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  1. Article ; Online: Concussion management plans' compliance with NCAA requirements: Preliminary evidence suggesting possible improvement.

    Baugh, Christine M / Kroshus, Emily / Perry, Kaitlyn I / Bourlas, Alexandra P

    The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics

    2017  Volume 45, Issue 2, Page(s) 231–237

    Abstract: This study examined the extent to which concussion management plans at National Collegiate Athletic Association (NCAA) member schools were in line with NCAA Concussion Policy and best practice recommendations in absence of any process to ensure ... ...

    Abstract This study examined the extent to which concussion management plans at National Collegiate Athletic Association (NCAA) member schools were in line with NCAA Concussion Policy and best practice recommendations in absence of any process to ensure compliance. Most schools' concussion management plans were in compliance with 3 (60%) or 4 (25.6%) of the NCAA's 4 required components. Annual athlete education and acknowledgement was the requirement least often included, representing an area for improvement. Further, schools tended to more often include best practices that were more medically-oriented (e.g., including baseline examination), compared to best practices that were less medical in nature (e.g., avoiding flagrant head hits).
    Language English
    Publishing date 2017-07-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1168812-9
    ISSN 1748-720X ; 1073-1105 ; 0277-8459
    ISSN (online) 1748-720X
    ISSN 1073-1105 ; 0277-8459
    DOI 10.1177/1073110517720652
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Requiring athletes to acknowledge receipt of concussion-related information and responsibility to report symptoms: a study of the prevalence, variation, and possible improvements.

    Baugh, Christine M / Kroshus, Emily / Bourlas, Alexandra P / Perry, Kaitlyn I

    The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics

    2014  Volume 42, Issue 3, Page(s) 297–313

    Abstract: State concussion laws and sport-league policies are important tools for protecting public health, but also present implementation challenges. Both state laws and league policies often require athletes provide written acknowledgement of having received ... ...

    Abstract State concussion laws and sport-league policies are important tools for protecting public health, but also present implementation challenges. Both state laws and league policies often require athletes provide written acknowledgement of having received concussion-related information and/or of their responsibility to report concussion-related symptoms. This paper examines these requirements in two ways: an analysis of the variation in state laws and sport-league policies and a study of their effects in a cohort of collegiate football players.
    MeSH term(s) Athletes/legislation & jurisprudence ; Athletic Injuries/diagnosis ; Athletic Injuries/prevention & control ; Brain Concussion/diagnosis ; Brain Concussion/prevention & control ; Health Education/legislation & jurisprudence ; Humans ; Safety/legislation & jurisprudence ; Sports Medicine/legislation & jurisprudence ; State Government ; United States
    Language English
    Publishing date 2014
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1168812-9
    ISSN 1748-720X ; 1073-1105 ; 0277-8459
    ISSN (online) 1748-720X
    ISSN 1073-1105 ; 0277-8459
    DOI 10.1111/jlme.12147
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Age of first exposure to football and later-life cognitive impairment in former NFL players.

    Stamm, Julie M / Bourlas, Alexandra P / Baugh, Christine M / Fritts, Nathan G / Daneshvar, Daniel H / Martin, Brett M / McClean, Michael D / Tripodis, Yorghos / Stern, Robert A

    Neurology

    2015  Volume 84, Issue 11, Page(s) 1114–1120

    Abstract: Objective: To determine the relationship between exposure to repeated head impacts through tackle football prior to age 12, during a key period of brain development, and later-life executive function, memory, and estimated verbal IQ.: Methods: Forty- ... ...

    Abstract Objective: To determine the relationship between exposure to repeated head impacts through tackle football prior to age 12, during a key period of brain development, and later-life executive function, memory, and estimated verbal IQ.
    Methods: Forty-two former National Football League (NFL) players ages 40-69 from the Diagnosing and Evaluating Traumatic Encephalopathy using Clinical Tests (DETECT) study were matched by age and divided into 2 groups based on their age of first exposure (AFE) to tackle football: AFE <12 and AFE ≥12. Participants completed the Wisconsin Card Sort Test (WCST), Neuropsychological Assessment Battery List Learning test (NAB-LL), and Wide Range Achievement Test, 4th edition (WRAT-4) Reading subtest as part of a larger neuropsychological testing battery.
    Results: Former NFL players in the AFE <12 group performed significantly worse than the AFE ≥12 group on all measures of the WCST, NAB-LL, and WRAT-4 Reading tests after controlling for total number of years of football played and age at the time of evaluation, indicating executive dysfunction, memory impairment, and lower estimated verbal IQ.
    Conclusions: There is an association between participation in tackle football prior to age 12 and greater later-life cognitive impairment measured using objective neuropsychological tests. These findings suggest that incurring repeated head impacts during a critical neurodevelopmental period may increase the risk of later-life cognitive impairment. If replicated with larger samples and longitudinal designs, these findings may have implications for safety recommendations for youth sports.
    MeSH term(s) Adolescent ; Adult ; Age Factors ; Aged ; Brain Concussion/diagnosis ; Brain Concussion/epidemiology ; Brain Concussion/psychology ; Child ; Cognition Disorders/diagnosis ; Cognition Disorders/epidemiology ; Cognition Disorders/psychology ; Cohort Studies ; Football/injuries ; Football/trends ; Humans ; Male ; Middle Aged ; Neuropsychological Tests ; Risk Factors
    Language English
    Publishing date 2015-03-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000001358
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 374: Show issues

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  4. Article ; Online: Age at First Exposure to Football Is Associated with Altered Corpus Callosum White Matter Microstructure in Former Professional Football Players.

    Stamm, Julie M / Koerte, Inga K / Muehlmann, Marc / Pasternak, Ofer / Bourlas, Alexandra P / Baugh, Christine M / Giwerc, Michelle Y / Zhu, Anni / Coleman, Michael J / Bouix, Sylvain / Fritts, Nathan G / Martin, Brett M / Chaisson, Christine / McClean, Michael D / Lin, Alexander P / Cantu, Robert C / Tripodis, Yorghos / Stern, Robert A / Shenton, Martha E

    Journal of neurotrauma

    2015  Volume 32, Issue 22, Page(s) 1768–1776

    Abstract: Youth football players may incur hundreds of repetitive head impacts (RHI) in one season. Our recent research suggests that exposure to RHI during a critical neurodevelopmental period prior to age 12 may lead to greater later-life mood, behavioral, and ... ...

    Abstract Youth football players may incur hundreds of repetitive head impacts (RHI) in one season. Our recent research suggests that exposure to RHI during a critical neurodevelopmental period prior to age 12 may lead to greater later-life mood, behavioral, and cognitive impairments. Here, we examine the relationship between age of first exposure (AFE) to RHI through tackle football and later-life corpus callosum (CC) microstructure using magnetic resonance diffusion tensor imaging (DTI). Forty retired National Football League (NFL) players, ages 40-65, were matched by age and divided into two groups based on their AFE to tackle football: before age 12 or at age 12 or older. Participants underwent DTI on a 3 Tesla Siemens (TIM-Verio) magnet. The whole CC and five subregions were defined and seeded using deterministic tractography. Dependent measures were fractional anisotropy (FA), trace, axial diffusivity, and radial diffusivity. Results showed that former NFL players in the AFE <12 group had significantly lower FA in anterior three CC regions and higher radial diffusivity in the most anterior CC region than those in the AFE ≥12 group. This is the first study to find a relationship between AFE to RHI and later-life CC microstructure. These results suggest that incurring RHI during critical periods of CC development may disrupt neurodevelopmental processes, including myelination, resulting in altered CC microstructure.
    MeSH term(s) Adolescent ; Adult ; Age of Onset ; Aged ; Anisotropy ; Child ; Child, Preschool ; Corpus Callosum/injuries ; Corpus Callosum/pathology ; Diffusion Tensor Imaging ; Football/injuries ; Humans ; Male ; Middle Aged ; White Matter/injuries ; White Matter/pathology ; Young Adult
    Language English
    Publishing date 2015-09-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 645092-1
    ISSN 1557-9042 ; 0897-7151
    ISSN (online) 1557-9042
    ISSN 0897-7151
    DOI 10.1089/neu.2014.3822
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    Zs.A 2016: Show issues Location:
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  5. Article ; Online: Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans.

    Mez, Jesse / Chung, Jaeyoon / Jun, Gyungah / Kriegel, Joshua / Bourlas, Alexandra P / Sherva, Richard / Logue, Mark W / Barnes, Lisa L / Bennett, David A / Buxbaum, Joseph D / Byrd, Goldie S / Crane, Paul K / Ertekin-Taner, Nilüfer / Evans, Denis / Fallin, M Daniele / Foroud, Tatiana / Goate, Alison / Graff-Radford, Neill R / Hall, Kathleen S /
    Kamboh, M Ilyas / Kukull, Walter A / Larson, Eric B / Manly, Jennifer J / Haines, Jonathan L / Mayeux, Richard / Pericak-Vance, Margaret A / Schellenberg, Gerard D / Lunetta, Kathryn L / Farrer, Lindsay A

    Alzheimer's & dementia : the journal of the Alzheimer's Association

    2016  Volume 13, Issue 2, Page(s) 119–129

    Abstract: Introduction: African Americans' (AAs) late-onset Alzheimer's disease (LOAD) genetic risk profile is incompletely understood. Including clinical covariates in genetic analyses using informed conditioning might improve study power.: Methods: We ... ...

    Abstract Introduction: African Americans' (AAs) late-onset Alzheimer's disease (LOAD) genetic risk profile is incompletely understood. Including clinical covariates in genetic analyses using informed conditioning might improve study power.
    Methods: We conducted a genome-wide association study (GWAS) in AAs employing informed conditioning in 1825 LOAD cases and 3784 cognitively normal controls. We derived a posterior liability conditioned on age, sex, diabetes status, current smoking status, educational attainment, and affection status, with parameters informed by external prevalence information. We assessed association between the posterior liability and a genome-wide set of single-nucleotide polymorphisms (SNPs), controlling for APOE and ABCA7, identified previously in a LOAD GWAS of AAs.
    Results: Two SNPs at novel loci, rs112404845 (P = 3.8 × 10
    Discussion: An informed conditioning approach can detect LOAD genetic associations in AAs not identified by traditional GWAS.
    MeSH term(s) ATP-Binding Cassette Transporters/genetics ; Black or African American/genetics ; Aged ; Aged, 80 and over ; Alzheimer Disease/ethnology ; Alzheimer Disease/genetics ; Apolipoproteins E/genetics ; Diabetes Complications/ethnology ; Diabetes Complications/genetics ; Educational Status ; Female ; Genetic Loci ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Male ; Microfilament Proteins/genetics ; Organic Anion Transporters, Sodium-Dependent/genetics ; Polymorphism, Single Nucleotide ; Prevalence ; Smoking/ethnology ; Smoking/genetics ; Symporters/genetics
    Chemical Substances ABCA7 protein, human ; ATP-Binding Cassette Transporters ; Apolipoproteins E ; Cobl protein, human ; Microfilament Proteins ; Organic Anion Transporters, Sodium-Dependent ; Symporters ; sodium-bile acid cotransporter (145420-23-1)
    Language English
    Publishing date 2016-10-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2211627-8
    ISSN 1552-5279 ; 1552-5260
    ISSN (online) 1552-5279
    ISSN 1552-5260
    DOI 10.1016/j.jalz.2016.09.002
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  6. Article: Assessing clinicopathological correlation in chronic traumatic encephalopathy: rationale and methods for the UNITE study.

    Mez, Jesse / Solomon, Todd M / Daneshvar, Daniel H / Murphy, Lauren / Kiernan, Patrick T / Montenigro, Philip H / Kriegel, Joshua / Abdolmohammadi, Bobak / Fry, Brian / Babcock, Katharine J / Adams, Jason W / Bourlas, Alexandra P / Papadopoulos, Zachary / McHale, Lisa / Ardaugh, Brent M / Martin, Brett R / Dixon, Diane / Nowinski, Christopher J / Chaisson, Christine /
    Alvarez, Victor E / Tripodis, Yorghos / Stein, Thor D / Goldstein, Lee E / Katz, Douglas I / Kowall, Neil W / Cantu, Robert C / Stern, Robert A / McKee, Ann C

    Alzheimer's research & therapy

    2015  Volume 7, Issue 1, Page(s) 62

    Abstract: Introduction: Chronic traumatic encephalopathy (CTE) is a progressive neurodegeneration associated with repetitive head impacts. Understanding Neurologic Injury and Traumatic Encephalopathy (UNITE) is a U01 project recently funded by the National ... ...

    Abstract Introduction: Chronic traumatic encephalopathy (CTE) is a progressive neurodegeneration associated with repetitive head impacts. Understanding Neurologic Injury and Traumatic Encephalopathy (UNITE) is a U01 project recently funded by the National Institute of Neurological Disorders and Stroke and the National Institute of Biomedical Imaging and Bioengineering. The goal of the UNITE project is to examine the neuropathology and clinical presentation of brain donors designated as "at risk" for the development of CTE based on prior athletic or military exposure. Here, we present the rationale and methodology for UNITE.
    Methods: Over the course of 4 years, we will analyze the brains and spinal cords of 300 deceased subjects who had a history of repetitive head impacts sustained during participation in contact sports at the professional or collegiate level or during military service. Clinical data are collected through medical record review and retrospective structured and unstructured family interviews conducted by a behavioral neurologist or neuropsychologist. Blinded to the clinical data, a neuropathologist conducts a comprehensive assessment for neurodegenerative disease, including CTE, using published criteria. At a clinicopathological conference, a panel of physicians and neuropsychologists, blinded to the neuropathological data, reaches a clinical consensus diagnosis using published criteria, including proposed clinical research criteria for CTE.
    Results: We will investigate the validity of these clinical criteria and sources of error by using recently validated neuropathological criteria as a gold standard for CTE diagnosis. We also will use statistical modeling to identify diagnostic features that best predict CTE pathology.
    Conclusions: The UNITE study is a novel and methodologically rigorous means of assessing clinicopathological correlation in CTE. Our findings will be critical for developing future iterations of CTE clinical diagnostic criteria.
    MeSH term(s) Athletes ; Athletic Injuries/complications ; Brain/pathology ; Brain Injury, Chronic/etiology ; Brain Injury, Chronic/pathology ; Brain Injury, Chronic/physiopathology ; Consensus ; Female ; Humans ; Immunohistochemistry ; Interviews as Topic ; Male ; Military Personnel ; Neurodegenerative Diseases/etiology ; Neurodegenerative Diseases/pathology ; Neurodegenerative Diseases/physiopathology ; Retrospective Studies ; Spinal Cord/pathology ; War-Related Injuries/complications
    Language English
    Publishing date 2015-10-12
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2506521-X
    ISSN 1758-9193
    ISSN 1758-9193
    DOI 10.1186/s13195-015-0148-8
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