Article ; Online: BAFFR controls early memory B cell responses but is dispensable for germinal center function.
The Journal of experimental medicine
2020 Volume 218, Issue 2
Abstract: The TNF superfamily ligand BAFF maintains the survival of naive B cells by signaling through its surface receptor, BAFFR. Activated B cells maintain expression of BAFFR after they differentiate into germinal center (GC) or memory B cells (MBCs). However, ...
Abstract | The TNF superfamily ligand BAFF maintains the survival of naive B cells by signaling through its surface receptor, BAFFR. Activated B cells maintain expression of BAFFR after they differentiate into germinal center (GC) or memory B cells (MBCs). However, the functions of BAFFR in these antigen-experienced B cell populations remain unclear. Here, we show that B cell-intrinsic BAFFR does not play a significant role in the survival or function of GC B cells or in the generation of the somatically mutated MBCs derived from them. Instead, BAFF/BAFFR signaling was required to generate the unmutated, GC-independent MBCs that differentiate directly from activated B cell blasts early in the response. Furthermore, amplification of BAFFR signaling in responding B cells did not affect GCs or the generation of GC-derived MBCs but greatly expanded the GC-independent MBC response. Although BAFF/BAFFR signaling specifically controlled the formation of the GC-independent MBC response, both types of MBCs required input from this pathway for optimal long-term survival. |
---|---|
MeSH term(s) | Animals ; B-Cell Activating Factor/immunology ; B-Cell Activating Factor/metabolism ; B-Cell Activation Factor Receptor/immunology ; B-Cell Activation Factor Receptor/metabolism ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; Germinal Center/immunology ; Germinal Center/metabolism ; Immunologic Memory/immunology ; Mice ; Mice, Inbred C57BL ; Signal Transduction/physiology |
Chemical Substances | B-Cell Activating Factor ; B-Cell Activation Factor Receptor ; Tnfrsf13c protein, mouse |
Language | English |
Publishing date | 2020-11-23 |
Publishing country | United States |
Document type | Journal Article ; Research Support, Non-U.S. Gov't |
ZDB-ID | 218343-2 |
ISSN | 1540-9538 ; 0022-1007 |
ISSN (online) | 1540-9538 |
ISSN | 0022-1007 |
DOI | 10.1084/jem.20191167 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
Ua VI Zs.107: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
|||
Zs.MG 45: Show issues |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.