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  1. Article: Real-world approach to managing dysgeusia following the use of esketamine nasal spray: a case report.

    Bossaller, Nicholas A / Shelton, Richard C

    Annals of general psychiatry

    2020  Volume 19, Page(s) 13

    Abstract: Background: Patients with depression who are treated with esketamine nasal spray may commonly experience dysgeusia (bad/metallic/bitter taste) and related side effects such as nausea and vomiting. While pretreatment with antiemetics can mitigate or ... ...

    Abstract Background: Patients with depression who are treated with esketamine nasal spray may commonly experience dysgeusia (bad/metallic/bitter taste) and related side effects such as nausea and vomiting. While pretreatment with antiemetics can mitigate or prevent nausea and vomiting, it may not address dysgeusia as a contributing factor. Alternative interventions could help to manage vomiting due to dysgeusia following administration of esketamine nasal spray in those patients who are affected.
    Case presentation: A 40-year-old man presented to the emergency department with depression and started treatment with an oral antidepressant. After providing informed consent to participate in a clinical trial evaluating the efficacy and safety of esketamine for major depressive disorder with active suicidal ideation with intent, he received 84 mg of esketamine nasal spray twice per week for 4 weeks. On the first 2 days of esketamine administration, the patient reported dysgeusia lasting several hours and intermittent retching lasting approximately 20 min. The patient was then given a fruit punch-flavored powdered drink (Crystal Light Fruit Punch™) approximately 25 min after nasal spray administration during the study period. The use of a fruit punch drink resulted in notable improvement of dysgeusia and associated vomiting, with time to resolution occurring within 30 min of the report of the adverse event.
    Conclusions: A fruit punch-flavored powdered drink mix taken shortly after administration of esketamine nasal spray may rapidly manage and prevent vomiting due to dysgeusia.
    Language English
    Publishing date 2020-02-26
    Publishing country England
    Document type Case Reports
    ZDB-ID 2090401-0
    ISSN 1744-859X ; 1475-2832
    ISSN 1744-859X ; 1475-2832
    DOI 10.1186/s12991-020-00262-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Effort-based decision-making in major depressive disorder: a translational model of motivational anhedonia.

    Treadway, Michael T / Bossaller, Nicholas A / Shelton, Richard C / Zald, David H

    Journal of abnormal psychology

    2012  Volume 121, Issue 3, Page(s) 553–558

    Abstract: Anhedonia is a core feature of major depressive disorder (MDD), but the precise nature of anhedonic symptoms is unknown. Whereas anhedonia has traditionally been viewed as a deficit in the experience of pleasure, more recent evidence suggests that ... ...

    Abstract Anhedonia is a core feature of major depressive disorder (MDD), but the precise nature of anhedonic symptoms is unknown. Whereas anhedonia has traditionally been viewed as a deficit in the experience of pleasure, more recent evidence suggests that reduced anticipation and motivation may also be a core feature of this symptom. Here, we provide data from a study in MDD patients and healthy controls using a translational measure of reward motivation, the Effort Expenditure for Rewards Task (EEfRT or "effort"). This task offers subjects a series of trials where they may choose to expend more or less effort for the opportunity to win varying amounts of monetary rewards. We found that MDD patients were less willing to expend effort for rewards than controls. Additionally, we observed that patients were less able to effectively use information about magnitude and probability of rewards to guide their choice behavior. Finally, within the MDD patient group, duration of the current episode was a significant negative predictor of EEfRT task performance. These findings offer novel support for theoretical models proposing that anhedonia in MDD may reflect specific impairments in motivation and reward-based decision-making.
    MeSH term(s) Adult ; Anhedonia ; Decision Making ; Depressive Disorder, Major/psychology ; Female ; Humans ; Male ; Middle Aged ; Motivation ; Psychiatric Status Rating Scales ; Reward
    Language English
    Publishing date 2012-07-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3127-6
    ISSN 1939-1846 ; 0021-843X ; 0096-851X ; 0145-2339 ; 0145-2347
    ISSN (online) 1939-1846
    ISSN 0021-843X ; 0096-851X ; 0145-2339 ; 0145-2347
    DOI 10.1037/a0028813
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5071: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: A randomized open comparison of long-acting injectable risperidone and treatment as usual for prevention of relapse, rehospitalization, and urgent care referral in community-treated patients with rapid cycling bipolar disorder.

    Bobo, William V / Epstein, Richard A / Lynch, Alan / Patton, Tynya D / Bossaller, Nicholas A / Shelton, Richard C

    Clinical neuropharmacology

    2011  Volume 34, Issue 6, Page(s) 224–233

    Abstract: Objective: To compare adjunctive long-acting injectable risperidone plus treatment as usual (RLAI+TAU) versus TAU alone for relapse, rehospitalization, and urgent care events in patients with bipolar disorder in routine care settings.: Methods: This ... ...

    Abstract Objective: To compare adjunctive long-acting injectable risperidone plus treatment as usual (RLAI+TAU) versus TAU alone for relapse, rehospitalization, and urgent care events in patients with bipolar disorder in routine care settings.
    Methods: This was a 12-month randomized open comparison of RLAI+TAU (n = 20) and TAU alone (n = 25) in adults with rapid cycling, Mini International Neuropsychiatric Interview-confirmed bipolar I/II disorder and 4 or more illness relapses in the preceding 12 months. Clinical outcome was assessed every 2 weeks using the Longitudinal Interval Follow-up Evaluation instrument. Psychopathology and quality of life were assessed monthly using the Young Mania Rating Scale, Montgomery-Asberg Depression Rating Scale, Quick Inventory of Depressive Symptoms-Self Report 16 and Quality of Life, Enjoyment, and Satisfaction Questionnaire. Relapse was defined using symptom severity, necessary clinical adjustment of medications, and urgent care referrals. Relapse rates and duration were calculated per person per year of follow-up. All treatments were provided by community-based clinicians.
    Results: There were no significant between-groups differences in the total number or duration of relapse events (any cause) or in the number of manic or depressive relapses. Thirteen of 14 urgent care events (hospitalization, emergency department visit, intensive outpatient, or respite care referral) occurred with TAU alone (92.3%). Urgent care referral (P < 0.04) and necessary medication change rates (P = 0.01) were significantly lower in the RLAI+TAU group. There were no significant between-groups differences in the duration of follow-up, hospitalization rates, or psychopathology over time.
    Conclusions: Rates of any-cause relapse may not differ significantly between RLAI+TAU and TAU alone; however, RLAI may reduce the need for urgent care referrals or the frequency of medication adjustments to prevent relapse in community-treated patients with rapid cycling bipolar disorder. Additional investigation is warranted.
    MeSH term(s) Adult ; Bipolar Disorder/drug therapy ; Bipolar Disorder/prevention & control ; Bipolar Disorder/psychology ; Community Health Services/methods ; Community Health Services/trends ; Delayed-Action Preparations ; Emergency Medical Services/methods ; Emergency Medical Services/trends ; Female ; Follow-Up Studies ; Hospitalization/trends ; Humans ; Injections ; Longitudinal Studies ; Male ; Middle Aged ; Referral and Consultation/trends ; Risperidone/administration & dosage ; Secondary Prevention ; Treatment Outcome
    Chemical Substances Delayed-Action Preparations ; Risperidone (L6UH7ZF8HC)
    Language English
    Publishing date 2011-11-02
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 199293-4
    ISSN 1537-162X ; 0362-5664
    ISSN (online) 1537-162X
    ISSN 0362-5664
    DOI 10.1097/WNF.0b013e318237709a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Se 437: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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