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Article ; Online: A Quick Method to Assess Airway Distensibility in Mice.

Gill, Rebecka / Boucher, Magali / Henry, Cyndi / Bossé, Ynuk

2024

Abstract: Airway distensibility is defined as the ease whereby airways are dilating in response to inflating lung pressure. If measured swiftly and accurately, airway distensibility would be a useful readout to parse the various elements contributing to airway ... ...

Abstract	Airway distensibility is defined as the ease whereby airways are dilating in response to inflating lung pressure. If measured swiftly and accurately, airway distensibility would be a useful readout to parse the various elements contributing to airway wall stiffening, such as smooth muscle contraction, surface tension, and airway remodeling. The goal of the present study was to develop a method for measuring airway distensibility in mice. Lungs of BALB/c and C57BL/6 mice from either sex were subjected to stepwise changes in pressure. At each pressure step, an oscillometric perturbation was used to measure the impedance spectrum, on which the constant-phase model was fitted to deduce a surrogate for airway caliber called Newtonian conductance (G
Language	English
Publishing date	2024-04-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	185984-5
ISSN	1573-9686 ; 0191-5649 ; 0090-6964
ISSN (online)	1573-9686
ISSN	0191-5649 ; 0090-6964
DOI	10.1007/s10439-024-03518-9
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Article ; Online: Force adaptation through the intravenous route in naïve mice.

Boucher, Magali / Henry, Cyndi / Bossé, Ynuk

Experimental lung research

2023 Volume 49, Issue 1, Page(s) 131–141

Abstract: Aim of the study: ...

Abstract	Aim of the study:
MeSH term(s)	Male ; Female ; Animals ; Mice ; Methacholine Chloride/pharmacology ; Lung ; Respiratory Mechanics ; Bronchial Provocation Tests ; Airway Resistance
Chemical Substances	Methacholine Chloride (0W5ETF9M2K)
Language	English
Publishing date	2023-07-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603791-4
ISSN	1521-0499 ; 0190-2148
ISSN (online)	1521-0499
ISSN	0190-2148
DOI	10.1080/01902148.2023.2237127
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Zs.A 1568: Show issues

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Article ; Online: Sensitivity of the airway smooth muscle in terms of force, shortening and stiffness.

Gélinas, Louis / Rojas-Ruiz, Andrés / Boucher, Magali / Henry, Cyndi / Bossé, Ynuk

Respiratory physiology & neurobiology

2024 Volume 325, Page(s) 104264

Abstract: Eight pig tracheal strips were stimulated to contract with log increments of methacholine from ... ...

Abstract	Eight pig tracheal strips were stimulated to contract with log increments of methacholine from 10
MeSH term(s)	Animals ; Muscle, Smooth/physiology ; Muscle, Smooth/drug effects ; Methacholine Chloride/pharmacology ; Swine ; Trachea/physiology ; Trachea/drug effects ; Bronchoconstrictor Agents/pharmacology ; Muscle Contraction/physiology ; Muscle Contraction/drug effects ; Dose-Response Relationship, Drug ; Elasticity/physiology ; Isometric Contraction/physiology ; Isometric Contraction/drug effects
Chemical Substances	Methacholine Chloride (0W5ETF9M2K) ; Bronchoconstrictor Agents
Language	English
Publishing date	2024-04-09
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2077867-3
ISSN	1878-1519 ; 1569-9048
ISSN (online)	1878-1519
ISSN	1569-9048
DOI	10.1016/j.resp.2024.104264
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Article ; Online: More airway smooth muscle in males versus females in a mouse model of asthma: A blessing in disguise?

Gill, Rebecka / Rojas-Ruiz, Andrés / Boucher, Magali / Henry, Cyndi / Bossé, Ynuk

Experimental physiology

2023 Volume 108, Issue 8, Page(s) 1080–1091

Abstract: New findings: What is the central question of this study? The lung response to inhaled methacholine is reputed to be greater in male than in female mice. The underpinnings of this sex disparity are ill defined. What is the main finding and its ... ...

Abstract	New findings: What is the central question of this study? The lung response to inhaled methacholine is reputed to be greater in male than in female mice. The underpinnings of this sex disparity are ill defined. What is the main finding and its importance? We demonstrated that male airways exhibit a greater content of airway smooth muscle than female airways. We also found that, although a more muscular airway tree in males might contribute to their greater responsiveness to inhaled methacholine than females, it might also curb the heterogeneity in small airway narrowing. Abstract: Mouse models are helpful in unveiling the mechanisms underlying sex disparities in asthma. In comparison to their female counterparts, male mice are hyperresponsive to inhaled methacholine, a cardinal feature of asthma that contributes to its symptoms. The physiological details and the structural underpinnings of this hyperresponsiveness in males are currently unknown. Herein, BALB/c mice were exposed intranasally to either saline or house dust mite once daily for 10 consecutive days to induce experimental asthma. Twenty-four hours after the last exposure, respiratory mechanics were measured at baseline and after a single dose of inhaled methacholine that was adjusted to trigger the same degree of bronchoconstriction in both sexes (it was twice as high in females). Bronchoalveolar lavages were then collected, and the lungs were processed for histology. House dust mite increased the number of inflammatory cells in bronchoalveolar lavages to the same extent in both sexes (asthma, P = 0.0005; sex, P = 0.96). The methacholine response was also markedly increased by asthma in both sexes (e.g., P = 0.0002 for asthma on the methacholine-induced bronchoconstriction). However, for a well-matched bronchoconstriction between sexes, the increase in hysteresivity, an indicator of airway narrowing heterogeneity, was attenuated in males for both control and asthmatic mice (sex, P = 0.002). The content of airway smooth muscle was not affected by asthma but was greater in males (asthma, P = 0.31; sex, P < 0.0001). These results provide further insights regarding an important sex disparity in mouse models of asthma. The increased amount of airway smooth muscle in males might contribute functionally to their greater methacholine response and, possibly, to their decreased propensity for airway narrowing heterogeneity.
MeSH term(s)	Male ; Female ; Animals ; Mice ; Methacholine Chloride/pharmacology ; Asthma/pathology ; Lung ; Bronchoconstriction ; Muscle, Smooth/physiology
Chemical Substances	Methacholine Chloride (0W5ETF9M2K)
Language	English
Publishing date	2023-06-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1016295-1
ISSN	1469-445X ; 0958-0670
ISSN (online)	1469-445X
ISSN	0958-0670
DOI	10.1113/EP091236
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Article ; Online: The cumulative effect of methacholine on large and small airways when deep inspirations are avoided.

Henry, Cyndi / Boucher, Magali / Boulay, Marie-Ève / Côté, Andréanne / Boulet, Louis-Philippe / Bossé, Ynuk

Respirology (Carlton, Vic.)

2022 Volume 28, Issue 3, Page(s) 226–235

Abstract: Background and objective: The effect of serial incremental concentrations of methacholine is only slightly cumulative when assessed by spirometry. This limited cumulative effect may be attributed to the bronchodilator effect of deep inspirations that ... ...

Abstract	Background and objective: The effect of serial incremental concentrations of methacholine is only slightly cumulative when assessed by spirometry. This limited cumulative effect may be attributed to the bronchodilator effect of deep inspirations that are required between concentrations to measure lung function. Using oscillometry, the response to methacholine can be measured without deep inspirations. Conveniently, oscillometry can also dissociate the contribution of large versus small airways. Herein, oscillometry was used to assess the cumulative effect of methacholine in the absence of deep inspirations on large and small airways. Methods: Healthy and asthmatic volunteers underwent a multiple-concentration methacholine challenge on visit 1 and a single-concentration challenge on visit 2 using the highest concentration of visit 1. The maximal response was compared between visits to assess the cumulative effect of methacholine. The lung volume was also measured after the final concentration to assess hyperinflation. Results: In both healthy and asthmatic subjects, increases in resistance at 19 Hz (R Conclusion: Without deep inspirations, the effect of methacholine is cumulative on small airways but not on large airways. Lung hyperinflation and derecruitment may partially explain these different responses.
MeSH term(s)	Humans ; Methacholine Chloride/pharmacology ; Asthma/diagnosis ; Respiratory System ; Bronchial Provocation Tests ; Lung Volume Measurements ; Airway Resistance/physiology ; Forced Expiratory Volume
Chemical Substances	Methacholine Chloride (0W5ETF9M2K)
Language	English
Publishing date	2022-10-09
Publishing country	Australia
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1435849-9
ISSN	1440-1843 ; 1323-7799
ISSN (online)	1440-1843
ISSN	1323-7799
DOI	10.1111/resp.14387
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Zs.A 4957: Show issues

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Article ; Online: Lung stiffness of C57BL/6 versus BALB/c mice.

Rojas-Ruiz, Andrés / Boucher, Magali / Gill, Rebecka / Gélinas, Louis / Tom, Fun-Qun / Fereydoonzad, Liah / Graham, Percival / Soliz, Jorge / Bossé, Ynuk

Scientific reports

2023 Volume 13, Issue 1, Page(s) 17481

Abstract: This study was undertaken to determine whether a smaller lung volume or a stiffer lung tissue accounts for the greater lung elastance of C57BL/6 than BALB/c mice. The mechanical properties of the respiratory system and lung volumes were measured with the ...

Abstract	This study was undertaken to determine whether a smaller lung volume or a stiffer lung tissue accounts for the greater lung elastance of C57BL/6 than BALB/c mice. The mechanical properties of the respiratory system and lung volumes were measured with the flexiVent and compared between male C57BL/6 and BALB/c mice (n = 9). The size of the excised lung was also measured by volume liquid displacement. One lobe was then subjected to sinusoidal strains in vitro to directly assess the mechanical properties of the lung tissue, and another one was used to quantify the content of hydroxyproline. In vivo elastance was markedly greater in C57BL/6 than BALB/c mice based on 5 different readouts. For example, respiratory system elastance was 24.5 ± 1.7 vs. 21.5 ± 2.4 cmH
MeSH term(s)	Mice ; Animals ; Male ; Mice, Inbred BALB C ; Hydroxyproline ; Mice, Inbred C57BL ; Lung ; Lung Compliance
Chemical Substances	Hydroxyproline (RMB44WO89X)
Language	English
Publishing date	2023-10-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-44797-x
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Article ; Online: Bronchial thermoplasty attenuates bronchodilator responsiveness.

Henry, Cyndi / Biardel, Sabrina / Boucher, Magali / Godbout, Krystelle / Chakir, Jamila / Côté, Andréanne / Laviolette, Michel / Bossé, Ynuk

Respiratory medicine

2023 Volume 217, Page(s) 107340

Abstract: Introduction: Bronchial thermoplasty is an effective intervention to improve respiratory symptoms and to reduce the rate of exacerbations in uncontrolled severe asthma. A reduction in airway smooth muscle is arguably the most widely discussed mechanisms ...

Abstract	Introduction: Bronchial thermoplasty is an effective intervention to improve respiratory symptoms and to reduce the rate of exacerbations in uncontrolled severe asthma. A reduction in airway smooth muscle is arguably the most widely discussed mechanisms accounting for these clinical benefits. Yet, this smooth muscle reduction should also translate into an impaired response to bronchodilator drugs. This study was designed to address this question. Methods: Eight patients with clinical indication for thermoplasty were studied. They were uncontrolled severe asthmatics despite optimal environmental control, treatment of comorbidities, and the use of high-dose inhaled corticosteroids and long-acting β Results: Consistent with previous studies, thermoplasty yielded no benefits in terms of baseline lung function and respiratory mechanics, despite improving symptoms based on two asthma questionnaires (ACQ-5 and ACT-5). The response to salbutamol was also not affected by thermoplasty based on spirometric readouts, including forced expiratory volume in 1 s (FEV Conclusions: Thermoplasty attenuates the response to a bronchodilator. We argue that this result is a physiological proof of therapeutic efficacy, consistent with the well-described effect of thermoplasty in reducing the amount of airway smooth muscle.
MeSH term(s)	Humans ; Bronchodilator Agents/pharmacology ; Bronchodilator Agents/therapeutic use ; Bronchial Thermoplasty ; Asthma/drug therapy ; Asthma/surgery ; Asthma/diagnosis ; Albuterol/pharmacology ; Albuterol/therapeutic use ; Adrenal Cortex Hormones ; Forced Expiratory Volume
Chemical Substances	Bronchodilator Agents ; Albuterol (QF8SVZ843E) ; Adrenal Cortex Hormones
Language	English
Publishing date	2023-07-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1003348-8
ISSN	1532-3064 ; 0954-6111
ISSN (online)	1532-3064
ISSN	0954-6111
DOI	10.1016/j.rmed.2023.107340
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Article: Smooth Muscle Hypocontractility and Airway Normoresponsiveness in a Mouse Model of Pulmonary Allergic Inflammation.

Boucher, Magali / Henry, Cyndi / Dufour-Mailhot, Alexis / Khadangi, Fatemeh / Bossé, Ynuk

Frontiers in physiology

2021 Volume 12, Page(s) 698019

Abstract: The contractility of airway smooth muscle (ASM) is labile. Although this feature can greatly modulate the degree of airway ... ...

Abstract	The contractility of airway smooth muscle (ASM) is labile. Although this feature can greatly modulate the degree of airway responsiveness
Language	English
Publishing date	2021-06-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2021.698019
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Article ; Online: Double-chamber plethysmography

Boucher, Magali / Henry, Cyndi / Khadangi, Fatemeh / Dufour-Mailhot, Alexis / Bossé, Ynuk

Experimental lung research

2021 Volume 47, Issue 8, Page(s) 390–401

Abstract: Aim of the study: The current gold standard to assess respiratory mechanics in mice is oscillometry, a technique from which several readouts of the respiratory system can be deduced, such as resistance and elastance. However, these readouts are often ... ...

Abstract	Aim of the study: The current gold standard to assess respiratory mechanics in mice is oscillometry, a technique from which several readouts of the respiratory system can be deduced, such as resistance and elastance. However, these readouts are often not altered in mouse models of asthma. This is in stark contrast with humans, where asthma is generally associated with alterations when assessed by either oscillometry or other techniques. In the present study, we have used double-chamber plethysmography (DCP) to evaluate the breathing pattern and the degree of airflow obstruction in a mouse model of asthma. Materials and methods: Female C57BL/6 and BALB/c mice were studied at day 1 using DCP, as well as at day 11 using both DCP and oscillometry following a once-daily exposure to either house-dust mite (HDM) or saline for 10 consecutive days. Results: All DCP readouts used to describe either the breathing pattern (e.g., tidal volume and breathing frequency) or the degree of airflow obstruction (e.g., specific airway resistance) were different between mouse strains at day 1. Most of these strain differences persisted at day 11. Most oscillometric readouts (e.g., respiratory system resistance and elastance) were also different between strains. Changes caused by HDM were obvious with DCP, including decreases in tidal volume, minute ventilation, inspiratory time and mid-tidal expiratory flow and an increase in specific airway resistance. HDM also caused some strain specific alterations in breathing pattern, including increases in expiratory time and end inspiratory pause, which were only observed in C57BL/6 mice. Oscillometry also detected a small but significant increase in tissue elastance in HDM Conclusions: DCP successfully identified differences between C57BL/6 and BALB/c mice, as well as alterations in mice from both strains exposed to HDM. We conclude that, depending on the study purpose, DCP may sometimes outweigh oscillometry.
MeSH term(s)	Animals ; Asthma/diagnosis ; Female ; Lung ; Mice ; Mice, Inbred C57BL ; Oscillometry ; Plethysmography ; Pulmonary Disease, Chronic Obstructive
Language	English
Publishing date	2021-09-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603791-4
ISSN	1521-0499 ; 0190-2148
ISSN (online)	1521-0499
ISSN	0190-2148
DOI	10.1080/01902148.2021.1979693
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Article ; Online: In mice of both sexes, repeated contractions of smooth muscle in vivo greatly enhance the response of peripheral airways to methacholine.

Boucher, Magali / Dufour-Mailhot, Alexis / Tremblay-Pitre, Sophie / Khadangi, Fatemeh / Rojas-Ruiz, Andrés / Henry, Cyndi / Bossé, Ynuk

Respiratory physiology & neurobiology

2022 Volume 304, Page(s) 103938

Abstract: BALB/c mice from both sexes underwent one of two nebulized methacholine challenges that were preceded by a period of 20 min either with or without tone induced by repeated contractions of the airway smooth muscle. Impedance was monitored throughout and ... ...

Abstract	BALB/c mice from both sexes underwent one of two nebulized methacholine challenges that were preceded by a period of 20 min either with or without tone induced by repeated contractions of the airway smooth muscle. Impedance was monitored throughout and the constant phase model was used to dissociate the impact of tone on conducting airways (R
MeSH term(s)	Animals ; Female ; Lung ; Male ; Methacholine Chloride/pharmacology ; Mice ; Mice, Inbred BALB C ; Muscle Contraction/physiology ; Muscle, Smooth ; Trachea
Chemical Substances	Methacholine Chloride (0W5ETF9M2K)
Language	English
Publishing date	2022-06-15
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2077867-3
ISSN	1878-1519 ; 1569-9048
ISSN (online)	1878-1519
ISSN	1569-9048
DOI	10.1016/j.resp.2022.103938
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