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  1. Artikel ; Online: Phytochemical Analysis and Evaluation of the Antioxidant, Antiproliferative, Antibacterial, and Antibiofilm Effects of

    Nouir, Sahar / Dbeibia, Amal / Bouhajeb, Rim / Haddad, Houda / Khélifa, Amani / Achour, Lotfi / Ghardallou, Mariem / Zaïri, Amira

    Molecules (Basel, Switzerland)

    2023  Band 28, Heft 10

    Abstract: Globularia ... ...

    Abstract Globularia alypum
    Mesh-Begriff(e) Antioxidants/chemistry ; Plant Extracts/chemistry ; Staphylococcus aureus ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/analysis ; Phytochemicals/pharmacology ; Phytochemicals/analysis ; Plant Leaves/chemistry ; Biofilms ; Plantaginaceae ; Microbial Sensitivity Tests
    Chemische Substanzen Antioxidants ; Plant Extracts ; Anti-Bacterial Agents ; Phytochemicals
    Sprache Englisch
    Erscheinungsdatum 2023-05-11
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28104019
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.MO 81: Hefte anzeigen

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  2. Artikel: HPLC-DAD Analysis and Investigation of Biological Properties of the Leaves of

    Nouir, Sahar / Laouani, Aicha / Loghmari, Ahmed / Bouassida, Khaireddine / Slim, Raoudha / Bouhajeb, Rim / Hasni, Yosra / Saguem, Khaled / Ouni, Bouraoui / Zaïri, Amira

    Pharmaceuticals (Basel, Switzerland)

    2023  Band 16, Heft 12

    Abstract: Globularia ... ...

    Abstract Globularia alypum
    Sprache Englisch
    Erscheinungsdatum 2023-12-14
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16121726
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Erica multiflora extract rich in quercetin-3-O-glucoside and kaempferol-3-O-glucoside alleviates high fat and fructose diet-induced fatty liver disease by modulating metabolic and inflammatory pathways in Wistar rats

    Khlifi, Rihab / Dhaouefi, Zaineb / Toumia, Imène Ben / Lahmar, Aida / Sioud, Fairouz / Bouhajeb, Rim / Bellalah, Ahlem / Chekir-Ghedira, Leila

    Journal of nutritional biochemistry. 2020 Dec., v. 86

    2020  

    Abstract: The wide morbidity of obesity has heightened interest in providing natural and safe compounds to maintain optimal health. The present study was designed to determine the chemical constituents and the effects of methanol leaf extract from Erica multiflora ...

    Abstract The wide morbidity of obesity has heightened interest in providing natural and safe compounds to maintain optimal health. The present study was designed to determine the chemical constituents and the effects of methanol leaf extract from Erica multiflora (M-EML) on mitigating high-fat and high-fructose diet (HFFD)-induced metabolic syndrome (MS).LC–MS/MS characterization of M-EML allowed the identification of 14 secondary metabolites and showed that quercetin-3-O-glucoside and kaempferol-3-O-glucoside were the main compounds of our extract. In the in vivo study, the oral administration of M-EML (250 mg/kg) during the last 4 weeks of the experimentation alleviated HFFD-induced obesity, insulin resistance (IR) and cardiovascular diseases. Thus, M-EML treatment significantly normalized body and liver weight, allowed to a sharp decline in plasma levels of TC, TG and LDL-c by 32%, 35% and 66%, respectively. Moreover, hepatic enzymes, total and direct bilirubin, lipase and uric acid levels have been diminished in treated group. Histopathology of the liver confirmed the changes induced by HFFD and the hepatoprotective effect of M-EML. The supply of M-EML reduced NO production and cellular lysosomal enzyme activity by 44% and 60%, respectively compared to HFFD. Besides, M-EML showed decreased pro-inflammatory cytokines levels (259.5±47.35 pg/ml and 56.08±1.56 pg/ml) of TNF-α and IL-6, respectively.In addition, M-EML reduced liver malondialdehyde (MDA) content and enhanced superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities. In contrast, these enzymatic activities have been disrupted in HFFD rats.Overall, M-EML prevented obesity through the modulation of metabolic syndrome, reducing inflammation and promoting antioxidant enzymes activities.
    Schlagwörter Erica multiflora ; bilirubin ; carboxylic ester hydrolases ; catalase ; enzyme activity ; fatty liver ; fructose ; glutathione peroxidase ; hepatoprotective effect ; high fructose diet ; histopathology ; inflammation ; insulin resistance ; interleukin-6 ; leaf extracts ; liver ; malondialdehyde ; metabolic syndrome ; methanol ; morbidity ; obesity ; oral administration ; secondary metabolites ; superoxide dismutase ; uric acid
    Sprache Englisch
    Erscheinungsverlauf 2020-12
    Erscheinungsort Elsevier Inc.
    Dokumenttyp Artikel
    Anmerkung NAL-light
    ZDB-ID 1014929-6
    ISSN 1873-4847 ; 0955-2863
    ISSN (online) 1873-4847
    ISSN 0955-2863
    DOI 10.1016/j.jnutbio.2020.108490
    Datenquelle NAL Katalog (AGRICOLA)

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    Verfügbar in ZB MED Bonn

    Z 5044: Hefte anzeigen

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  4. Artikel ; Online: Chemical Composition Analysis, Antioxidant, and Antibacterial Activities of Eggplant Leaves.

    Bouhajeb, Rim / Selmi, Salima / Nakbi, Amel / Jlassi, Ibrahim / Montevecchi, Giuseppe / Flamini, Guido / Zarrad, Imen / Dabbou, Samia

    Chemistry & biodiversity

    2020  Band 17, Heft 12, Seite(n) e2000405

    Abstract: Agricultural by-products represent one of the biggest pollutants for the environment, therefore, investigating new sources for the extraction of bioactive compounds is a topic of great interest for the entire scientific community. This work is aimed at ... ...

    Abstract Agricultural by-products represent one of the biggest pollutants for the environment, therefore, investigating new sources for the extraction of bioactive compounds is a topic of great interest for the entire scientific community. This work is aimed at studying the chemical composition (pigments, phenolics, volatile compounds) and biological activities (antioxidant and antimicrobial properties) of young and mature leaves of five eggplant cultivars (Solanum melongena L.) grown in Tunisia (Tizona, A1014, Nawel, A336, and Mirval). Pigment analysis showed no statistical variations between the two types of leaves, whereas higher levels of anthocyanins were recorded in young leaves of three out of five cultivars (24.7-52.8 mg 100 g
    Mesh-Begriff(e) Anti-Bacterial Agents/pharmacology ; Antifungal Agents/pharmacology ; Antioxidants/pharmacology ; Candida albicans/drug effects ; Microbial Sensitivity Tests ; Plant Leaves/chemistry ; Solanum melongena/chemistry ; Staphylococcus aureus/drug effects
    Chemische Substanzen Anti-Bacterial Agents ; Antifungal Agents ; Antioxidants
    Sprache Englisch
    Erscheinungsdatum 2020-11-10
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2139001-0
    ISSN 1612-1880 ; 1612-1872
    ISSN (online) 1612-1880
    ISSN 1612-1872
    DOI 10.1002/cbdv.202000405
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Erica multiflora extract rich in quercetin-3-O-glucoside and kaempferol-3-O-glucoside alleviates high fat and fructose diet-induced fatty liver disease by modulating metabolic and inflammatory pathways in Wistar rats.

    Khlifi, Rihab / Dhaouefi, Zaineb / Toumia, Imène Ben / Lahmar, Aida / Sioud, Fairouz / Bouhajeb, Rim / Bellalah, Ahlem / Chekir-Ghedira, Leila

    The Journal of nutritional biochemistry

    2020  Band 86, Seite(n) 108490

    Abstract: The wide morbidity of obesity has heightened interest in providing natural and safe compounds to maintain optimal health. The present study was designed to determine the chemical constituents and the effects of methanol leaf extract from Erica multiflora ...

    Abstract The wide morbidity of obesity has heightened interest in providing natural and safe compounds to maintain optimal health. The present study was designed to determine the chemical constituents and the effects of methanol leaf extract from Erica multiflora (M-EML) on mitigating high-fat and high-fructose diet (HFFD)-induced metabolic syndrome (MS). LC-MS/MS characterization of M-EML allowed the identification of 14 secondary metabolites and showed that quercetin-3-O-glucoside and kaempferol-3-O-glucoside were the main compounds of our extract. In the in vivo study, the oral administration of M-EML (250 mg/kg) during the last 4 weeks of the experimentation alleviated HFFD-induced obesity, insulin resistance (IR) and cardiovascular diseases. Thus, M-EML treatment significantly normalized body and liver weight, allowed to a sharp decline in plasma levels of TC, TG and LDL-c by 32%, 35% and 66%, respectively. Moreover, hepatic enzymes, total and direct bilirubin, lipase and uric acid levels have been diminished in treated group. Histopathology of the liver confirmed the changes induced by HFFD and the hepatoprotective effect of M-EML. The supply of M-EML reduced NO production and cellular lysosomal enzyme activity by 44% and 60%, respectively compared to HFFD. Besides, M-EML showed decreased pro-inflammatory cytokines levels (259.5±47.35 pg/ml and 56.08±1.56 pg/ml) of TNF-α and IL-6, respectively. In addition, M-EML reduced liver malondialdehyde (MDA) content and enhanced superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities. In contrast, these enzymatic activities have been disrupted in HFFD rats. Overall, M-EML prevented obesity through the modulation of metabolic syndrome, reducing inflammation and promoting antioxidant enzymes activities.
    Mesh-Begriff(e) Animals ; Diet, High-Fat/adverse effects ; Dietary Fats ; Ericales/chemistry ; Fatty Liver/metabolism ; Fructose/adverse effects ; Glucosides/chemistry ; Glucosides/pharmacology ; Inflammation/metabolism ; Insulin Resistance ; Kaempferols/pharmacology ; Liver/metabolism ; Male ; Metabolic Syndrome/metabolism ; Methanol/chemistry ; Monosaccharides/pharmacology ; Oxidative Stress ; Plant Extracts/pharmacology ; Quercetin/analogs & derivatives ; Quercetin/pharmacology ; Rats ; Rats, Wistar ; Reactive Oxygen Species/metabolism ; Tandem Mass Spectrometry
    Chemische Substanzen Dietary Fats ; Glucosides ; Kaempferols ; Monosaccharides ; Plant Extracts ; Reactive Oxygen Species ; kaempferol-3-O-glucoside ; quercetin 3'-O-glucoside ; Fructose (30237-26-4) ; Quercetin (9IKM0I5T1E) ; Methanol (Y4S76JWI15)
    Sprache Englisch
    Erscheinungsdatum 2020-09-11
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1014929-6
    ISSN 1873-4847 ; 0955-2863
    ISSN (online) 1873-4847
    ISSN 0955-2863
    DOI 10.1016/j.jnutbio.2020.108490
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 2838: Hefte anzeigen Standort:
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