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  1. Book ; Online ; E-Book: Melanoma development

    Bosserhoff, Anja K.

    molecular biology, genetics and clinical application

    2017  

    Author's details Anja K. Bosserhoff editor
    Keywords Melanoma / metabolism ; Melanoma / genetics ; Melanoma / pathology ; Cell Transformation, Neoplastic
    Language English
    Size 1 Online-Ressource (viii, 447 Seiten), Illustrationen
    Edition Second edition
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019390841
    ISBN 978-3-319-41319-8 ; 9783319413174 ; 3-319-41319-8 ; 3319413171
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Melanoma development

    Bosserhoff, Anja-Katrin

    molecular biology, genetics and clinical application

    2011  

    Author's details Anja Bosserhoff (ed.)
    Language English
    Size XI, 376 S. : Ill.,graf. Darst.
    Publisher Springer
    Publishing place Wienu.a.
    Publishing country Austria
    Document type Book
    HBZ-ID HT016831308
    ISBN 978-3-7091-0370-8 ; 3-7091-0370-3 ; 9783709103715 ; 3709103711
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2011 A 3110 order for loan Magazin

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  3. Book: Joint meeting of the German Society for Cell Biology and the German Melanoma Research Network

    Bosserhoff, Anja-Katrin

    University of Regensburg, March 10 - 13, 2010

    (European journal of cell biology : Suppl. ; 60 ; Abstracts / German Society for Cell Biology ; 33)

    2010  

    Institution Deutsche Gesellschaft für Zellbiologie
    Author's details local organizers: Anja Bosserhoff
    Series title European journal of cell biology : Suppl. ; 60
    Abstracts / German Society for Cell Biology ; 33
    Abstracts / DGZ
    European journal of cell biology
    European journal of cell biology ; Suppl.
    Collection Abstracts / DGZ
    European journal of cell biology
    European journal of cell biology ; Suppl.
    Language English
    Size 75 S.
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT016300755
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 667 -Suppl.60- not available for loan Zeitschriften-Lesesaal

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  4. Book ; Online ; Thesis: Die Rolle der miR-101-3p als Tumorsuppressor in Bezug auf die genomische Integrität des malignen Melanoms

    Lämmerhirt, Lisa [Verfasser] / Boßerhoff, Anja Katrin [Akademischer Betreuer] / Boßerhoff, Anja Katrin [Gutachter] / Slany, Robert [Gutachter]

    2024  

    Author's details Lisa Lämmerhirt ; Gutachter:  Anja Katrin Boßerhoff,  Robert Slany ; Betreuer: Anja Katrin Boßerhoff
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
    Publishing place Erlangen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  5. Book ; Online ; Thesis: Analyse des onkogenen EGR2-Signalwegs im malignen Melanom

    Schaar, Dominik [Verfasser] / Bosserhoff, Anja [Akademischer Betreuer] / Bosserhoff, Anja [Gutachter]

    2022  

    Author's details Dominik Schaar ; Gutachter: Anja Bosserhoff ; Betreuer: Anja Bosserhoff
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
    Publishing place Erlangen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  6. Book ; Online ; Thesis: Molekulare Mechanismen des Durchbrechens der Onkogen-induzierten Seneszenz im Rahmen der Melanomentstehung

    Kluge, Viola [Verfasser] / Bosserhoff, Anja [Akademischer Betreuer] / Winkler, Thomas [Gutachter]

    2024  

    Author's details Viola Kluge ; Gutachter: Thomas Winkler ; Betreuer: Anja Bosserhoff
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
    Publishing place Erlangen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  7. Article ; Online: NRN1 interacts with Notch to increase oncogenic STAT3 signaling in melanoma.

    Devitt, Lucia / Westphal, Dana / Pieger, Katharina / Schneider, Nadja / Bosserhoff, Anja Katrin / Kuphal, Silke

    Cell communication and signaling : CCS

    2024  Volume 22, Issue 1, Page(s) 256

    Abstract: Background: Melanoma is a highly heterogeneous cancer, in which frequent changes in activation of signaling pathways lead to a high adaptability to ever changing tumor microenvironments. The elucidation of cancer specific signaling pathways is of great ... ...

    Abstract Background: Melanoma is a highly heterogeneous cancer, in which frequent changes in activation of signaling pathways lead to a high adaptability to ever changing tumor microenvironments. The elucidation of cancer specific signaling pathways is of great importance, as demonstrated by the inhibitor of the common BrafV600E mutation PLX4032 in melanoma treatment. We therefore investigated signaling pathways that were influenced by neurotrophin NRN1, which has been shown to be upregulated in melanoma.
    Methods: Using a cell culture model system with an NRN1 overexpression, we investigated the influence of NRN1 on melanoma cells' functionality and signaling. We employed real time cell analysis and spheroid formation assays, while for investigation of molecular mechanisms we used a kinase phosphorylation kit as well as promotor activity analysis followed by mRNA and protein analysis.
    Results: We revealed that NRN1 interacts directly with the cleaved intracellular domain (NICD) of Notch1 and Notch3, causing a potential retention of NICD in the cytoplasm and thereby reducing the expression of its direct downstream target Hes1. This leads to decreased sequestration of JAK and STAT3 in a Hes1-driven phosphorylation complex. Consequently, our data shows less phosphorylation of STAT3 while presenting an accumulation of total protein levels of STAT3 in association with NRN1 overexpression. The potential of the STAT3 signaling pathway to act in both a tumor suppressive and oncogenic manner led us to investigate specific downstream targets - namely Vegf A, Mdr1, cMet - which were found to be upregulated under oncogenic levels of NRN1.
    Conclusions: In summary, we were able to show that NRN1 links oncogenic signaling events between Notch and STAT3 in melanoma. We also suggest that in future research more attention should be payed to cellular regulation of signaling molecules outside of the classically known phosphorylation events.
    MeSH term(s) Humans ; Carcinogenesis/genetics ; Carcinogenesis/metabolism ; Cell Line, Tumor ; Melanoma/metabolism ; Melanoma/genetics ; Melanoma/pathology ; Phosphorylation ; Protein Binding ; Receptor, Notch1/metabolism ; Receptor, Notch1/genetics ; Receptor, Notch3/metabolism ; Receptor, Notch3/genetics ; Signal Transduction ; STAT3 Transcription Factor/metabolism ; STAT3 Transcription Factor/genetics ; Neuropeptides
    Chemical Substances Receptor, Notch1 ; Receptor, Notch3 ; STAT3 protein, human ; STAT3 Transcription Factor ; NRN1 protein, human ; Neuropeptides
    Language English
    Publishing date 2024-05-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2126315-2
    ISSN 1478-811X ; 1478-811X
    ISSN (online) 1478-811X
    ISSN 1478-811X
    DOI 10.1186/s12964-024-01632-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Role of Amino Acid Transporter SNAT1/SLC38A1 in Human Melanoma.

    Böhme-Schäfer, Ines / Lörentz, Sandra / Bosserhoff, Anja Katrin

    Cancers

    2022  Volume 14, Issue 9

    Abstract: The tumor metabolism is an important driver of cancer cell survival and growth, as rapidly dividing tumor cells exhibit a high demand for energetic sources and must adapt to microenvironmental changes. Therefore, metabolic reprogramming of cancer cells ... ...

    Abstract The tumor metabolism is an important driver of cancer cell survival and growth, as rapidly dividing tumor cells exhibit a high demand for energetic sources and must adapt to microenvironmental changes. Therefore, metabolic reprogramming of cancer cells and the associated deregulation of nutrient transporters are a hallmark of cancer cells. Amino acids are essential for cancer cells to synthesize the necessary amount of protein, DNA, and RNA. Although cancer cells can synthesize glutamine de novo, most cancer cells show an increased uptake of glutamine from the tumor microenvironment. Especially SNAT1/SLC38A1, a member of the sodium neutral amino acid transporter (SNAT) family, plays an essential role during major net import of glutamine. In this study, we revealed a significant upregulation of SNAT1 expression in human melanoma tissue in comparison to healthy epidermis and an increased SNAT1 expression level in human melanoma cell lines when compared to normal human melanocytes (NHEMs). We demonstrated that functional inhibition of SNAT1 with α-(methylamino) isobutyric acid (MeAIB), as well as siRNA-mediated downregulation reduces cancer cell growth, cellular migration, invasion, and leads to induction of senescence in melanoma cells. Consequently, these results demonstrate that the amino acid transporter SNAT1 is essential for cancer growth, and indicates a potential target for cancer chemotherapy.
    Language English
    Publishing date 2022-04-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14092151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Thesis: Expressionsregulation, funktionelle Bedeutung und klinische Relevanz des Proteins MIA (Melanoma inhibitory activity) im malignen Melanom

    Bosserhoff, Anja-Katrin

    2000  

    Author's details vorgelegt von Anja-Katrin Boßerhoff
    Language German
    Size III, 131 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Aachen, Techn. Hochsch., Habil.-Schr., 2000
    HBZ-ID HT012940473
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2002 E 90 order to use in reading room Magazin

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  10. Book ; Online ; Thesis: Die Funktion des Tumorsuppressors CYLD in endothelial-assoziierten und epigenetischen Prozessen im malignen Melanom

    Schott, Mandy [Verfasser] / Boßerhoff, Anja Katrin [Akademischer Betreuer] / Boßerhoff, Anja Katrin [Gutachter]

    2022  

    Author's details Mandy Schott ; Gutachter: Anja Katrin Boßerhoff ; Betreuer: Anja Katrin Boßerhoff
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
    Publishing place Erlangen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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