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  1. Article ; Online: Perspective: Linkage Maps, Communities of Geneticists, and Genome Databases.

    Botstein, David

    Genetics

    2020  Volume 216, Issue 2, Page(s) 261–262

    Abstract: The Thomas Hunt Morgan Medal recognizes lifetime contributions to the field of genetics. The 2020 recipient is David Botstein of Calico Labs and Princeton University, recognizing his multiple contributions to genetics, including the collaborative ... ...

    Abstract The Thomas Hunt Morgan Medal recognizes lifetime contributions to the field of genetics. The 2020 recipient is David Botstein of Calico Labs and Princeton University, recognizing his multiple contributions to genetics, including the collaborative development of methods for defining genetic pathways, mapping genomes, and analyzing gene expression.
    MeSH term(s) Awards and Prizes ; Communication ; Databases, Genetic/history ; Genetic Linkage ; Genetics/history ; History, 20th Century ; History, 21st Century
    Language English
    Publishing date 2020-10-05
    Publishing country United States
    Document type Historical Article ; Journal Article
    ZDB-ID 2167-2
    ISSN 1943-2631 ; 0016-6731
    ISSN (online) 1943-2631
    ISSN 0016-6731
    DOI 10.1534/genetics.120.303647
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Lasker∼Koshland to genetics pioneer.

    Botstein, David

    Cell

    2014  Volume 158, Issue 6, Page(s) 1230–1232

    Abstract: The 2014 Lasker∼Koshland Special Achievement Award will be presented to Mary-Claire King, a pioneer and visionary who revolutionized the use of genetics to identify disease genes, provide insights into human evolution, and champion human rights causes. ...

    Abstract The 2014 Lasker∼Koshland Special Achievement Award will be presented to Mary-Claire King, a pioneer and visionary who revolutionized the use of genetics to identify disease genes, provide insights into human evolution, and champion human rights causes.
    MeSH term(s) Animals ; Awards and Prizes ; Biological Evolution ; Disease/genetics ; Female ; Genetics, Medical/history ; History, 20th Century ; Human Rights ; Humans ; United States
    Language English
    Publishing date 2014-09-11
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2014.08.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Why we need more basic biology research, not less.

    Botstein, David

    Molecular biology of the cell

    2012  Volume 23, Issue 21, Page(s) 4160–4161

    Abstract: Much of the spectacular progress in biomedical science over the last half-century is the direct consequence of the work of thousands of basic scientists whose primary goal was understanding of the fundamental working of living things. Despite this, many ... ...

    Abstract Much of the spectacular progress in biomedical science over the last half-century is the direct consequence of the work of thousands of basic scientists whose primary goal was understanding of the fundamental working of living things. Despite this, many politicians, funders, and even scientists have come to believe that the pace of successful applications to medical diagnosis and therapy is limited by our willingness to focus directly on human health, rather than a continuing deficit of understanding. By this theory, curiosity-driven research, aimed at understanding, is no longer important or even useful. What is advocated instead is "translational" research aimed directly at treating disease. I believe this idea to be deeply mistaken. Recent history suggests instead that what we have learned in the last 50 years is only the beginning. The way forward is to invest more in basic science, not less.
    MeSH term(s) Biology ; Biotechnology ; Humans ; Molecular Sequence Annotation ; Research ; Translational Medical Research
    Language English
    Publishing date 2012-10-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1098979-1
    ISSN 1939-4586 ; 1059-1524
    ISSN (online) 1939-4586
    ISSN 1059-1524
    DOI 10.1091/mbc.E12-05-0406
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Decoding the language of genetics

    Botstein, David

    2015  

    Abstract: In this book, the distinguished geneticist David Botstein offers help and advice to scientists and physicians daunted by the arcane technical terms that flourish in his discipline. As knowledge of gene function has progressed over the past century, it ... ...

    Author's details David Botstein
    Abstract "In this book, the distinguished geneticist David Botstein offers help and advice to scientists and physicians daunted by the arcane technical terms that flourish in his discipline. As knowledge of gene function has progressed over the past century, it has acquired a vocabulary of specialized, sometimes confusing, terms to explain some of its fundamental principles; how traits and diseases are inherited; how genes are organized and regulated in the genome; and how the genetic code is read and translated by cells. These terms often prevent the less expert from fully understanding the concepts that underlie the power of genetic studies. This is not just a theoretical handicap. As more and more individuals learn about their genomes, the information these sequences contain cannot be understood or explained without reference to the basic ideas of genetics. Botstein draws on his long experience as a teacher and pioneering scientist to explain and illuminate what many genetic terms mean and how they entered common usage. To colleagues in the field, his message is one of encouragement, to "make our work more generally accessible by modernizing, clarifying, and simplifying the language we use and teach.""--

    "This is a book about the conceptual language of genetics. There is a need for special words and terms to deal with some of the essential abstractions in genetics; these are the focus of this book. It is intended to help readers with diverse interests and experience to think about genetic analysis in a more sophisticated and creative way"--
    MeSH term(s) Genetics ; Terminology as Topic
    Language English
    Size xiii, 223 pages :, illustrations (some color) ;, 24 cm
    Document type Book
    ISBN 9781621820925 ; 1621820920
    Database Catalogue of the US National Library of Medicine (NLM)

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  5. Book: Decoding the language of genetics

    Botstein, David

    2015  

    Abstract: In this book, the distinguished geneticist David Botstein offers help and advice to scientists and physicians daunted by the arcane technical terms that flourish in his discipline. As knowledge of gene function has progressed over the past century, it ... ...

    Author's details David Botstein
    Abstract "In this book, the distinguished geneticist David Botstein offers help and advice to scientists and physicians daunted by the arcane technical terms that flourish in his discipline. As knowledge of gene function has progressed over the past century, it has acquired a vocabulary of specialized, sometimes confusing, terms to explain some of its fundamental principles; how traits and diseases are inherited; how genes are organized and regulated in the genome; and how the genetic code is read and translated by cells. These terms often prevent the less expert from fully understanding the concepts that underlie the power of genetic studies. This is not just a theoretical handicap. As more and more individuals learn about their genomes, the information these sequences contain cannot be understood or explained without reference to the basic ideas of genetics. Botstein draws on his long experience as a teacher and pioneering scientist to explain and illuminate what many genetic terms mean and how they entered common usage. To colleagues in the field, his message is one of encouragement, to "make our work more generally accessible by modernizing, clarifying, and simplifying the language we use and teach.""--

    "This is a book about the conceptual language of genetics. There is a need for special words and terms to deal with some of the essential abstractions in genetics; these are the focus of this book. It is intended to help readers with diverse interests and experience to think about genetic analysis in a more sophisticated and creative way"--
    Keywords Genetics
    Language English
    Size xiii, 223 pages, Illustrationen, 24 cm
    Publisher Cold Spring Harbor Laboratory Press
    Publishing place Cold Spring Harbor, New York
    Document type Book
    Note Includes bibliographical references and index
    ISBN 1621820920 ; 9781621820925
    Database Friedrich Loeffler-Institute, Federal Research Institute for Animal Health

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  6. Article ; Online: Genome-sequencing anniversary. Fruits of genome sequences for biology.

    Botstein, David

    Science (New York, N.Y.)

    2011  Volume 331, Issue 6020, Page(s) 1025

    MeSH term(s) Animals ; Biological Evolution ; Genes ; Human Genome Project/economics ; Humans ; Proteins/genetics ; Proteins/physiology ; Sequence Analysis, DNA/economics
    Chemical Substances Proteins
    Language English
    Publishing date 2011-02-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.1204038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Lasker∼Koshland to Genetics Pioneer

    Botstein, David

    Cell. 2014 Sept. 11, v. 158

    2014  

    Abstract: The 2014 Lasker∼Koshland Special Achievement Award will be presented to Mary-Claire King, a pioneer and visionary who revolutionized the use of genetics to identify disease genes, provide insights into human evolution, and champion human rights causes. ...

    Abstract The 2014 Lasker∼Koshland Special Achievement Award will be presented to Mary-Claire King, a pioneer and visionary who revolutionized the use of genetics to identify disease genes, provide insights into human evolution, and champion human rights causes.
    Keywords evolution ; genes ; genetics ; human rights ; humans
    Language English
    Dates of publication 2014-0911
    Size p. 1230-1232.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2014.08.020
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Technological innovation leads to fundamental understanding in cell biology.

    Botstein, David

    Molecular biology of the cell

    2010  Volume 21, Issue 22, Page(s) 3791–3792

    MeSH term(s) Cell Biology/instrumentation ; Cell Biology/trends ; Microscopy/methods ; Molecular Biology/methods ; Molecular Biology/trends
    Language English
    Publishing date 2010-11-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1098979-1
    ISSN 1939-4586 ; 1059-1524
    ISSN (online) 1939-4586
    ISSN 1059-1524
    DOI 10.1091/mbc.E10-04-0366
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: It's the data!

    Botstein, David

    Molecular biology of the cell

    2010  Volume 21, Issue 1, Page(s) 4–6

    Abstract: Three articles from the early years of Molecular Biology of the Cell (MBoC) have had remarkably many citations in the literature since their publication approximately 10 years ago. As a coauthor of these articles and the former editor of MBoC, I was ... ...

    Abstract Three articles from the early years of Molecular Biology of the Cell (MBoC) have had remarkably many citations in the literature since their publication approximately 10 years ago. As a coauthor of these articles and the former editor of MBoC, I was asked for possible explanations. I believe the answer lies in the unusual nature of these articles: each presents and summarizes gene expression data for nearly every gene in the yeast or human genomes. Continuing interest in the data themselves by cell biologists, rather than results or conclusions drawn by the authors, best accounts for the citation history. The flatness of the numbers of citations over time, the continuing high rate of accesses to individual Web sites set up to allow searching and display of the underlying data, and the large fraction of citations in journals focused on mathematics and computation all support the same conclusion: it's the data.
    MeSH term(s) Access to Information ; Bibliometrics/history ; Databases as Topic ; Editorial Policies ; History, 20th Century ; History, 21st Century ; Humans ; Saccharomyces cerevisiae/genetics ; Statistics as Topic
    Language English
    Publishing date 2010-01-04
    Publishing country United States
    Document type Historical Article ; Journal Article ; Comment
    ZDB-ID 1098979-1
    ISSN 1939-4586 ; 1059-1524
    ISSN (online) 1939-4586
    ISSN 1059-1524
    DOI 10.1091/mbc.E09-07-0575
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book: Evolution and cancer

    Botstein, David

    2012  

    Abstract: CIT): There is a broad consensus that cancer is the result of somatic cells having serially gained, by a series of mutations, the ability to grow independently, to recruit resources from the circulation and the stroma, to invade local tissues, and to ... ...

    Institution National Institutes of Health (U.S.)
    Author's details David Botstein
    Abstract (CIT): There is a broad consensus that cancer is the result of somatic cells having serially gained, by a series of mutations, the ability to grow independently, to recruit resources from the circulation and the stroma, to invade local tissues, and to found anatomically distant metastases, ultimately killing the host. From the point of view of the cancer-causing somatic cell population, this is evolution driven by mutation and selection. Genomics has resulted in a parallel consensus that the central functions of all eukaryotes are highly conserved, not only at the level of individual protein functions, but also complex biological pathways and systems. These ideas motivated a comparison between results of molecular genetic studies of experimental evolution in yeast and the molecular genetic phenomena associated with tumorigenesis and tumor progression. We find some very striking similarities, including recurring genomic rearrangements, alterations of the regulation of specific growth-promoting genes, population-genetic features that affect the fitness trajectories of growth rate variants in evolving populations, and physiological and metabolic similarities derived from the conservation of the basic plan of growth and cell multiplication among all eukaryotes. It is hoped that some of the insights from yeast will aid the interpretation of sequence changes found in tumors, especially in the urgent necessity to distinguish "driver" from "passenger" mutations." David Botstein"s fundamental contributions to modern genetics include the development of genetic methods for understanding biological functions and the discovery of the functions of many yeast and bacterial genes. In 1980, Botstein and three colleagues proposed a method for mapping human genes that laid the groundwork for the Human Genome Project. The basic principle of the mapping scheme was to develop, by recombinant DNA techniques, random single-copy DNA probes capable of detecting DNA sequence polymorphisms when hybridized to restriction digests, or specific fragments, of an individual's DNA. The method was used in subsequent years to identify several human disease genes, such as Huntington's and BRCA1. Variations of this method enabled the sequencing phase of the Human Genome Project.
    MeSH term(s) Neoplasms/etiology ; Biological Evolution ; Neoplasms/genetics
    Language English
    Size 1 online resource (1 streaming video file (59 min.) :, sd., col.)
    Publisher National Institutes of Health
    Publishing place Bethesda, Md
    Document type Book
    Note Closed-captioned.
    Database Catalogue of the US National Library of Medicine (NLM)

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