10-13
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells9102279
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Genetics of Marine Organisms Associated with Human Health.

    Herak Bosnar, Maja / Ćetković, Helena / Harcet, Matija

    Marine drugs

    2020  Volume 18, Issue 11

    Abstract: Marine habitats harbour a large variety of organisms that belong to diverse taxa; from bacteria and unicellular eukaryotes to fungi, animals, and plants. Although we have only started to understand the diversity and structure of marine communities, it is ...

    Abstract Marine habitats harbour a large variety of organisms that belong to diverse taxa; from bacteria and unicellular eukaryotes to fungi, animals, and plants. Although we have only started to understand the diversity and structure of marine communities, it is clear that numerous marine species have or might have an impact on human health. Some are a source of natural products with potential or actual medical applications, others are toxic and harmful to humans, and some are used in biomedical research to help understand the molecular basis of human diseases. New molecular genetics and genomic methods provide powerful and ever more indispensable tools for studying marine organisms and all aspects of their influence on human health. Herein, we present work using the latest research, which mostly uses genomics, to tackle the questions related with the topic of the issue.
    MeSH term(s) Animals ; Aquatic Organisms/classification ; Aquatic Organisms/genetics ; Aquatic Organisms/metabolism ; Biological Products/isolation & purification ; Biological Products/therapeutic use ; Genome ; Health Status ; Humans ; Marine Toxins/adverse effects ; Marine Toxins/metabolism ; Risk Assessment
    Chemical Substances Biological Products ; Marine Toxins
    Language English
    Publishing date 2020-11-02
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md18110548
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Cholinesterase Inhibitory and Anti-Inflammatory Activity of the Naphtho- and Thienobenzo-Triazole Photoproducts: Experimental and Computational Study.

    Mlakić, Milena / Faraho, Ivan / Odak, Ilijana / Kovačević, Borislav / Raspudić, Anamarija / Šagud, Ivana / Bosnar, Martina / Škorić, Irena / Barić, Danijela

    International journal of molecular sciences

    2023  Volume 24, Issue 19

    Abstract: New 1,2,3-triazolo(thieno)stilbenes were synthesized as mixtures of isomers and efficiently photochemically transformed to their corresponding substituted thienobenzo/naphtho-triazoles in high isolated yields. The resulting photoproducts were studied as ... ...

    Abstract New 1,2,3-triazolo(thieno)stilbenes were synthesized as mixtures of isomers and efficiently photochemically transformed to their corresponding substituted thienobenzo/naphtho-triazoles in high isolated yields. The resulting photoproducts were studied as acetyl- (AChE) and butyrylcholinesterase (BChE) inhibitors without or with interconnected inhibition potential of TNF-α cytokine production. The most promising anti-inflammatory activity was shown again by naphtho-triazoles, with a derivative featuring 4-pentenyl substituents exhibiting notable potential as a cholinesterase inhibitor. To identify interactions between ligands and the active site of cholinesterases, molecular docking was performed for the best potential inhibitors. Additionally, molecular dynamics simulations were employed to assess and validate the stability and flexibility of the protein-ligand complexes generated through docking.
    MeSH term(s) Butyrylcholinesterase/metabolism ; Acetylcholinesterase/metabolism ; Triazoles/pharmacology ; Triazoles/chemistry ; Molecular Docking Simulation ; Structure-Activity Relationship ; Cholinesterase Inhibitors/pharmacology ; Cholinesterase Inhibitors/chemistry ; Ligands
    Chemical Substances Butyrylcholinesterase (EC 3.1.1.8) ; Acetylcholinesterase (EC 3.1.1.7) ; Triazoles ; Cholinesterase Inhibitors ; Ligands
    Language English
    Publishing date 2023-09-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241914676
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Sponges: A Reservoir of Genes Implicated in Human Cancer.

    Ćetković, Helena / Halasz, Mirna / Herak Bosnar, Maja

    Marine drugs

    2018  Volume 16, Issue 1

    Abstract: Recently, it was shown that the majority of genes linked to human diseases, such as cancer genes, evolved in two major evolutionary transitions-the emergence of unicellular organisms and the transition to multicellularity. Therefore, it has been widely ... ...

    Abstract Recently, it was shown that the majority of genes linked to human diseases, such as cancer genes, evolved in two major evolutionary transitions-the emergence of unicellular organisms and the transition to multicellularity. Therefore, it has been widely accepted that the majority of disease-related genes has already been present in species distantly related to humans. An original way of studying human diseases relies on analyzing genes and proteins that cause a certain disease using model organisms that belong to the evolutionary level at which these genes have emerged. This kind of approach is supported by the simplicity of the genome/proteome, body plan, and physiology of such model organisms. It has been established for quite some time that sponges are an ideal model system for such studies, having a vast variety of genes known to be engaged in sophisticated processes and signalling pathways associated with higher animals. Sponges are considered to be the simplest multicellular animals and have changed little during evolution. Therefore, they provide an insight into the metazoan ancestor genome/proteome features. This review compiles current knowledge of cancer-related genes/proteins in marine sponges.
    MeSH term(s) Animals ; Evolution, Molecular ; Genome/genetics ; Humans ; Neoplasms/genetics ; Porifera/genetics ; Proteome/genetics ; Signal Transduction/genetics
    Chemical Substances Proteome
    Language English
    Publishing date 2018-01-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md16010020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Structure and function of cancer-related developmentally regulated GTP-binding protein 1 (DRG1) is conserved between sponges and humans.

    Beljan, Silvestar / Dominko, Kristina / Talajić, Antea / Hloušek-Kasun, Andrea / Škrobot Vidaček, Nikolina / Herak Bosnar, Maja / Vlahoviček, Kristian / Ćetković, Helena

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 11379

    Abstract: Cancer is a disease caused by errors within the multicellular system and it represents a major health issue in multicellular organisms. Although cancer research has advanced substantially, new approaches focusing on fundamental aspects of cancer origin ... ...

    Abstract Cancer is a disease caused by errors within the multicellular system and it represents a major health issue in multicellular organisms. Although cancer research has advanced substantially, new approaches focusing on fundamental aspects of cancer origin and mechanisms of spreading are necessary. Comparative genomic studies have shown that most genes linked to human cancer emerged during the early evolution of Metazoa. Thus, basal animals without true tissues and organs, such as sponges (Porifera), might be an innovative model system for understanding the molecular mechanisms of proteins involved in cancer biology. One of these proteins is developmentally regulated GTP-binding protein 1 (DRG1), a GTPase stabilized by interaction with DRG family regulatory protein 1 (DFRP1). This study reveals a high evolutionary conservation of DRG1 gene/protein in metazoans. Our biochemical analysis and structural predictions show that both recombinant sponge and human DRG1 are predominantly monomers that form complexes with DFRP1 and bind non-specifically to RNA and DNA. We demonstrate the conservation of sponge and human DRG1 biological features, including intracellular localization and DRG1:DFRP1 binding, function of DRG1 in α-tubulin dynamics, and its role in cancer biology demonstrated by increased proliferation, migration and colonization in human cancer cells. These results suggest that the ancestor of all Metazoa already possessed DRG1 that is structurally and functionally similar to the human DRG1, even before the development of real tissues or tumors, indicating an important function of DRG1 in fundamental cellular pathways.
    MeSH term(s) Animals ; GTP-Binding Proteins ; Genomics ; Humans ; Neoplasms/genetics ; Oncogenes ; RNA ; Transcription Factors
    Chemical Substances Transcription Factors ; developmentally regulated GTP-binding protein (149371-72-2) ; RNA (63231-63-0) ; GTP-Binding Proteins (EC 3.6.1.-)
    Language English
    Publishing date 2022-07-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-15242-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Characterization of Vemurafenib-Resistant Melanoma Cell Lines Reveals Novel Hallmarks of Targeted Therapy Resistance.

    Radić, Martina / Vlašić, Ignacija / Jazvinšćak Jembrek, Maja / Horvat, Anđela / Tadijan, Ana / Sabol, Maja / Dužević, Marko / Herak Bosnar, Maja / Slade, Neda

    International journal of molecular sciences

    2022  Volume 23, Issue 17

    Abstract: Regardless of the significant improvements in treatment of melanoma, the majority of patients develop resistance whose mechanisms are still not completely understood. Hence, we generated and characterized two melanoma-derived cell lines, primary WM793B ... ...

    Abstract Regardless of the significant improvements in treatment of melanoma, the majority of patients develop resistance whose mechanisms are still not completely understood. Hence, we generated and characterized two melanoma-derived cell lines, primary WM793B and metastatic A375M, with acquired resistance to the RAF inhibitor vemurafenib. The morphology of the resistant primary WM793B melanoma cells showed EMT-like features and exhibited a hybrid phenotype with both epithelial and mesenchymal characteristics. Surprisingly, the vemurafenib-resistant melanoma cells showed a decreased migration ability but also displayed a tendency to collective migration. Signaling pathway analysis revealed the reactivation of MAPK and the activation of the PI3K/AKT pathway depending on the vemurafenib-resistant cell line. The acquired resistance to vemurafenib caused resistance to chemotherapy in primary WM793B melanoma cells. Furthermore, the cell-cycle analysis and altered levels of cell-cycle regulators revealed that resistant cells likely transiently enter into cell cycle arrest at the G0/G1 phase and gain slow-cycling cell features. A decreased level of NME1 and NME2 metastasis suppressor proteins were found in WM793B-resistant primary melanoma, which is possibly the result of vemurafenib-acquired resistance and is one of the causes of increased PI3K/AKT signaling. Further studies are needed to reveal the vemurafenib-dependent negative regulators of NME proteins, their role in PI3K/AKT signaling, and their influence on vemurafenib-resistant melanoma cell characteristics.
    MeSH term(s) Cell Line, Tumor ; Drug Resistance, Neoplasm/genetics ; Humans ; Indoles/pharmacology ; Indoles/therapeutic use ; Melanoma/drug therapy ; Melanoma/genetics ; Melanoma/pathology ; Phosphatidylinositol 3-Kinases ; Proto-Oncogene Proteins B-raf/genetics ; Proto-Oncogene Proteins B-raf/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Sulfonamides/pharmacology ; Sulfonamides/therapeutic use ; Vemurafenib/pharmacology ; Vemurafenib/therapeutic use
    Chemical Substances Indoles ; Sulfonamides ; Vemurafenib (207SMY3FQT) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2022-08-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23179910
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: New naphtho/thienobenzo-triazoles with interconnected anti-inflammatory and cholinesterase inhibitory activity.

    Mlakić, Milena / Odak, Ilijana / Faraho, Ivan / Talić, Stanislava / Bosnar, Martina / Lasić, Kornelija / Barić, Danijela / Škorić, Irena

    European journal of medicinal chemistry

    2022  Volume 241, Page(s) 114616

    Abstract: New 1,2,3-triazolo(thieno)stilbenes were synthesized by Wittig reaction and photochemically transformed to corresponding substituted thienobenzo/naphtho-triazoles in high isolated yields. They were prepared to study the acetyl- and butyrylcholinesterase ... ...

    Abstract New 1,2,3-triazolo(thieno)stilbenes were synthesized by Wittig reaction and photochemically transformed to corresponding substituted thienobenzo/naphtho-triazoles in high isolated yields. They were prepared to study the acetyl- and butyrylcholinesterase inhibition associated with the inhibition of TNFα cytokine production and anti-inflammatory activity. The best experimental results were achieved with the allyl-thienobenzotriazole and isopropyl, p-methoxybenzyl, and hydroxybutyl substituted naphthotriazoles bearing additional chloro or methoxy groups. The allyl-thienobenzotriazole photoproduct is twice as potent an inhibitor of eqBChE compared to the standard galantamine. At the same time, this compound strongly inhibited TNFα production in PBMCs in response to the LPS stimulus. The complexes between selected compounds with the active site of BChE and AChE are assessed by docking, providing insight into the stabilizing interactions between the potential inhibitor and the active site.
    MeSH term(s) Acetylcholinesterase/metabolism ; Anti-Inflammatory Agents/pharmacology ; Butyrylcholinesterase/metabolism ; Cholinesterase Inhibitors/chemistry ; Cholinesterase Inhibitors/pharmacology ; Molecular Docking Simulation ; Structure-Activity Relationship ; Triazoles/chemistry ; Triazoles/pharmacology ; Tumor Necrosis Factor-alpha
    Chemical Substances Anti-Inflammatory Agents ; Cholinesterase Inhibitors ; Triazoles ; Tumor Necrosis Factor-alpha ; Acetylcholinesterase (EC 3.1.1.7) ; Butyrylcholinesterase (EC 3.1.1.8)
    Language English
    Publishing date 2022-07-19
    Publishing country France
    Document type Journal Article
    ZDB-ID 188597-2
    ISSN 1768-3254 ; 0009-4374 ; 0223-5234
    ISSN (online) 1768-3254
    ISSN 0009-4374 ; 0223-5234
    DOI 10.1016/j.ejmech.2022.114616
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  10. Article: Direct potentiometric determination of diastase activity in honey

    Sak-Bosnar, M. / Sakac, N.

    Food chemistry

    2012  Volume 135, Issue 2, Page(s) 827

    Language English
    Document type Article
    ZDB-ID 243123-3
    ISSN 0308-8146
    Database Current Contents Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Z 3634: Show issues

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