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  1. Article ; Online: How can we prevent diarrhea induced by systemic treatments in oncological patients? An evaluation of phase II trials.

    Esposito, Andrea / Bossi, Paolo

    Expert opinion on emerging drugs

    2023  Volume 28, Issue 4, Page(s) 213–216

    MeSH term(s) Humans ; Diarrhea/prevention & control ; Clinical Trials, Phase II as Topic ; Neoplasms/complications
    Language English
    Publishing date 2023-12-26
    Publishing country England
    Document type Editorial
    ZDB-ID 2061369-6
    ISSN 1744-7623 ; 1472-8214
    ISSN (online) 1744-7623
    ISSN 1472-8214
    DOI 10.1080/14728214.2023.2264182
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Se 1925: Show issues Location:
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  2. Article ; Online: Understanding Protective Mechanisms of an Oral Probiotic in Reducing Radiation-Induced Oral Mucositis.

    Wardill, Hannah R / Bossi, Paolo / Sonis, Stephen T

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2024  Volume 42, Issue 12, Page(s) 1436–1438

    MeSH term(s) Humans ; Stomatitis ; Radiation Injuries ; Probiotics ; Mucositis ; Head and Neck Neoplasms
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.23.02706
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 650: Show issues

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  3. Article: Human Papilloma Virus (HPV) driven oropharyngeal cancer in current or previous heavy smokers: should we look for a different treatment paradigm?

    Lorini, Luigi / Bossi, Paolo / Psyrri, Amanda / Bonomo, Pierluigi

    Frontiers in oncology

    2024  Volume 14, Page(s) 1383019

    Abstract: Introduction: Human papillomavirus Virus (HPV)-associated oropharyngeal squamous cell carcinoma (OSCC) has increased in incidence in recent decades and represents a heterogeneous disease entity in the context of Head and Neck Squamous Cell Carcinoma ( ... ...

    Abstract Introduction: Human papillomavirus Virus (HPV)-associated oropharyngeal squamous cell carcinoma (OSCC) has increased in incidence in recent decades and represents a heterogeneous disease entity in the context of Head and Neck Squamous Cell Carcinoma (HNSCC), in terms of disease prognosis. Treatment of locoregionally advanced OSCC is mainly based on concurrent chemoradiotherapy. Given the younger age of patients, if compared with HPV-negative counterparts, and the high cure rates, the acute- and long-term toxicity in survivors represents a field of interest. However, patient selection for de-escalation trials remains a major challenge due to the lack of robust validated prognostic indicators within the HPV-associated OSCC.
    Discussion: The impact of smoking status on HPV-associated OSCC prognosis has been demonstrated in the majority of studies. However, the magnitude of the association is unclear due to variability in smoking metrics and study outcomes. Smoking status has been identified as a potential confounding factor in HPV-positive de-escalation trials. Smokers with HPV-positive OSCC have a worse prognosis in most studies than non-smokers and may require different and more aggressive therapeutic strategies.
    Language English
    Publishing date 2024-04-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2024.1383019
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  4. Article: Prognostic Nutritional Index: an easy nutritional screening for patients with head and neck cancer?

    Bossi, Paolo

    ESMO open

    2018  Volume 3, Issue 6, Page(s) e000449

    Language English
    Publishing date 2018-10-24
    Publishing country England
    Document type Journal Article
    ISSN 2059-7029
    ISSN 2059-7029
    DOI 10.1136/esmoopen-2018-000449
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Personalized Medicine in Skull Base and Sinonasal Tumors.

    Mattavelli, Davide / Bossi, Paolo

    Journal of personalized medicine

    2022  Volume 12, Issue 12

    Abstract: Skull base and sinonasal tumors (SBSNTs) represent a considerable challenge for clinicians in view of their rarity, anatomical complexity of the site of origin, and great histological variety [ ... ]. ...

    Abstract Skull base and sinonasal tumors (SBSNTs) represent a considerable challenge for clinicians in view of their rarity, anatomical complexity of the site of origin, and great histological variety [...].
    Language English
    Publishing date 2022-12-01
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm12121983
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Immunotherapy for Cutaneous Squamous Cell Carcinoma: Results and Perspectives.

    Alberti, Andrea / Bossi, Paolo

    Frontiers in oncology

    2022  Volume 11, Page(s) 727027

    Abstract: Although initial surgical excision cures 95% of patients, a minority of cutaneous squamous cell carcinomas (cSCCs) are judged to be unresectable, either locally advanced or with unresectable regional lymph nodes or distant metastases. These patients are ... ...

    Abstract Although initial surgical excision cures 95% of patients, a minority of cutaneous squamous cell carcinomas (cSCCs) are judged to be unresectable, either locally advanced or with unresectable regional lymph nodes or distant metastases. These patients are offered systemic treatments. Response rate to chemotherapy is relatively low and not durable, as well as the results obtained with epidermal growth factor inhibitors (EGFRi). Like other cutaneous tumors, cSCCs have high immunogenicity, driven by the high mutational burden, the ultraviolet signature, and the overexpressed tumor antigens. Two checkpoint inhibitors, cemiplimab and pembrolizumab, achieved high response rate and survival with fewer toxicities than other available systemic agents. These promising results prompted to investigate new combination strategies of systemic therapy and surgery or radiotherapy. Subgroup analysis showed promising role of immunotherapy to facilitate surgery in locally advanced cSCC and, in a small group of patients, long-term survivals without resection. However, some cSCCs treated with immunotherapy develop either early or late resistance, so new drugs and new combinations are in a clinical study to overcome the mechanism underpinning these resistances. The present review focuses on the progress with immunotherapy to date and on new therapeutic strategies for cSCC.
    Language English
    Publishing date 2022-01-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2021.727027
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  7. Article ; Online: Pembrolizumab with or without chemotherapy in recurrent or metastatic head and neck squamous cell carcinoma: Hypothesis coming from the subgroup analysis.

    De Felice, Francesca / Bossi, Paolo

    Oral oncology

    2022  Volume 137, Page(s) 106275

    MeSH term(s) Humans ; Squamous Cell Carcinoma of Head and Neck/drug therapy ; Antibodies, Monoclonal, Humanized/therapeutic use ; Carcinoma, Squamous Cell/pathology ; Head and Neck Neoplasms/drug therapy ; Neoplasm Recurrence, Local/drug therapy ; Neoplasm Recurrence, Local/pathology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use
    Chemical Substances pembrolizumab (DPT0O3T46P) ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2022-12-19
    Publishing country England
    Document type Letter
    ZDB-ID 1120465-5
    ISSN 1879-0593 ; 0964-1955 ; 1368-8375
    ISSN (online) 1879-0593
    ISSN 0964-1955 ; 1368-8375
    DOI 10.1016/j.oraloncology.2022.106275
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4869: Show issues Location:
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    Zs.A 456: Show issues Location:
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  8. Article ; Online: The Burning Question: Prophylactic Gabapentin for Mucositis-Related Pain in Patients Undergoing Chemoradiation Therapy for Head and Neck Cancer?

    McDowell, Lachlan / Bossi, Paolo

    International journal of radiation oncology, biology, physics

    2022  Volume 112, Issue 4, Page(s) 938–941

    MeSH term(s) Chemoradiotherapy/adverse effects ; Gabapentin/therapeutic use ; Head and Neck Neoplasms/radiotherapy ; Humans ; Mucositis/etiology ; Pain/etiology
    Chemical Substances Gabapentin (6CW7F3G59X)
    Language English
    Publishing date 2022-02-21
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2021.12.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1218: Show issues Location:
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  9. Article ; Online: Measuring financial toxicity in head and neck cancer: a systematic review.

    Raggini, Elisa / Mattavelli, Davide / Zigliani, Gabriele / Bossi, Paolo / Piazza, Cesare

    Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale

    2024  Volume 44, Issue 1, Page(s) 1–12

    Abstract: Objective: The current study systematically reviews the literature about financial toxicity (FT) in head and neck cancer patients. Three databases were reviewed: PubMed, Scopus and Web of Science.: Methods: Full text English papers published from ... ...

    Abstract Objective: The current study systematically reviews the literature about financial toxicity (FT) in head and neck cancer patients. Three databases were reviewed: PubMed, Scopus and Web of Science.
    Methods: Full text English papers published from 2000 to 2022 reporting on quantitative results about FT in head and neck cancer survivors collected through structured questionnaires or interviews were included.
    Results: Twenty-seven articles were included. Most of the articles were published after 2015 and from United States. There was a slight prevalence of papers dealing with oropharyngeal cancer, squamous-cell carcinoma and locally advanced head and neck cancer. Measures of FT were obtained through validated questionnaires like COST, FIT and FDQ. Collected data were mostly referrable to financial spending, financial resources, psychosocial aspect, support seeking, coping care and coping lifestyle subdomain. FT scores by COST were found to be worse in the COVID era. Financial counseling and adequate information about the costs of treatment were two effective strategies to mitigate FT.
    Conclusions: FT is a relatively new challenge in head and neck cancer treatment, whose expenses are higher than therapies for other cancers. A universal method to assess FT and a unified guideline for the administration of questionnaires are needed to mitigate FT and to improve patient outcomes.
    MeSH term(s) Humans ; Financial Stress ; Head and Neck Neoplasms/economics ; Oropharyngeal Neoplasms/economics ; Quality of Life ; Surveys and Questionnaires
    Language English
    Publishing date 2024-02-14
    Publishing country Italy
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 604898-5
    ISSN 1827-675X ; 0392-100X
    ISSN (online) 1827-675X
    ISSN 0392-100X
    DOI 10.14639/0392-100X-N2762
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Bridging gaps in cancer cachexia Care: Current insights and future perspectives.

    Bianchini, Carlotta / Bonomo, Pierluigi / Bossi, Paolo / Caccialanza, Riccardo / Fabi, Alessandra

    Cancer treatment reviews

    2024  Volume 125, Page(s) 102717

    Abstract: Cachexia is characterized by severe weight loss and skeletal muscle depletion, and is a threat to cancer patients by worsening their prognosis. International guidelines set indications for the screening and diagnosis of cancer cachexia and suggest ... ...

    Abstract Cachexia is characterized by severe weight loss and skeletal muscle depletion, and is a threat to cancer patients by worsening their prognosis. International guidelines set indications for the screening and diagnosis of cancer cachexia and suggest interventions (nutritional support, physical exercise, and pharmacological treatments). Nevertheless, real-life experience not always aligns with such indications. We aimed to review the current state of the field and the main advancements, with a focus on real-life clinical practice from the perspectives of oncologists, nutrition professionals, and radiologists. Pragmatic solutions are proposed to improve the current management of the disease, emphasizing the importance of increasing awareness of clinical nutrition's benefits, fostering multidisciplinary collaboration, promoting early identification of at-risk patients, and leveraging available resources. Given the distinct needs of patients who are receiving oncologic anti-cancer treatments and those in the follow-up phase, the use of tailored approaches is encouraged. The pivotal role of healthcare professionals in managing patients in active treatment is highlighted, while patient and caregiver empowerment should be strengthened in the follow-up phase. Telemedicine and web-based applications represent valuable tools for continuous monitoring of patients, facilitating timely and personalized intervention through effective communication between patients and healthcare providers. These actions can potentially improve the outcomes, well-being, and survival of cancer patients with cachexia.
    MeSH term(s) Humans ; Cachexia/diagnosis ; Cachexia/etiology ; Cachexia/therapy ; Neoplasms/complications ; Neoplasms/therapy ; Prognosis
    Language English
    Publishing date 2024-03-13
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 125102-8
    ISSN 1532-1967 ; 0305-7372
    ISSN (online) 1532-1967
    ISSN 0305-7372
    DOI 10.1016/j.ctrv.2024.102717
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    Zs.MO 611: Show issues

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