Article ; Online: Sutureless Lyophilized Amniotic Membrane Grafting for Corneal Epithelial Defects.
2022 Volume 48, Issue 10, Page(s) 430–432
Abstract: Objectives: To report the tolerability, safety, and efficacy of the lyophilized amniotic membrane (AM) Visio-AMTRIX placed under a bandage contact lens (BCL) in treating persistent epithelial defects (PEDs).: Methods: This retrospective study ... ...
Abstract | Objectives: To report the tolerability, safety, and efficacy of the lyophilized amniotic membrane (AM) Visio-AMTRIX placed under a bandage contact lens (BCL) in treating persistent epithelial defects (PEDs). Methods: This retrospective study included consecutive patients with PEDs treated with a lyophilized AM placed under the BCL. Patients with PEDs who did not respond to medical treatment were included. Patients with a follow-up time less than 3 months were excluded. Results: Eleven eyes of 11 patients (mean age, 61.6±15.9 years) were included. Time from PED presentation to AM transplantation (AMT) was 27.7±4.9 days, with the mean PED area of 13.2±11.3 mm2. Complete resolution was achieved in 8 of 11 eyes after a single AM graft. The epithelial defect persisted after the first AMT in three eyes (27.3%), and a second graft was necessary to achieve complete healing. The corneal epithelial defect healed in an average of 11.0±4.4 days after grafting. After PED resolution, the best-corrected visual acuity significantly improved from 0.66±0.30 logMAR (20/91 Snellen) to 0.58±0.24 logMAR (20/77 Snellen) (P=0.036) compared with baseline. The AM resorbed within 2 weeks in all cases. No complication or recurrence was observed. Conclusions: A sutureless lyophilized AM under the BCL can resolve PEDs with a significant improvement in vision. |
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MeSH term(s) | Aged ; Amnion/transplantation ; Corneal Diseases/etiology ; Corneal Diseases/surgery ; Epithelium, Corneal ; Humans ; Middle Aged ; Retrospective Studies ; Treatment Outcome |
Language | English |
Publishing date | 2022-06-23 |
Publishing country | United States |
Document type | Journal Article |
ZDB-ID | 2103049-2 |
ISSN | 1542-233X ; 1542-2321 |
ISSN (online) | 1542-233X |
ISSN | 1542-2321 |
DOI | 10.1097/ICL.0000000000000913 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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