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Article ; Online: Sudden Cardiac Arrest During Sports in Children and Adolescents.

Bohm, Philipp / Barra, Sergio / Weizman, Orianne / Narayanan, Kumar / Meyer, Tim / Schmied, Christian / Bougouin, Wulfran / Jouven, Xavier / Marijon, Eloi

Circulation

2024 Volume 149, Issue 10, Page(s) 794–796

MeSH term(s)	Child ; Adolescent ; Humans ; Death, Sudden, Cardiac/epidemiology ; Death, Sudden, Cardiac/etiology ; Death, Sudden, Cardiac/prevention & control ; Heart Arrest/diagnosis ; Heart Arrest/etiology ; Heart Arrest/therapy ; Sports
Language	English
Publishing date	2024-03-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80099-5
ISSN	1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
ISSN (online)	1524-4539
ISSN	0009-7322 ; 0069-4193 ; 0065-8499
DOI	10.1161/CIRCULATIONAHA.123.064739
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Ui IV Zs.60: Show issues

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Article ; Online: Immediate postcardiac arrest treatment: coronary catherization or not?

Dumas, Florence / Bougouin, Wulfran / Cariou, Alain

Current opinion in critical care

2021 Volume 27, Issue 3, Page(s) 232–238

Abstract: Purpose of review: Early coronary angiogram (CAG) remains a cornerstone in postcardiac arrest management as coronary disease (CAD)-related cardiac arrest is the leading cause of sudden death in adults. The opportunity to treat the cause early on with ... ...

Abstract	Purpose of review: Early coronary angiogram (CAG) remains a cornerstone in postcardiac arrest management as coronary disease (CAD)-related cardiac arrest is the leading cause of sudden death in adults. The opportunity to treat the cause early on with immediate CAG may improve outcome in cardiac arrest patients with AMI. Identifying the patients who will benefit from such an early invasive strategy is an unanswered question. Recent and ongoing trials may improve the level of evidence on this problematic, especially for some subgroup; however, current guidelines remain founded upon a very heterogeneous level of evidence. Recent findings: The key variable to argue for immediate CAD remains the pattern of the ECG monitored after return of spontaneous of circulation (ROSC). ST-segment elevation (STE) on postresuscitation ECG is the strongest argument to rule for an early CAG strategy. In other situations, identifying the best candidates for early CAG is very challenging. Different approaches including elements, such as circumstances of cardiac arrest and expected outcomes. may also drive the strategy. Summary: This review aims to provide an overview of these different discussion points. The indication for early CAG should rely on multiple factors and an individual approach.
MeSH term(s)	Adult ; Cardiopulmonary Resuscitation ; Coronary Angiography ; Electrocardiography ; Humans ; Out-of-Hospital Cardiac Arrest/therapy ; Percutaneous Coronary Intervention
Language	English
Publishing date	2021-04-26
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1235629-3
ISSN	1531-7072 ; 1070-5295
ISSN (online)	1531-7072
ISSN	1070-5295
DOI	10.1097/MCC.0000000000000831
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Zs.A 4999: Show issues

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Article ; Online: Mode of death after cardiac arrest: We need to know.

Bougouin, Wulfran / Cariou, Alain

Resuscitation

2019 Volume 138, Page(s) 282–283

MeSH term(s)	Death ; Heart Arrest ; Humans
Language	English
Publishing date	2019-04-04
Publishing country	Ireland
Document type	Editorial ; Comment
ZDB-ID	189901-6
ISSN	1873-1570 ; 0300-9572
ISSN (online)	1873-1570
ISSN	0300-9572
DOI	10.1016/j.resuscitation.2019.03.040
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Article ; Online: Return to work after out of hospital cardiac arrest, insights from a prospective multicentric French cohort.

Flajoliet, Nolwen / Bourenne, Jeremy / Marin, Nathalie / Chelly, Jonathan / Lascarrou, Jean Baptiste / Daubin, Cédric / Bougouin, Wulfran / Cariou, Alain / Geri, Guillaume

Resuscitation

2024 Volume 199, Page(s) 110225

Abstract: Rationale: About 60 to 70% of out-of-hospital cardiac arrest (OHCA) survivors who worked before cardiac arrest return to work within one year but the precise conditions for this resumption of professional activity remain little known. The objective of ... ...

Abstract	Rationale: About 60 to 70% of out-of-hospital cardiac arrest (OHCA) survivors who worked before cardiac arrest return to work within one year but the precise conditions for this resumption of professional activity remain little known. The objective of this study was to assess components of return to work among OHCA survivors. Patients and methods: We used the French national multicentric cohort AfterRosc to include OHCA survivors admitted between April 1st 2021 and March 31st 2022, discharged alive from the Intensive Care Unit (ICU), and who were less than 65 years old. A phone-call interview was performed one year after OHCA to assess return to work, level of education, former level of occupation as well as neurological recovery. Geographic and socio-economic data from the patient's residential neighborhoods were also collected. Comparisons were performed between patients who returned to work and those who did not, using non-parametric tests. Results: Of the 251 patients included in the registry, 86 were alive at ICU discharge and 31 patients that worked prior to the OHCA were included for analysis. Seventeen survivors returned to work after a median delay of 112 days [92-157] Among them, nine (53%) had required initial work adjustments. Overall, only 6 patients (19%) had returned to work ad integrum. Higher educational level, work which required higher competence-level, higher income, living in a better socio-economical neighborhood, as well as better scores on all three standardized MPAI-4 score components (abilities, adjustment and participation) were significantly associated with return to work. Participants that had not returned to work had a significant drop of income (p = 0.0025). Conclusion: In this prospective study regarding French OHCA survivors, return to work is associated with better socio-economical individual and environmental status, as well as better scores on all MPAI-4 components.
Language	English
Publishing date	2024-04-27
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	189901-6
ISSN	1873-1570 ; 0300-9572
ISSN (online)	1873-1570
ISSN	0300-9572
DOI	10.1016/j.resuscitation.2024.110225
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Article ; Online: Extracorporeal cardiopulmonary resuscitation in out-of-hospital cardiac arrest: do not neglect potential for organ donation!

Bougouin, Wulfran / Cariou, Alain / Jouven, Xavier

European heart journal

2020 Volume 41, Issue 37, Page(s) 3588

MeSH term(s)	Cardiopulmonary Resuscitation ; Humans ; Out-of-Hospital Cardiac Arrest/therapy ; Registries ; Tissue and Organ Procurement
Language	English
Publishing date	2020-08-28
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	603098-1
ISSN	1522-9645 ; 0195-668X
ISSN (online)	1522-9645
ISSN	0195-668X
DOI	10.1093/eurheartj/ehaa626
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Zs.A 1563: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Long-term heart function in cardiac-arrest survivors.

Raphalen, Jean-Herlé / Soumagnac, Tal / Delord, Marc / Bougouin, Wulfran / Georges, Jean-Louis / Paul, Marine / Legriel, Stéphane

Resuscitation plus

2023 Volume 16, Page(s) 100481

Abstract: Purpose: To assess outcomes and predictors of long-term myocardial dysfunction after cardiac arrest (CA) of cardiac origin.: Methods: We retrospectively included consecutive, single-center, prospective-registry patients who survived to hospital ... ...

Abstract	Purpose: To assess outcomes and predictors of long-term myocardial dysfunction after cardiac arrest (CA) of cardiac origin. Methods: We retrospectively included consecutive, single-center, prospective-registry patients who survived to hospital discharge for adult out-of-hospital and in-hospital CA of cardiac origin in 2005-2019. The primary objective was to collect the 1-year New York Heart Association Functional Class (NYHA-FC) and major adverse cardiovascular events (MACE). Results: Of 135 patients, 94 (72%) had their NYHA-FC determined after 1 year, including 75 (75/94, 80%) who were I, 17 (17/94, 18%) II, 2 (2/94, 2%) III, and none IV. The echocardiographic left ventricular ejection fraction was abnormal in 87/130 (67%) patients on day 1, 52/123 (42%) at hospital discharge, and 17/52 (33%) at 6 months. During the median follow-up of 796 [283-1975] days, 38/119 (32%) patients experienced a MACE. These events were predominantly related to acute heart failure (13/38) or ischemic cardiovascular events (16/38), with acute coronary syndrome being the most prevalent among them (8/16). Pre-CA cardiovascular disease was a risk factor for 1-year NYHA-FC > I ( Conclusion: Most patients had no heart-failure symptoms a year after adult out-of hospital or in-hospital CA of cardiac origin, and absence of bystander cardiopulmonary resuscitation was the only treatment component significantly associated with NYHA-FC > I at 1 year. Nearly a third experienced MACE and the most common types of MACE were ischemic cardiovascular events and acute heart failure. Early left ventricular dysfunction recovered within 6 months in half the patients with available values.
Language	English
Publishing date	2023-10-12
Publishing country	Netherlands
Document type	Journal Article
ISSN	2666-5204
ISSN (online)	2666-5204
DOI	10.1016/j.resplu.2023.100481
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Article ; Online: Cardiac Issues in Cardiac Arrest.

Bougouin, Wulfran / Cariou, Alain

Seminars in neurology

2017 Volume 37, Issue 1, Page(s) 13–18

Abstract: The prognosis of cardiac arrest (CA) remains poor, with a survival rate at hospital discharge between 6 and 10%. To improve this disappointing outcome, efforts are needed regarding each step in the chain of survival. In this review, the authors focus on ... ...

Abstract	The prognosis of cardiac arrest (CA) remains poor, with a survival rate at hospital discharge between 6 and 10%. To improve this disappointing outcome, efforts are needed regarding each step in the chain of survival. In this review, the authors focus on cardiac issues, as the heart itself could be both a cause and a target in this setting. Acute myocardial infarction is very illustrative of this duality. As it is a frequent cause of CA, an early invasive strategy (through immediate coronary angiography) has been proposed by several teams and is now recommended in specific situations. In addition, a postresuscitation syndrome is commonly observed in these patients, which often includes transient myocardial dysfunction. Identification and management of this cardiac complication is a key target in the hemodynamic management of these patients. Finally, regarding survivors at hospital discharge, secondary prevention targeting the risk of recurrence of cardiac arrhythmia is mandatory in specific indications (especially through implantable cardiac defibrillators). Overall and as a truism, cardiac issues are crucial before, during, and after occurrence of CA.
MeSH term(s)	Defibrillators, Implantable ; Heart Arrest/therapy ; Humans ; Myocardial Infarction/therapy ; Prognosis
Language	English
Publishing date	2017-02-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	603165-1
ISSN	1098-9021 ; 0271-8235
ISSN (online)	1098-9021
ISSN	0271-8235
DOI	10.1055/s-0036-1593861
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Zs.A 1737: Show issues

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Article ; Online: Aetiologies of cardiac arrest: Seek and ye shall find.

Bougouin, Wulfran / Cariou, Alain

Resuscitation

2017 Volume 116, Page(s) A3–A4

Language	English
Publishing date	2017-07
Publishing country	Ireland
Document type	Editorial
ZDB-ID	189901-6
ISSN	1873-1570 ; 0300-9572
ISSN (online)	1873-1570
ISSN	0300-9572
DOI	10.1016/j.resuscitation.2017.04.030
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Zs.A 1048: Show issues

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Article ; Online: Long-term follow-up of cardiac arrest survivors: Protocol of the DESAC (Devenir des survivants d'Arrets Cardiaques) study, a French multicentric prospective cohort.

Dumas, F / Bougouin, W / Perier, M C / Marin, N / Goulenok, C / Vieillard-Baron, A / Diehl, J L / Legriel, S / Deye, N / Cronier, P / Ricôme, S / Chemouni, F / Mekontso Dessap, A / Beganton, F / Marijon, E / Jouven, X / Empana, J P / Cariou, A

Resuscitation plus

2023 Volume 16, Page(s) 100460

Abstract: Background: While the short-term prognosis of cardiac arrest patients - nearly 250,000 new cases per year in Europe - has been extensively studied, less is known regarding the mid and long-term outcome of survivors.: Objective: The aim of the DESAC ... ...

Abstract	Background: While the short-term prognosis of cardiac arrest patients - nearly 250,000 new cases per year in Europe - has been extensively studied, less is known regarding the mid and long-term outcome of survivors. Objective: The aim of the DESAC study is to describe mid- and long-term survival rate and functional status of cardiac arrest survivors, and to assess the influence of pre and intra hospital therapeutic strategies on these two outcomes. Methods: Between Jul 2015 and Oct 2018, adult patients over 18 years who were discharged alive from any intensive care units (public and private hospitals) in the Ile-de-France area (Paris and suburbs, France) after a non-traumatic cardiac arrest were screened for participation in this multicentric study. Survivors were included after they signed (or the proxies) an informed consent before discharge during initial hospitalisation. We calculated that including 600 patients in total would allow an 80% power to demonstrate a 2 years survival rate difference of 10% between patients who did and those who did not receive therapeutic hypothermia after resuscitation. Pre- and in-hospital data related to the circumstances surrounding the event and to the therapeutic interventions (such as cardio-pulmonary resuscitation, defibrillation, emergent coronary revascularization, neuroprotective therapeutics) were collected. After discharge, patients were interviewed at 3 months, 6 months and every year thereafter for a minimum follow-up of 26 months and a maximum follow-up of 48 months. Information on vital status, occurrence of cardiovascular events, medications and a comprehensive assessment of the functional status (qualitive of life as assessed by the Short-Form General Health Survey (SF36) scale, activities of daily living (ADL) scale, neurological Cerebral Performance Categories (CPC) and Overall Performance Categories (OPC) scales, socio-professional activities) were collected at follow-up interviews. Discussion: The DESAC study should provide important information regarding several dimensions of the mid and long-term prognosis of cardiac arrest survivors and on the benefit (and potentially harm) of early therapeutic strategies.
Language	English
Publishing date	2023-08-31
Publishing country	Netherlands
Document type	Journal Article
ISSN	2666-5204
ISSN (online)	2666-5204
DOI	10.1016/j.resplu.2023.100460
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Article: Organ donation after out-of-hospital cardiac arrest: a population-based study of data from the Paris Sudden Death Expertise Center.

Renaudier, M / Binois, Y / Dumas, F / Lamhaut, L / Beganton, F / Jost, D / Charpentier, J / Lesieur, O / Marijon, E / Jouven, X / Cariou, A / Bougouin, W

Annals of intensive care

2022 Volume 12, Issue 1, Page(s) 48

Abstract: Background: Organ shortage is a major public health issue, and patients who die after out-of-hospital cardiac arrest (OHCA) could be a valuable source of organs. Here, our objective was to identify factors associated with organ donation after brain ... ...

Abstract	Background: Organ shortage is a major public health issue, and patients who die after out-of-hospital cardiac arrest (OHCA) could be a valuable source of organs. Here, our objective was to identify factors associated with organ donation after brain death complicating OHCA, in unselected patients entered into a comprehensive real-life registry covering a well-defined geographic area. Methods: We prospectively analyzed consecutive adults with OHCA who were successfully resuscitated, but died in intensive care units in the Paris region in 2011-2018. The primary outcome was organ donation after brain death. Independent risk factors were identified using logistic regression analysis. One-year graft survival was assessed using Cox and log-rank tests. Results: Of the 3061 included patients, 136 (4.4%) became organ donors after brain death, i.e., 28% of the patients with brain death. An interaction between admission pH and post-resuscitation shock was identified. By multivariate analysis, in patients with post-resuscitation shock, factors associated with organ donation were neurological cause of OHCA (odds ratio [OR], 14.5 [7.6-27.4], P < 0.001), higher pH (OR/0.1 increase, 1.3 [1.1-1.6], P < 0.001); older age was negatively associated with donation (OR/10-year increase, 0.7 [0.6-0.8], P < 0.001). In patients without post-resuscitation shock, the factor associated with donation was neurological cause of OHCA (OR, 6.9 [3.0-15.9], P < 0.001); higher pH (OR/0.1 increase, 0.8 [0.7-1.0], P = 0.04) and OHCA at home (OR, 0.4 [0.2-0.7], P = 0.006) were negatively associated with organ donation. One-year graft survival did not differ according to Utstein characteristics of the donor. Conclusions: 4% of patients who died in ICU after OHCA led to organ donation. Patients with OHCA constitute a valuable source of donated organs, and special attention should be paid to young patients with OHCA of neurological cause.
Language	English
Publishing date	2022-06-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2617094-2
ISSN	2110-5820
ISSN	2110-5820
DOI	10.1186/s13613-022-01023-7
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