Article ; Online: AKAP150-anchored PKA regulates synaptic transmission and plasticity, neuronal excitability and CRF neuromodulation in the mouse lateral habenula.
Communications biology
2024 Volume 7, Issue 1, Page(s) 345
Abstract: The scaffolding A-kinase anchoring protein 150 (AKAP150) is critically involved in kinase and phosphatase regulation of synaptic transmission/plasticity, and neuronal excitability. Emerging evidence also suggests that AKAP150 signaling may play a key ... ...
| Abstract | The scaffolding A-kinase anchoring protein 150 (AKAP150) is critically involved in kinase and phosphatase regulation of synaptic transmission/plasticity, and neuronal excitability. Emerging evidence also suggests that AKAP150 signaling may play a key role in brain's processing of rewarding/aversive experiences, however its role in the lateral habenula (LHb, as an important brain reward circuitry) is completely unknown. Using whole cell patch clamp recordings in LHb of male wildtype and ΔPKA knockin mice (with deficiency in AKAP-anchoring of PKA), here we show that the genetic disruption of PKA anchoring to AKAP150 significantly reduces AMPA receptor-mediated glutamatergic transmission and prevents the induction of presynaptic endocannabinoid-mediated long-term depression in LHb neurons. Moreover, ΔPKA mutation potentiates GABA |
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| MeSH term(s) | Animals ; Male ; Mice ; A Kinase Anchor Proteins/genetics ; A Kinase Anchor Proteins/metabolism ; Corticotropin-Releasing Hormone/metabolism ; Endocannabinoids ; Habenula/metabolism ; Neuronal Plasticity/physiology ; Neurons/physiology ; Receptors, AMPA/genetics ; Receptors, AMPA/metabolism ; Receptors, GABA-A/metabolism ; Synaptic Transmission/physiology |
| Chemical Substances | A Kinase Anchor Proteins ; Corticotropin-Releasing Hormone (9015-71-8) ; Endocannabinoids ; Receptors, AMPA ; Receptors, GABA-A ; Akap5 protein, mouse |
| Language | English |
| Publishing date | 2024-03-20 |
| Publishing country | England |
| Document type | Journal Article |
| ISSN | 2399-3642 |
| ISSN (online) | 2399-3642 |
| DOI | 10.1038/s42003-024-06041-8 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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