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  1. Book ; Online: Towards Data Redaction in Bitcoin

    Botta, Vincenzo / Iovino, Vincenzo / Visconti, Ivan

    2023  

    Abstract: A major issue for many applications of blockchain technology is the tension between immutability and compliance to regulations. For instance, the GDPR in the EU requires to guarantee, under some circumstances, the right to be forgotten. This could imply ... ...

    Abstract A major issue for many applications of blockchain technology is the tension between immutability and compliance to regulations. For instance, the GDPR in the EU requires to guarantee, under some circumstances, the right to be forgotten. This could imply that at some point one might be forced to delete some data from a locally stored blockchain, therefore irreparably hurting the security and transparency of such decentralized platforms. Motivated by such data protection and consistency issues, in this work we design and implement a mechanism for securely deleting data from Bitcoin blockchain. We use zero-knowledge proofs to allow any node to delete some data from Bitcoin transactions, still preserving the public verifiability of the correctness of the spent and spendable coins. Moreover, we specifically use STARK proofs to exploit the transparency that they provide. Our solution, unlike previous approaches, avoids the complications of asking nodes to reach consensus on the content to delete. In particular, our design allows every node to delete some specific data without coordinating this decision with others. In our implementation, data removal can be performed (resp., verified) in minutes (resp., seconds) on a standard laptop rather than in days as required in previous designs based on consensus.
    Keywords Computer Science - Cryptography and Security
    Subject code 005
    Publishing date 2023-05-17
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Book ; Online: Secure Blockchain-Based Supply Chain Management with Verifiable Digital Twins

    Botta, Vincenzo / Fusco, Laura / Mondelli, Attilio / Visconti, Ivan

    2021  

    Abstract: A major problem in blockchain-based supply chain management is the potential unreliability of digital twins when considering digital representations of physical goods. Indeed, the use of blockchain technology to trace goods is obviously ineffective if ... ...

    Abstract A major problem in blockchain-based supply chain management is the potential unreliability of digital twins when considering digital representations of physical goods. Indeed, the use of blockchain technology to trace goods is obviously ineffective if there is no strong correspondence between what is physically exchanged and the digital information that appears in blockchain transactions. In this work, we propose a model for strengthening the supply chain management of physical goods by leveraging blockchain technology along with a digital-twin verification feature. Our model can be instantiated in various scenarios and we have in particular considered the popular case of food traceability. In contrast to other models known in the literature that propose their own ad-hoc properties to assess the robustness of their supply chain management systems, in this work we use the formalism of secure computation, where processes are described through generic and natural ideal functionalities.
    Keywords Computer Science - Cryptography and Security
    Subject code 005
    Publishing date 2021-09-08
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Rentabilitätsbewertung in der Rehabilitation

    Botta, V.

    Physikalische Medizin, Rehabilitationsmedizin, Kurortmedizin

    (Wie rentabel ist Rehabilitation?)

    2006  Volume 16, Issue 03, Page(s) 119–125

    Abstract: Das ökonomische Ergebnis jeder Aktivität kann finanziell beurteilt werden. Dies gilt auch für Rehabilitationsaktivitäten. Dieser Artikel behandelt die wirtschaftliche Beurteilung, aber nicht eine politisch orientierte Bemessung von Budgets für ... ...

    Series title Wie rentabel ist Rehabilitation?
    Abstract Das ökonomische Ergebnis jeder Aktivität kann finanziell beurteilt werden. Dies gilt auch für Rehabilitationsaktivitäten. Dieser Artikel behandelt die wirtschaftliche Beurteilung, aber nicht eine politisch orientierte Bemessung von Budgets für Rehabilitationsaktivitäten. Der Artikel zeigt die Anwendung von grundökonomischen Erfahrungen und Instrumenten auf die Berechnung der Kapitalrendite von Rehabilitationsaktivitäten. Einige grundökonomische Konzepte müssen deshalb zuvor geklärt werden. Dies betrifft die ökonomischen Bedeutungen von Ausdrücken wie Gültigkeit, Effizienz, Kosten, Einnahmen, Produktivität, Investition, Kapitalrendite und ihre Interdependenzen. Dann wird ein Beispiel verwendet, um die Transformation von nicht finanziellem Nutzen von Rehabilitationsaktivitäten in finanziellen Zahlen zu verdeutlichen, die für die Beurteilung der Kapitalrendite jener Aktivitäten unentbehrlich sind.
    Keywords Rehabilitation ; Kosten ; Effizienz ; Nutzen ; Kosteneffektivität ; Rehabilitation ; costs ; efficiency ; revenues ; cost-effectiveness
    Language German
    Publishing date 2006-06-01
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 1089088-9
    ISSN 1439-085X ; 0940-6689
    ISSN (online) 1439-085X
    ISSN 0940-6689
    DOI 10.1055/s-2006-932593
    Database Thieme publisher's database

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  4. Article: Rentabilitätsbewertung in der Rehabilitation

    Botta, V.

    Physikalische Medizin, Rehabilitationsmedizin, Kurortmedizin

    2006  Volume 16, Issue 3, Page(s) 119

    Language German
    Document type Article
    ZDB-ID 1089088-9
    ISSN 0940-6689
    Database Current Contents Medicine

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  5. Article ; Online: Exploiting SNP correlations within random forest for genome-wide association studies.

    Botta, Vincent / Louppe, Gilles / Geurts, Pierre / Wehenkel, Louis

    PloS one

    2014  Volume 9, Issue 4, Page(s) e93379

    Abstract: The primary goal of genome-wide association studies (GWAS) is to discover variants that could lead, in isolation or in combination, to a particular trait or disease. Standard approaches to GWAS, however, are usually based on univariate hypothesis tests ... ...

    Abstract The primary goal of genome-wide association studies (GWAS) is to discover variants that could lead, in isolation or in combination, to a particular trait or disease. Standard approaches to GWAS, however, are usually based on univariate hypothesis tests and therefore can account neither for correlations due to linkage disequilibrium nor for combinations of several markers. To discover and leverage such potential multivariate interactions, we propose in this work an extension of the Random Forest algorithm tailored for structured GWAS data. In terms of risk prediction, we show empirically on several GWAS datasets that the proposed T-Trees method significantly outperforms both the original Random Forest algorithm and standard linear models, thereby suggesting the actual existence of multivariate non-linear effects due to the combinations of several SNPs. We also demonstrate that variable importances as derived from our method can help identify relevant loci. Finally, we highlight the strong impact that quality control procedures may have, both in terms of predictive power and loci identification. Variable importance results and T-Trees source code are all available at www.montefiore.ulg.ac.be/~botta/ttrees/ and github.com/0asa/TTree-source respectively.
    MeSH term(s) Algorithms ; Genetic Loci/genetics ; Genome-Wide Association Study/methods ; Humans ; Linear Models ; Linkage Disequilibrium/genetics ; Models, Genetic ; Polymorphism, Single Nucleotide/genetics ; Risk ; Software
    Language English
    Publishing date 2014-04-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0093379
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  6. Article: Aspekte eines ganzheitlichen Dienstleistungscontrolling

    Botta, Volkmar

    Organisation und Personal : Festschrift für Rolf Bühner , p. 797-815

    2004  , Page(s) 797–815

    Author's details Volkmar Botta
    Keywords Dienstleistungsmanagement ; Controlling
    Language German
    Publisher TCW, Transfer-Centrum
    Publishing place München
    Document type Article
    Note Literaturangaben
    Database ECONomics Information System

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  7. Article ; Online: The Impact of Early Recurrence on Quality of Life after Cytoreduction with HIPEC.

    Hinkle, Nathan M / Botta, Vandana / Sharpe, John P / Dickson, Paxton / Deneve, Jeremiah / Munene, Gitonga

    The American surgeon

    2017  Volume 83, Issue 6, Page(s) 633–639

    Abstract: Improved oncological outcomes after cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) in highly selected patients have been well documented. The extensive nature of the procedure adversely affects quality of life (QoL). ... ...

    Abstract Improved oncological outcomes after cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) in highly selected patients have been well documented. The extensive nature of the procedure adversely affects quality of life (QoL). The aim of this study is to longitudinally evaluate QoL following CRS/HIPEC. This is a retrospective review of a prospectively maintained database of patients with peritoneal malignancies undergoing CRS/HIPEC. Clinicopathological data, oncologic outcomes, and QoL were analyzed preoperatively and postoperatively at 2 weeks, and 1, 3, 6, and 12 months. The Functional Assessment of Cancer Therapy-Colorectal instrument was used to determine changes in QoL after CRS/HIPEC and the impact of early recurrence (<12 months) on QoL. Thirty-six patients underwent CRS/HIPEC over 36 months. The median peritoneal cancer index score was 18 and the completeness of cytoreduction-0/1 rate was 97.2 per cent. Postoperative major morbidity was 16.7 per cent with one perioperative death. Disease-free survival was 12.6 months in patients with high-grade tumors versus 31.0 months in those with low-grade tumors (P = 0.03). QoL decreased postoperatively and improved to baseline in six months. Patients with early recurrence had a decrease in global QoL compared with preoperative QoL at 6 (P < 0.03) and 12 months (P < 0.05). This correlation was not found in patients who had not recurred. Patients who undergo CRS/HIPEC have a decrease in QoL that plateaus in 3 to 6 months. Early recurrence adversely impacts QoL at 6 and 12 months. This study emphasizes the importance of patient selection for CRS/HIPEC. The expected QoL trajectory in patients at risk for early recurrence must be carefully weighed against the potential oncological benefit of CRS/HIPEC.
    MeSH term(s) Adolescent ; Adult ; Aged ; Chemotherapy, Cancer, Regional Perfusion ; Cytoreduction Surgical Procedures/methods ; Female ; Follow-Up Studies ; Hospitals, University ; Humans ; Hyperthermia, Induced/methods ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Neoplasm Recurrence, Local/mortality ; Neoplasm Recurrence, Local/therapy ; Peritoneal Neoplasms/mortality ; Peritoneal Neoplasms/therapy ; Prospective Studies ; Quality of Life ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2017-06-01
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 202465-2
    ISSN 1555-9823 ; 0003-1348
    ISSN (online) 1555-9823
    ISSN 0003-1348
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  8. Article: Hepatitis B and C infection in an institution for the mentally handicapped

    Botta, V.

    Infection

    1993  Volume 21, Issue 6, Page(s) 410–411

    Institution Viale Borri 57, I-21100 Varese Division of Infectious Diseases, Regional Hospital
    Keywords Geistigbehinderter ; Gemeinschaftsunterbringung ; Hepatitis B ; Hepatitis C ; Durchseuchung ; Praevalenz ; Infektionsquelle
    Language English
    Document type Article
    Database Social Medicine (SOMED)

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  9. Article: Ganzheitliche Steuerung mittelständischer Unternehmen als Aufgabe des Controlling

    Botta, Volkmar

    Mittelstandscontrolling , p. 77-87

    2002  , Page(s) 77–87

    Author's details Volkmar Botta
    Keywords Controlling ; Strategisches Management ; KMU ; Theorie ; Balanced Scorecard
    Language German
    Size graph. Darst
    Publisher Gabler
    Publishing place Wiesbaden
    Document type Article
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  10. Article ; Online: Bacteria and parasites in Podarcis sicula and P. sicula klemmerii.

    Dipineto, Ludovico / Raia, Pasquale / Varriale, Lorena / Borrelli, Luca / Botta, Vittorio / Serio, Carmela / Capasso, Michele / Rinaldi, Laura

    BMC veterinary research

    2018  Volume 14, Issue 1, Page(s) 392

    Abstract: Background: New epidemiological data on bacterial and parasitic infections in 24 Italian wall lizards, namely Podarcis sicula (mainland population) and P. sicula klemmerii (insular population) in southern Italy were provided. To achieve this goal, ... ...

    Abstract Background: New epidemiological data on bacterial and parasitic infections in 24 Italian wall lizards, namely Podarcis sicula (mainland population) and P. sicula klemmerii (insular population) in southern Italy were provided. To achieve this goal, samples were collected from individuals belonging to the two populations and analysed by microbiological and parasitological methods.
    Results: A wide range of bacteria (e.g. Pantoea spp., Citrobacter spp., Morganella spp., Pseudomonas, Enterobacter spp., Staphylococcus spp. and Escherichia coli) and parasites (e.g. Ophionyssus natricis, coccidia, Dicrocoelidae) were detected in both P. sicula and P. sicula klemmerii individuals. Insular population presented similar bacterial and parasitic diversity to its mainland counterpart. Ampicillin was the antimicrobial with the highest resistance rate.
    Conclusion: This study highlighted various bacteria and parasites, some of them potentially zoonotic. Further studies are needed to better understand the epidemiology and transmission routes of these pathogens along with their impact on the welfare and behaviour of Italian wall lizards.
    MeSH term(s) Acari ; Animals ; Bacterial Infections/epidemiology ; Bacterial Infections/microbiology ; Bacterial Infections/veterinary ; Coccidia ; Coccidiosis/epidemiology ; Coccidiosis/parasitology ; Coccidiosis/veterinary ; Female ; Italy/epidemiology ; Lizards/microbiology ; Lizards/parasitology ; Male ; Mite Infestations/epidemiology ; Mite Infestations/parasitology ; Mite Infestations/veterinary
    Language English
    Publishing date 2018-12-10
    Publishing country England
    Document type Journal Article
    ISSN 1746-6148
    ISSN (online) 1746-6148
    DOI 10.1186/s12917-018-1708-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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