Article ; Online: Optimization of biologics to reduce treatment failure in inflammatory bowel diseases.
Current opinion in pharmacology
2020 Volume 54, Page(s) 51–58
Abstract: Moderate to severe inflammatory bowel disease patients can fail to respond to conventional therapy and/or to biologic treatment. In the era of TNFα antagonists and other non-anti-TNF biologic drugs, it is important to review the literature on biologic ... ...
Abstract | Moderate to severe inflammatory bowel disease patients can fail to respond to conventional therapy and/or to biologic treatment. In the era of TNFα antagonists and other non-anti-TNF biologic drugs, it is important to review the literature on biologic treatment failure, which could be defined as primary non-response, secondary loss of response and intolerance. Therapeutic drug monitoring (TDM), that is, drug trough level and antidrug antibodies, should enable to determine the mechanisms of treatment failure and to optimize drug efficacy. There is a consensus on reactive TDM at the time of loss of response. Proactive TDM could be of interest during induction and/or maintenance, but randomized controlled trials are required. |
---|---|
MeSH term(s) | Antibodies, Monoclonal, Humanized/therapeutic use ; Biological Products/therapeutic use ; Drug Monitoring ; Drug Resistance ; Gastrointestinal Agents/therapeutic use ; Humans ; Inflammatory Bowel Diseases/drug therapy ; Treatment Failure ; Tumor Necrosis Factor-alpha/antagonists & inhibitors ; Ustekinumab/therapeutic use |
Chemical Substances | Antibodies, Monoclonal, Humanized ; Biological Products ; Gastrointestinal Agents ; Tumor Necrosis Factor-alpha ; vedolizumab (9RV78Q2002) ; Ustekinumab (FU77B4U5Z0) |
Language | English |
Publishing date | 2020-09-15 |
Publishing country | England |
Document type | Journal Article ; Review |
ZDB-ID | 2037057-X |
ISSN | 1471-4973 ; 1471-4892 |
ISSN (online) | 1471-4973 |
ISSN | 1471-4892 |
DOI | 10.1016/j.coph.2020.07.012 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
Zs.A 5608: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.