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  1. Article ; Online: Microbial synthesis of health-promoting inositols.

    Yoshida, Ken-Ichi / Bott, Michael

    Current opinion in biotechnology

    2024  Volume 87, Page(s) 103114

    Abstract: D-chiro-inositol and scyllo-inositol are known for their health-promoting properties and promising as ingredients for functional foods. Strains of Bacillus subtilis and Corynebacterium glutamicum were created by metabolic engineering capable of ... ...

    Abstract D-chiro-inositol and scyllo-inositol are known for their health-promoting properties and promising as ingredients for functional foods. Strains of Bacillus subtilis and Corynebacterium glutamicum were created by metabolic engineering capable of inexpensive production of these two rare inositols from myo-inositol, which is the most common inositol in nature. In addition, further modifications have enabled the synthesis of the two rare inositols from the much-cheaper carbon sources, glucose or sucrose.
    Language English
    Publishing date 2024-03-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1052045-4
    ISSN 1879-0429 ; 0958-1669
    ISSN (online) 1879-0429
    ISSN 0958-1669
    DOI 10.1016/j.copbio.2024.103114
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3071: Show issues Location:
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  2. Book: Amino acid fermentation

    Yokota, Atsushi / Ikeda, Masato / Bott, Michael

    (Advances in biochemical engineering, biotechnology ; 159)

    2017  

    Author's details Atsushi Yokota, Masato Ikeda, editors ; with contributions by M. Bott, L. Eggeling [und weiteren]
    Series title Advances in biochemical engineering, biotechnology ; 159
    Collection
    Keywords Amino acid ; Bacteriology ; Biotechnology ; Fermentation ; Industrial production ; Metabolic engineering
    Subject code 570
    Language English
    Size viii, 310 Seiten, Illustrationen, Diagramme, 23.5 cm x 15.5 cm, 0 g
    Publisher Springer
    Publishing place Tokyo
    Publishing country Japan
    Document type Book
    HBZ-ID HT019350081
    ISBN 978-4-431-56518-5 ; 4-431-56518-3
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    178/91 available for loan (reading room) Freihandmagazin (U1)

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  3. Book ; Online ; Thesis: Studies on the cAMP-responsive regulatory network of Corynebacterium glutamicum

    Wolf, Natalie [Verfasser] / Bott, Michael [Gutachter]

    2024  

    Author's details Natalie Wolf ; Gutachter: Michael Bott
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
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  4. Article ; Online: Alternative routes for production of the drug candidate d-chiro-inositol with Corynebacterium glutamicum using endogenous or promiscuous plant enzymes.

    Ramp, Paul / Mack, Christina / Wirtz, Astrid / Bott, Michael

    Metabolic engineering

    2023  Volume 78, Page(s) 1–10

    Abstract: d-chiro-Inositol (DCI) is a promising drug candidate for treating insulin resistance and associated diseases such as type 2 diabetes or polycystic ovary syndrome. In this study, we developed two production processes for DCI using Corynebacterium ... ...

    Abstract d-chiro-Inositol (DCI) is a promising drug candidate for treating insulin resistance and associated diseases such as type 2 diabetes or polycystic ovary syndrome. In this study, we developed two production processes for DCI using Corynebacterium glutamicum as host. In the first process, myo-inositol (MI) is oxidized to 2-keto-myo-inositol (2KMI) by the inositol dehydrogenase (IDH) IolG and then isomerized to 1-keto-d-chiro-inositol (1KDCI) by the isomerases Cg0212 or Cg2312, both of which were identified in this work. 1KDCI is then reduced to DCI by IolG. Overproduction of IolG and Cg0212 in a chassis strain unable to degrade inositols allowed the production of 1.1 g/L DCI from 10 g/L MI. As both reactions involved are reversible, only a partial conversion of MI to DCI can be achieved. To enable higher conversion ratios, a novel route towards DCI was established by utilizing the promiscuous activity of two plant-derived enzymes, the NAD
    MeSH term(s) Humans ; Female ; Corynebacterium glutamicum/genetics ; Corynebacterium glutamicum/metabolism ; Diabetes Mellitus, Type 2/drug therapy ; Inositol/genetics ; Inositol/metabolism ; Polycystic Ovary Syndrome/drug therapy ; Polycystic Ovary Syndrome/metabolism ; Glucose ; Oxidoreductases
    Chemical Substances Inositol (4L6452S749) ; Glucose (IY9XDZ35W2) ; Oxidoreductases (EC 1.-)
    Language English
    Publishing date 2023-05-03
    Publishing country Belgium
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1470383-x
    ISSN 1096-7184 ; 1096-7176
    ISSN (online) 1096-7184
    ISSN 1096-7176
    DOI 10.1016/j.ymben.2023.04.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6288: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Book ; Online ; Thesis: Analysis of the signal transduction cascade tuning the 2-oxoglutarate dehydrogenase activity in Corynebacterium glutamicum

    Sundermeyer, Lea [Verfasser] / Bott, Michael [Gutachter]

    2023  

    Author's details Lea Sundermeyer ; Gutachter: Michael Bott
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
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  6. Article ; Online: Alternative routes for production of the drug candidate d-chiro-inositol with Corynebacterium glutamicum using endogenous or promiscuous plant enzymes

    Ramp, Paul / Mack, Christina / Wirtz, Astrid / Bott, Michael

    International Metabolic Engineering Society Metabolic Engineering. 2023 July, v. 78 p.1-10

    2023  

    Abstract: d-chiro-Inositol (DCI) is a promising drug candidate for treating insulin resistance and associated diseases such as type 2 diabetes or polycystic ovary syndrome. In this study, we developed two production processes for DCI using Corynebacterium ... ...

    Abstract d-chiro-Inositol (DCI) is a promising drug candidate for treating insulin resistance and associated diseases such as type 2 diabetes or polycystic ovary syndrome. In this study, we developed two production processes for DCI using Corynebacterium glutamicum as host. In the first process, myo-inositol (MI) is oxidized to 2-keto-myo-inositol (2KMI) by the inositol dehydrogenase (IDH) IolG and then isomerized to 1-keto-d-chiro-inositol (1KDCI) by the isomerases Cg0212 or Cg2312, both of which were identified in this work. 1KDCI is then reduced to DCI by IolG. Overproduction of IolG and Cg0212 in a chassis strain unable to degrade inositols allowed the production of 1.1 g/L DCI from 10 g/L MI. As both reactions involved are reversible, only a partial conversion of MI to DCI can be achieved. To enable higher conversion ratios, a novel route towards DCI was established by utilizing the promiscuous activity of two plant-derived enzymes, the NAD⁺-dependent d-ononitol dehydrogenase MtOEPa and the NADPH-dependent d-pinitol dehydrogenase MtOEPb from Medicago truncatula (barrelclover). Heterologous production of these enzymes in the chassis strain led to the production of 1.6 g/L DCI from 10 g/L MI. For replacing the substrate MI by glucose, the two plant genes were co-expressed with the endogenous myo-inositol-1-phosphate synthase gene ino1 either as a synthetic operon or using a novel, bicistronic T7-based expression vector. With the single operon construct, 0.75 g/L DCI was formed from 20 g/L glucose, whereas with the bicistronic construct 1.2 g/L DCI was obtained, disclosing C. glutamicum as an attractive host for of d-chiro-inositol production.
    Keywords Corynebacterium glutamicum ; Medicago truncatula ; drugs ; genetic vectors ; glucose ; inositol-3-phosphate synthase ; insulin resistance ; isomerization ; myo-inositol ; noninsulin-dependent diabetes mellitus ; operon ; oxidoreductases ; polycystic ovary syndrome ; DCI ; MI ; SI ; 2KMI ; 1KDCI ; IDH ; IPTG ; CV
    Language English
    Dates of publication 2023-07
    Size p. 1-10.
    Publishing place Elsevier Inc.
    Document type Article ; Online
    ZDB-ID 1470383-x
    ISSN 1096-7184 ; 1096-7176
    ISSN (online) 1096-7184
    ISSN 1096-7176
    DOI 10.1016/j.ymben.2023.04.013
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6288: Show issues Location:
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  7. Book ; Online ; Thesis: Communities of Niche-optimized Strains (CoNoS) – a novel concept

    Zuchowski, Rico [Verfasser] / Bott, Michael [Gutachter] / Zurbriggen, Matias [Gutachter]

    2024  

    Author's details Rico Zuchowski ; Gutachter: Michael Bott, Matias Zurbriggen
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
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  8. Article ; Online: Vibriosis:: What You and Your Patients Need To Know.

    Bell, Andrew / Bott, Michael

    Delaware journal of public health

    2021  Volume 7, Issue 1, Page(s) 14–21

    Language English
    Publishing date 2021-01-21
    Publishing country United States
    Document type Journal Article
    ISSN 2639-6378
    ISSN (online) 2639-6378
    DOI 10.32481/djph.2021.001.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book: Handbook of corynebacterium glutamicum

    Eggeling, Lothar / Bott, Michael

    2005  

    Author's details edited by Lothar Eggeling, Michael Bott
    Language English
    Size 616 S. : Ill., graph. Darst.
    Publisher Taylor & Francis
    Publishing place Boca Raton u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT014124969
    ISBN 0-8493-1821-1 ; 978-0-8493-1821-4
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    058/2016 available for loan (reading room) Freihandmagazin (U1)

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  10. Article ; Online: Biochemical characterisation of a novel broad pH spectrum subtilisin from Fictibacillus arsenicus DSM 15822

    Falkenberg, Fabian / Kohn, Sophie / Bott, Michael / Bongaerts, Johannes / Siegert, Petra

    FEBS open bio

    2023  Volume 13, Issue 11, Page(s) 2035–2046

    Abstract: Subtilisins from microbial sources, especially from the Bacillaceae family, are of particular interest for biotechnological applications and serve the currently growing enzyme market as efficient and novel biocatalysts. Biotechnological applications ... ...

    Abstract Subtilisins from microbial sources, especially from the Bacillaceae family, are of particular interest for biotechnological applications and serve the currently growing enzyme market as efficient and novel biocatalysts. Biotechnological applications include use in detergents, cosmetics, leather processing, wastewater treatment and pharmaceuticals. To identify a possible candidate for the enzyme market, here we cloned the gene of the subtilisin SPFA from Fictibacillus arsenicus DSM 15822
    MeSH term(s) Subtilisin/chemistry ; Phylogeny ; Sodium Chloride ; Bacillaceae/genetics ; Hydrogen-Ion Concentration
    Chemical Substances Subtilisin (EC 3.4.21.62) ; Sodium Chloride (451W47IQ8X)
    Language English
    Publishing date 2023-09-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2651702-4
    ISSN 2211-5463 ; 2211-5463
    ISSN (online) 2211-5463
    ISSN 2211-5463
    DOI 10.1002/2211-5463.13701
    Database MEDical Literature Analysis and Retrieval System OnLINE

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