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  1. Article ; Online: Diagnostic des angioedèmes héréditaires.

    Bouillet, Laurence

    Presse medicale (Paris, France : 1983)

    2015  Volume 44, Issue 1, Page(s) 52–56

    Abstract: Hereditary angioedema is a rare disease, potentially life-threatening. It requires a specific treatment. Angioedema without wheals associated with abdominal attacks are very specific of this disease. Antigenemy and functional C1Inhibitor assays are ... ...

    Title translation Diagnosis of hereditary angioedema.
    Abstract Hereditary angioedema is a rare disease, potentially life-threatening. It requires a specific treatment. Angioedema without wheals associated with abdominal attacks are very specific of this disease. Antigenemy and functional C1Inhibitor assays are necessary for the diagnosis. The hereditary angioedema with normal C1Inh (type III) is a diagnostic challenge. Bradykinin, secondary to kallikrein-kinin system activation is the key mediator of hereditary angioedema. Female are more symptomatic. Attacks can be induced by menstruations, pregnancies or contraceptive pills.
    MeSH term(s) Angioedemas, Hereditary/diagnosis ; Angioedemas, Hereditary/etiology ; Bradykinin/adverse effects ; Bradykinin/physiology ; Complement C1 Inhibitor Protein/genetics ; Female ; Humans ; Kallikreins/metabolism ; Kinins/metabolism ; Pregnancy
    Chemical Substances Complement C1 Inhibitor Protein ; Kinins ; Kallikreins (EC 3.4.21.-) ; Bradykinin (S8TIM42R2W)
    Language French
    Publishing date 2015-01
    Publishing country France
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 120943-7
    ISSN 2213-0276 ; 0032-7867 ; 0755-4982 ; 0301-1518
    ISSN (online) 2213-0276
    ISSN 0032-7867 ; 0755-4982 ; 0301-1518
    DOI 10.1016/j.lpm.2014.06.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Profile of serious angioedema requiring an urgent advice from a national reference call center.

    Simon, Nicolas / Bocquet, Alexis / Boccon-Gibod, Isabelle / Bouillet, Laurence

    Medicine

    2022  Volume 101, Issue 31, Page(s) e29513

    Abstract: Angioedema (AE) is a reason for emergency care when it is severe. Care is difficult when the diagnostic is not known before the attack: mast cell (MC) or bradykinin (BK) mediated. One is very common but often benign, the other rare but potentially fatal. ...

    Abstract Angioedema (AE) is a reason for emergency care when it is severe. Care is difficult when the diagnostic is not known before the attack: mast cell (MC) or bradykinin (BK) mediated. One is very common but often benign, the other rare but potentially fatal. The French national reference center of angioedema (CREAK) provides emergency physicians with a hotline and a guideline to help them manage their patients. This study aimed to describe the clinical features of AE episodes prompting a call on the CREAK hotline and classify patients depending on the suspected cause of the AE. This is a retrospective study between March and August 2019. Each physician calling on the CREAK hotline was asked to fill a clinical description form for the AE emergency. Known patients of CREAK was excluded. Eighty four patients were included. Forty one (48.8%) in the angiotensin converting enzyme inhibitors induced acquired angioedema (ACEi-AAE), 39 (46.4%) in the mast cell induced angioedema, and 4 (4.8%) in the Bradykinin mediated angioedema. The mast cell induced angioedema patients have more history of hives (29.3%) than ACEi-AAE (2.4%, P = .0004). ACEi-AAE mainly affected the tongue (58.5% vs 25.6%, P = .003) and larynx (29.3% vs 13%, P = .001). In 65.5% of cases, the etiological diagnosis was not mentioned by the appellant, but made by the hotline. In 31% of cases, the hotline suggested the administration of a specific treatment not previously provided by the caller. All the doctors who called the hotline appreciate this tele-expertise especially in case of ACEi-AAE presumptions. In addition to providing rapid AE expertise, this service also allows to educate physicians in the management of AE irrespective of its origin.
    MeSH term(s) Angioedema/diagnosis ; Angioedema/etiology ; Angioedema/therapy ; Bradykinin/therapeutic use ; Call Centers ; Humans ; Retrospective Studies
    Chemical Substances Bradykinin (S8TIM42R2W)
    Language English
    Publishing date 2022-08-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000029513
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  3. Article ; Online: Treatment of non-systemic Sjögren's syndrome: Potential prevention of systematization with immunosuppressant agent/biotherapy.

    Belbézier, Aude / Nguyen, Thi Thu Thuy / Arnaud, Mélanie / Ducotterd, Bruna / Vangout, Marie / Deroux, Alban / Mansard, Catherine / Sarrot-Reynauld, Françoise / Bouillet, Laurence

    Journal of translational autoimmunity

    2024  Volume 8, Page(s) 100238

    Abstract: Sjögren's syndrome (SS) is a systemic autoimmune pathology manifested mainly by a dry syndrome, intense asthenia and arthromyalgia. Systemic manifestations may also occur. Since 2019, immunosuppressant agents (IS) or biotherapies are recommended only for ...

    Abstract Sjögren's syndrome (SS) is a systemic autoimmune pathology manifested mainly by a dry syndrome, intense asthenia and arthromyalgia. Systemic manifestations may also occur. Since 2019, immunosuppressant agents (IS) or biotherapies are recommended only for patients with systemic involvement. However, before 2019, in some cases, paucisymptomatic patients had been treated with IS/biotherapies, often off-label.
    Language English
    Publishing date 2024-03-03
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2589-9090
    ISSN (online) 2589-9090
    DOI 10.1016/j.jtauto.2024.100238
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  4. Article ; Online: Efficacy of lanadelumab in acquired angioedema with C1-inhibitor deficiency.

    Belbézier, Aude / Boccon-Gibod, Isabelle / Bouillet, Laurence

    The journal of allergy and clinical immunology. In practice

    2021  Volume 9, Issue 6, Page(s) 2490–2491

    MeSH term(s) Angioedema/drug therapy ; Angioedemas, Hereditary/drug therapy ; Antibodies, Monoclonal, Humanized ; Complement C1 Inactivator Proteins ; Complement C1 Inhibitor Protein/therapeutic use ; Humans
    Chemical Substances Antibodies, Monoclonal, Humanized ; Complement C1 Inactivator Proteins ; Complement C1 Inhibitor Protein ; lanadelumab (2372V1TKXK)
    Language English
    Publishing date 2021-02-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2021.01.040
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  5. Article ; Online: Efficacy of omalizumab for extracutaneous symptoms of chronic spontaneous urticaria.

    Belbezier, Aude / Boccon-Gibod, Isabelle / Bouillet, Laurence

    European journal of dermatology : EJD

    2021  Volume 31, Issue 1, Page(s) 86–87

    MeSH term(s) Adolescent ; Adult ; Aged ; Anti-Allergic Agents/therapeutic use ; Chronic Urticaria/diagnosis ; Chronic Urticaria/drug therapy ; Female ; Humans ; Male ; Middle Aged ; Omalizumab/therapeutic use ; Retrospective Studies ; Treatment Outcome ; Young Adult
    Chemical Substances Anti-Allergic Agents ; Omalizumab (2P471X1Z11)
    Language English
    Publishing date 2021-03-26
    Publishing country France
    Document type Letter
    ZDB-ID 1128666-0
    ISSN 1952-4013 ; 1167-1122
    ISSN (online) 1952-4013
    ISSN 1167-1122
    DOI 10.1684/ejd.2020.3717
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    Zs.A 3484: Show issues Location:
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  6. Article ; Online: Hereditary angioedema in women

    Bouillet Laurence

    Allergy, Asthma & Clinical Immunology, Vol 6, Iss 1, p

    2010  Volume 17

    Abstract: Abstract Women with hereditary angioedema (HAE) are more likely to be symptomatic that men. Hormonal factors (puberty, contraception, pregnancy,.) play a significant role in the precipitation or worsening of the condition in women. So, combined ... ...

    Abstract Abstract Women with hereditary angioedema (HAE) are more likely to be symptomatic that men. Hormonal factors (puberty, contraception, pregnancy,.) play a significant role in the precipitation or worsening of the condition in women. So, combined contraceptive pills are not indicated and progestogen pill must be preferred. During pregnancy, attack rate can increase (38-48% of women). C1Inhibitor concentrate and tranexamic acid can be used during pregnancy. Attenuated androgens for long term prophylaxis are effective but side effects appear more often in female patients. These side effects are dose dependant and can be attenuated by titrating the dose down the lowest effective level.
    Keywords Immunologic diseases. Allergy ; RC581-607 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Allergy and Immunology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2010-07-01T00:00:00Z
    Publisher BioMed Central
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Angiotensin-converting enzyme and dipeptidyl peptidase-4 inhibitor-induced angioedema: A disproportionality analysis of the WHO pharmacovigilance database.

    Lepelley, Marion / Khouri, Charles / Lacroix, Clémence / Bouillet, Laurence

    The journal of allergy and clinical immunology. In practice

    2020  Volume 8, Issue 7, Page(s) 2406–2408.e1

    MeSH term(s) Angioedema/chemically induced ; Angioedema/epidemiology ; Angiotensins ; Dipeptidyl-Peptidase IV Inhibitors/adverse effects ; Humans ; Pharmacovigilance ; World Health Organization
    Chemical Substances Angiotensins ; Dipeptidyl-Peptidase IV Inhibitors
    Language English
    Publishing date 2020-03-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2020.03.015
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    Zs.A 7086: Show issues Location:
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  8. Article: Idiopathic Angioedema: Current Challenges.

    Belbézier, Aude / Bocquet, Alexis / Bouillet, Laurence

    Journal of asthma and allergy

    2020  Volume 13, Page(s) 137–144

    Abstract: The etiological diagnosis of isolated recurrent angioedema poses problems because it must often be done urgently. Angioedema secondary to nonspecific mast cell activation (MC-AE) is the most frequent form and is usually mild. Bradykinin mediated ... ...

    Abstract The etiological diagnosis of isolated recurrent angioedema poses problems because it must often be done urgently. Angioedema secondary to nonspecific mast cell activation (MC-AE) is the most frequent form and is usually mild. Bradykinin mediated angioedema (BK-AE) is rarer but potentially fatal in the absence of the correct treatment. Few biological markers exist. The C1-inhibitor (C1-inh) functional assay can exclude AE due to C1-inh deficiency. Genetic diagnoses of hereditary AE due to abnormal C1-inh AE have progressed with four currently known mutations. However, determining the physiopathological mechanism leading to some isolated AE cases is sometimes very difficult. In such cases, therapeutic tests are then the only solution: antihistamines at high doses and omalizumab for suspected MC-AE, icatibant for suspected AE-BK. Identifying new markers would be a great help.
    Language English
    Publishing date 2020-04-17
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2494877-9
    ISSN 1178-6965
    ISSN 1178-6965
    DOI 10.2147/JAA.S205709
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  9. Article ; Online: Icatibant in hereditary angioedema: news and challenges.

    Bouillet, Laurence

    Expert review of clinical immunology

    2011  Volume 7, Issue 3, Page(s) 267–272

    Abstract: Hereditary angioedema (HAE) is a rare condition. Its prognosis depends on whether there is laryngeal involvement with a risk of asphyxia, which is present in 25% of such cases. Improved understanding of the pathophysiology of this disease has resulted in ...

    Abstract Hereditary angioedema (HAE) is a rare condition. Its prognosis depends on whether there is laryngeal involvement with a risk of asphyxia, which is present in 25% of such cases. Improved understanding of the pathophysiology of this disease has resulted in the development of targeted therapies including icatibant, which acts as an antagonist at bradykinin B2 receptors. This agent has been shown to be effective in the treatment of attacks of HAE in three Phase III randomized double-blind published studies. Efficacy data have been collected in all types of attack: cutaneous, abdominal and laryngeal. Safety data are also encouraging. Icatibant is administered subcutaneously, with the potential for patients to self-administer. In the future, this therapy may offer increased independence for HAE patients.
    MeSH term(s) Angioedemas, Hereditary/drug therapy ; Bradykinin/analogs & derivatives ; Bradykinin/therapeutic use ; Clinical Trials, Phase III as Topic ; Double-Blind Method ; Humans ; Randomized Controlled Trials as Topic ; Vasodilator Agents/therapeutic use
    Chemical Substances Vasodilator Agents ; icatibant (7PG89G35Q7) ; Bradykinin (S8TIM42R2W)
    Language English
    Publishing date 2011-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2274260-8
    ISSN 1744-8409 ; 1744-666X
    ISSN (online) 1744-8409
    ISSN 1744-666X
    DOI 10.1586/eci.11.16
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  10. Article ; Online: Effectiveness of lanadelumab in patients with hereditary angioedema with normal C1 inhibitor and FXII mutation.

    Bouillet, Laurence / Bocquet, Alexis / Belbezier, Aude / Boccon-Gibod, Isabelle

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2021  Volume 127, Issue 3, Page(s) 391–392

    MeSH term(s) Adult ; Angioedemas, Hereditary/drug therapy ; Angioedemas, Hereditary/genetics ; Antibodies, Monoclonal, Humanized/therapeutic use ; Complement C1 Inhibitor Protein/therapeutic use ; Factor XII/genetics ; Female ; Humans ; Middle Aged ; Mutation ; Treatment Outcome
    Chemical Substances Antibodies, Monoclonal, Humanized ; Complement C1 Inhibitor Protein ; lanadelumab (2372V1TKXK) ; Factor XII (9001-30-3)
    Language English
    Publishing date 2021-05-31
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2021.05.028
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