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Article ; Online: [No title information]

Bouhanick, Béatrice

2021

Title translation	Hommage du Collège national des enseignants de thérapeutique au Pr Karine Lacut, PU-PH de Thérapeutique à Brest.
Language	French
Publishing date	2021-04-20
Publishing country	France
Document type	Journal Article
ZDB-ID	603474-3
ISSN	1958-5578 ; 0040-5957
ISSN (online)	1958-5578
ISSN	0040-5957
DOI	10.1016/j.therap.2021.04.005
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Article: Le bon usage du médicament.

Bouhanick, Béatrice

La Revue du praticien

2019 Volume 68, Issue 10, Page(s) e393

Title translation	Proper use of drugs.
MeSH term(s)	Drug Therapy ; Humans
Language	French
Publishing date	2019-03-14
Publishing country	France
Document type	Journal Article
ZDB-ID	205365-2
ISSN	2101-017X ; 0035-2640
ISSN (online)	2101-017X
ISSN	0035-2640
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Article ; Online: [No title information]

Bouhanick, Béatrice / Cracowski, Jean-Luc / Faillie, Jean-Luc

Therapie

2021 Volume 76, Issue 4, Page(s) 359–360

Title translation	DPP-4 inhibitors and severe course of illness in patients with COVID-19.
MeSH term(s)	COVID-19 ; Dipeptidyl-Peptidase IV Inhibitors ; Humans ; SARS-CoV-2
Chemical Substances	Dipeptidyl-Peptidase IV Inhibitors
Language	French
Publishing date	2021-01-18
Publishing country	France
Document type	Editorial ; Comment
ZDB-ID	603474-3
ISSN	1958-5578 ; 0040-5957
ISSN (online)	1958-5578
ISSN	0040-5957
DOI	10.1016/j.therap.2021.01.051
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Article ; Online: Diabetes and COVID-19.

Bouhanick, Béatrice / Cracowski, Jean-Luc / Faillie, Jean-Luc

Therapie

2020 Volume 75, Issue 4, Page(s) 327–333

Abstract: According to previous reports, diabetes seems to be a risk factor which worsens the serious clinical events caused by COVID-19. But is diabetes per se a risk factor that increases the probability of getting the virus? This paper will discuss this point. ... ...

Abstract	According to previous reports, diabetes seems to be a risk factor which worsens the serious clinical events caused by COVID-19. But is diabetes per se a risk factor that increases the probability of getting the virus? This paper will discuss this point. There are not many research data on antidiabetic drugs in this context. The potential influence of glucose-lowering agents on the severity of COVID-19 has not been described yet. Dipeptidylpeptidase-4 (DPP-4) is a cell surface protein ubiquitously expressed in many tissues and it is also a soluble molecule found in serum/plasma fluids. DPP-4 is involved in infection of cells by some viruses. This paper reviews data about the use of DPP-4 inhibitors and others diabetes drugs on COVID-19 patients. As such, no available evidence has yet suggested that glucose-lowering drugs - including those targeting DPP4-related pathways - produce any significant harm or benefit in the context of human infections. However, insulin must remain the first-choice agent in the management of critically ill-hospitalized patients, while it is recommended to suspend other agents in unstable patients. This paper provides related French and international recommendations for people with diabetes who got infected by COVID-19 and upholds that infections may alter glucose control and may require additional vigilance.
MeSH term(s)	Animals ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/physiopathology ; Diabetes Mellitus/drug therapy ; Diabetes Mellitus/epidemiology ; Dipeptidyl-Peptidase IV Inhibitors/administration & dosage ; Dipeptidyl-Peptidase IV Inhibitors/adverse effects ; Dipeptidyl-Peptidase IV Inhibitors/pharmacology ; Humans ; Hypoglycemic Agents/administration & dosage ; Hypoglycemic Agents/adverse effects ; Hypoglycemic Agents/pharmacology ; Insulin/administration & dosage ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/physiopathology ; Risk Factors ; Severity of Illness Index
Chemical Substances	Dipeptidyl-Peptidase IV Inhibitors ; Hypoglycemic Agents ; Insulin
Keywords	covid19
Language	English
Publishing date	2020-05-15
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	603474-3
ISSN	1958-5578 ; 0040-5957
ISSN (online)	1958-5578
ISSN	0040-5957
DOI	10.1016/j.therap.2020.05.006
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Article ; Online: Diabète et COVID-19.

Bouhanick, Béatrice / Cracowski, Jean-Luc / Faillie, Jean-Luc

Therapie

2020

Abstract: According to previous reports, diabetes seems to be associated with serious clinical events due to COVID-19. But is diabetes per se a risk factor of being infected by the virus? We discuss these points. Data about the antidiabetic drugs are scarce. ... ...

Title translation	Diabetes and COVID-19.
Abstract	According to previous reports, diabetes seems to be associated with serious clinical events due to COVID-19. But is diabetes per se a risk factor of being infected by the virus? We discuss these points. Data about the antidiabetic drugs are scarce. Dipeptidylpeptidase-4 (DPP-4) is found as both a cell surface protein ubiquitously expressed in many tissues and as a soluble molecule found in serum/plasma, fluids. DPP-4 is involved in infection of cells by some viruses. We relate data about the use of DPP-4 inhibitors in diabetic patients. We conclude relating French and international recommendations in people with diabetes.
Language	French
Publishing date	2020-04-23
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	603474-3
ISSN	1958-5578 ; 0040-5957
ISSN (online)	1958-5578
ISSN	0040-5957
DOI	10.1016/j.therap.2020.04.004
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Article ; Online: Dosage des médicaments antihypertenseurs en France en 2019 et observance.

Bouhanick, Béatrice / Vaïsse, Bernard / Schavgoulidze, Anaïs / Gandia, Peggy

Presse medicale (Paris, France : 1983)

2019 Volume 48, Issue 12, Page(s) 1520–1526

Abstract: Non-adherence to antihypertensive treatment is one of the critical contributors to sub-optimal blood pressure control. The French Society of Hypertension remembered that urine and serum biochemical detection of antihypertensive drugs could be useful in a ...

Title translation	Assessment for antihypertensive drug intake in France in 2019 and adherence.
Abstract	Non-adherence to antihypertensive treatment is one of the critical contributors to sub-optimal blood pressure control. The French Society of Hypertension remembered that urine and serum biochemical detection of antihypertensive drugs could be useful in a patient with resistant hypertension. Talking to a patient with biochemically confirmed non-adherence to blood pressure-lowering therapy and repeating them improved adherence to drugs. Despite its usefulness, biochemical detection of antihypertensive drugs is not routinely effective in France as they are not reimbursed by French Medical Care, except in patients attending hospitals. The list of blood pressure-lowering drugs able to be biochemically detected in France and their modalities are recorded here.
MeSH term(s)	Antihypertensive Agents/economics ; Antihypertensive Agents/therapeutic use ; Blood Pressure/drug effects ; Dosage Forms ; Drug Costs ; France/epidemiology ; Humans ; Hypertension/drug therapy ; Hypertension/economics ; Hypertension/epidemiology ; Medication Adherence/statistics & numerical data
Chemical Substances	Antihypertensive Agents ; Dosage Forms
Language	French
Publishing date	2019-11-21
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	120943-7
ISSN	2213-0276 ; 0032-7867 ; 0755-4982 ; 0301-1518
ISSN (online)	2213-0276
ISSN	0032-7867 ; 0755-4982 ; 0301-1518
DOI	10.1016/j.lpm.2019.08.009
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Drugs acting on renin angiotensin system and use in ill patients with COVID-19.

Alexandre, Joachim / Cracowski, Jean-Luc / Richard, Vincent / Bouhanick, Béatrice

Therapie

2020 Volume 75, Issue 4, Page(s) 319–325

Abstract: Some concerns about the prescription of drugs acting on the renin-angiotensin system (angiotensin-converting enzyme 1 (ACE1) inhibitors, ACEi; angiotensin II type 1 receptor blockers, ARB) have emerged due to SARS COV2 and COVID-19 pandemic. These very ... ...

Abstract	Some concerns about the prescription of drugs acting on the renin-angiotensin system (angiotensin-converting enzyme 1 (ACE1) inhibitors, ACEi; angiotensin II type 1 receptor blockers, ARB) have emerged due to SARS COV2 and COVID-19 pandemic. These very legitimate questions are directly the consequence of the recent recognition of the fundamental role of ACE2 (angiotensin-converting enzyme 2) in COVID-19 infection. Indeed, SARS COV2 utilizes ACE2 as a membrane receptor to enter target cells. Consequently, the putative impact of drugs modulating the renin-angiotensin system on the risk of developing severe or fatal severe acute respiratory syndrome in case of COVID-19 infection emerged. As a membrane-bound enzyme (carboxypeptidase), ACE2 inactivates angiotensin II and therefore physiologically counters its effects. Due to a different structure compared with ACE1, ACE2 is insensitive to ACEIs. In vitro, both ARBs and ACEi appear able to upregulate ACE2 tissue expression and activity but these results were not confirmed in Humans. The exact impact of both ARBs and ACEis on COVID-19 infection is definitively known and preliminary results are even in favor of a protective role confers by these drugs. Due to the crucial role of ACE2, some groups support the hypothesis that a modulation of ACE2 expression could represent a valuable therapeutic target could confer protective properties against inflammatory tissue damage in COVID-19 infection. So, studies are currently ongoing to test the impact of elevated ACE2 membrane expression, administration of ARB and infusion of soluble ACE2. In summary, based on the currently available evidences and as recommended by several medical societies, ACEi or ARB should not be systematically discontinued because to date no safety signal was raised with the use of these drugs.
MeSH term(s)	Angiotensin II Type 1 Receptor Blockers/administration & dosage ; Angiotensin II Type 1 Receptor Blockers/pharmacology ; Angiotensin-Converting Enzyme 2 ; Angiotensin-Converting Enzyme Inhibitors/administration & dosage ; Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Animals ; Betacoronavirus/drug effects ; Betacoronavirus/isolation & purification ; COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/virology ; Humans ; Pandemics ; Peptidyl-Dipeptidase A/drug effects ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/virology ; Renin-Angiotensin System/drug effects ; SARS-CoV-2 ; COVID-19 Drug Treatment
Chemical Substances	Angiotensin II Type 1 Receptor Blockers ; Angiotensin-Converting Enzyme Inhibitors ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Keywords	covid19
Language	English
Publishing date	2020-05-20
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	603474-3
ISSN	1958-5578 ; 0040-5957
ISSN (online)	1958-5578
ISSN	0040-5957
DOI	10.1016/j.therap.2020.05.009
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Article ; Online: Renin-angiotensin-aldosterone system and COVID-19 infection.

Alexandre, Joachim / Cracowski, Jean-Luc / Richard, Vincent / Bouhanick, Béatrice

Annales d'endocrinologie

2020 Volume 81, Issue 2-3, Page(s) 63–67

Abstract: With the multiplication of COVID-19 severe acute respiratory syndrome cases due to SARS-COV2, some concerns about angiotensin-converting enzyme 1 (ACE1) inhibitors (ACEi) and angiotensin II type 1 receptor blockers (ARB) have emerged. Since the ACE2 ( ... ...

Abstract	With the multiplication of COVID-19 severe acute respiratory syndrome cases due to SARS-COV2, some concerns about angiotensin-converting enzyme 1 (ACE1) inhibitors (ACEi) and angiotensin II type 1 receptor blockers (ARB) have emerged. Since the ACE2 (angiotensin-converting enzyme 2) enzyme is the receptor that allows SARS COV2 entry into cells, the fear was that pre-existing treatment with ACEi or ARB might increase the risk of developing severe or fatal severe acute respiratory syndrome in case of COVID-19 infection. The present article discusses these concerns. ACE2 is a membrane-bound enzyme (carboxypeptidase) that contributes to the inactivation of angiotensin II and therefore physiologically counters angiotensin II effects. ACEis do not inhibit ACE2. Although ARBs have been shown to up-regulate ACE2 tissue expression in experimental animals, evidence was not always consistent in human studies. Moreover, to date there is no evidence that ACEi or ARB administration facilitates SARS-COV2 cell entry by increasing ACE2 tissue expression in either animal or human studies. Finally, some studies support the hypothesis that elevated ACE2 membrane expression and tissue activity by administration of ARB and/or infusion of soluble ACE2 could confer protective properties against inflammatory tissue damage in COVID-19 infection. In summary, based on the currently available evidence and as advocated by many medical societies, ACEi or ARB should not be discontinued because of concerns with COVID-19 infection, except when the hemodynamic situation is precarious and case-by-case adjustment is required.
MeSH term(s)	Aldosterone/metabolism ; Aldosterone/physiology ; Angiotensin II Type 1 Receptor Blockers/therapeutic use ; Angiotensin-Converting Enzyme 2 ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Betacoronavirus/metabolism ; Blood Pressure/physiology ; COVID-19 ; Comorbidity ; Coronavirus Infections/epidemiology ; Coronavirus Infections/pathology ; Coronavirus Infections/physiopathology ; Humans ; Hypertension/drug therapy ; Hypertension/epidemiology ; Hypertension/physiopathology ; Pandemics ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/pathology ; Pneumonia, Viral/physiopathology ; Practice Guidelines as Topic ; Renin-Angiotensin System/physiology ; SARS-CoV-2 ; Severity of Illness Index ; Withholding Treatment
Chemical Substances	Angiotensin II Type 1 Receptor Blockers ; Angiotensin-Converting Enzyme Inhibitors ; Aldosterone (4964P6T9RB) ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Keywords	covid19
Language	English
Publishing date	2020-04-21
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	299-9
ISSN	2213-3941 ; 0003-4266
ISSN (online)	2213-3941
ISSN	0003-4266
DOI	10.1016/j.ando.2020.04.005
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Article ; Online: Diabetes and COVID-19

Bouhanick, Béatrice / Cracowski, Jean-Luc / Faillie, Jean-Luc

Therapies

2020 Volume 75, Issue 4, Page(s) 327–333

Keywords	Pharmacology (medical) ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	603474-3
ISSN	1958-5578 ; 0040-5957
ISSN (online)	1958-5578
ISSN	0040-5957
DOI	10.1016/j.therap.2020.05.006
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: THERAP–COVID-19

Bouhanick, Béatrice / Cracowski, Jean-Luc / Faillie, Jean-Luc

Therapie

Abstract: Summary According to previous reports, diabetes seems to be associated with serious clinical events due to COVID-19. But is diabetes per se a risk factor of being infected by the virus? We discuss these points. Data about the antidiabetic drugs are ... ...

Abstract	Summary According to previous reports, diabetes seems to be associated with serious clinical events due to COVID-19. But is diabetes per se a risk factor of being infected by the virus? We discuss these points. Data about the antidiabetic drugs are scarce. Dipeptidylpeptidase-4 (DPP-4) is found as both a cell surface protein ubiquitously expressed in many tissues and as a soluble molecule found in serum/plasma, fluids. DPP-4 is involved in infection of cells by some viruses. We relate data about the use of DPP-4 inhibitors in diabetic patients. We conclude relating French and international recommendations in people with diabetes.
Keywords	covid19
Publisher	Elsevier; PMC
Document type	Article ; Online
DOI	10.1016/j.therap.2020.04.004
Database	COVID19

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